CN102470179A - 微针阵列 - Google Patents

微针阵列 Download PDF

Info

Publication number
CN102470179A
CN102470179A CN2010800255119A CN201080025511A CN102470179A CN 102470179 A CN102470179 A CN 102470179A CN 2010800255119 A CN2010800255119 A CN 2010800255119A CN 201080025511 A CN201080025511 A CN 201080025511A CN 102470179 A CN102470179 A CN 102470179A
Authority
CN
China
Prior art keywords
microneedle
polylactic acid
microneedles
microneedle array
average molecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800255119A
Other languages
English (en)
Chinese (zh)
Inventor
寺原孝明
德本诚治
田村章
山田由美子
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Toppan Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Toppan Printing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc, Toppan Printing Co Ltd filed Critical Hisamitsu Pharmaceutical Co Inc
Publication of CN102470179A publication Critical patent/CN102470179A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
    • A61B5/1405—Devices for taking blood samples
    • A61B5/1411—Devices for taking blood samples by percutaneous method, e.g. by lancet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A61B5/150427—Specific tip design, e.g. for improved penetration characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150503—Single-ended needles
    • A61B5/150511—Details of construction of shaft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Manufacturing & Machinery (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Anesthesiology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
CN2010800255119A 2009-07-23 2010-07-15 微针阵列 Pending CN102470179A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009172525 2009-07-23
JP2009-172525 2009-07-23
PCT/JP2010/062008 WO2011010605A1 (ja) 2009-07-23 2010-07-15 マイクロニードルアレイ

Publications (1)

Publication Number Publication Date
CN102470179A true CN102470179A (zh) 2012-05-23

Family

ID=43499078

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800255119A Pending CN102470179A (zh) 2009-07-23 2010-07-15 微针阵列

Country Status (8)

Country Link
US (1) US8696638B2 (https=)
EP (1) EP2457592B1 (https=)
JP (1) JP5620911B2 (https=)
KR (1) KR101686692B1 (https=)
CN (1) CN102470179A (https=)
ES (1) ES2826882T3 (https=)
IN (1) IN2012DN00906A (https=)
WO (1) WO2011010605A1 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105126242A (zh) * 2015-07-26 2015-12-09 北京化工大学 一种便于抗生素皮试的高分子涂层微针贴片及其制备方法
CN107569238A (zh) * 2016-07-04 2018-01-12 中山大学 一种粘贴式烟囱型微针阵列及其制造方法
CN110475581A (zh) * 2017-05-10 2019-11-19 林治远 具有增强药物装载能力的棱锥形微针和制造方法
CN112569465A (zh) * 2020-12-29 2021-03-30 华东理工大学 一种微针贴片的制备方法
CN113171551A (zh) * 2015-03-23 2021-07-27 考司美德制药株式会社 一种微针及其制造方法
CN115227976A (zh) * 2022-07-20 2022-10-25 上海交通大学 一种控温射频微针系统

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
ES2817249T3 (es) 2007-04-16 2021-04-06 Corium Inc Matrices de microagujas obtenidas mediante disolución y colada que contienen un principio activo
EP2429627B1 (en) * 2009-04-24 2017-06-14 Corium International, Inc. Methods for manufacturing microprojection arrays
ES2691259T3 (es) * 2009-06-10 2018-11-26 Hisamitsu Pharmaceutical Co., Inc. Dispositivo de microagujas
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
EP2566501B1 (en) 2010-05-04 2019-03-13 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
WO2013051568A1 (ja) 2011-10-06 2013-04-11 久光製薬株式会社 アプリケータ
AU2012323782B2 (en) 2011-10-12 2017-04-06 Vaxxas Pty Limited Delivery device
JP2013162861A (ja) * 2012-02-10 2013-08-22 Bioserentack Co Ltd 細胞間液モニター用マイクロニードル
WO2013166162A1 (en) 2012-05-01 2013-11-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
EP2934660B1 (en) 2012-12-21 2019-07-17 Corium, Inc. Microarray for delivery of therapeutic agent and method of making same
EP4094799A1 (en) 2013-03-12 2022-11-30 Corium, Inc. Microprojection applicators
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
KR101712413B1 (ko) * 2013-03-22 2017-03-06 쓰리엠 이노베이티브 프로퍼티즈 컴파니 카운터 조립체를 포함하는 마이크로니들 어플리케이터
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
JP6001043B2 (ja) * 2014-12-15 2016-10-05 日本写真印刷株式会社 マイクロニードルアレイ製造装置及びマイクロニードルアレイの製造方法並びにマイクロニードルアレイを有する製品
WO2016123665A1 (en) * 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP6760282B2 (ja) * 2015-07-07 2020-09-23 凸版印刷株式会社 経皮投与デバイス
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
KR101610598B1 (ko) * 2015-09-21 2016-04-07 비엔엘바이오테크 주식회사 잇몸 굴곡에 맞게 유연하며 치과용 물질 전달을 위한 마이크로 니들 및 그 제작방법
CA2999538A1 (en) 2015-09-28 2017-04-06 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
ES2960937T3 (es) 2017-03-31 2024-03-07 Vaxxas Pty Ltd Dispositivo y método para recubrir superficies
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
EP4473998A3 (en) 2017-08-04 2025-02-26 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
US20190093150A1 (en) * 2017-09-22 2019-03-28 Uchicago Argonne, Llc Nanotextured materials
US11247896B2 (en) 2018-07-31 2022-02-15 Uchicago Argonne, Llc Localized functionalization of nanotextured surfaces
AU2020275934B2 (en) 2019-05-16 2025-09-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Microneedle arrays with undercut features for cutaneous and non-cutaneous drug delivery
JP7712553B2 (ja) * 2019-12-25 2025-07-24 サンスター株式会社 歯ブラシ
JPWO2024005176A1 (https=) * 2022-06-30 2024-01-04

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006341089A (ja) * 2005-05-13 2006-12-21 Fujikura Ltd 医薬物運搬用器具およびその製造方法
JP2008212588A (ja) * 2007-03-08 2008-09-18 Toppan Printing Co Ltd 針状体、針状体製造方法および薬物輸送デバイス
JP2009072271A (ja) * 2007-09-19 2009-04-09 Toppan Printing Co Ltd 針状体および針状体の製造方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2747306B2 (ja) * 1988-12-24 1998-05-06 富士通株式会社 半導体装置
EP0957972B1 (en) 1996-12-20 2003-03-19 Alza Corporation Device and method for enhancing transdermal agent flux
JPH11286439A (ja) 1998-04-01 1999-10-19 Senju Pharmaceut Co Ltd 生分解性ポリマー型薬物放出システム
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
JP2005021677A (ja) * 2003-06-10 2005-01-27 Medorekkusu:Kk 経皮投薬用パッドベース、及び注射針
JP2005021678A (ja) 2003-06-10 2005-01-27 Medorekkusu:Kk 経皮投薬用パッドベースの製造方法及び経皮投薬用パッドベース、並びに注射針
US7347835B2 (en) 2003-06-10 2008-03-25 Medrx Co., Ltd. Process for producing pad base for endermism, and pad base for endermism, and injection needle
WO2005044366A2 (en) 2003-10-31 2005-05-19 Alza Corporation System and method for transdermal vaccine delivery
JP2007519446A (ja) 2004-01-09 2007-07-19 アルザ・コーポレーシヨン 振動支援型の経皮的な薬剤の送達法および系
WO2005075016A1 (ja) 2004-02-03 2005-08-18 Hisamitsu Pharmaceutical Co., Inc. 経皮薬物投与装置用インタフェース
WO2006016647A1 (ja) 2004-08-12 2006-02-16 Hisamitsu Pharmaceutical Co., Inc. マイクロニードル付き経皮薬物投与装置
JPWO2006075689A1 (ja) 2005-01-14 2008-06-12 久光製薬株式会社 医薬物運搬用器具とその製造方法
JP5053645B2 (ja) 2005-01-14 2012-10-17 久光製薬株式会社 医薬物運搬用器具とその製造方法
JP5020080B2 (ja) 2005-05-13 2012-09-05 久光製薬株式会社 医薬物運搬用器具の製造方法
CA2614927A1 (en) 2005-07-25 2007-02-01 Nanotechnology Victoria Pty Ltd Microarray device
JP5000866B2 (ja) 2005-08-01 2012-08-15 久光製薬株式会社 生体無毒性医薬物運搬用器具
WO2007091608A1 (ja) 2006-02-10 2007-08-16 Hisamitsu Pharmaceutical Co., Inc. マイクロニードル付き経皮薬物投与装置
JP4908893B2 (ja) 2006-03-30 2012-04-04 久光製薬株式会社 医薬物運搬用器具とその製造方法及び医薬物運搬用器具製造用金型の製造方法
WO2007116959A1 (ja) 2006-04-07 2007-10-18 Hisamitsu Pharmaceutical Co., Inc. マイクロニードルデバイスおよびマイクロニードル付き経皮薬物投与装置
EP2119469B1 (en) 2007-02-06 2014-05-14 Hisamitsu Pharmaceutical Co., Inc. Microneedle device for diagnosis of allergy
JP5298011B2 (ja) 2007-05-15 2013-09-25 久光製薬株式会社 マイクロニードルのコーティング方法
JP5194632B2 (ja) 2007-08-15 2013-05-08 凸版印刷株式会社 針状体の製造方法
JP5419702B2 (ja) 2007-10-18 2014-02-19 久光製薬株式会社 マイクロニードルデバイス

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006341089A (ja) * 2005-05-13 2006-12-21 Fujikura Ltd 医薬物運搬用器具およびその製造方法
JP2008212588A (ja) * 2007-03-08 2008-09-18 Toppan Printing Co Ltd 針状体、針状体製造方法および薬物輸送デバイス
JP2009072271A (ja) * 2007-09-19 2009-04-09 Toppan Printing Co Ltd 針状体および針状体の製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
田怡 等: "聚乳酸的结构、性能与展望", 《石化技术与应用》, vol. 24, no. 03, 31 May 2006 (2006-05-31), pages 233 - 237 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113171551A (zh) * 2015-03-23 2021-07-27 考司美德制药株式会社 一种微针及其制造方法
CN113171551B (zh) * 2015-03-23 2024-06-28 考司美德制药株式会社 一种微针及其制造方法
CN105126242A (zh) * 2015-07-26 2015-12-09 北京化工大学 一种便于抗生素皮试的高分子涂层微针贴片及其制备方法
CN107569238A (zh) * 2016-07-04 2018-01-12 中山大学 一种粘贴式烟囱型微针阵列及其制造方法
CN110475581A (zh) * 2017-05-10 2019-11-19 林治远 具有增强药物装载能力的棱锥形微针和制造方法
CN112569465A (zh) * 2020-12-29 2021-03-30 华东理工大学 一种微针贴片的制备方法
CN115227976A (zh) * 2022-07-20 2022-10-25 上海交通大学 一种控温射频微针系统

Also Published As

Publication number Publication date
EP2457592A4 (en) 2013-01-02
IN2012DN00906A (https=) 2015-04-03
EP2457592B1 (en) 2020-09-16
KR101686692B1 (ko) 2016-12-14
US8696638B2 (en) 2014-04-15
ES2826882T3 (es) 2021-05-19
KR20120037910A (ko) 2012-04-20
WO2011010605A1 (ja) 2011-01-27
US20120136312A1 (en) 2012-05-31
JP5620911B2 (ja) 2014-11-05
JPWO2011010605A1 (ja) 2012-12-27
EP2457592A1 (en) 2012-05-30

Similar Documents

Publication Publication Date Title
CN102470179A (zh) 微针阵列
CN102458359B (zh) 微针装置
CN102770176B (zh) 微针装置及其制造方法
JP5050130B2 (ja) マイクロニードル
CN102264429B (zh) 微针装置
KR101747099B1 (ko) 생체적합성 고분자를 이용한 마이크로니들의 제조방법
EP2957297B1 (en) Microneedle-coating composition and microneedle device
EP2842595B1 (en) Microneedle and microneedle array
JP2019076752A (ja) 治療剤の送達のためのマイクロアレイ、使用方法および製造方法
CN105982842B (zh) 微针制剂以及微针制剂的制造方法
KR20150100807A (ko) 치료제의 전달을 위한 마이크로어레이 및 그것의 사용방법
CN115551583A (zh) 高性能微针阵列
JP6799005B2 (ja) マイクロニードル・シート
CN113827544B (zh) 一种耐热型可植入式聚合物微针及其制备方法和应用
JP5852280B1 (ja) マイクロニードルおよびその製造
EP3979984A1 (en) Microneedles, and methods for the manufacture thereof
CN121604990A (zh) 微针阵列
TW201306890A (zh) 微針裝置及其製造方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20120523