CN1025786C - 氨基甲酰基衍生物的制备方法 - Google Patents

氨基甲酰基衍生物的制备方法 Download PDF

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Publication number
CN1025786C
CN1025786C CN90110406A CN90110406A CN1025786C CN 1025786 C CN1025786 C CN 1025786C CN 90110406 A CN90110406 A CN 90110406A CN 90110406 A CN90110406 A CN 90110406A CN 1025786 C CN1025786 C CN 1025786C
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CN
China
Prior art keywords
methyl
formula
acid
compound
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN90110406A
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English (en)
Chinese (zh)
Other versions
CN1053604A (zh
Inventor
罗伯特·汤姆斯·雅各布斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Syngenta Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of CN1053604A publication Critical patent/CN1053604A/zh
Application granted granted Critical
Publication of CN1025786C publication Critical patent/CN1025786C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN90110406A 1989-12-11 1990-12-11 氨基甲酰基衍生物的制备方法 Expired - Lifetime CN1025786C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898927981A GB8927981D0 (en) 1989-12-11 1989-12-11 Carbamoyl derivative
GB8927981.4 1989-12-11

Publications (2)

Publication Number Publication Date
CN1053604A CN1053604A (zh) 1991-08-07
CN1025786C true CN1025786C (zh) 1994-08-31

Family

ID=10667774

Family Applications (1)

Application Number Title Priority Date Filing Date
CN90110406A Expired - Lifetime CN1025786C (zh) 1989-12-11 1990-12-11 氨基甲酰基衍生物的制备方法

Country Status (32)

Country Link
EP (1) EP0432984B1 (enExample)
JP (1) JPH0822849B2 (enExample)
KR (1) KR100192999B1 (enExample)
CN (1) CN1025786C (enExample)
AP (1) AP192A (enExample)
AT (1) ATE163641T1 (enExample)
AU (1) AU642182B2 (enExample)
BG (2) BG60015B2 (enExample)
CA (1) CA2031897C (enExample)
CZ (1) CZ614690A3 (enExample)
DE (1) DE69032083T2 (enExample)
DK (1) DK0432984T3 (enExample)
ES (1) ES2112832T3 (enExample)
FI (1) FI95029C (enExample)
GB (2) GB8927981D0 (enExample)
GR (1) GR3026279T3 (enExample)
HK (1) HK1003830A1 (enExample)
HR (1) HRP930326B1 (enExample)
HU (2) HU210441B (enExample)
IE (1) IE904448A1 (enExample)
IL (1) IL96621A (enExample)
MY (1) MY106363A (enExample)
NO (1) NO174198C (enExample)
PL (2) PL166516B1 (enExample)
PT (1) PT96154B (enExample)
RO (1) RO108562B1 (enExample)
RU (1) RU2002740C1 (enExample)
SI (1) SI9012330A (enExample)
SK (1) SK614690A3 (enExample)
TW (1) TW219329B (enExample)
YU (1) YU48218B (enExample)
ZA (1) ZA909898B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE113581T1 (de) * 1990-05-04 1994-11-15 Ciba Geigy Ag Substituierte indole.
GB9020338D0 (en) * 1990-09-18 1990-10-31 Lilly Industries Ltd Pharmaceutical compounds
GB9026425D0 (en) * 1990-12-05 1991-01-23 Ici Plc Process
GB9026427D0 (en) * 1990-12-05 1991-01-23 Ici Plc Chemical process
GB9119001D0 (en) * 1991-09-05 1991-10-23 Ici Plc Pharmaceutical agents
ES2050611B1 (es) * 1992-10-08 1994-12-16 Ici Plc Una nueva forma fisica de un derivado de carbamoilindol con propiedades antagonistas de leucotrienos.
GR1001368B (el) * 1992-10-08 1993-10-29 Ici Plc Φαρμακευτικοί φορείς.
KR970706287A (ko) * 1994-09-16 1997-11-03 다께다 구니오 트리아졸로피리다진의 제조 방법, 그의 제조를 위한 중간체 및 약제로서의 그의 용도(triazolopyridazines process and intermediates for their preparation and their use as medicaments)
US7166638B2 (en) * 2003-05-27 2007-01-23 Nicox S.A. Statin derivatives
EP1812388B1 (en) * 2004-10-12 2011-02-23 Decode Genetics, Ehf Sulfonamide peri-substituted bicyclics for occlusive artery disease
CA2599348C (en) * 2005-02-25 2013-07-23 Ono Pharmaceutical Co., Ltd. Indole compound and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524152A (en) * 1982-12-30 1985-06-18 Pennwalt Corporation 1-Cyano-3-(fluoroalkyl)guanidines for lowering blood pressure
JPH07107047B2 (ja) * 1985-10-17 1995-11-15 アイ・シ−・アイ・アメリカス・インコ−ポレイテツド 新規ヘテロ環式化合物及びその製法
GB8623429D0 (en) * 1985-10-17 1986-11-05 Ici America Inc Carboximide derivatives
MY103259A (en) * 1987-04-15 1993-05-29 Ici America Inc Aliphatic carboxamides
GB8906032D0 (en) * 1988-04-14 1989-04-26 Ici America Inc Hetera-aliphatic carboxamides
GB9026425D0 (en) * 1990-12-05 1991-01-23 Ici Plc Process

Also Published As

Publication number Publication date
EP0432984A2 (en) 1991-06-19
GB8927981D0 (en) 1990-02-14
IL96621A (en) 1994-11-28
AP9000230A0 (en) 1991-01-31
GB9026797D0 (en) 1991-01-30
KR100192999B1 (ko) 1999-06-15
GB2238790A (en) 1991-06-12
FI906084L (fi) 1991-06-12
CZ282068B6 (cs) 1997-05-14
ES2112832T3 (es) 1998-04-16
DK0432984T3 (da) 1998-11-30
HUT56345A (en) 1991-08-28
JPH0770061A (ja) 1995-03-14
NO174198C (no) 1994-04-06
SI9012330A (en) 1997-12-31
MY106363A (en) 1995-05-30
AU6791790A (en) 1991-06-13
CA2031897C (en) 2001-12-18
GR3026279T3 (en) 1998-06-30
PT96154A (pt) 1991-09-30
EP0432984B1 (en) 1998-03-04
FI95029C (fi) 1995-12-11
EP0432984A3 (en) 1992-04-22
KR910011780A (ko) 1991-08-07
YU233090A (sh) 1993-05-28
PL288184A1 (en) 1992-04-21
NO174198B (no) 1993-12-20
ZA909898B (en) 1991-08-28
IL96621A0 (en) 1991-09-16
PL167449B1 (pl) 1995-09-30
ATE163641T1 (de) 1998-03-15
RO108562B1 (ro) 1994-06-30
PL166516B1 (pl) 1995-05-31
BG60015B2 (bg) 1993-06-30
CA2031897A1 (en) 1991-06-12
GB2238790B (en) 1993-06-30
HU210877A9 (en) 1995-09-28
TW219329B (enExample) 1994-01-21
BG50606A3 (bg) 1992-09-15
PT96154B (pt) 1998-05-29
JPH0822849B2 (ja) 1996-03-06
RU2002740C1 (ru) 1993-11-15
HK1003830A1 (en) 1998-11-06
DE69032083T2 (de) 1998-07-16
SK278528B6 (en) 1997-08-06
NO905327D0 (no) 1990-12-10
DE69032083D1 (de) 1998-04-09
YU48218B (sh) 1997-08-22
HU908137D0 (en) 1991-06-28
AP192A (en) 1992-06-30
HRP930326B1 (en) 1998-12-31
CN1053604A (zh) 1991-08-07
SK614690A3 (en) 1997-08-06
HU210441B (en) 1995-04-28
IE904448A1 (en) 1991-06-19
FI95029B (fi) 1995-08-31
AU642182B2 (en) 1993-10-14
HRP930326A2 (en) 1996-06-30
NO905327L (no) 1991-06-12
FI906084A0 (fi) 1990-12-11
CZ614690A3 (en) 1997-05-14

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Applicant after: ZENECA Ltd.

Applicant before: Imperial Chemical Industries PLC

CB04 Change of attorney information

Agency after: Patent and Trademark Office of China Council For The Promotion Of International Trade

Agency before: China Patent Agent (H.K.) Ltd.

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: IMPERIAL CHEMICAL CORPORATION TO: ZENECA CO., LTD.; AGENCY; FROM: CHINA PATENT AGENT(XIANG GANG)LTD. TO: CCPIT PATENT + TRADEMARK LAW OFFICE

C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Applicant after: ZENECA Ltd.

Applicant before: Imperial Chemical Industries PLC

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: IMPERIAL CHEMICAL CORPORATION TO: ZENECA LTD

CI01 Publication of corrected invention patent application

Correction item: Patentee

Correct: Zeneca Limited

False: Zeneca Limited

Number: 36

Page: 132

Volume: 10

ERR Gazette correction

Free format text: CORRECT: PATENTEE; FROM: ZENECA CO., LTD. TO: ZENECA LTD

C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
ASS Succession or assignment of patent right

Owner name: ASTRAZENECA (UK) LIMITED

Free format text: FORMER OWNER: SIGENTIS CO., LTD.

Effective date: 20061229

C41 Transfer of patent application or patent right or utility model
C56 Change in the name or address of the patentee

Owner name: SIGENTIS CO., LTD.

Free format text: FORMER NAME OR ADDRESS: ZENECA LTD

CP03 Change of name, title or address

Address after: surrey

Patentee after: SYNGENTA LTD.

Address before: England

Patentee before: ZENECA Ltd.

TR01 Transfer of patent right

Effective date of registration: 20061229

Address after: London, England

Patentee after: ASTRAZENECA UK LTD.

Address before: surrey

Patentee before: SYNGENTA LTD.

C17 Cessation of patent right
CX01 Expiry of patent term

Expiration termination date: 20101211

Granted publication date: 19940831