CN102459253B - 作为pi3-激酶抑制剂的*唑取代的吲唑化合物 - Google Patents
作为pi3-激酶抑制剂的*唑取代的吲唑化合物 Download PDFInfo
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- CN102459253B CN102459253B CN201080030329.2A CN201080030329A CN102459253B CN 102459253 B CN102459253 B CN 102459253B CN 201080030329 A CN201080030329 A CN 201080030329A CN 102459253 B CN102459253 B CN 102459253B
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- base
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- indazole
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- 0 CC*c1cc(C(CC2N)=CC(c3ncc(CN4C[C@@](C)*C(C)C4)[o]3)=C2C=N)cnc1I Chemical compound CC*c1cc(C(CC2N)=CC(c3ncc(CN4C[C@@](C)*C(C)C4)[o]3)=C2C=N)cnc1I 0.000 description 2
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17403309P | 2009-04-30 | 2009-04-30 | |
US61/174033 | 2009-04-30 | ||
US61/174,033 | 2009-04-30 | ||
PCT/EP2010/055666 WO2010125082A1 (en) | 2009-04-30 | 2010-04-28 | Oxazole substituted indazoles as pi3-kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102459253A CN102459253A (zh) | 2012-05-16 |
CN102459253B true CN102459253B (zh) | 2015-03-25 |
Family
ID=42225106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201080030329.2A Active CN102459253B (zh) | 2009-04-30 | 2010-04-28 | 作为pi3-激酶抑制剂的*唑取代的吲唑化合物 |
Country Status (40)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107660204A (zh) * | 2015-06-02 | 2018-02-02 | 葛兰素史克知识产权开发有限公司 | 制备吲唑衍生物的方法 |
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WO2009147188A1 (en) * | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | Benzpyrazol derivatives as inhibitors of pi3 kinases |
WO2009147190A1 (en) * | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | Novel compounds |
JP5656880B2 (ja) | 2009-03-09 | 2015-01-21 | グラクソ グループ リミテッドGlaxo Group Limited | Pi3キナーゼの阻害剤としての4−オキサジアゾール−2−イル−インダゾール |
PT2424864E (pt) | 2009-04-30 | 2015-02-27 | Glaxo Group Ltd | Indazoles substituídos com oxazole como inibidores de pi3-cinase |
CN102372675B (zh) * | 2010-08-14 | 2013-12-18 | 王娜 | 6-氯-4-碘吲唑及其制备方法与应用 |
WO2012032065A1 (en) | 2010-09-08 | 2012-03-15 | Glaxo Group Limited | Indazole derivatives for use in the treatment of influenza virus infection |
US9102668B2 (en) | 2010-09-08 | 2015-08-11 | Glaxo Group Limited | Polymorphs and salts |
ES2548036T3 (es) * | 2010-09-08 | 2015-10-13 | Glaxosmithkline Intellectual Property Development Limited | Polimorfos y sales de N-[5-[4-(5-{[(2R,6S)-2,6-dimetil-4-morfolinil]metil}-1,3-oxazol-2-il)-1H-indazol-6-il]-2-(metiloxi)-3-piridinil]metanosulfonamida |
GB201018124D0 (en) * | 2010-10-27 | 2010-12-08 | Glaxo Group Ltd | Polymorphs and salts |
EP2638014B1 (en) * | 2010-11-08 | 2017-01-04 | Lycera Corporation | N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of ror-gamma activity and the treatment of diseases |
CA2857302C (en) | 2011-12-15 | 2020-08-25 | Novartis Ag | Use of inhibitors of the activity or function of pi3k |
WO2013169864A2 (en) | 2012-05-08 | 2013-11-14 | Lycera Corporation | TETRAHYDRO[1,8]NAPHTHYRIDINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORƴ AND THE TREATMENT OF DISEASE |
KR20150007300A (ko) | 2012-05-08 | 2015-01-20 | 머크 샤프 앤드 돔 코포레이션 | Ror감마 활성의 억제를 위한 테트라히드로나프티리딘 및 관련 비시클릭 화합물 및 질환의 치료 |
ES2661394T3 (es) * | 2012-07-16 | 2018-03-28 | Neuropore Therapies, Inc. | Derivados de di- y tri-heteroarilo como inhibidores de la agregación de proteínas |
US20150258127A1 (en) | 2012-10-31 | 2015-09-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preventing antiphospholipid syndrome (aps) |
JPWO2014098232A1 (ja) * | 2012-12-21 | 2017-01-12 | 学校法人東京理科大学 | Pi3キナーゼ阻害剤を含む医薬組成物、ビタミンd受容体に作用する化合物を含む医薬組成物、凍結乾燥組成物、凍結乾燥組成物の製造方法、及び経肺投与用医薬組成物 |
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KR20160062178A (ko) * | 2013-10-17 | 2016-06-01 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 호흡기 질병의 치료를 위한 pi3k 억제제 |
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CN104086538B (zh) * | 2014-06-13 | 2016-07-06 | 南京药石科技股份有限公司 | 一种pi3k激酶抑制剂的中间体及其制备方法与应用 |
WO2016059220A1 (en) | 2014-10-16 | 2016-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Tcr-activating agents for use in the treatment of t-all |
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WO2016179343A1 (en) | 2015-05-05 | 2016-11-10 | Lycera Corporation | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE |
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