SG177676A1 - Novel fluorescent dyes and uses thereof - Google Patents
Novel fluorescent dyes and uses thereof Download PDFInfo
- Publication number
- SG177676A1 SG177676A1 SG2012003125A SG2012003125A SG177676A1 SG 177676 A1 SG177676 A1 SG 177676A1 SG 2012003125 A SG2012003125 A SG 2012003125A SG 2012003125 A SG2012003125 A SG 2012003125A SG 177676 A1 SG177676 A1 SG 177676A1
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- Singapore
- Prior art keywords
- dye
- carbon
- bonds
- group
- alkyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B7/00—Indigoid dyes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
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- General Engineering & Computer Science (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Thiazole And Isothizaole Compounds (AREA)
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| US22598509P | 2009-07-16 | 2009-07-16 | |
| PCT/US2010/042063 WO2011008912A1 (en) | 2009-07-16 | 2010-07-15 | Novel fluorescent dyes and uses thereof |
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| JP (2) | JP5777169B2 (enExample) |
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| CN (1) | CN102498177B (enExample) |
| AU (1) | AU2010273431B2 (enExample) |
| BR (1) | BR112012001043A2 (enExample) |
| CA (1) | CA2768352C (enExample) |
| IN (1) | IN2012DN00454A (enExample) |
| NZ (1) | NZ597512A (enExample) |
| SG (1) | SG177676A1 (enExample) |
| WO (1) | WO2011008912A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5905402B2 (ja) * | 2010-03-11 | 2016-04-20 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | シアノベンゾチアゾール化合物を使用する生物発光アッセイ |
| CN102937576B (zh) * | 2012-06-26 | 2015-10-21 | 广东德美精细化工股份有限公司 | 一种织物除油剂的防沾性能的评价方法 |
| EP2719703A1 (en) * | 2012-10-12 | 2014-04-16 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Precursor molecule for the synthesis of D-luciferin |
| CN102942537B (zh) * | 2012-11-09 | 2014-07-02 | 浙江大学 | 一种用作pH荧光探针的苯并噻唑-苯胺类化合物及其制备方法 |
| US9817929B1 (en) | 2014-06-04 | 2017-11-14 | Calypto Design Systems, Inc. | Formal verification using microtransactions |
| EP4641204A2 (en) | 2016-04-06 | 2025-10-29 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes with spacing linker groups |
| US10400264B2 (en) | 2016-12-01 | 2019-09-03 | Promega Corporation | 5,5-disubstituted luciferins and their use in luciferase-based assays |
| JP7563668B2 (ja) * | 2018-06-05 | 2024-10-08 | プロメガ コーポレイション | 熱安定性ルシフェリンと共に生物発光アッセイに使用するためのルシフェラーゼ酵素 |
| JP7580689B2 (ja) | 2018-06-27 | 2024-11-12 | ソニーグループ株式会社 | デオキシリボースを含むリンカー基を有するポリマー色素 |
| CN112399996A (zh) * | 2018-07-13 | 2021-02-23 | 索尼公司 | 具有包含有机磷酸酯单元的主链的聚合的染料 |
| CN110724114B (zh) * | 2018-07-16 | 2022-10-21 | 北京工商大学 | 一种检测亚硫酸氢根及硫化氢的荧光探针 |
| CN109633151B (zh) * | 2018-12-26 | 2022-03-11 | 西北农林科技大学 | 一种肠炎沙门氏菌检测方法、试纸条及应用 |
| CN110361378B (zh) * | 2019-07-25 | 2021-04-02 | 浙江大学 | 基于荧光素乙酯的orac抗氧化活性评价方法及荧光指示剂 |
| WO2021061057A2 (en) * | 2019-09-26 | 2021-04-01 | Vidyasirimedhi Institute Of Science And Technology | Luciferin derivatives and a method for synthesis thereof |
| EP4256078A1 (en) | 2020-12-07 | 2023-10-11 | Sony Group Corporation | Spacing linker group design for brightness enhancement in dimeric or polymeric dyes |
| EP4310074A4 (en) | 2021-03-19 | 2025-03-26 | Kanto Denka Kogyo Co., Ltd. | D-luciferin, d-luciferin derivative, precursor of these compounds and method for producing these compounds |
| CN116046735B (zh) * | 2022-12-26 | 2025-08-22 | 南京大学 | 一种利用染料组成的传感器阵列检测全氟化合物的方法 |
| CN119462681B (zh) * | 2024-10-16 | 2025-09-30 | 聊城柏莱斯生物科技有限公司 | 一种荧光定量pcr参比染料及其制备方法与应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3537877A1 (de) * | 1985-10-24 | 1987-04-30 | Geiger Reinhard | Luciferin-derivate und immunoassays unter einsatz derartiger luciferin-derivate |
| DE68928412T2 (de) * | 1988-07-08 | 1998-05-20 | Jbl Scient Inc | Herstellung und verwendung von fluoreszierenden benzothiazolderivaten |
| US6140051A (en) * | 1997-07-21 | 2000-10-31 | Promega Biosciences, Inc. | Fluorescent dibenzazole derivatives and methods related thereto |
| US7413536B1 (en) * | 1999-09-14 | 2008-08-19 | Xenoport, Inc. | Substrates and screening methods for transport proteins |
| JP4354280B2 (ja) * | 2002-03-01 | 2009-10-28 | イミューノメディクス、インコーポレイテッド | Ｒｓ７抗体 |
| US7541440B2 (en) * | 2002-09-30 | 2009-06-02 | Immunomedics, Inc. | Chimeric, human and humanized anti-granulocyte antibodies and methods of use |
| CN100572555C (zh) * | 2002-10-23 | 2009-12-23 | 犹他大学研究基金会 | 使用饱和染料的扩增子解链分析 |
| DE10302787A1 (de) * | 2003-01-24 | 2004-08-12 | Schering Ag | Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik |
| JP2006219381A (ja) * | 2005-02-08 | 2006-08-24 | Univ Of Electro-Communications | 複素環化合物及び発光甲虫ルシフェラーゼ発光系用発光基質 |
| EP3312292B1 (en) * | 2005-05-31 | 2019-09-25 | Promega Corporation | Luminogenic and fluorogenic compounds and methods to detect molecules or conditions |
| US20100190180A1 (en) * | 2005-07-06 | 2010-07-29 | Heidi Kay | Materials and Methods for Screening, Diagnosis and Prognosis of Conditions Associated With Stat Protein Expression |
| KR100704007B1 (ko) * | 2006-01-17 | 2007-04-04 | 한국과학기술연구원 | 화학발광 및 형광을 이용한 신속진단키트 및 이의 사용방법 |
| JP5194258B2 (ja) * | 2006-03-27 | 2013-05-08 | 国立大学法人電気通信大学 | 複素環化合物及び発光方法 |
| CN101784897A (zh) * | 2007-05-23 | 2010-07-21 | 应用生物系统有限公司 | 通过从活化的化学发光的基质将能量转移至能量受体染料来检测生物分子的试剂、试剂盒和方法 |
| CN101270105B (zh) * | 2008-04-08 | 2011-09-14 | 杨得锁 | 用于酶活性分析和酶抑制剂筛选的香豆素类化合物及合成方法 |
| US8551721B2 (en) * | 2008-09-09 | 2013-10-08 | Promega Corporation | Bioluminescent detection of cyanohydroxy benzothiazole compounds |
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2010
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- 2010-07-15 BR BR112012001043A patent/BR112012001043A2/pt active Search and Examination
- 2010-07-15 JP JP2012520764A patent/JP5777169B2/ja active Active
- 2010-07-15 SG SG2012003125A patent/SG177676A1/en unknown
- 2010-07-15 AU AU2010273431A patent/AU2010273431B2/en active Active
- 2010-07-15 US US12/836,747 patent/US8367842B2/en active Active
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- 2010-07-15 WO PCT/US2010/042063 patent/WO2011008912A1/en not_active Ceased
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| HK1168122A1 (en) | 2012-12-21 |
| BR112012001043A2 (pt) | 2016-03-15 |
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| US20110014599A1 (en) | 2011-01-20 |
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| AU2010273431B2 (en) | 2016-08-25 |
| EP2454329B1 (en) | 2018-04-18 |
| EP2454329A1 (en) | 2012-05-23 |
| KR101809758B1 (ko) | 2017-12-15 |
| CN102498177A (zh) | 2012-06-13 |
| WO2011008912A1 (en) | 2011-01-20 |
| CN102498177B (zh) | 2014-12-24 |
| JP5777169B2 (ja) | 2015-09-09 |
| JP2012533654A (ja) | 2012-12-27 |
| KR20120037486A (ko) | 2012-04-19 |
| NZ597512A (en) | 2014-03-28 |
| CA2768352C (en) | 2016-10-11 |
| IN2012DN00454A (enExample) | 2015-05-15 |
| JP2015165031A (ja) | 2015-09-17 |
| CA2768352A1 (en) | 2011-01-20 |
| US20130131324A1 (en) | 2013-05-23 |
| AU2010273431A1 (en) | 2012-02-02 |
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