CN102725632A - 肺病的miRNA生物标志物 - Google Patents

肺病的miRNA生物标志物 Download PDF

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CN102725632A
CN102725632A CN201080048520XA CN201080048520A CN102725632A CN 102725632 A CN102725632 A CN 102725632A CN 201080048520X A CN201080048520X A CN 201080048520XA CN 201080048520 A CN201080048520 A CN 201080048520A CN 102725632 A CN102725632 A CN 102725632A
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mir
mirna
cancer
lung cancer
mirnas
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E.马姆博
D.布朗
A.T.阿达伊
T.桑福德
S.沃尔兹
A.乔达里
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Asuragen Inc
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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CN201080048520XA 2009-08-28 2010-08-27 肺病的miRNA生物标志物 Pending CN102725632A (zh)

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US23797209P 2009-08-28 2009-08-28
US61/237,972 2009-08-28
PCT/US2010/046916 WO2011025919A1 (en) 2009-08-28 2010-08-27 Mirna biomarkers of lung disease

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US (2) US8735074B2 (cg-RX-API-DMAC7.html)
EP (2) EP2775300A3 (cg-RX-API-DMAC7.html)
JP (1) JP5995721B2 (cg-RX-API-DMAC7.html)
CN (1) CN102725632A (cg-RX-API-DMAC7.html)
WO (1) WO2011025919A1 (cg-RX-API-DMAC7.html)

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103555724A (zh) * 2013-10-24 2014-02-05 浙江理工大学 2型糖尿病的血清miRNA生物标志物及其应用
CN103602678A (zh) * 2013-06-18 2014-02-26 潘世扬 非小细胞肺癌预后检测组合物及其应用
CN103751801A (zh) * 2013-09-10 2014-04-30 上海大学 非小细胞肺癌中miR-143基因的应用
CN104313142A (zh) * 2014-10-16 2015-01-28 上海交通大学医学院附属仁济医院 miRNA-30a作为标记分子在制备诊断试剂中的用途
CN104306993A (zh) * 2013-11-26 2015-01-28 上海中医药大学附属岳阳中西医结合医院 循环miR-505在高血压早期诊断及靶器官早期损伤预警作用中的应用
CN104784704A (zh) * 2015-05-01 2015-07-22 北京泱深生物信息技术有限公司 肺腺癌转移相关的组合物及其应用
CN105087794A (zh) * 2015-08-17 2015-11-25 广东省结核病控制中心 一种检测结核病的试剂盒
CN105561339A (zh) * 2015-12-21 2016-05-11 江苏省人民医院 一种miRNA的组合制备抗非小细胞肺癌药物中的应用
EP3026121A1 (en) * 2014-11-27 2016-06-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Micro-RNA-based diagnosis of tuberculosis
WO2016177343A1 (zh) * 2015-05-05 2016-11-10 江苏命码生物科技有限公司 一种新的前体miRNA及其在肿瘤治疗中的应用
CN106164290A (zh) * 2014-01-05 2016-11-23 拜奥米尔纳控股有限公司 使用mirna比率确定肺癌
WO2017101172A1 (zh) * 2015-12-15 2017-06-22 中国人民解放军第二军医大学 一种适用于后纵韧带骨化诊断的血清miRNA标志物及应用
CN107250378A (zh) * 2015-02-24 2017-10-13 株式会社遗传科技 癌的脑转移的诊断、预防及治疗方法、以及用于通过血脑屏障的药物传输系统
CN107841560A (zh) * 2017-10-27 2018-03-27 广东省实验动物监测所 一种非小细胞肺癌miRNA检测试剂盒及其应用
CN108220427A (zh) * 2018-03-20 2018-06-29 南京大学 一种用于鉴别诊断BHD综合征与原发性自发性气胸的血浆microRNA标记物及应用
WO2018170622A1 (zh) * 2017-03-18 2018-09-27 深圳市博奥康生物科技有限公司 一种同步下调微小rna-152和微小rna-185表达的方法
CN108753770A (zh) * 2018-06-01 2018-11-06 临沂大学 一种用于靶向肺癌治疗的基因纳米探针及其制备方法和应用
CN108743521A (zh) * 2018-06-01 2018-11-06 临沂大学 一种用于肺癌靶向治疗的rna纳米水凝胶及其制备方法和应用
CN108841962A (zh) * 2018-08-01 2018-11-20 博奥生物集团有限公司 一种非小细胞肺癌检测试剂盒及其应用
CN109036571A (zh) * 2014-12-08 2018-12-18 20/20基因系统股份有限公司 用于预测患有癌症的可能性或风险的方法和机器学习系统
CN113373216A (zh) * 2021-07-13 2021-09-10 南京迈迪森亚生物科技有限公司 一种同时定量检测血清中3种急性心肌梗死相关microRNA荧光探针的制备方法
CN114214422A (zh) * 2020-03-30 2022-03-22 中国医学科学院肿瘤医院 用于肺癌诊断的试剂盒、装置及方法
CN114525331A (zh) * 2021-11-23 2022-05-24 中山大学 一种快速识别重症肺炎的检测产品
CN114767865A (zh) * 2022-05-12 2022-07-22 中南大学湘雅医院 血浆外泌体对aaad伴肺损伤药物研制中应用
CN117248029A (zh) * 2023-11-17 2023-12-19 北京热景生物技术股份有限公司 一种基于外泌体miRNA的肝癌诊断标志物及其应用

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100035244A1 (en) 2005-04-14 2010-02-11 The Trustees Of Boston University Diagnostic for lung disorders using class prediction
AU2007223788B2 (en) 2006-03-09 2012-11-29 The Trustees Of Boston University Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells
WO2009039457A1 (en) 2007-09-19 2009-03-26 The Trustees Of Boston University Identification of novel pathways for drug development for lung disease
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
US20100240049A1 (en) 2009-01-16 2010-09-23 Cepheid Methods of Detecting Cervical Cancer
CN102459636B (zh) 2009-05-07 2016-08-17 威拉赛特公司 用于诊断甲状腺病症的方法和组合物
EP2505663A1 (en) 2011-03-30 2012-10-03 IFOM Fondazione Istituto Firc di Oncologia Molecolare A method to identify asymptomatic high-risk individuals with early stage lung cancer by means of detecting miRNAs in biologic fluids
WO2012103355A2 (en) 2011-01-26 2012-08-02 Cepheid Methods of detecting lung cancer
JP6021893B2 (ja) 2011-04-18 2016-11-09 ディアミール, エルエルシーDiamir, Llc 軽度認知機能障害（ＭＣＩ）およびアルツハイマー病（ＡＤ）の早期検出ならびにモニタリングのために体液からのｍｉＲＮＡを使用する方法
EE201100037A (et) 2011-05-16 2012-12-17 Tartu Ülikool MikroRNAde kasutamine biomarkeritena ja sihtm„rkidena raku proliferatiivsete omaduste m?jutamiseks ja meetod ning komplekt nende ekspressioonitaseme tuvastamiseks
CN102851283B (zh) * 2011-06-30 2014-07-30 上海市肿瘤研究所 用于区分转移与非转移肺鳞癌的microRNA标志物
CN102851282B (zh) * 2011-06-30 2014-10-08 上海市肿瘤研究所 用于区分原发性肺癌与癌旁组织的microRNA标志物
CA2844197A1 (en) 2011-08-03 2013-02-07 The Charlotte-Mecklenburg Hospital Authority D/B/A Carolina Healthcare System Treatment of fibrosis using microrna-19b
US20130040303A1 (en) * 2011-08-08 2013-02-14 Eugenia Wang Biomarker for Alzheimer's Disease and/or Mild Cognitive Impairment, and Use Thereof
EP2751292A4 (en) * 2011-09-01 2015-05-20 Allegro Diagnostics Corp METHOD AND COMPOSITIONS FOR DETECTING CANCER BASED ON MIRNA EXPRESSION PROFILES
US9745578B2 (en) 2011-11-30 2017-08-29 Cedars-Sinai Medical Center Targeting microRNA miR-409-3P to treat prostate cancer
CA2799163C (en) 2011-12-18 2025-01-07 20/20 Genesystems, Inc. METHODS AND ALGORITHMS TO AID IN CANCER DETECTION
EP2800820B1 (en) 2011-12-19 2020-04-08 Valley Health System Methods and kits for detecting subjects having pancreatic cancer
CN102533983A (zh) * 2011-12-19 2012-07-04 苏州福英基因科技有限公司 癌症病理演变前期microrna-330水平原位杂交检测试剂盒及检测方法和应用
JP2015512249A (ja) 2012-03-19 2015-04-27 プレスティズィアＰｒｅｓｔｉｚｉａ 循環から採取される身体試料中のウイルス、特に、ｈｉｖの親和性及び受容体使用の決定方法
CN102743765A (zh) * 2012-05-24 2012-10-24 上海大学 非小细胞肺癌中miR-10a基因的应用
WO2014186036A1 (en) 2013-03-14 2014-11-20 Allegro Diagnostics Corp. Methods for evaluating copd status
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
ES2813699T3 (es) 2013-11-18 2021-03-24 Diamir Llc Métodos de uso de miARN de fluidos corporales para la detección y monitoreo de la enfermedad de Parkinson (PD)
WO2015156964A1 (en) * 2014-03-16 2015-10-15 H. Lee Moffitt Cancer Center And Research Institute, Inc. Microrna signature for predicting progression of barrett's esophagus
CN103937826B (zh) * 2014-04-04 2016-04-06 东华大学 一种中枢神经系统中特异表达miR-505的载体的制备方法
FR3019901B1 (fr) * 2014-04-09 2020-10-30 Bio Rad Innovations Marqueur de controle pour la mise en oeuvre de procedes d'analyse sur spots
EP3967769A3 (en) 2014-06-18 2022-06-15 Toray Industries, Inc. Lung cancer detection kit or device, and detection method
US12297505B2 (en) 2014-07-14 2025-05-13 Veracyte, Inc. Algorithms for disease diagnostics
US20160108405A1 (en) * 2014-10-17 2016-04-21 Biomirna Holdings Ltd Lung cancer diagnostics and therapeutics with mir-660
JP7356788B2 (ja) 2014-11-05 2023-10-05 ベラサイト インコーポレイテッド 機械学習および高次元転写データを使用して経気管支生検における特発性肺線維症を診断するシステムおよび方法
WO2016071729A1 (en) * 2014-11-05 2016-05-12 Biomirna Holdings, Ltd. Methods of using micro-rna biomarkers for haemolysis detection
CN105457041B (zh) * 2015-12-09 2020-09-08 上海大学 miR-26a在非小细胞肺癌中的应用
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
WO2017165458A1 (en) 2016-03-21 2017-09-28 Diamir, Llc Methods of using mirnas from bodily fluids for detection and differentiation of neurodegenerative diseases
ES2646826B1 (es) * 2016-05-13 2018-10-01 Servicio Andaluz De Salud MicroARNs como biomarcadores para el diagnóstico del cáncer de pulmón
WO2018009915A1 (en) 2016-07-08 2018-01-11 Trustees Of Boston University Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions
WO2018187624A1 (en) 2017-04-06 2018-10-11 The United States Government As Represented By The Department Of Veterans Affairs Methods of detecting lung cancer
WO2018220089A1 (en) 2017-05-31 2018-12-06 Koninklijke Philips N.V. Machine learning on raw medical imaging data for clinical decision support
US11505830B2 (en) * 2017-05-31 2022-11-22 Roche Molecular Systems, Inc. Multiplex PCR detection of ALK, RET, and ROS fusions
KR20250006333A (ko) 2017-06-29 2025-01-10 도레이 카부시키가이샤 폐암의 검출을 위한 키트, 디바이스 및 방법
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
KR102190910B1 (ko) * 2019-05-24 2020-12-15 한국과학기술연구원 miR-195 또는 miR-497를 활용한 폐암 치료제의 스크리닝 방법
EP4022094A4 (en) * 2019-08-26 2022-11-30 Liquid Lung DX BIOMARKERS FOR DIAGNOSIS OF LUNG CANCER
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
JP7392224B2 (ja) * 2020-02-19 2023-12-06 国立医薬品食品衛生研究所長 びまん性肺胞傷害型薬剤性間質性肺炎のｍｉＲＮＡ診断バイオマーカー
US20240301504A1 (en) * 2021-06-22 2024-09-12 The Curators Of The University Of Missouri Multianalyte biomarkers for lung cancer
CN117106919B (zh) * 2023-10-25 2024-01-23 上海秤信生物科技有限公司 外泌体miRNA组合在早期肺癌检测中的应用

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713619B1 (en) * 1980-08-29 2004-03-30 Massachusetts Institute Of Technology Oncogenes and methods for their detection
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
EP0515506B1 (en) 1990-02-16 2000-01-05 F. Hoffmann-La Roche Ag Improvements in the specificity and convenience of the polymerase chain reaction
US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
US5965364A (en) 1990-10-09 1999-10-12 Benner; Steven Albert Method for selecting functional deoxyribonucleotide derivatives
US5413924A (en) 1992-02-13 1995-05-09 Kosak; Kenneth M. Preparation of wax beads containing a reagent for release by heating
US5767259A (en) 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
CA2168712A1 (en) 1995-02-07 1996-08-08 John William Henderson Sutherland Use of exonuclease and/or glycosylase as supplements to anti-polymerase antibody to increase specificity in polymerase chain reaction
PT938320E (pt) 1996-03-26 2010-09-22 Michael S Kopreski Método que permite a utilização de arn extracelular extraído de plasma ou de soro para detectar, monitorizar ou avaliar o cancro
US6020481A (en) 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
EP0892808B1 (en) 1996-04-12 2008-05-14 PHRI Properties, Inc. Detection probes, kits and assays
US5847162A (en) 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
US5863727A (en) 1996-05-03 1999-01-26 The Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US5945526A (en) 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US5800996A (en) 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
SE506700C2 (sv) 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US6008379A (en) 1997-10-01 1999-12-28 The Perkin-Elmer Corporation Aromatic-substituted xanthene dyes
US6355421B1 (en) 1997-10-27 2002-03-12 Boston Probes, Inc. Methods, kits and compositions pertaining to PNA molecular beacons
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
US5936087A (en) 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US20060204989A1 (en) * 1998-09-22 2006-09-14 Kopreski Michael S Comparative analysis of extracellular RNA species
US6140054A (en) 1998-09-30 2000-10-31 University Of Utah Research Foundation Multiplex genotyping using fluorescent hybridization probes
US6383752B1 (en) 1999-03-31 2002-05-07 Hybridon, Inc. Pseudo-cyclic oligonucleobases
US6117981A (en) * 1999-06-03 2000-09-12 Cytoclonal Pharmaceutics, Inc. Hybridomas for lung cancer marker and monoclonal antibodies thereof
US6140500A (en) 1999-09-03 2000-10-31 Pe Corporation Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use
US6528254B1 (en) 1999-10-29 2003-03-04 Stratagene Methods for detection of a target nucleic acid sequence
US6191278B1 (en) 1999-11-03 2001-02-20 Pe Corporation Water-soluble rhodamine dyes and conjugates thereof
US6596490B2 (en) 2000-07-14 2003-07-22 Applied Gene Technologies, Inc. Nucleic acid hairpin probes and uses thereof
US6350580B1 (en) 2000-10-11 2002-02-26 Stratagene Methods for detection of a target nucleic acid using a probe comprising secondary structure
US6403341B1 (en) 2001-08-02 2002-06-11 Wayne M. Barnes Magnesium precipitate hot start method for PCR
WO2003020739A2 (en) 2001-09-04 2003-03-13 Exiqon A/S Novel lna compositions and uses thereof
US6593091B2 (en) 2001-09-24 2003-07-15 Beckman Coulter, Inc. Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer
EP1713938A2 (en) * 2004-02-09 2006-10-25 Thomas Jefferson University DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES
EP1771563A2 (en) * 2004-05-28 2007-04-11 Ambion, Inc. METHODS AND COMPOSITIONS INVOLVING MicroRNA
US20090186353A1 (en) * 2004-10-04 2009-07-23 Rosetta Genomics Ltd. Cancer-related nucleic acids
US20060078894A1 (en) 2004-10-12 2006-04-13 Winkler Matthew M Methods and compositions for analyzing nucleic acids
EP2514433B1 (en) * 2006-01-05 2015-10-21 The Ohio State University Research Foundation MicroRNA-based methods for the diagnosis, prognosis and treatment of lung cancer
WO2007081196A1 (en) * 2006-01-10 2007-07-19 Koninklijke Nederlandse Akademie Van Wetenschappen New nucleic acid molecules and collections thereof, their application and identification
US7955848B2 (en) * 2006-04-03 2011-06-07 Trustees Of Dartmouth College MicroRNA biomarkers for human breast and lung cancer
EP2115138A2 (en) * 2006-09-19 2009-11-11 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
WO2008147974A1 (en) * 2007-05-23 2008-12-04 University Of South Florida Micro-rnas modulating immunity and inflammation
EP2613149B1 (en) * 2007-07-25 2014-09-17 University Of Louisville Research Foundation, Inc. Exosome-associated microRNA as a diagnostic marker
US7993831B2 (en) * 2007-09-14 2011-08-09 Asuragen, Inc. Methods of normalization in microRNA detection assays
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
CN101424640B (zh) 2007-11-02 2012-07-25 江苏命码生物科技有限公司 血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法
CA2705486C (en) * 2007-11-19 2019-04-02 Celera Corporation Lung cancer markers and uses thereof
CN101918594A (zh) * 2007-11-30 2010-12-15 俄亥俄州立大学研究基金会 肺癌中外周血中的微rna表达特征谱和靶向
WO2010004562A2 (en) 2008-07-09 2010-01-14 Rosetta Genomics Ltd. Methods and compositions for detecting colorectal cancer

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US10533173B2 (en) 2015-05-05 2020-01-14 Jiangsu Micromedmark Biotech Co., Ltd. Precursor miRNA and applications in tumor therapy thereof
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