CN102498177B - 新荧光染料及其用途 - Google Patents
新荧光染料及其用途 Download PDFInfo
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- CN102498177B CN102498177B CN201080040648.1A CN201080040648A CN102498177B CN 102498177 B CN102498177 B CN 102498177B CN 201080040648 A CN201080040648 A CN 201080040648A CN 102498177 B CN102498177 B CN 102498177B
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- 229960004132 diethyl ether Drugs 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
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- PXJJSXABGXMUSU-UHFFFAOYSA-N disulfur dichloride Chemical compound ClSSCl PXJJSXABGXMUSU-UHFFFAOYSA-N 0.000 description 1
- GUVUOGQBMYCBQP-UHFFFAOYSA-N dmpu Chemical compound CN1CCCN(C)C1=O GUVUOGQBMYCBQP-UHFFFAOYSA-N 0.000 description 1
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- 239000002532 enzyme inhibitor Substances 0.000 description 1
- SDJHDRMYZQFJJO-UHFFFAOYSA-N ethanethioic s-acid;potassium Chemical compound [K].CC(S)=O SDJHDRMYZQFJJO-UHFFFAOYSA-N 0.000 description 1
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- MCYHPZGUONZRGO-VKHMYHEASA-N methyl L-cysteinate Chemical compound COC(=O)[C@@H](N)CS MCYHPZGUONZRGO-VKHMYHEASA-N 0.000 description 1
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- JJVOROULKOMTKG-UHFFFAOYSA-N oxidized Photinus luciferin Chemical compound S1C2=CC(O)=CC=C2N=C1C1=NC(=O)CS1 JJVOROULKOMTKG-UHFFFAOYSA-N 0.000 description 1
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- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
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- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B7/00—Indigoid dyes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22598509P | 2009-07-16 | 2009-07-16 | |
| US61/225,985 | 2009-07-16 | ||
| PCT/US2010/042063 WO2011008912A1 (en) | 2009-07-16 | 2010-07-15 | Novel fluorescent dyes and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102498177A CN102498177A (zh) | 2012-06-13 |
| CN102498177B true CN102498177B (zh) | 2014-12-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080040648.1A Active CN102498177B (zh) | 2009-07-16 | 2010-07-15 | 新荧光染料及其用途 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8367842B2 (enExample) |
| EP (1) | EP2454329B1 (enExample) |
| JP (2) | JP5777169B2 (enExample) |
| KR (1) | KR101809758B1 (enExample) |
| CN (1) | CN102498177B (enExample) |
| AU (1) | AU2010273431B2 (enExample) |
| BR (1) | BR112012001043A2 (enExample) |
| CA (1) | CA2768352C (enExample) |
| IN (1) | IN2012DN00454A (enExample) |
| NZ (1) | NZ597512A (enExample) |
| SG (1) | SG177676A1 (enExample) |
| WO (1) | WO2011008912A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5905402B2 (ja) * | 2010-03-11 | 2016-04-20 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | シアノベンゾチアゾール化合物を使用する生物発光アッセイ |
| CN102937576B (zh) * | 2012-06-26 | 2015-10-21 | 广东德美精细化工股份有限公司 | 一种织物除油剂的防沾性能的评价方法 |
| EP2719703A1 (en) * | 2012-10-12 | 2014-04-16 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Precursor molecule for the synthesis of D-luciferin |
| CN102942537B (zh) * | 2012-11-09 | 2014-07-02 | 浙江大学 | 一种用作pH荧光探针的苯并噻唑-苯胺类化合物及其制备方法 |
| US9817929B1 (en) | 2014-06-04 | 2017-11-14 | Calypto Design Systems, Inc. | Formal verification using microtransactions |
| EP4641204A2 (en) | 2016-04-06 | 2025-10-29 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes with spacing linker groups |
| US10400264B2 (en) | 2016-12-01 | 2019-09-03 | Promega Corporation | 5,5-disubstituted luciferins and their use in luciferase-based assays |
| JP7563668B2 (ja) * | 2018-06-05 | 2024-10-08 | プロメガ コーポレイション | 熱安定性ルシフェリンと共に生物発光アッセイに使用するためのルシフェラーゼ酵素 |
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| HK1168122A1 (en) | 2012-12-21 |
| BR112012001043A2 (pt) | 2016-03-15 |
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| US20110014599A1 (en) | 2011-01-20 |
| US8367842B2 (en) | 2013-02-05 |
| AU2010273431B2 (en) | 2016-08-25 |
| EP2454329B1 (en) | 2018-04-18 |
| EP2454329A1 (en) | 2012-05-23 |
| KR101809758B1 (ko) | 2017-12-15 |
| CN102498177A (zh) | 2012-06-13 |
| WO2011008912A1 (en) | 2011-01-20 |
| JP5777169B2 (ja) | 2015-09-09 |
| JP2012533654A (ja) | 2012-12-27 |
| SG177676A1 (en) | 2012-02-28 |
| KR20120037486A (ko) | 2012-04-19 |
| NZ597512A (en) | 2014-03-28 |
| CA2768352C (en) | 2016-10-11 |
| IN2012DN00454A (enExample) | 2015-05-15 |
| JP2015165031A (ja) | 2015-09-17 |
| CA2768352A1 (en) | 2011-01-20 |
| US20130131324A1 (en) | 2013-05-23 |
| AU2010273431A1 (en) | 2012-02-02 |
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