CN102405214A - C-吡嗪-甲胺的制备 - Google Patents
C-吡嗪-甲胺的制备 Download PDFInfo
- Publication number
- CN102405214A CN102405214A CN2010800174272A CN201080017427A CN102405214A CN 102405214 A CN102405214 A CN 102405214A CN 2010800174272 A CN2010800174272 A CN 2010800174272A CN 201080017427 A CN201080017427 A CN 201080017427A CN 102405214 A CN102405214 A CN 102405214A
- Authority
- CN
- China
- Prior art keywords
- reaction
- alkyl
- heteroaryl
- formula
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *C(c1nccnc1Cl)N Chemical compound *C(c1nccnc1Cl)N 0.000 description 3
- HEMCGZPSGYRIOL-UHFFFAOYSA-N C(C1)C11CCCC1 Chemical compound C(C1)C11CCCC1 HEMCGZPSGYRIOL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/16—Halogen atoms; Nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17091109P | 2009-04-20 | 2009-04-20 | |
| US61/170,911 | 2009-04-20 | ||
| PCT/US2010/031547 WO2010123792A1 (en) | 2009-04-20 | 2010-04-19 | Preparation of c-pyrazine-methylamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102405214A true CN102405214A (zh) | 2012-04-04 |
Family
ID=42269933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800174272A Pending CN102405214A (zh) | 2009-04-20 | 2010-04-19 | C-吡嗪-甲胺的制备 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8513415B2 (https=) |
| EP (1) | EP2421837A1 (https=) |
| JP (1) | JP2012524119A (https=) |
| KR (1) | KR20120020099A (https=) |
| CN (1) | CN102405214A (https=) |
| BR (1) | BRPI1016245A2 (https=) |
| CA (1) | CA2752826A1 (https=) |
| MX (1) | MX2011011025A (https=) |
| WO (1) | WO2010123792A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103214424A (zh) * | 2013-04-25 | 2013-07-24 | 兰州康寓信生物科技有限公司 | 吡嗪甲胺衍生物的合成方法 |
| CN109182286A (zh) * | 2018-09-21 | 2019-01-11 | 泰州学院 | 一种改进的氰基还原酶及其在合成3-氯吡嗪-2甲胺中的应用 |
| CN109553570A (zh) * | 2017-09-27 | 2019-04-02 | 胜兴化工(上海)有限公司 | 3-氯-5-三氟甲基-2-吡啶甲胺盐的制备方法 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI378934B (en) | 2004-04-02 | 2012-12-11 | Osi Pharm Inc | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
| US8778964B2 (en) | 2012-11-05 | 2014-07-15 | Bayer Pharma Aktiengesellschaft | Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use |
| US9422285B2 (en) | 2013-08-08 | 2016-08-23 | Bayer Pharma Aktiengesellschaft | Substituted pyrazolo[1,5-A]-pyridine-3-carboxamides and use thereof |
| CN107257796A (zh) | 2014-12-02 | 2017-10-17 | 拜耳医药股份有限公司 | 取代的吡唑并[1,5‑a]吡啶和咪唑并[1,2‑a]吡嗪及其用途 |
| CN107567446A (zh) | 2015-02-05 | 2018-01-09 | 拜耳制药股份公司 | 取代的吡唑并[1,5‑a]吡啶‑3‑甲酰胺及其用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1422220A1 (en) * | 2002-11-20 | 2004-05-26 | Bayer CropScience SA | Process for the preparation of 2-aminomethylpyridine derivative |
| US20060235031A1 (en) * | 2004-04-02 | 2006-10-19 | Arnold Lee D | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors |
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-
2010
- 2010-04-19 WO PCT/US2010/031547 patent/WO2010123792A1/en not_active Ceased
- 2010-04-19 MX MX2011011025A patent/MX2011011025A/es not_active Application Discontinuation
- 2010-04-19 JP JP2012507282A patent/JP2012524119A/ja active Pending
- 2010-04-19 US US13/265,363 patent/US8513415B2/en not_active Expired - Fee Related
- 2010-04-19 BR BRPI1016245-3A patent/BRPI1016245A2/pt not_active IP Right Cessation
- 2010-04-19 KR KR1020117020844A patent/KR20120020099A/ko not_active Withdrawn
- 2010-04-19 EP EP10714546A patent/EP2421837A1/en not_active Withdrawn
- 2010-04-19 CA CA2752826A patent/CA2752826A1/en not_active Abandoned
- 2010-04-19 CN CN2010800174272A patent/CN102405214A/zh active Pending
-
2013
- 2013-05-23 US US13/901,054 patent/US20130261306A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1422220A1 (en) * | 2002-11-20 | 2004-05-26 | Bayer CropScience SA | Process for the preparation of 2-aminomethylpyridine derivative |
| US20060235031A1 (en) * | 2004-04-02 | 2006-10-19 | Arnold Lee D | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors |
Non-Patent Citations (1)
| Title |
|---|
| RICHARD A. HARTZ ET AL.: "Synthesis and Evaluation of Imidazo[1,5-a]pyrazines as Corticotropin Releasing Hormone Receptor Ligands", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103214424A (zh) * | 2013-04-25 | 2013-07-24 | 兰州康寓信生物科技有限公司 | 吡嗪甲胺衍生物的合成方法 |
| CN103214424B (zh) * | 2013-04-25 | 2015-05-13 | 兰州康寓信生物科技有限公司 | 吡嗪甲胺衍生物的合成方法 |
| CN109553570A (zh) * | 2017-09-27 | 2019-04-02 | 胜兴化工(上海)有限公司 | 3-氯-5-三氟甲基-2-吡啶甲胺盐的制备方法 |
| CN109182286A (zh) * | 2018-09-21 | 2019-01-11 | 泰州学院 | 一种改进的氰基还原酶及其在合成3-氯吡嗪-2甲胺中的应用 |
| CN109182286B (zh) * | 2018-09-21 | 2021-07-30 | 泰州学院 | 一种改进的氰基还原酶及其在合成3-氯吡嗪-2甲胺中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2421837A1 (en) | 2012-02-29 |
| US20130261306A1 (en) | 2013-10-03 |
| CA2752826A1 (en) | 2010-10-28 |
| JP2012524119A (ja) | 2012-10-11 |
| US8513415B2 (en) | 2013-08-20 |
| WO2010123792A1 (en) | 2010-10-28 |
| KR20120020099A (ko) | 2012-03-07 |
| US20120041202A1 (en) | 2012-02-16 |
| BRPI1016245A2 (pt) | 2015-09-01 |
| MX2011011025A (es) | 2011-11-02 |
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