BG50606A3 - Method for the preparation of 3- methoxy- 4- /1- methyl- 5-/ 2- methyl- 4, 4, 4- trifluorobutylcarbamoil/indol- 3- il- methyl/n- /2- methylphenylsulfonyl/benzamide - Google Patents

Method for the preparation of 3- methoxy- 4- /1- methyl- 5-/ 2- methyl- 4, 4, 4- trifluorobutylcarbamoil/indol- 3- il- methyl/n- /2- methylphenylsulfonyl/benzamide

Info

Publication number
BG50606A3
BG50606A3 BG095502A BG9550290A BG50606A3 BG 50606 A3 BG50606 A3 BG 50606A3 BG 095502 A BG095502 A BG 095502A BG 9550290 A BG9550290 A BG 9550290A BG 50606 A3 BG50606 A3 BG 50606A3
Authority
BG
Bulgaria
Prior art keywords
methyl
benzamide
trifluorobutylcarbamoil
methylphenylsulfonyl
indol
Prior art date
Application number
BG095502A
Other languages
Bulgarian (bg)
English (en)
Inventor
Robert Jacobs
Original Assignee
Astra - Zeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra - Zeneca Ab filed Critical Astra - Zeneca Ab
Publication of BG50606A3 publication Critical patent/BG50606A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG095502A 1989-12-11 1990-12-10 Method for the preparation of 3- methoxy- 4- /1- methyl- 5-/ 2- methyl- 4, 4, 4- trifluorobutylcarbamoil/indol- 3- il- methyl/n- /2- methylphenylsulfonyl/benzamide BG50606A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898927981A GB8927981D0 (en) 1989-12-11 1989-12-11 Carbamoyl derivative
BG093426A BG60015B2 (bg) 1989-12-11 1990-12-10 Метод за получаване на 3-метокси-4-/1-метил-5- /2-метил-4,4,4-трифлуорбутилкарбамоил/индол-3- ил-метил/-n-/2-метилфенилсулфонил/бензамид

Publications (1)

Publication Number Publication Date
BG50606A3 true BG50606A3 (en) 1992-09-15

Family

ID=10667774

Family Applications (2)

Application Number Title Priority Date Filing Date
BG093426A BG60015B2 (bg) 1989-12-11 1990-12-10 Метод за получаване на 3-метокси-4-/1-метил-5- /2-метил-4,4,4-трифлуорбутилкарбамоил/индол-3- ил-метил/-n-/2-метилфенилсулфонил/бензамид
BG095502A BG50606A3 (en) 1989-12-11 1990-12-10 Method for the preparation of 3- methoxy- 4- /1- methyl- 5-/ 2- methyl- 4, 4, 4- trifluorobutylcarbamoil/indol- 3- il- methyl/n- /2- methylphenylsulfonyl/benzamide

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BG093426A BG60015B2 (bg) 1989-12-11 1990-12-10 Метод за получаване на 3-метокси-4-/1-метил-5- /2-метил-4,4,4-трифлуорбутилкарбамоил/индол-3- ил-метил/-n-/2-метилфенилсулфонил/бензамид

Country Status (32)

Country Link
EP (1) EP0432984B1 (xx)
JP (1) JPH0822849B2 (xx)
KR (1) KR100192999B1 (xx)
CN (1) CN1025786C (xx)
AP (1) AP192A (xx)
AT (1) ATE163641T1 (xx)
AU (1) AU642182B2 (xx)
BG (2) BG60015B2 (xx)
CA (1) CA2031897C (xx)
CZ (1) CZ614690A3 (xx)
DE (1) DE69032083T2 (xx)
DK (1) DK0432984T3 (xx)
ES (1) ES2112832T3 (xx)
FI (1) FI95029C (xx)
GB (2) GB8927981D0 (xx)
GR (1) GR3026279T3 (xx)
HK (1) HK1003830A1 (xx)
HR (1) HRP930326B1 (xx)
HU (2) HU210441B (xx)
IE (1) IE904448A1 (xx)
IL (1) IL96621A (xx)
MY (1) MY106363A (xx)
NO (1) NO174198C (xx)
PL (2) PL166516B1 (xx)
PT (1) PT96154B (xx)
RO (1) RO108562B1 (xx)
RU (1) RU2002740C1 (xx)
SI (1) SI9012330A (xx)
SK (1) SK278528B6 (xx)
TW (1) TW219329B (xx)
YU (1) YU48218B (xx)
ZA (1) ZA909898B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2063479T3 (es) * 1990-05-04 1995-01-01 Ciba Geigy Ag Indoles substituidos.
GB9020338D0 (en) * 1990-09-18 1990-10-31 Lilly Industries Ltd Pharmaceutical compounds
GB9026427D0 (en) * 1990-12-05 1991-01-23 Ici Plc Chemical process
GB9026425D0 (en) * 1990-12-05 1991-01-23 Ici Plc Process
GB9119001D0 (en) * 1991-09-05 1991-10-23 Ici Plc Pharmaceutical agents
ES2050611B1 (es) * 1992-10-08 1994-12-16 Ici Plc Una nueva forma fisica de un derivado de carbamoilindol con propiedades antagonistas de leucotrienos.
GR1001368B (el) * 1992-10-08 1993-10-29 Ici Plc Φαρμακευτικοί φορείς.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524152A (en) * 1982-12-30 1985-06-18 Pennwalt Corporation 1-Cyano-3-(fluoroalkyl)guanidines for lowering blood pressure
GB8623429D0 (en) * 1985-10-17 1986-11-05 Ici America Inc Carboximide derivatives
IE862737L (en) * 1985-10-17 1987-04-17 Staehler Theo Heterocyclic compounds
MY103259A (en) * 1987-04-15 1993-05-29 Ici America Inc Aliphatic carboxamides
GB8906032D0 (en) * 1988-04-14 1989-04-26 Ici America Inc Hetera-aliphatic carboxamides
GB9026425D0 (en) * 1990-12-05 1991-01-23 Ici Plc Process

Also Published As

Publication number Publication date
YU233090A (sh) 1993-05-28
KR910011780A (ko) 1991-08-07
FI906084A (fi) 1991-06-12
HK1003830A1 (en) 1998-11-06
PT96154A (pt) 1991-09-30
PL166516B1 (pl) 1995-05-31
FI95029C (fi) 1995-12-11
PT96154B (pt) 1998-05-29
AU6791790A (en) 1991-06-13
CA2031897C (en) 2001-12-18
DE69032083T2 (de) 1998-07-16
RU2002740C1 (ru) 1993-11-15
FI906084A0 (fi) 1990-12-11
JPH0822849B2 (ja) 1996-03-06
HU210441B (en) 1995-04-28
MY106363A (en) 1995-05-30
CN1053604A (zh) 1991-08-07
AP192A (en) 1992-06-30
AP9000230A0 (en) 1991-01-31
GB2238790A (en) 1991-06-12
ES2112832T3 (es) 1998-04-16
NO905327D0 (no) 1990-12-10
CA2031897A1 (en) 1991-06-12
CZ282068B6 (cs) 1997-05-14
CZ614690A3 (en) 1997-05-14
EP0432984B1 (en) 1998-03-04
GB8927981D0 (en) 1990-02-14
JPH0770061A (ja) 1995-03-14
IE904448A1 (en) 1991-06-19
IL96621A0 (en) 1991-09-16
EP0432984A3 (en) 1992-04-22
RO108562B1 (ro) 1994-06-30
SI9012330A (en) 1997-12-31
CN1025786C (zh) 1994-08-31
NO174198C (no) 1994-04-06
GR3026279T3 (en) 1998-06-30
SK614690A3 (en) 1997-08-06
NO905327L (no) 1991-06-12
GB2238790B (en) 1993-06-30
KR100192999B1 (ko) 1999-06-15
SK278528B6 (en) 1997-08-06
YU48218B (sh) 1997-08-22
HU908137D0 (en) 1991-06-28
EP0432984A2 (en) 1991-06-19
HRP930326B1 (en) 1998-12-31
HUT56345A (en) 1991-08-28
PL167449B1 (pl) 1995-09-30
NO174198B (no) 1993-12-20
ZA909898B (en) 1991-08-28
IL96621A (en) 1994-11-28
GB9026797D0 (en) 1991-01-30
ATE163641T1 (de) 1998-03-15
FI95029B (fi) 1995-08-31
HRP930326A2 (en) 1996-06-30
DK0432984T3 (da) 1998-11-30
BG60015B2 (bg) 1993-06-30
HU210877A9 (en) 1995-09-28
TW219329B (xx) 1994-01-21
AU642182B2 (en) 1993-10-14
PL288184A1 (en) 1992-04-21
DE69032083D1 (de) 1998-04-09

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