CN102459643B - 检测获得性免疫的方法 - Google Patents
检测获得性免疫的方法 Download PDFInfo
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- CN102459643B CN102459643B CN201080028875.2A CN201080028875A CN102459643B CN 102459643 B CN102459643 B CN 102459643B CN 201080028875 A CN201080028875 A CN 201080028875A CN 102459643 B CN102459643 B CN 102459643B
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
- G06F17/10—Complex mathematical operations
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Medical Informatics (AREA)
- Theoretical Computer Science (AREA)
- Data Mining & Analysis (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Software Systems (AREA)
- Databases & Information Systems (AREA)
- Spectroscopy & Molecular Physics (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22034409P | 2009-06-25 | 2009-06-25 | |
| US61/220,344 | 2009-06-25 | ||
| PCT/US2010/037477 WO2010151416A1 (en) | 2009-06-25 | 2010-06-04 | Method of measuring adaptive immunity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102459643A CN102459643A (zh) | 2012-05-16 |
| CN102459643B true CN102459643B (zh) | 2016-06-01 |
Family
ID=42543134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080028875.2A Active CN102459643B (zh) | 2009-06-25 | 2010-06-04 | 检测获得性免疫的方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (10) | US20100330571A1 (enExample) |
| EP (2) | EP2446052B1 (enExample) |
| JP (2) | JP2012531202A (enExample) |
| KR (2) | KR20140146180A (enExample) |
| CN (1) | CN102459643B (enExample) |
| AU (1) | AU2010263172B2 (enExample) |
| CA (1) | CA2765949C (enExample) |
| IL (1) | IL217200A (enExample) |
| RU (2) | RU2539032C2 (enExample) |
| SG (2) | SG10201403451QA (enExample) |
| WO (1) | WO2010151416A1 (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009137255A2 (en) | 2008-04-16 | 2009-11-12 | Hudsonalpha Institute For Biotechnology | Method for evaluating and comparing immunorepertoires |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| WO2010053587A2 (en) | 2008-11-07 | 2010-05-14 | Mlc Dx Incorporated | Methods of monitoring conditions by sequence analysis |
| US8691510B2 (en) | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| DK3059337T3 (da) | 2009-01-15 | 2019-07-22 | Adaptive Biotechnologies Corp | Adaptive immunity profiling og metoder til frembringelse af monoklonale antibodier |
| SG10201403451QA (en) * | 2009-06-25 | 2014-09-26 | Hutchinson Fred Cancer Res | Method of measuring adaptive immunity |
| US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
| WO2011106738A2 (en) | 2010-02-25 | 2011-09-01 | Fred Hutchinson Cancer Research Center | Use of tcr clonotypes as biomarkers for disease |
| DK2663864T3 (da) * | 2011-01-14 | 2019-06-24 | Irepertoire Inc | Fremgangsmåde til at vurdere immundiversitet og anvendelse af denne |
| US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
| CA2853088C (en) | 2011-10-21 | 2018-03-13 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| EP3388535B1 (en) | 2011-12-09 | 2021-03-24 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
| WO2013097744A1 (zh) * | 2011-12-27 | 2013-07-04 | 深圳华大基因科技有限公司 | 用于扩增cdr3编码序列的引物组合物及其用途 |
| CN103289994B (zh) * | 2012-03-05 | 2015-08-05 | 深圳华大基因科技有限公司 | 用于扩增T细胞受体α链CDR3编码序列的引物组合物及其用途 |
| CN103184216B (zh) * | 2011-12-27 | 2015-03-18 | 深圳华大基因科技有限公司 | 用于扩增免疫球蛋白重链cdr3编码序列的引物组合物及其用途 |
| CN103205420B (zh) * | 2012-01-13 | 2015-04-01 | 深圳华大基因科技有限公司 | 用于扩增T细胞受体β链CDR3编码序列的引物组合物及其用途 |
| US10077478B2 (en) | 2012-03-05 | 2018-09-18 | Adaptive Biotechnologies Corp. | Determining paired immune receptor chains from frequency matched subunits |
| CN104520440B (zh) | 2012-05-08 | 2017-10-03 | 适应生物技术公司 | 用于测量和校准多重pcr反应中的扩增偏倚的组合物和方法 |
| JP2015519909A (ja) | 2012-06-15 | 2015-07-16 | アダプティブ バイオテクノロジーズ コーポレイション | 複合遺伝子セットにおける固有にタグ付加された再構成適応性免疫受容体遺伝子 |
| CA2878291A1 (en) * | 2012-07-03 | 2014-01-09 | Sloan Kettering Institute For Cancer Research | Quantitative assessment of human t-cell repertoire recovery after allogeneic hematopoietic stem cell transplantation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US10041127B2 (en) | 2012-09-04 | 2018-08-07 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| DK2904111T3 (en) | 2012-10-01 | 2018-03-12 | Adaptive Biotechnologies Corp | Immune competence evaluation of adaptive immune receptor diversity and clonality characterization |
| WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| SG11201506991VA (en) | 2013-03-15 | 2015-10-29 | Adaptive Biotechnologies Corp | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| US9816088B2 (en) | 2013-03-15 | 2017-11-14 | Abvitro Llc | Single cell bar-coding for antibody discovery |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| US11203783B2 (en) | 2013-11-21 | 2021-12-21 | Repertoire Genesis Incorporation | T cell receptor and B cell receptor repertoire analysis system, and use of same in treatment and diagnosis |
| JP2017506500A (ja) * | 2013-12-10 | 2017-03-09 | コネクシオ ゲノミクス ピーティーワイ リミテッド | 遺伝子アリルを同定するための方法及びプローブ |
| CN106062214B (zh) | 2013-12-28 | 2020-06-09 | 夸登特健康公司 | 用于检测遗传变异的方法和系统 |
| WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| US10202640B2 (en) * | 2014-05-07 | 2019-02-12 | The Board Of Trustees Of The Leland Stanford Junior University | Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing |
| EP3536786B1 (en) | 2014-09-15 | 2021-06-30 | AbVitro LLC | High-throughput nucleotide library sequencing |
| WO2016069886A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corporation | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| WO2016086029A1 (en) | 2014-11-25 | 2016-06-02 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| WO2016138122A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| WO2016161273A1 (en) | 2015-04-01 | 2016-10-06 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
| CN105040111B (zh) * | 2015-05-28 | 2017-07-14 | 眭维国 | 系统性红斑狼疮图谱模型的构建方法 |
| US9422547B1 (en) | 2015-06-09 | 2016-08-23 | Gigagen, Inc. | Recombinant fusion proteins and libraries from immune cell repertoires |
| US10539564B2 (en) | 2015-07-22 | 2020-01-21 | Roche Sequencing Solutions, Inc. | Identification of antigen epitopes and immune sequences recognizing the antigens |
| WO2017013170A1 (en) | 2015-07-22 | 2017-01-26 | F. Hoffmann-La Roche Ag | Identification of antigen epitopes and immune sequences recognizing the antigens |
| WO2017027373A1 (en) * | 2015-08-07 | 2017-02-16 | Beth Israel Deaconess Medical Center, Inc. | Estimation of descriptive parameters from a sample |
| CN105154440B (zh) * | 2015-08-14 | 2016-11-30 | 深圳市瀚海基因生物科技有限公司 | 一种基于高通量测序构建白血病微小残留病灶tcr文库的多重pcr引物和方法 |
| WO2017086394A1 (ja) * | 2015-11-18 | 2017-05-26 | 国立研究開発法人海洋研究開発機構 | 標的核酸の定量方法及びそのためのキット |
| JP2019507585A (ja) | 2015-12-17 | 2019-03-22 | ガーダント ヘルス, インコーポレイテッド | 無細胞dnaの分析による腫瘍遺伝子コピー数を決定するための方法 |
| CN105447336B (zh) * | 2015-12-29 | 2018-06-19 | 北京百迈客生物科技有限公司 | 基于生物云平台的微生物多样性分析系统 |
| US11306356B2 (en) | 2016-06-01 | 2022-04-19 | Roche Sequencing Solutions, Inc. | Immuno-PETE |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| CN106957905B (zh) * | 2016-12-23 | 2020-12-04 | 孙涛 | 一种用于评估肿瘤免疫治疗效果的分子检测方法及引物组合物及试剂盒 |
| GB201718238D0 (en) * | 2017-11-03 | 2017-12-20 | Univ Oxford Innovation Ltd | Method and system for determining the disease status of a subject |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| RU2694412C9 (ru) * | 2017-12-25 | 2019-09-18 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет им. Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) | Моноклональные антитела и способы их применения |
| US20210361768A1 (en) * | 2018-06-01 | 2021-11-25 | Mayo Foundation For Medical Education And Research | Methods and materials for assessing and treating cancers |
| JP2021526824A (ja) * | 2018-06-11 | 2021-10-11 | モノクアント・ピーティーワイ・リミテッド | 増幅方法及びそこで使用されるプライマー |
| CN112292600A (zh) | 2018-06-15 | 2021-01-29 | 豪夫迈·罗氏有限公司 | 用于鉴定被表达在肿瘤浸润性淋巴细胞上的t细胞受体识别的抗原的系统 |
| RU2712251C1 (ru) * | 2018-12-25 | 2020-01-27 | Федеральное государственное автономное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) | Гуманизированные антитела против участка бета цепи 9-го семейства TRBV9 TKP человека, и способы их применения |
| AR117735A1 (es) * | 2018-12-25 | 2021-08-25 | Joint Stock Company Biocad | ANTICUERPOS MONOCLONALES QUE SE UNEN ESPECÍFICAMENTE A LA REGIÓN b DE LA FAMILIA TRBV-9 DEL RECEPTOR DE CÉLULAS T HUMANO, Y LOS MÉTODOS PARA SU USO |
| EP3941491A4 (en) | 2019-03-21 | 2023-03-29 | Gigamune, Inc. | ENGINEERED CELLS EXPRESSING ANTIVIRAL T-CELL RECEPTORS AND METHODS OF USE |
| CN109929924B (zh) * | 2019-03-27 | 2022-11-08 | 上海科医联创医学检验所有限公司 | 一种基于高通量测序的igh基因重排检测方法 |
| CN111755075B (zh) * | 2019-03-28 | 2023-09-29 | 深圳华大生命科学研究院 | 对免疫组库高通量测序样本间序列污染进行过滤的方法 |
| CN110246539B (zh) * | 2019-04-15 | 2020-04-28 | 成都益安博生物技术有限公司 | 一种免疫力水平评估的方法及装置 |
| US12263179B1 (en) | 2019-08-01 | 2025-04-01 | Adaptive Biotechnologies Corporation | Lyme disease-associated T cell receptor-related methods |
| WO2021053008A1 (en) | 2019-09-20 | 2021-03-25 | F. Hoffmann-La Roche Ag | Immune repertoire profiling by primer extension target enrichment |
| US12266425B1 (en) | 2020-06-10 | 2025-04-01 | Adaptive Biotechnologies Corporation | T cell receptor sequences diagnostic for COVID-19 and related compositions |
| WO2023201265A1 (en) * | 2022-04-12 | 2023-10-19 | The Johns Hopkins University | Method of measuring level of immune suppression |
| CN116153407A (zh) * | 2023-04-03 | 2023-05-23 | 广州华银医学检验中心有限公司 | 基于基因测序判断受试者抗新冠免疫力强弱的系统 |
| WO2025070334A1 (ja) * | 2023-09-27 | 2025-04-03 | 国立大学法人大阪大学 | 情報処理方法、学習モデルの生成方法、学習モデル、コンピュータプログラム及び情報処理装置 |
Family Cites Families (327)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3270960A (en) | 1964-09-11 | 1966-09-06 | Sperry Rand Corp | Fluid sensor |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| DE3211263A1 (de) | 1981-03-31 | 1983-01-27 | Otsuka Pharmaceutical Co. Ltd., Tokyo | Human-interferon verwandte peptide, antigene und antikoerper, sowie verfahren zu deren herstellung |
| DE3238353A1 (de) | 1982-10-15 | 1984-04-19 | Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Verfahren zur simultanen quantitativen bestimmung der blutzellen und reagenz hierfuer |
| US5189147A (en) | 1984-06-13 | 1993-02-23 | Massachusetts Institute Of Technology | Meterodimeric T lymphocyte receptor antibody |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| DE3541033A1 (de) | 1985-11-19 | 1987-05-21 | Boehringer Mannheim Gmbh | Verfahren zur quantifizierung von zellpopulationen bzw. subpopulationen sowie hierfuer geeignetes reagenz |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5149625A (en) | 1987-08-11 | 1992-09-22 | President And Fellows Of Harvard College | Multiplex analysis of DNA |
| US4942124A (en) | 1987-08-11 | 1990-07-17 | President And Fellows Of Harvard College | Multiplex sequencing |
| US5667967A (en) | 1990-05-01 | 1997-09-16 | The Board Of Trustees Of The Leland Stanford Junior University | T-cell receptor varible transcripts as disease related markers |
| US5506126A (en) | 1988-02-25 | 1996-04-09 | The General Hospital Corporation | Rapid immunoselection cloning method |
| US5168038A (en) | 1988-06-17 | 1992-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | In situ transcription in cells and tissues |
| JP2781438B2 (ja) | 1988-10-20 | 1998-07-30 | モーリィ,アリグザンダー,アラン | 白血病及びリンパ腫におけるモノクローナリテイーの診断法 |
| US5075217A (en) | 1989-04-21 | 1991-12-24 | Marshfield Clinic | Length polymorphisms in (dC-dA)n ·(dG-dT)n sequences |
| US5231012A (en) | 1989-06-28 | 1993-07-27 | Schering Corporation | Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10) |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| US5298396A (en) | 1989-11-15 | 1994-03-29 | National Jewish Center For Immunology And Respiratory Medicine | Method for identifying T cells disease involved in autoimmune disease |
| US5336598A (en) | 1989-11-15 | 1994-08-09 | National Jewish Center For Immunology And Respiratory Medicine | Method for diagnosing a superantigen caused pathologial condition via assay of T-cells |
| US5126022A (en) | 1990-02-28 | 1992-06-30 | Soane Tecnologies, Inc. | Method and device for moving molecules by the application of a plurality of electrical fields |
| US6054034A (en) | 1990-02-28 | 2000-04-25 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
| US6916605B1 (en) | 1990-07-10 | 2005-07-12 | Medical Research Council | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| EP0542810A1 (en) | 1990-08-02 | 1993-05-26 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| IE76732B1 (en) | 1990-08-07 | 1997-11-05 | Becton Dickinson Co | One step test for absolute counts |
| US5699798A (en) | 1990-08-10 | 1997-12-23 | University Of Washington | Method for optically imaging solid tumor tissue |
| US5635354A (en) | 1991-01-09 | 1997-06-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for describing the repertoires of antibodies (Ab) and of T-cell receptors (TcR) of an individual's immune system |
| US5364759B2 (en) | 1991-01-31 | 1999-07-20 | Baylor College Medicine | Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats |
| JPH06502997A (ja) * | 1991-02-12 | 1994-04-07 | ルセル ユクラフ | ヒトTリンパ球レセプターのβ鎖の可変領域をコードするヌクレオチド配列対応するペプチドセグメント並びに診断及び治療への利用 |
| JP3080178B2 (ja) | 1991-02-18 | 2000-08-21 | 東洋紡績株式会社 | 核酸配列の増幅方法およびそのための試薬キット |
| US6091000A (en) | 1991-03-15 | 2000-07-18 | Duke University | SCID mouse engrafted with human synovium tissue |
| JP3266311B2 (ja) | 1991-05-02 | 2002-03-18 | 生化学工業株式会社 | 新規ポリペプチドおよびこれを用いる抗hiv剤 |
| US5674679A (en) | 1991-09-27 | 1997-10-07 | Amersham Life Science, Inc. | DNA cycle sequencing |
| US5981179A (en) | 1991-11-14 | 1999-11-09 | Digene Diagnostics, Inc. | Continuous amplification reaction |
| US5213960A (en) | 1992-03-09 | 1993-05-25 | Tanox Biosystems, Inc. | Methods for selecting low frequency antigen-specific single B lymphocytes |
| US5256542A (en) | 1992-03-09 | 1993-10-26 | Tanox Biosystems, Inc. | Selecting low frequency antigen-specific single B lymphocytes with correction for background noise |
| US5837447A (en) | 1992-04-15 | 1998-11-17 | Blood Center Research Foundation, Inc., The | Monitoring an immune response by analysis of amplified immunoglobulin or T-cell-receptor nucleic acid |
| US5498392A (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
| US5587128A (en) | 1992-05-01 | 1996-12-24 | The Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification devices |
| US5981176A (en) | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| JPH10504181A (ja) | 1994-04-18 | 1998-04-28 | ニューヨーク ソサエティ フォー ザ リリーフ オブ ザ ラプチャード アンド クリップルド メインティニング ザ ホスピタル フォー スペシャル サージェリー | 保存されたt細胞レセプター配列 |
| US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
| US6090592A (en) | 1994-08-03 | 2000-07-18 | Mosaic Technologies, Inc. | Method for performing amplification of nucleic acid on supports |
| FR2724182B1 (fr) | 1994-09-02 | 1996-12-13 | Pasteur Institut | Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations |
| US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
| US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| US5776737A (en) | 1994-12-22 | 1998-07-07 | Visible Genetics Inc. | Method and composition for internal identification of samples |
| US6919434B1 (en) | 1995-02-20 | 2005-07-19 | Sankyo Co., Ltd. | Monoclonal antibodies that bind OCIF |
| US5698396A (en) | 1995-06-07 | 1997-12-16 | Ludwig Institute For Cancer Research | Method for identifying auto-immunoreactive substances from a subject |
| WO1997013868A1 (en) | 1995-10-11 | 1997-04-17 | Leonard Adleman | Large scale dna sequencing by position sensitive hybridization |
| WO1997013877A1 (en) | 1995-10-12 | 1997-04-17 | Lynx Therapeutics, Inc. | Measurement of gene expression profiles in toxicity determination |
| US6087096A (en) | 1995-11-13 | 2000-07-11 | Dau; Peter C. | Method of intrafamily fragment analysis of the T cell receptor α and β chain CDR3 regions |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| KR19990087749A (ko) | 1996-03-13 | 1999-12-27 | 시오노 요시히코 | 류마티스성 관절염에 특이적인 인간 티 세포 클론 |
| US6458530B1 (en) | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
| AU736742B2 (en) | 1996-06-03 | 2001-08-02 | Governors Of The University Of Alberta, The | Methods for detection of rearranged DNA |
| EP0912766B2 (en) | 1996-06-04 | 2011-12-14 | University of Utah Research Foundation | Monitoring hybridization during pcr |
| WO1998001738A2 (en) | 1996-06-20 | 1998-01-15 | Cornell Research Foundation, Inc. | Identification of abnormalities in the expression of t and b cell antigen receptors as disease indicators |
| US6074827A (en) | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
| PT937251E (pt) | 1996-09-06 | 2007-01-31 | Ortho Mcneil Pharm Inc | Purificação de células específicas de antigénio |
| US5935793A (en) | 1996-09-27 | 1999-08-10 | The Chinese University Of Hong Kong | Parallel polynucleotide sequencing method using tagged primers |
| GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
| GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| EP1591541B1 (en) | 1997-04-01 | 2012-02-15 | Illumina Cambridge Limited | Method of nucleic acid sequencing |
| US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| DK1019496T3 (da) | 1997-07-07 | 2005-01-10 | Medical Res Council | In vitro-sorteringsmetode |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US7572582B2 (en) | 1997-09-12 | 2009-08-11 | Exiqon A/S | Oligonucleotide analogues |
| CA2306126A1 (en) | 1997-10-15 | 1999-04-22 | Aclara Biosciences, Inc. | Laminate microstructure device and method for making same |
| CA2307177C (en) | 1997-10-23 | 2004-06-29 | Exact Laboratories, Inc. | Methods for detecting contamination in molecular diagnostics using pcr |
| US7351578B2 (en) | 1999-12-10 | 2008-04-01 | Invitrogen Corp. | Use of multiple recombination sites with unique specificity in recombinational cloning |
| US6210910B1 (en) | 1998-03-02 | 2001-04-03 | Trustees Of Tufts College | Optical fiber biosensor array comprising cell populations confined to microcavities |
| DE19833738A1 (de) | 1998-07-27 | 2000-02-03 | Michael Giesing | Verfahren zur Isolierung von Krebszellen aus zellhaltigen Körperflüssigkeiten sowie Sets zur Durchführung dieses Verfahrens |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| DE19844931C1 (de) | 1998-09-30 | 2000-06-15 | Stefan Seeger | Verfahren zur DNS- oder RNS-Sequenzierung |
| US6541608B1 (en) * | 1999-02-23 | 2003-04-01 | Baylor College Of Medicine | T cell receptor Vβ-Dβ-Jβ sequence and methods for its detection |
| US6307024B1 (en) | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
| US6300070B1 (en) | 1999-06-04 | 2001-10-09 | Mosaic Technologies, Inc. | Solid phase methods for amplifying multiple nucleic acids |
| US6440706B1 (en) | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
| US20040209314A1 (en) | 1999-09-06 | 2004-10-21 | Institut National De La Sante Et De La Recherche Medicale France | Means for detection and purification of CD8+ T lymphocyte populations specific to peptides presented in the context of HLA |
| US6235483B1 (en) | 2000-01-31 | 2001-05-22 | Agilent Technologies, Inc. | Methods and kits for indirect labeling of nucleic acids |
| US20040170977A1 (en) | 2000-03-31 | 2004-09-02 | Peter Laird | Epigenetic sequences for esophageal adenocarcinoma |
| AUPQ687600A0 (en) | 2000-04-13 | 2000-05-11 | Flinders Technologies Pty Ltd | A method of detection |
| US20030207300A1 (en) | 2000-04-28 | 2003-11-06 | Matray Tracy J. | Multiplex analytical platform using molecular tags |
| GB0016138D0 (en) * | 2000-06-30 | 2000-08-23 | Novartis Ag | Organic compounds |
| US6596492B2 (en) | 2000-07-11 | 2003-07-22 | Colorado State University Research Foundation | PCR materials and methods useful to detect canine and feline lymphoid malignancies |
| US7567870B1 (en) | 2000-07-31 | 2009-07-28 | Institute For Systems Biology | Multiparameter analysis for predictive medicine |
| US6939451B2 (en) | 2000-09-19 | 2005-09-06 | Aclara Biosciences, Inc. | Microfluidic chip having integrated electrodes |
| EP1366192B8 (en) | 2000-10-24 | 2008-10-29 | The Board of Trustees of the Leland Stanford Junior University | Direct multiplex characterization of genomic dna |
| US6778724B2 (en) | 2000-11-28 | 2004-08-17 | The Regents Of The University Of California | Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices |
| ATE488576T1 (de) | 2001-02-20 | 2010-12-15 | Univ Georgia | Schnellproduktion monoklonaler antikörper |
| US7265208B2 (en) | 2001-05-01 | 2007-09-04 | The Regents Of The University Of California | Fusion molecules and treatment of IgE-mediated allergic diseases |
| WO2002094009A2 (en) | 2001-05-24 | 2002-11-28 | Guard Inc. | Methods for selecting and producing animals having a predicted level of immune response |
| US20050260570A1 (en) | 2001-05-29 | 2005-11-24 | Mao Jen-I | Sequencing by proxy |
| US6720144B1 (en) | 2001-06-21 | 2004-04-13 | Quest Diagnostics | Detection of clonal T-cell receptor-γ gene rearrangement by PCR/temporal temperature gradient gel electrophoresis (TTGE) |
| US7112423B2 (en) | 2001-07-15 | 2006-09-26 | Keck Graduate Institute | Nucleic acid amplification using nicking agents |
| US20030096277A1 (en) | 2001-08-30 | 2003-05-22 | Xiangning Chen | Allele specific PCR for genotyping |
| AU2002322518A1 (en) | 2001-08-31 | 2003-03-18 | Rosetta Inpharmactis Llc | Methods for preparing nucleic acid samples |
| AU2002321581C1 (en) | 2001-08-31 | 2008-09-18 | Adaptimmune Limited | Soluble T cell receptor |
| US7306906B2 (en) | 2001-09-19 | 2007-12-11 | Alexion Pharmaceuticals, Inc. | Engineered templates and their use in single primer amplification |
| EP1451340B1 (en) | 2001-11-09 | 2014-01-08 | Life Technologies Corporation | Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles |
| GB2382137A (en) | 2001-11-20 | 2003-05-21 | Mats Gullberg | Nucleic acid enrichment |
| GB0128153D0 (en) | 2001-11-23 | 2002-01-16 | Bayer Ag | Profiling of the immune gene repertoire |
| WO2003052101A1 (en) | 2001-12-14 | 2003-06-26 | Rosetta Inpharmatics, Inc. | Sample tracking using molecular barcodes |
| GB0130267D0 (en) | 2001-12-19 | 2002-02-06 | Neutec Pharma Plc | Focussed antibody technology |
| WO2003059155A2 (en) | 2002-01-09 | 2003-07-24 | Maxx Genetech Co. Ltd | Method of detecting t-cell proliferation for diagnosis of diseases by gene array |
| US7157274B2 (en) | 2002-06-24 | 2007-01-02 | Cytonome, Inc. | Method and apparatus for sorting particles |
| WO2004046098A2 (en) | 2002-05-16 | 2004-06-03 | Vanderbilt University | Method for predicting autoimmune diseases |
| EP1573636A2 (en) | 2002-07-01 | 2005-09-14 | Institut Pasteur | System, method, device, and computer program product for extraction, gathering, manipulation, and analysis of peak data from an automated sequencer |
| US7691994B2 (en) | 2002-07-03 | 2010-04-06 | Brewer Jamie L | Compositions and methods for the detection of human T cell receptor variable family gene expression |
| CA2493081C (en) | 2002-07-12 | 2013-04-23 | The Johns Hopkins University | Reagents and methods for engaging unique clonotypic lymphocyte receptors |
| ATE470722T1 (de) | 2002-07-19 | 2010-06-15 | Althea Technologies Inc | Strategien zur genexpressionsanalyse |
| US7157228B2 (en) | 2002-09-09 | 2007-01-02 | Bioarray Solutions Ltd. | Genetic analysis and authentication |
| US7459273B2 (en) | 2002-10-04 | 2008-12-02 | Affymetrix, Inc. | Methods for genotyping selected polymorphism |
| WO2004033728A2 (en) * | 2002-10-11 | 2004-04-22 | Erasmus Universiteit Rotterdam | Nucleic acid amplification primers for pcr-based clonality studies |
| US20050009096A1 (en) | 2002-10-11 | 2005-01-13 | The Regents Of The University Of California | Method for diagnosis and prognosis of multiple sclerosis |
| US20060147925A1 (en) | 2002-11-13 | 2006-07-06 | Morley Alexander A | Method of detection |
| EP2365331B1 (en) | 2002-11-14 | 2015-11-04 | Valneva | Method to clone a single antigen-specfic lymphocyte. |
| AU2003300919A1 (en) | 2002-12-11 | 2004-06-30 | Coley Pharmaceutical Gmbh | 5' cpg nucleic acids and methods of use |
| WO2004063706A2 (en) | 2003-01-08 | 2004-07-29 | Maxx Genetech Co., Ltd. | Method of detecting over-expression of t-cell receptor genes by real-time pcr |
| US20040185484A1 (en) | 2003-01-29 | 2004-09-23 | Costa Gina L. | Method for preparing single-stranded DNA libraries |
| GB0304068D0 (en) | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
| US20070042349A1 (en) | 2003-04-24 | 2007-02-22 | Ogle Brenda M | Methods for assessing biologic diversity |
| AU2003902299A0 (en) | 2003-05-13 | 2003-05-29 | Flinders Medical Centre | A method of analysing a marker nucleic acid molecule |
| US20070105105A1 (en) | 2003-05-23 | 2007-05-10 | Mount Sinai School Of Medicine Of New York University | Surrogate cell gene expression signatures for evaluating the physical state of a subject |
| US20050010030A1 (en) | 2003-07-02 | 2005-01-13 | Zang Jingwu Z. | T cell receptor CDR3 sequence and methods for detecting and treating rheumatoid arthritis |
| JP5183063B2 (ja) | 2003-07-05 | 2013-04-17 | ザ ジョンズ ホプキンス ユニバーシティ | 遺伝的変異の検出および列挙のための方法ならびに組成物 |
| US20060228350A1 (en) * | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
| US20050048498A1 (en) | 2003-08-29 | 2005-03-03 | Applera Corporation | Compositions, methods, and kits for assembling probes |
| WO2005026686A2 (en) | 2003-09-09 | 2005-03-24 | Compass Genetics, Llc | Multiplexed analytical platform |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| FR2863274B1 (fr) * | 2003-12-05 | 2012-11-16 | Commissariat Energie Atomique | Procede d'evaluation quantitative d'un rearrangement ou d'une recombinaison genetique ciblee d'un individu et ses applications. |
| US20070238099A1 (en) | 2003-12-08 | 2007-10-11 | Cohen Irun R | Antigen Receptor Variable Region Typing |
| EP1704251A1 (en) | 2003-12-15 | 2006-09-27 | Institut Pasteur | Repertoire determination of a lymphocyte b population |
| US20080166718A1 (en) | 2003-12-15 | 2008-07-10 | Institut Pasteur | Repertoire determination of a lymphocyte B population |
| ATE421998T1 (de) | 2003-12-15 | 2009-02-15 | Pasteur Institut | Ermittlung des repertoires von b-lymphozyten populationen |
| CA2556981C (en) | 2004-02-18 | 2015-10-13 | The Trustees Of Boston University | Method for detecting and quantifying rare mutations or polymorphisms |
| US20060046258A1 (en) | 2004-02-27 | 2006-03-02 | Lapidus Stanley N | Applications of single molecule sequencing |
| US20070161001A1 (en) | 2004-03-04 | 2007-07-12 | Dena Leshkowitz | Quantifying and profiling antibody and t cell receptor gene expression |
| JP4480423B2 (ja) | 2004-03-08 | 2010-06-16 | 独立行政法人科学技術振興機構 | 免疫細胞クローンの拡大の有無の判定方法 |
| DE102004016437A1 (de) | 2004-04-04 | 2005-10-20 | Oligene Gmbh | Verfahren zur Erkennung von Signaturen in komplexen Genexpressionsprofilen |
| US20050250147A1 (en) | 2004-05-10 | 2005-11-10 | Macevicz Stephen C | Digital profiling of polynucleotide populations |
| JP2007536939A (ja) | 2004-05-14 | 2007-12-20 | アモークス インコーポレーティッド | 免疫細胞バイオセンサーおよびその使用方法 |
| EP1598429A1 (en) | 2004-05-19 | 2005-11-23 | Amplion Ltd. | Detection of amplicon contamination during PCR exhibiting two different annealing temperatures |
| GB0412973D0 (en) | 2004-06-10 | 2004-07-14 | Celltech R&D Ltd | Identification of antibody producing cells |
| US20060020397A1 (en) | 2004-07-21 | 2006-01-26 | Kermani Bahram G | Methods for nucleic acid and polypeptide similarity search employing content addressable memories |
| WO2006014869A1 (en) | 2004-07-26 | 2006-02-09 | Parallele Bioscience, Inc. | Simultaneous analysis of multiple genomes |
| US7820382B2 (en) | 2004-08-03 | 2010-10-26 | Bauer A Robert | Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the donor and in the recipient and their associated conditions related and unrelated to the organ transplantation |
| US20060094018A1 (en) | 2004-08-03 | 2006-05-04 | Bauer A R Jr | Discovery and a method for the early detection of pancreatic cancer and other disease conditions |
| ATE465181T1 (de) | 2004-08-05 | 2010-05-15 | Genentech Inc | Humanisierte anti-cmet-antagonisten |
| US7915036B2 (en) | 2004-09-13 | 2011-03-29 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compositions comprising T cell receptors and methods of use thereof |
| US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
| US8053235B2 (en) | 2004-10-29 | 2011-11-08 | Benaroya Research Institute At Virginia Mason | Methods of generating antigen-specific CD4+CD25+regulatory T cells, compositions and methods of use |
| US7966988B2 (en) | 2005-01-11 | 2011-06-28 | Exxonmobil Research And Engineering Company | Method for controlling soot induced lubricant viscosity increase |
| US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
| FR2881436B1 (fr) | 2005-02-03 | 2007-04-27 | Commissariat Energie Atomique | Procede de determination de la diversite des lymphocytes t dans un echantillon biologique |
| US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
| CN101156067A (zh) | 2005-02-16 | 2008-04-02 | 惠氏公司 | 用于白血病诊断、预后和治疗选择的方法和系统 |
| US7537894B2 (en) | 2005-03-02 | 2009-05-26 | The University Of Chicago | Methods and kits for monitoring Barrett's metaplasia |
| WO2006099164A2 (en) | 2005-03-10 | 2006-09-21 | Applera Corporation | Methods for multiplex amplification |
| EP1856293A2 (en) | 2005-03-16 | 2007-11-21 | Compass Genetics, Llc | Methods and compositions for assay readouts on multiple analytical platforms |
| WO2006110855A2 (en) * | 2005-04-12 | 2006-10-19 | 454 Life Sciences Corporation | Methods for determining sequence variants using ultra-deep sequencing |
| WO2006116155A2 (en) | 2005-04-21 | 2006-11-02 | The Regents Of The University Of California | A method for diagnosis and prognosis of multiple sclerosis subtypes |
| US20060263789A1 (en) | 2005-05-19 | 2006-11-23 | Robert Kincaid | Unique identifiers for indicating properties associated with entities to which they are attached, and methods for using |
| US7208795B2 (en) | 2005-05-24 | 2007-04-24 | Atmel Corporation | Low-cost, low-voltage single-layer polycrystalline EEPROM memory cell integration into BiCMOS technology |
| US7709197B2 (en) | 2005-06-15 | 2010-05-04 | Callida Genomics, Inc. | Nucleic acid analysis by random mixtures of non-overlapping fragments |
| US20070020670A1 (en) | 2005-07-07 | 2007-01-25 | Hematologics, Inc. | Methods for detecting and confirming minimal disease |
| US20070020640A1 (en) | 2005-07-21 | 2007-01-25 | Mccloskey Megan L | Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis |
| GB0521521D0 (en) | 2005-10-21 | 2005-11-30 | Medical Res Council | Diagnostic methods and kits |
| GB0522310D0 (en) * | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| US20070105165A1 (en) | 2005-11-04 | 2007-05-10 | Charles Goolsby | Composite profiles of cell antigens and target signal transduction proteins for analysis and clinical management of hematologic cancers |
| US7375211B2 (en) * | 2005-11-18 | 2008-05-20 | Kou Zhong C | Method for detection and quantification of T-cell receptor Vβ repertoire |
| US8137936B2 (en) | 2005-11-29 | 2012-03-20 | Macevicz Stephen C | Selected amplification of polynucleotides |
| WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
| EP1987162A4 (en) | 2006-01-23 | 2009-11-25 | Population Genetics Technologi | NUCLEIC ACID ANALYSIS ABOUT SEQUENCE TOKENS |
| SG170028A1 (en) | 2006-02-24 | 2011-04-29 | Callida Genomics Inc | High throughput genome sequencing on dna arrays |
| CA2638833A1 (en) | 2006-03-06 | 2007-09-13 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
| ES2546848T3 (es) | 2006-03-10 | 2015-09-29 | Epigenomics Ag | Un método para identificar una muestra biológica para el análisis de la metilación |
| WO2007114693A2 (en) | 2006-04-04 | 2007-10-11 | Keygene N.V. | High throughput detection of molecular markers based on aflp and high throughput sequencing |
| US20100323401A1 (en) | 2006-05-11 | 2010-12-23 | Lewis George K | General method for generating human antibody responses in vitro |
| WO2007136518A2 (en) | 2006-05-17 | 2007-11-29 | Torrey Pines Institute For Molecular Studies | Treatment of autoimmune disorders |
| AU2006345511B2 (en) | 2006-05-25 | 2013-03-21 | Institute For Advanced Study | Methods for identifying sequence motifs, and applications thereof |
| US7833716B2 (en) | 2006-06-06 | 2010-11-16 | Gen-Probe Incorporated | Tagged oligonucleotides and their use in nucleic acid amplification methods |
| EP2027253A4 (en) | 2006-06-12 | 2014-04-30 | Pacific Biosciences California | SUBSTATES FOR EFFECTING ANALYSIS REACTIONS |
| US20100027896A1 (en) * | 2006-06-28 | 2010-02-04 | Amir Geva | Automated application interaction using a virtual operator |
| EP2044217A2 (en) | 2006-06-30 | 2009-04-08 | Applera Corporation | Reversible terminator nucleotides and methods of use |
| WO2008108803A2 (en) | 2006-07-13 | 2008-09-12 | Amaox, Ltd. | Immune cell biosensors and methods of using same |
| US8394590B2 (en) | 2006-08-02 | 2013-03-12 | California Institute Of Technology | Capture agents and related methods and systems for detecting and/or sorting targets |
| US20080274904A1 (en) | 2006-08-10 | 2008-11-06 | Niall Anthony Gormley | Method of target enrichment |
| WO2008026927A2 (en) | 2006-08-30 | 2008-03-06 | Academisch Medisch Centrum | Process for displaying t- and b-cell receptor repertoires |
| WO2008039818A2 (en) | 2006-09-26 | 2008-04-03 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Modified t cell receptors and related materials and methods |
| WO2008039694A2 (en) | 2006-09-26 | 2008-04-03 | St. Jude Children's Research Hospital | Methods and compositions for monitoring t cell receptor diversity |
| JP5026047B2 (ja) | 2006-10-18 | 2012-09-12 | 株式会社膠原病研究所 | 自己免疫疾患の発症に関わる自己応答性t細胞またはt細胞受容体の同定方法、およびその利用 |
| WO2008140484A2 (en) | 2006-11-09 | 2008-11-20 | Xdx, Inc. | Methods for diagnosing and monitoring the status of systemic lupus erythematosus |
| US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| US7862999B2 (en) | 2007-01-17 | 2011-01-04 | Affymetrix, Inc. | Multiplex targeted amplification using flap nuclease |
| PL2121920T3 (pl) | 2007-03-01 | 2012-01-31 | Symphogen As | Sposób klonowania pokrewnych przeciwciał |
| WO2008147879A1 (en) | 2007-05-22 | 2008-12-04 | Ryan Golhar | Automated method and device for dna isolation, sequence determination, and identification |
| EP2164985A4 (en) | 2007-06-01 | 2014-05-14 | 454 Life Sciences Corp | SYSTEM AND METHOD FOR IDENTIFYING INDIVIDUAL SAMPLES FROM A MULTIPLEX MIXTURE |
| US8454906B2 (en) | 2007-07-24 | 2013-06-04 | The Regents Of The University Of California | Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions |
| CN101802220B (zh) | 2007-07-26 | 2013-07-31 | 加利福尼亚太平洋生物科学股份有限公司 | 分子冗余测序法 |
| ITRM20070429A1 (it) | 2007-08-06 | 2009-02-07 | Uni Cattolica Del Sacro Cuor E | Mezzi per la diagnosi la prevenzione e la cura dell'artrite reumatoide. |
| CN104307581B (zh) | 2007-08-09 | 2017-04-12 | 诺思可有限公司 | 关联的多参数单细胞测定及残余生物材料回收的方法和装置 |
| US8268564B2 (en) | 2007-09-26 | 2012-09-18 | President And Fellows Of Harvard College | Methods and applications for stitched DNA barcodes |
| WO2009045898A2 (en) | 2007-09-28 | 2009-04-09 | Mayo Foundation For Medical Education And Research | Assessing t cell repertoires |
| US7960116B2 (en) | 2007-09-28 | 2011-06-14 | Pacific Biosciences Of California, Inc. | Nucleic acid sequencing methods and systems |
| US9068230B2 (en) | 2007-11-07 | 2015-06-30 | Genentech, Inc. | Methods and compositions for assessing responsiveness of B-cell lymphoma to treatment with anti-CD40 antibodies |
| WO2009070767A2 (en) | 2007-11-28 | 2009-06-04 | Whitehead Institute For Biomedical Research | Systemic instigation systems to study tumor growth or metastasis |
| EP2062982A1 (fr) | 2007-11-26 | 2009-05-27 | ImmunID | Procédé d'étude de la diversité combinatoire V(D)J |
| CN101225441B (zh) | 2007-12-05 | 2010-12-01 | 浙江大学 | 一种检测克隆特异性t淋巴细胞tcr bv cdr3基因组成的方法 |
| US8621502B2 (en) | 2007-12-21 | 2013-12-31 | Microsoft Corporation | Obtaining user reactions to video |
| US7767400B2 (en) | 2008-02-03 | 2010-08-03 | Helicos Biosciences Corporation | Paired-end reads in sequencing by synthesis |
| EP2088432A1 (en) | 2008-02-11 | 2009-08-12 | MorphoSys AG | Methods for identification of an antibody or a target |
| WO2009108860A2 (en) | 2008-02-28 | 2009-09-03 | The Ohio University Rasearch Foundation | Microrna-based methods and compositions for the diagnosis, pronosis and treatment of prostate related disorders |
| JP2011516033A (ja) | 2008-02-28 | 2011-05-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 急性骨髄性性白血病(aml)における細胞遺伝学および予後と関連するマイクロrnaシグネチャーおよびその使用 |
| US20090226975A1 (en) | 2008-03-10 | 2009-09-10 | Illumina, Inc. | Constant cluster seeding |
| TW200938840A (en) | 2008-03-12 | 2009-09-16 | Emo Biomedicine Corp | A method for in vitro study of immune modulation using pig blood cell |
| US8143007B2 (en) | 2008-03-13 | 2012-03-27 | National Institute Of Immunology | Nested primer sets for amplifying mouse immunoglobulin variable gene segments |
| AU2009229157B2 (en) | 2008-03-28 | 2015-01-29 | Pacific Biosciences Of California, Inc. | Compositions and methods for nucleic acid sequencing |
| ATE530497T1 (de) | 2008-03-31 | 2011-11-15 | Sony Deutschland Gmbh | Verfahren zur herstellung einer membran mit konischer pore |
| WO2009137255A2 (en) | 2008-04-16 | 2009-11-12 | Hudsonalpha Institute For Biotechnology | Method for evaluating and comparing immunorepertoires |
| US8911948B2 (en) | 2008-04-30 | 2014-12-16 | Integrated Dna Technologies, Inc. | RNase H-based assays utilizing modified RNA monomers |
| JP2012500964A (ja) | 2008-05-09 | 2012-01-12 | デューク ユニバーシティ | 癌の検出と治療における自己抗体 |
| US9068181B2 (en) | 2008-05-23 | 2015-06-30 | The General Hospital Corporation | Microfluidic droplet encapsulation |
| DE102008025656B4 (de) | 2008-05-28 | 2016-07-28 | Genxpro Gmbh | Verfahren zur quantitativen Analyse von Nukleinsäuren, Marker dafür und deren Verwendung |
| CN102112624A (zh) | 2008-05-30 | 2011-06-29 | 麻省理工学院 | 用于对细胞进行空间分割以及筛选的组合物以及方法 |
| WO2009151628A2 (en) | 2008-06-12 | 2009-12-17 | Gov't Of The Usa, As Represented By The Secretary, Department Of Health Human Services | Monitoring tcr-b to determine hiv therapy and disease progression |
| EA201170088A1 (ru) | 2008-06-25 | 2011-10-31 | Бейлор Рисёч Инститьют | Транскрипционная сигнатура крови инфекции mycobacterium tuberculosis |
| WO2010011894A1 (en) | 2008-07-24 | 2010-01-28 | The Board Of Regents Of The University Of Texas System | Vh4 codon signature for multiple sclerosis |
| CN102177438A (zh) | 2008-07-25 | 2011-09-07 | 理查德·W·瓦格纳 | 蛋白筛选方法 |
| US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| CA3210271A1 (en) | 2008-09-23 | 2010-04-01 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| US8699361B2 (en) | 2008-09-30 | 2014-04-15 | Qualcomm Incorporated | Out-of-synchronization handling method and apparatus |
| US8546128B2 (en) | 2008-10-22 | 2013-10-01 | Life Technologies Corporation | Fluidics system for sequential delivery of reagents |
| US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| WO2010053587A2 (en) | 2008-11-07 | 2010-05-14 | Mlc Dx Incorporated | Methods of monitoring conditions by sequence analysis |
| US9394567B2 (en) | 2008-11-07 | 2016-07-19 | Adaptive Biotechnologies Corporation | Detection and quantification of sample contamination in immune repertoire analysis |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| US8691510B2 (en) | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US20140234835A1 (en) | 2008-11-07 | 2014-08-21 | Sequenta, Inc. | Rare clonotypes and uses thereof |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US20110105343A1 (en) | 2008-11-21 | 2011-05-05 | Emory University | Systems Biology Approach Predicts Immunogenicity of Vaccines |
| US8367330B2 (en) | 2008-12-22 | 2013-02-05 | Quest Diagnostics Investments Incorporated | Methods for detecting TCR-gamma gene rearrangement |
| KR20110110247A (ko) | 2008-12-30 | 2011-10-06 | 센토코 오르토 바이오테크 인코포레이티드 | 강직성 척추염 환자에서 항-TNFα 항체에 대한 임상적 반응을 예측하는 혈청 마커 |
| DK3059337T3 (da) | 2009-01-15 | 2019-07-22 | Adaptive Biotechnologies Corp | Adaptive immunity profiling og metoder til frembringelse af monoklonale antibodier |
| CN102333891A (zh) | 2009-01-20 | 2012-01-25 | 利兰·斯坦福青年大学托管委员会 | 用于药靶诊断、预后和鉴别的单细胞基因表达 |
| US20100323348A1 (en) | 2009-01-31 | 2010-12-23 | The Regents Of The University Of Colorado, A Body Corporate | Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process |
| US8673627B2 (en) | 2009-05-29 | 2014-03-18 | Life Technologies Corporation | Apparatus and methods for performing electrochemical reactions |
| US8574835B2 (en) | 2009-05-29 | 2013-11-05 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
| SG10201403451QA (en) | 2009-06-25 | 2014-09-26 | Hutchinson Fred Cancer Res | Method of measuring adaptive immunity |
| WO2011008502A2 (en) | 2009-06-29 | 2011-01-20 | California Institute Of Technology | Isolation of unknown rearranged t-cell receptors from single cells |
| CN102575292B (zh) | 2009-09-22 | 2015-07-29 | 霍夫曼-拉罗奇有限公司 | 与疾病相关的kir单元型的测定 |
| US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
| US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US8545248B2 (en) | 2010-01-07 | 2013-10-01 | Life Technologies Corporation | System to control fluid flow based on a leak detected by a sensor |
| KR101323827B1 (ko) | 2010-01-08 | 2013-10-31 | 키스트 유럽 에프게엠베하 | 강직성척추염 진단용 프라이머 및 이를 이용한 강직성 척추염 진단 방법 |
| GB201000375D0 (en) | 2010-01-09 | 2010-02-24 | Univ Cardiff | T Cell clonotypes |
| WO2011106738A2 (en) | 2010-02-25 | 2011-09-01 | Fred Hutchinson Cancer Research Center | Use of tcr clonotypes as biomarkers for disease |
| EP2367000A1 (en) | 2010-03-04 | 2011-09-21 | Charité Universitätsmedizin Berlin | High throughput analysis of T-cell receptor repertoires |
| JP6085249B2 (ja) | 2010-05-06 | 2017-02-22 | アダプティヴ バイオテクノロジーズ コーポレーション | 複雑なアンプリコンの配列解析 |
| US9234240B2 (en) | 2010-05-07 | 2016-01-12 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and comparison of immune diversity by high-throughput sequencing |
| US20130123120A1 (en) | 2010-05-18 | 2013-05-16 | Natera, Inc. | Highly Multiplex PCR Methods and Compositions |
| WO2011156707A2 (en) | 2010-06-11 | 2011-12-15 | Life Technologies Corporation | Alternative nucleotide flows in sequencing-by-synthesis methods |
| WO2012027503A2 (en) | 2010-08-24 | 2012-03-01 | Fred Hutchinson Cancer Research Center | Method of measuring adaptive immunity |
| ES2595433T3 (es) | 2010-09-21 | 2016-12-30 | Population Genetics Technologies Ltd. | Aumento de la confianza en las identificaciones de alelos con el recuento molecular |
| EP2622103B2 (en) | 2010-09-30 | 2022-11-16 | Bio-Rad Laboratories, Inc. | Sandwich assays in droplets |
| DK2625320T3 (da) | 2010-10-08 | 2019-07-01 | Harvard College | High-throughput enkeltcellestregkodning |
| EP2625295B1 (en) | 2010-10-08 | 2019-03-13 | President and Fellows of Harvard College | High-throughput immune sequencing |
| WO2012055929A1 (en) | 2010-10-26 | 2012-05-03 | Illumina, Inc. | Sequencing methods |
| WO2012061832A1 (en) | 2010-11-05 | 2012-05-10 | Illumina, Inc. | Linking sequence reads using paired code tags |
| US9193997B2 (en) | 2010-12-15 | 2015-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Measuring and monitoring of cell clonality |
| WO2012083225A2 (en) | 2010-12-16 | 2012-06-21 | Gigagen, Inc. | System and methods for massively parallel analysis of nycleic acids in single cells |
| WO2012118555A1 (en) | 2010-12-29 | 2012-09-07 | Life Technologies Corporation | Time-warped background signal for sequencing-by-synthesis operations |
| EP3582224A1 (en) | 2010-12-30 | 2019-12-18 | Life Technologies Corporation | Models for analyzing data from sequencing-by-synthesis operations |
| US8759036B2 (en) | 2011-03-21 | 2014-06-24 | Affymetrix, Inc. | Methods for synthesizing pools of probes |
| EP2697397B1 (en) | 2011-04-15 | 2017-04-05 | The Johns Hopkins University | Safe sequencing system |
| WO2012159754A2 (en) | 2011-05-24 | 2012-11-29 | Biontech Ag | Individualized vaccines for cancer |
| WO2013033721A1 (en) | 2011-09-02 | 2013-03-07 | Atreca, Inc. | Dna barcodes for multiplexed sequencing |
| US20140356339A1 (en) | 2011-09-09 | 2014-12-04 | Sequenta Inc. | Sequence-based measures of immune response |
| US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
| WO2013055595A1 (en) | 2011-10-11 | 2013-04-18 | Sequenta, Inc. | Determining responsiveness of autoimmune patients to dmard treatment |
| CA2853088C (en) | 2011-10-21 | 2018-03-13 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| US20150252422A1 (en) | 2011-11-04 | 2015-09-10 | Sequenta Llc | T-cell receptor clonotypes shared among ankylosing spondylitis patients |
| WO2013085855A1 (en) | 2011-12-05 | 2013-06-13 | Sequenta, Inc. | Clonotypes as biometric specimen tags |
| JP2015501644A (ja) | 2011-12-09 | 2015-01-19 | シーケンタ インコーポレイテッド | 免疫活性化を測定する方法 |
| EP3388535B1 (en) | 2011-12-09 | 2021-03-24 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| WO2013090390A2 (en) | 2011-12-13 | 2013-06-20 | Sequenta, Inc. | Method of measuring immune activation |
| US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
| JP2015504661A (ja) | 2011-12-20 | 2015-02-16 | シーケンタ インコーポレイテッド | 免疫レパートリー解析による、濾胞性リンパ腫からびまん性大細胞型b細胞リンパ腫への形質転換のモニタリング |
| US20150031555A1 (en) | 2012-01-24 | 2015-01-29 | Gigagen, Inc. | Method for correction of bias in multiplexed amplification |
| WO2013130512A2 (en) | 2012-02-27 | 2013-09-06 | The University Of North Carolina At Chapel Hill | Methods and uses for molecular tags |
| WO2013131074A1 (en) | 2012-03-02 | 2013-09-06 | Diogenix, Inc. | Methods and reagents for evaluating autoimmune disease and determining antibody repertoire |
| WO2013134302A1 (en) | 2012-03-05 | 2013-09-12 | Sequenta, Inc. | Monitoring immune responsiveness to cancer vaccination |
| US20150038346A1 (en) | 2012-03-05 | 2015-02-05 | Sequenta, Inc. | Monitoring immune responsiveness to cancer vaccination |
| US10077478B2 (en) | 2012-03-05 | 2018-09-18 | Adaptive Biotechnologies Corp. | Determining paired immune receptor chains from frequency matched subunits |
| AU2013246050B2 (en) | 2012-04-13 | 2017-03-16 | Adaptive Biotechnologies Corp. | Detection and quantitation of sample contamination in immune repertoire analysis |
| WO2013158936A1 (en) | 2012-04-20 | 2013-10-24 | Sequenta, Inc | Monitoring immunoglobulin heavy chain evolution in b-cell acute lymphoblastic leukemia |
| CN104520440B (zh) | 2012-05-08 | 2017-10-03 | 适应生物技术公司 | 用于测量和校准多重pcr反应中的扩增偏倚的组合物和方法 |
| US20150247201A1 (en) | 2012-05-31 | 2015-09-03 | Malek Faham | Predicting relapse of chronic lymphocytic leukemia patients treated by allogeneic stem cell transplantation |
| US20130324422A1 (en) | 2012-06-04 | 2013-12-05 | Sequenta, Inc. | Detecting disease-correlated clonotypes from fixed samples |
| CA2875542A1 (en) | 2012-06-11 | 2013-12-19 | Sequenta, Inc. | Method of sequence determination using sequence tags |
| JP2015519909A (ja) | 2012-06-15 | 2015-07-16 | アダプティブ バイオテクノロジーズ コーポレイション | 複合遺伝子セットにおける固有にタグ付加された再構成適応性免疫受容体遺伝子 |
| US20150247182A1 (en) | 2012-07-24 | 2015-09-03 | Adaptive Biotechnologies Corp. | Single cell analysis using sequence tags |
| WO2014026031A1 (en) | 2012-08-10 | 2014-02-13 | Sequenta, Inc. | High sensitivity mutation detection using sequence tags |
| DE112013004650T5 (de) | 2012-09-24 | 2015-06-18 | Cb Biotechnologies, Inc. | Multiplexpyrosequenzierung unter Verwendung nichtinterferierender, rauschbeendender Polynukleotididentifikationstags |
| WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| JP2015534806A (ja) | 2012-10-19 | 2015-12-07 | シーケンタ・インコーポレイテッド | 末梢血試料によるびまん性大細胞型b細胞性リンパ腫のモニタリング関連出願の相互参照本出願は、2012年10月19日出願の米国特許仮出願第61/716,270号の利益を主張するものであり、当該出願は参照により本明細書にその全体が組み込まれる。 |
| JP2015535178A (ja) | 2012-10-19 | 2015-12-10 | シーケンタ・インコーポレイテッド | 末梢血における形質細胞増殖障害のクロノタイプのモニタリング |
| US20150299800A1 (en) | 2012-10-22 | 2015-10-22 | Sequenta, Inc. | Monitoring mantle cell lymphoma clonotypes in peripheral blood after immunotransplant |
| JP6513035B2 (ja) | 2013-02-22 | 2019-05-15 | アダプティヴ バイオテクノロジーズ コーポレーション | 希少クロノタイプおよびその用途 |
| US20140255944A1 (en) | 2013-03-08 | 2014-09-11 | Sequenta, Inc. | Monitoring treatment-resistant clones in lymphoid and myeloid neoplasms by relative levels of evolved clonotypes |
| US20140255929A1 (en) | 2013-03-11 | 2014-09-11 | Sequenta, Inc. | Mosaic tags for labeling templates in large-scale amplifications |
| US20160169890A1 (en) * | 2013-05-20 | 2016-06-16 | The Trustees Of Columbia University In The City Of New York | Tracking donor-reactive tcr as a biomarker in transplantation |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| US20160186260A1 (en) | 2013-07-26 | 2016-06-30 | Sequenta, Llc | Cancer vaccination with antigen evolution |
| WO2015058159A1 (en) | 2013-10-18 | 2015-04-23 | Sequenta, Inc. | Predicting patient responsiveness to immune checkpoint inhibitors |
| US20150218656A1 (en) | 2014-02-03 | 2015-08-06 | Adaptive Biotechnologies Corp. | Methods for detection and diagnosis of a lymphoid malignancy using high throughput sequencing |
| WO2016069886A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corporation | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
-
2010
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- 2010-06-04 KR KR1020147031470A patent/KR20140146180A/ko not_active Ceased
- 2010-06-04 WO PCT/US2010/037477 patent/WO2010151416A1/en not_active Ceased
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2011
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2013
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2014
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- 2014-02-18 US US14/183,177 patent/US20140206549A1/en not_active Abandoned
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2015
- 2015-07-31 JP JP2015151866A patent/JP6125578B2/ja active Active
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2016
- 2016-03-04 US US15/061,827 patent/US9809813B2/en active Active
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2017
- 2017-09-20 US US15/709,719 patent/US11214793B2/en active Active
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2018
- 2018-06-29 US US16/023,010 patent/US11905511B2/en active Active
Non-Patent Citations (2)
| Title |
|---|
| comprehensive assessment of the tcrbv repertoire in small T-cell samples by means of an improved and convenient multiplex pcr method;mariani sara et al.;《experimental hematology》;20090520;第37卷(第6期);728-738 * |
| molecular analysis of t cell repertoires: spectratypes generated by multiplex polymerase chain reaction and evaluated by radioactivity or fluorescence;maslanka krystyna et al.;《human immunology》;19951231;第44卷(第1期);28-34 * |
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