CN102596958A - 用于抗病毒治疗的2’-氟代carba-核苷类似物 - Google Patents
用于抗病毒治疗的2’-氟代carba-核苷类似物 Download PDFInfo
- Publication number
- CN102596958A CN102596958A CN201080041902XA CN201080041902A CN102596958A CN 102596958 A CN102596958 A CN 102596958A CN 201080041902X A CN201080041902X A CN 201080041902XA CN 201080041902 A CN201080041902 A CN 201080041902A CN 102596958 A CN102596958 A CN 102596958A
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- 0 CP(*#C)(N=C=C)=* Chemical compound CP(*#C)(N=C=C)=* 0.000 description 16
- IHKOXYNAMXNNDK-OLQVQODUSA-N C(CO1)[C@H]2[C@@H]1OCC2 Chemical compound C(CO1)[C@H]2[C@@H]1OCC2 IHKOXYNAMXNNDK-OLQVQODUSA-N 0.000 description 1
- DXMJGMVMMDPPLH-RRJANDQUSA-N CC(C)OC([C@H](C)NP(OC(C1)C11O[C@]2(c3ccc4[n]3ncnc4N)C#N)(O[C@H]1[C@@]2(C)F)=O)=O Chemical compound CC(C)OC([C@H](C)NP(OC(C1)C11O[C@]2(c3ccc4[n]3ncnc4N)C#N)(O[C@H]1[C@@]2(C)F)=O)=O DXMJGMVMMDPPLH-RRJANDQUSA-N 0.000 description 1
- IBALGJQRTAVNRW-JPDPYMSYSA-N CC(C)OC([C@H](C)NP(OC[C@H]([C@H]([C@@]1(C)F)O)O[C@]1(c1ccc2[n]1ncnc2N)C#N)(Oc(cc1)ccc1Cl)=O)=O Chemical compound CC(C)OC([C@H](C)NP(OC[C@H]([C@H]([C@@]1(C)F)O)O[C@]1(c1ccc2[n]1ncnc2N)C#N)(Oc(cc1)ccc1Cl)=O)=O IBALGJQRTAVNRW-JPDPYMSYSA-N 0.000 description 1
- NOEUPJXIXBXMJN-UHFFFAOYSA-N CCCCCCC[O](CCC(CC)CN)(C=N)=O Chemical compound CCCCCCC[O](CCC(CC)CN)(C=N)=O NOEUPJXIXBXMJN-UHFFFAOYSA-N 0.000 description 1
- PBZHOTHYDFDYRN-WWFMAZNKSA-N C[C@@H]1[C@@](c2ccc3[n]2ncnc3N)(C#N)O[C@H](COP(NCCc2c[nH]c3ccccc23)(O)=O)[C@H]1O Chemical compound C[C@@H]1[C@@](c2ccc3[n]2ncnc3N)(C#N)O[C@H](COP(NCCc2c[nH]c3ccccc23)(O)=O)[C@H]1O PBZHOTHYDFDYRN-WWFMAZNKSA-N 0.000 description 1
- JJMRWZGUOHWNNW-HZLHGAJGSA-N C[C@@]1([C@H](c2cnc(c(N)n3)[n]2nc3SC)O[C@H](CO)[C@H]1O)F Chemical compound C[C@@]1([C@H](c2cnc(c(N)n3)[n]2nc3SC)O[C@H](CO)[C@H]1O)F JJMRWZGUOHWNNW-HZLHGAJGSA-N 0.000 description 1
- BNWKIMUJGYHAIU-UHFFFAOYSA-N Cc(cc1)ccc1NCC(N(C)C)=O Chemical compound Cc(cc1)ccc1NCC(N(C)C)=O BNWKIMUJGYHAIU-UHFFFAOYSA-N 0.000 description 1
- JIPPLQKITODFEO-UHFFFAOYSA-N Cc(cc1)ccc1NCC(N)=O Chemical compound Cc(cc1)ccc1NCC(N)=O JIPPLQKITODFEO-UHFFFAOYSA-N 0.000 description 1
- JFJODJVMRSQHPG-UHFFFAOYSA-N Cc(cc1)ccc1OCC(N)=O Chemical compound Cc(cc1)ccc1OCC(N)=O JFJODJVMRSQHPG-UHFFFAOYSA-N 0.000 description 1
- ZUSCIMZVMLVQAT-UHFFFAOYSA-N Cc(cc1)ccc1OCCC(N)=O Chemical compound Cc(cc1)ccc1OCCC(N)=O ZUSCIMZVMLVQAT-UHFFFAOYSA-N 0.000 description 1
- QMCZTSMEXWHJQR-UHFFFAOYSA-N Cc(cc1)ccc1OCCNC(N)=O Chemical compound Cc(cc1)ccc1OCCNC(N)=O QMCZTSMEXWHJQR-UHFFFAOYSA-N 0.000 description 1
- WWGKAIVKCGQLSR-UHFFFAOYSA-N Cc(cc1)ccc1OCCOC(N)=O Chemical compound Cc(cc1)ccc1OCCOC(N)=O WWGKAIVKCGQLSR-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
- G03C7/00—Multicolour photographic processes or agents therefor; Regeneration of such processing agents; Photosensitive materials for multicolour processes
- G03C7/30—Colour processes using colour-coupling substances; Materials therefor; Preparing or processing such materials
- G03C7/32—Colour coupling substances
- G03C7/36—Couplers containing compounds with active methylene groups
- G03C7/38—Couplers containing compounds with active methylene groups in rings
- G03C7/381—Heterocyclic compounds
- G03C7/382—Heterocyclic compounds with two heterocyclic rings
- G03C7/3825—Heterocyclic compounds with two heterocyclic rings the nuclei containing only nitrogen as hetero atoms
- G03C7/3835—Heterocyclic compounds with two heterocyclic rings the nuclei containing only nitrogen as hetero atoms four nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24429709P | 2009-09-21 | 2009-09-21 | |
| US61/244,297 | 2009-09-21 | ||
| PCT/US2010/049471 WO2011035231A1 (en) | 2009-09-21 | 2010-09-20 | 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102596958A true CN102596958A (zh) | 2012-07-18 |
Family
ID=43031517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080041902XA Pending CN102596958A (zh) | 2009-09-21 | 2010-09-20 | 用于抗病毒治疗的2’-氟代carba-核苷类似物 |
Country Status (32)
| Country | Link |
|---|---|
| EP (2) | EP3150608B1 (OSRAM) |
| JP (3) | JP5795766B2 (OSRAM) |
| KR (2) | KR101818779B1 (OSRAM) |
| CN (1) | CN102596958A (OSRAM) |
| AP (1) | AP2012006189A0 (OSRAM) |
| AU (4) | AU2010295373B2 (OSRAM) |
| BR (3) | BR122021012877B8 (OSRAM) |
| CA (1) | CA2773772C (OSRAM) |
| CL (1) | CL2012000707A1 (OSRAM) |
| CR (2) | CR20190103A (OSRAM) |
| CY (1) | CY1118605T1 (OSRAM) |
| DK (1) | DK2480552T3 (OSRAM) |
| EA (1) | EA201200525A1 (OSRAM) |
| EC (1) | ECSP12011817A (OSRAM) |
| ES (2) | ES2730805T3 (OSRAM) |
| HR (1) | HRP20170197T1 (OSRAM) |
| HU (1) | HUE032252T2 (OSRAM) |
| IL (2) | IL218599A (OSRAM) |
| LT (1) | LT2480552T (OSRAM) |
| ME (1) | ME02656B (OSRAM) |
| MX (1) | MX352646B (OSRAM) |
| NZ (1) | NZ599402A (OSRAM) |
| PE (3) | PE20210668A1 (OSRAM) |
| PL (1) | PL2480552T3 (OSRAM) |
| PT (1) | PT2480552T (OSRAM) |
| RS (1) | RS55699B1 (OSRAM) |
| SG (1) | SG179194A1 (OSRAM) |
| SI (1) | SI2480552T1 (OSRAM) |
| SM (2) | SMT201700091T1 (OSRAM) |
| UA (1) | UA110466C2 (OSRAM) |
| WO (1) | WO2011035231A1 (OSRAM) |
| ZA (1) | ZA201202175B (OSRAM) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103108876A (zh) * | 2010-09-20 | 2013-05-15 | 吉里德科学公司 | 用于抗病毒治疗的2’-氟取代的carba-核苷类似物 |
| WO2014059902A1 (en) * | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | 2'-disubstituted substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases |
| WO2014059901A1 (en) * | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | 2'-cyano substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases |
| CN104945437A (zh) * | 2015-05-19 | 2015-09-30 | 广州诺威生物技术有限公司 | 一种嘧啶类新化合物 |
| CN106083962A (zh) * | 2016-06-08 | 2016-11-09 | 成都倍特药业有限公司 | 一种具有环磷酰胺结构的化合物及其制备方法 |
| CN113454086A (zh) * | 2019-02-07 | 2021-09-28 | 百济神州有限公司 | 作为tlr7激动剂的咪唑并[2,1-f][1,2,4]三嗪-4-胺衍生物 |
| TWI740910B (zh) * | 2016-03-09 | 2021-10-01 | 美商艾洛斯生物製藥公司 | 非環抗病毒劑 |
| CN117396490A (zh) * | 2021-05-14 | 2024-01-12 | Bm医药咨询有限公司 | 用于预防和治疗病毒感染的双环杂环化合物 |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3237884B2 (ja) | 1991-12-27 | 2001-12-10 | 株式会社コーセー | 美爪料 |
| HRP20130048T1 (hr) | 2008-04-23 | 2013-02-28 | Gilead Sciences, Inc. | Karba-nukleozidni analozi za antivirusnu terapiju |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| JP6104504B2 (ja) | 2008-12-23 | 2017-03-29 | ギリアド ファーマセット エルエルシー | ヌクレオシド類似体 |
| TW201026715A (en) | 2008-12-23 | 2010-07-16 | Pharmasset Inc | Nucleoside phosphoramidates |
| CL2009002206A1 (es) | 2008-12-23 | 2011-08-26 | Gilead Pharmasset Llc | Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales. |
| TWI583692B (zh) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| AU2010295373B2 (en) * | 2009-09-21 | 2016-09-29 | Gilead Sciences, Inc. | 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment |
| US8455451B2 (en) | 2009-09-21 | 2013-06-04 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| US7973013B2 (en) * | 2009-09-21 | 2011-07-05 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| WO2011035250A1 (en) | 2009-09-21 | 2011-03-24 | Gilead Sciences, Inc. | Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs |
| CL2011000716A1 (es) * | 2010-03-31 | 2012-04-20 | Gilead Pharmasset Llc | Formas cristalinas 1 6 de (s)-isopropil-2-(((s)-(((2r.3r.4r.5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1(2h)-il)-4-fluoro-3-hidroxi-4-metil tetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato; composicion y combinacion farmaceutica; y su uso para tratar una infeccion por el virus de la hepatitis c. |
| TW201201815A (en) * | 2010-05-28 | 2012-01-16 | Gilead Sciences Inc | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
| EA025311B1 (ru) | 2010-07-19 | 2016-12-30 | Гайлид Сайэнсиз, Инк. | Способы получения диастереомерно чистых фосфорамидатных пролекарств |
| ES2524356T3 (es) | 2010-07-22 | 2014-12-05 | Gilead Sciences, Inc. | Métodos y compuestos para tratar infecciones provocadas por virus Paramyxoviridae |
| TW201305185A (zh) * | 2010-09-13 | 2013-02-01 | 吉李德科學股份有限公司 | 用於抗病毒治療之２’－氟取代之碳－核苷類似物 |
| TWI556840B (zh) | 2010-11-19 | 2016-11-11 | 吉李德科學股份有限公司 | 治療用組成物 |
| AU2011349844B2 (en) | 2010-12-20 | 2017-06-01 | Gilead Sciences, Inc. | Combinations for treating HCV |
| AR088441A1 (es) | 2011-09-12 | 2014-06-11 | Idenix Pharmaceuticals Inc | Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales |
| SI2709613T2 (sl) | 2011-09-16 | 2020-12-31 | Gilead Pharmasset LLC c/o Gilead Sciences, Inc. | Postopki za zdravljenje HCV |
| TW201331221A (zh) | 2011-10-14 | 2013-08-01 | Idenix Pharmaceuticals Inc | 嘌呤核苷酸化合物類之經取代的３’，５’－環磷酸酯及用於治療病毒感染之醫藥組成物 |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| KR102068856B1 (ko) * | 2012-03-13 | 2020-01-21 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 치료를 위한 2'-치환된 카바-뉴클레오시드 유사체 |
| AR092959A1 (es) | 2012-10-17 | 2015-05-06 | Merck Sharp & Dohme | Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
| WO2014078463A1 (en) | 2012-11-19 | 2014-05-22 | Merck Sharp & Dohme Corp. | 2 -alkynyl substituted nucleoside derivatives for treating viral diseases |
| NZ729172A (en) | 2013-01-31 | 2018-06-29 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
| US9765107B2 (en) | 2013-06-18 | 2017-09-19 | Merck Sharp & Dohme Corp. | Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| UA119050C2 (uk) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| EP3083654A1 (en) * | 2013-12-18 | 2016-10-26 | Idenix Pharmaceuticals LLC | 4'-or nucleosides for the treatment of hcv |
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