CN102421780A - 氨基磺酸((1s，2s，4r)-4-{4-[(1s)-2，3-二氢-1h-茚-1-基氨基]-7h-吡咯并[2，3-d]嘧啶-7-基}-2-羟基环戊基)甲酯盐酸盐 - Google Patents

氨基磺酸((1s，2s，4r)-4-{4-[(1s)-2，3-二氢-1h-茚-1-基氨基]-7h-吡咯并[2，3-d]嘧啶-7-基}-2-羟基环戊基)甲酯盐酸盐 Download PDF

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Publication number
CN102421780A
CN102421780A CN2010800213224A CN201080021322A CN102421780A CN 102421780 A CN102421780 A CN 102421780A CN 2010800213224 A CN2010800213224 A CN 2010800213224A CN 201080021322 A CN201080021322 A CN 201080021322A CN 102421780 A CN102421780 A CN 102421780A
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China
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compound
peaks
angles
crystalline
iii
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English (en)
Chinese (zh)
Inventor
伊恩·G·阿米蒂奇
里努·乔普拉
马丁·伊恩·库珀
玛丽安娜·兰斯顿
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Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
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Publication of CN102421780A publication Critical patent/CN102421780A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2010800213224A 2009-05-14 2010-05-13 氨基磺酸((1s，2s，4r)-4-{4-[(1s)-2，3-二氢-1h-茚-1-基氨基]-7h-吡咯并[2，3-d]嘧啶-7-基}-2-羟基环戊基)甲酯盐酸盐 Pending CN102421780A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21622109P 2009-05-14 2009-05-14
US61/216,221 2009-05-14
PCT/US2010/001415 WO2010132110A1 (en) 2009-05-14 2010-05-13 Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate

Related Child Applications (1)

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CN201410200959.XA Division CN104016987A (zh) 2009-05-14 2010-05-13 氨基磺酸((1s,2s,4r)-4-{4-[(1s)-2,3-二氢-1h-茚-1-基氨基]-7h-吡咯并[2,3-d]嘧啶-7-基}-2-羟基环戊基)甲酯盐酸盐

Publications (1)

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CN102421780A true CN102421780A (zh) 2012-04-18

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CN2010800213224A Pending CN102421780A (zh) 2009-05-14 2010-05-13 氨基磺酸((1s，2s，4r)-4-{4-[(1s)-2，3-二氢-1h-茚-1-基氨基]-7h-吡咯并[2，3-d]嘧啶-7-基}-2-羟基环戊基)甲酯盐酸盐
CN201410200959.XA Pending CN104016987A (zh) 2009-05-14 2010-05-13 氨基磺酸((1s,2s,4r)-4-{4-[(1s)-2,3-二氢-1h-茚-1-基氨基]-7h-吡咯并[2,3-d]嘧啶-7-基}-2-羟基环戊基)甲酯盐酸盐

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CN201410200959.XA Pending CN104016987A (zh) 2009-05-14 2010-05-13 氨基磺酸((1s,2s,4r)-4-{4-[(1s)-2,3-二氢-1h-茚-1-基氨基]-7h-吡咯并[2,3-d]嘧啶-7-基}-2-羟基环戊基)甲酯盐酸盐

Country Status (18)

Country Link
US (2) US9187482B2 (https=)
EP (2) EP3091020B1 (https=)
JP (3) JP2012526808A (https=)
KR (2) KR20170102381A (https=)
CN (2) CN102421780A (https=)
AU (1) AU2010248151B2 (https=)
BR (1) BRPI1012142A2 (https=)
CA (1) CA2761256C (https=)
IL (1) IL216201A (https=)
MX (1) MX2011012108A (https=)
NZ (2) NZ621128A (https=)
PE (2) PE20161222A1 (https=)
PH (1) PH12015501925A1 (https=)
RU (1) RU2562245C2 (https=)
SG (2) SG175929A1 (https=)
UA (1) UA108986C2 (https=)
WO (1) WO2010132110A1 (https=)
ZA (1) ZA201108347B (https=)

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JP2013541587A (ja) * 2010-11-05 2013-11-14 ミレニアム ファーマシューティカルズ， インコーポレイテッド Ｎｅｄｄ８活性化酵素阻害剤の投与
SG11201400102WA (en) * 2011-08-24 2014-03-28 Millennium Pharm Inc Inhibitors of nedd8-activating enzyme
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CN104136399B (zh) * 2012-02-17 2018-08-07 米伦纽姆医药公司 泛素活化酶的吡唑并嘧啶基抑制剂
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BR112016030787B1 (pt) 2014-07-01 2022-12-20 Takeda Pharmaceutical Company Limited Entidade química, composição farmacêutica e seu uso
CN106008394B (zh) * 2016-05-23 2018-12-04 中国人民解放军第二军医大学 巯基苯并噻唑酰胺类化合物及其制备与作为药物的用途
WO2019060536A1 (en) * 2017-09-21 2019-03-28 Millennium Pharmaceuticals, Inc. CO-CRYSTALLINE FORMS OF ((1S, 2S, 4R) -4- {4 - [(1S) -2,3-DIHYDRO-1H-INDEN-1-YLAMINO] -7H-PYRROLO [2,3-D] PYRIMIDIN -7-YL} -2-HYDROXYCYCLOPENTYL) METHYLSULFAMATE, THEIR FORMULATIONS AND USES
US20220133884A1 (en) * 2019-02-26 2022-05-05 Millennium Pharmaceuticals, Inc. Compounds useful as adjuvants
KR20210115680A (ko) 2020-03-16 2021-09-27 서희강 연설용 프롬프터
WO2022112951A1 (en) * 2020-11-25 2022-06-02 Takeda Pharmaceutical Company Limited Solid state forms of hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate

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ZA201108347B (en) 2014-05-26
US9187482B2 (en) 2015-11-17
JP2012526808A (ja) 2012-11-01
CA2761256C (en) 2021-01-05
JP2015096547A (ja) 2015-05-21
US20170000792A9 (en) 2017-01-05
KR20170102381A (ko) 2017-09-08
BRPI1012142A2 (pt) 2016-03-29
JP2017105816A (ja) 2017-06-15
UA108986C2 (uk) 2015-07-10
CN104016987A (zh) 2014-09-03
MX2011012108A (es) 2011-12-08
US20110021544A1 (en) 2011-01-27
CA2761256A1 (en) 2010-11-18
PE20161222A1 (es) 2016-12-01
NZ596470A (en) 2014-04-30
US10016427B2 (en) 2018-07-10
EP2430026A1 (en) 2012-03-21
NZ621128A (en) 2015-08-28
IL216201A (en) 2015-11-30
AU2010248151A1 (en) 2011-12-01
PH12015501925A1 (en) 2018-01-22
US20160030432A1 (en) 2016-02-04
WO2010132110A1 (en) 2010-11-18
EP3091020B1 (en) 2020-12-30
KR20120024715A (ko) 2012-03-14
SG175929A1 (en) 2011-12-29
RU2562245C2 (ru) 2015-09-10
EP3091020A2 (en) 2016-11-09
RU2011150826A (ru) 2013-06-20
PE20120907A1 (es) 2012-08-18
IL216201A0 (en) 2012-01-31
AU2010248151B2 (en) 2016-07-14
EP3091020A3 (en) 2017-01-11
SG10201402148SA (en) 2014-07-30

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Application publication date: 20120418