IN2012DN00454A - - Google Patents

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Publication number
IN2012DN00454A
IN2012DN00454A IN454DEN2012A IN2012DN00454A IN 2012DN00454 A IN2012DN00454 A IN 2012DN00454A IN 454DEN2012 A IN454DEN2012 A IN 454DEN2012A IN 2012DN00454 A IN2012DN00454 A IN 2012DN00454A
Authority
IN
India
Prior art keywords
fluorescent dyes
analyte
conjugates
dye
days
Prior art date
Application number
Inventor
Akhavantafti Hashem
De Silva Renuka
Wang Guoping
A Eickholt Robert
K Gupta Ravinder
S Kaanumalle Lakshmi
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Publication of IN2012DN00454A publication Critical patent/IN2012DN00454A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B7/00—Indigoid dyes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The present invention provides fluorescent dyes that are based on firefly luciferin structure. These days are optimally excited at shorter wavelengths and have Stokes shift of at least 50nm. The fluorescent dyes of the invention are useful for preparation of dye-conjugates, which can be used in detection of an analyte in a sample.
IN454DEN2012 2009-07-16 2010-07-15 IN2012DN00454A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22598509P 2009-07-16 2009-07-16
PCT/US2010/042063 WO2011008912A1 (en) 2009-07-16 2010-07-15 Novel fluorescent dyes and uses thereof

Publications (1)

Publication Number Publication Date
IN2012DN00454A true IN2012DN00454A (en) 2015-05-15

Family

ID=43218117

Family Applications (1)

Application Number Title Priority Date Filing Date
IN454DEN2012 IN2012DN00454A (en) 2009-07-16 2010-07-15

Country Status (12)

Country Link
US (2) US8367842B2 (en)
EP (1) EP2454329B1 (en)
JP (2) JP5777169B2 (en)
KR (1) KR101809758B1 (en)
CN (1) CN102498177B (en)
AU (1) AU2010273431B2 (en)
BR (1) BR112012001043A2 (en)
CA (1) CA2768352C (en)
IN (1) IN2012DN00454A (en)
NZ (1) NZ597512A (en)
SG (1) SG177676A1 (en)
WO (1) WO2011008912A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592172B2 (en) * 2010-03-11 2013-11-26 Promega Corporation Bioluminescent assays using cyanobenzothiazole compounds
CN102937576B (en) * 2012-06-26 2015-10-21 广东德美精细化工股份有限公司 A kind of evaluation method of releasing performance of fabric degreaser
EP2719703A1 (en) * 2012-10-12 2014-04-16 Ecole Polytechnique Fédérale de Lausanne (EPFL) Precursor molecule for the synthesis of D-luciferin
CN102942537B (en) * 2012-11-09 2014-07-02 浙江大学 Benzothiazole-aniline compound used as pH fluorescent probe and preparation method thereof
US9817929B1 (en) 2014-06-04 2017-11-14 Calypto Design Systems, Inc. Formal verification using microtransactions
WO2018102726A1 (en) * 2016-12-01 2018-06-07 Promega Corporation 5,5-disubstituted luciferins and their use in luciferase-based assays
JP7563668B2 (en) * 2018-06-05 2024-10-08 プロメガ コーポレイション Luciferase enzymes for use in bioluminescence assays together with thermostable luciferins - Patent Application 20070233333
JP7580689B2 (en) 2018-06-27 2024-11-12 ソニーグループ株式会社 Polymeric dyes with deoxyribose-containing linker groups
WO2020014634A1 (en) * 2018-07-13 2020-01-16 Sony Corporation Polymeric dyes having a backbone comprising organophosphate units
CN110724114B (en) * 2018-07-16 2022-10-21 北京工商大学 A fluorescent probe for the detection of bisulfite and hydrogen sulfide
CN109633151B (en) * 2018-12-26 2022-03-11 西北农林科技大学 A kind of Salmonella Enteritidis detection method, test strip and application
CN110361378B (en) * 2019-07-25 2021-04-02 浙江大学 ORAC antioxidant activity evaluation method based on fluorescein ethyl ester and fluorescent indicator
US20220372008A1 (en) * 2019-09-26 2022-11-24 Vidyasirimedhi Institute Of Science And Technology Luciferin derivatives and a method for synthesis thereof
KR20230158540A (en) 2021-03-19 2023-11-20 칸토 덴카 코교 가부시키가이샤 D-luciferin and D-luciferin derivatives and precursors of these compounds, and methods for their preparation
CN116046735B (en) * 2022-12-26 2025-08-22 南京大学 A method for detecting perfluorinated compounds using a sensor array composed of dyes
CN119462681B (en) * 2024-10-16 2025-09-30 聊城柏莱斯生物科技有限公司 A fluorescent quantitative PCR reference dye and its preparation method and application

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
DE3537877A1 (en) * 1985-10-24 1987-04-30 Geiger Reinhard LUCIFERIN DERIVATIVES AND IMMUNOASSAYS USING SUCH LUCIFERIN DERIVATIVES
WO1990000618A1 (en) * 1988-07-08 1990-01-25 Jbl Scientific, Inc. Preparation and use of fluorescent benzothiazole derivatives
US6140051A (en) * 1997-07-21 2000-10-31 Promega Biosciences, Inc. Fluorescent dibenzazole derivatives and methods related thereto
EP1212619B1 (en) * 1999-09-14 2007-05-23 Xenoport, Inc. Substrates and screening methods for transport proteins
DK3483183T3 (en) * 2002-03-01 2021-06-21 Immunomedics Inc IMMUNO CONJUGATE INCLUDING HUMANIZED RS7 ANTIBODIES
US7541440B2 (en) * 2002-09-30 2009-06-02 Immunomedics, Inc. Chimeric, human and humanized anti-granulocyte antibodies and methods of use
CN100572555C (en) * 2002-10-23 2009-12-23 犹他大学研究基金会 Use the amplicon melting analysis of saturable dye
DE10302787A1 (en) * 2003-01-24 2004-08-12 Schering Ag New indotricarbocyanine dyes are conjugated to biomolecules, used in fluorescence diagnosis of e.g. tumors
JP2006219381A (en) * 2005-02-08 2006-08-24 Univ Of Electro-Communications Heterocyclic compounds and luminescent substrates for luminescent beetle luciferase luminescent systems
EP2277872B1 (en) 2005-05-31 2016-03-23 Promega Corporation Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
US20100190180A1 (en) * 2005-07-06 2010-07-29 Heidi Kay Materials and Methods for Screening, Diagnosis and Prognosis of Conditions Associated With Stat Protein Expression
KR100704007B1 (en) * 2006-01-17 2007-04-04 한국과학기술연구원 Rapid Diagnostic Kit Using Chemiluminescence and Fluorescence and Its Use Method
WO2007116687A1 (en) * 2006-03-27 2007-10-18 The University Of Electro-Communications Heterocyclic compound and luminescence method
ATE533052T1 (en) * 2007-05-23 2011-11-15 Applied Biosystems Llc REAGENTS, KITS AND METHODS FOR DETECTING BIOLOGICAL MOLECULES USING ENERGY TRANSFER FROM AN ACTIVATED CHEMILUMINESCENCE SUBSTRATE TO AN ENERGY ACCEPTOR DYE
CN101270105B (en) * 2008-04-08 2011-09-14 杨得锁 Coumarin compound for enzymatic activity analysis and enzyme inhibitor sifting motion, and synthesizing process
JP5800711B2 (en) * 2008-09-09 2015-10-28 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ Bioluminescence assay using cyanobenzothiazole compounds

Also Published As

Publication number Publication date
SG177676A1 (en) 2012-02-28
KR20120037486A (en) 2012-04-19
EP2454329B1 (en) 2018-04-18
US20130131324A1 (en) 2013-05-23
CN102498177B (en) 2014-12-24
KR101809758B1 (en) 2017-12-15
JP5777169B2 (en) 2015-09-09
JP2012533654A (en) 2012-12-27
WO2011008912A1 (en) 2011-01-20
CA2768352A1 (en) 2011-01-20
US8367842B2 (en) 2013-02-05
AU2010273431A2 (en) 2012-03-01
EP2454329A1 (en) 2012-05-23
CN102498177A (en) 2012-06-13
JP2015165031A (en) 2015-09-17
AU2010273431B2 (en) 2016-08-25
BR112012001043A2 (en) 2016-03-15
HK1168122A1 (en) 2012-12-21
AU2010273431A1 (en) 2012-02-02
US8772501B2 (en) 2014-07-08
US20110014599A1 (en) 2011-01-20
NZ597512A (en) 2014-03-28
CA2768352C (en) 2016-10-11

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