CN102272327B - 通过序列分析监测状况的方法 - Google Patents

通过序列分析监测状况的方法 Download PDF

Info

Publication number
CN102272327B
CN102272327B CN200980153756.7A CN200980153756A CN102272327B CN 102272327 B CN102272327 B CN 102272327B CN 200980153756 A CN200980153756 A CN 200980153756A CN 102272327 B CN102272327 B CN 102272327B
Authority
CN
China
Prior art keywords
clonotypes
disease
cells
cell
patients
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200980153756.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN102272327A (zh
Inventor
M·法哈姆
T·威利斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adaptive Biotechnologies Corp
Sequenta Inc
Original Assignee
Sequenta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42153463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102272327(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sequenta Inc filed Critical Sequenta Inc
Priority to CN201410350386.9A priority Critical patent/CN104195227B/zh
Publication of CN102272327A publication Critical patent/CN102272327A/zh
Application granted granted Critical
Publication of CN102272327B publication Critical patent/CN102272327B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1072Differential gene expression library synthesis, e.g. subtracted libraries, differential screening
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN200980153756.7A 2008-11-07 2009-11-09 通过序列分析监测状况的方法 Active CN102272327B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410350386.9A CN104195227B (zh) 2008-11-07 2009-11-09 通过序列分析监测状况的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11269308P 2008-11-07 2008-11-07
US61/112,693 2008-11-07
PCT/US2009/006053 WO2010053587A2 (en) 2008-11-07 2009-11-09 Methods of monitoring conditions by sequence analysis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201410350386.9A Division CN104195227B (zh) 2008-11-07 2009-11-09 通过序列分析监测状况的方法

Publications (2)

Publication Number Publication Date
CN102272327A CN102272327A (zh) 2011-12-07
CN102272327B true CN102272327B (zh) 2015-11-25

Family

ID=42153463

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201410350386.9A Active CN104195227B (zh) 2008-11-07 2009-11-09 通过序列分析监测状况的方法
CN200980153756.7A Active CN102272327B (zh) 2008-11-07 2009-11-09 通过序列分析监测状况的方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201410350386.9A Active CN104195227B (zh) 2008-11-07 2009-11-09 通过序列分析监测状况的方法

Country Status (10)

Country Link
US (16) US8236503B2 (enExample)
EP (4) EP4335932A3 (enExample)
JP (2) JP5798926B2 (enExample)
CN (2) CN104195227B (enExample)
AU (1) AU2009311588B2 (enExample)
CA (1) CA2742380C (enExample)
ES (2) ES2453066T3 (enExample)
GB (5) GB2483810B (enExample)
SG (1) SG195652A1 (enExample)
WO (1) WO2010053587A2 (enExample)

Families Citing this family (262)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002055017A2 (en) * 2000-11-21 2002-07-18 Wake Forest University Method of treating autoimmune diseases
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
EP3756767B1 (en) 2007-10-02 2024-05-01 Labrador Diagnostics LLC Modular point-of-care devices and uses thereof
CA2878025C (en) 2008-01-18 2018-12-11 President And Fellows Of Harvard College Methods of detecting signatures of disease or conditions in bodily fluids
CN102066578B (zh) 2008-04-16 2016-07-06 哈森阿尔法生物技术研究院 用于评价和比较免疫组库的方法
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8691510B2 (en) 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
GB2483810B (en) 2008-11-07 2012-09-05 Sequenta Inc Methods for correlating clonotypes with diseases in a population
PT2387627E (pt) 2009-01-15 2016-06-03 Adaptive Biotechnologies Corp Determinação do perfil de imunidade adaptativa e métodos de geração de anticorpos monoclonais
US8383347B1 (en) * 2009-05-01 2013-02-26 University Of South Florida Method of diagnosing or assessing risk for Parkinson's disease or Alzheimer's disease using TCR clonality
JP2012531202A (ja) * 2009-06-25 2012-12-10 フレッド ハチンソン キャンサー リサーチ センター 適応免疫を測定する方法
US20120058902A1 (en) * 2009-06-25 2012-03-08 Livingston Robert J Method of measuring adaptive immunity
ES2656668T3 (es) * 2009-10-21 2018-02-28 Dolby International Ab Sobremuestreo en un banco de filtros de reemisor combinado
JP2013509883A (ja) 2009-11-06 2013-03-21 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 臓器移植患者における移植片拒絶反応の非侵襲的診断方法
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
US20130053253A1 (en) * 2010-02-22 2013-02-28 Population Genetics Technologies Ltd Region of Interest Extraction and Normalization Methods
PT2556171E (pt) 2010-04-05 2015-12-21 Prognosys Biosciences Inc Ensaios biológicos codificados espacialmente
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
EP3456847B1 (en) * 2010-05-06 2024-12-25 Adaptive Biotechnologies Corporation Monitoring solid transplant rejection using clonotype profiles
CA2796822C (en) 2010-05-07 2021-10-05 The Board Of Trustees Of The Leland Standford Junior University Measurement and comparison of immune diversity by high-throughput sequencing
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CA3207599A1 (en) 2010-05-18 2011-11-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CN101921874B (zh) * 2010-06-30 2013-09-11 深圳华大基因科技有限公司 基于Solexa测序法的检测人类乳头瘤病毒的方法
KR20130041961A (ko) 2010-07-23 2013-04-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 체액에서 질환 또는 상태의 특징을 검출하는 방법
WO2012012717A1 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
AU2011280997A1 (en) 2010-07-23 2013-02-28 President And Fellows Of Harvard College Methods of detecting autoimmune or immune-related diseases or conditions
MX2013000917A (es) 2010-07-23 2013-07-05 Harvard College Metodos para detectar las enfermedades o condiciones usando celulas fagociticas.
WO2012017081A1 (en) * 2010-08-06 2012-02-09 Ludwig-Maximilians-Universität München Identification of t cell target antigens
CN102409043B (zh) * 2010-09-21 2013-12-04 深圳华大基因科技服务有限公司 高通量低成本Fosmid文库构建的方法及其所使用标签和标签接头
CN102409044B (zh) * 2010-09-21 2014-05-07 深圳华大基因科技服务有限公司 用于数字基因表达谱的标签及其使用方法
CN101967476B (zh) * 2010-09-21 2012-11-14 深圳华大基因科技有限公司 一种基于接头连接的DNA PCR-Free标签文库构建方法
CN102409408B (zh) * 2010-09-21 2013-08-07 深圳华大基因科技服务有限公司 一种利用微量基因组dna进行全基因组甲基化位点精确检测的方法
CN102409045B (zh) * 2010-09-21 2013-09-18 深圳华大基因科技服务有限公司 一种基于dna接头连接的标签文库构建方法及其所使用标签和标签接头
EP2625295B1 (en) * 2010-10-08 2019-03-13 President and Fellows of Harvard College High-throughput immune sequencing
SG190344A1 (en) * 2010-11-30 2013-06-28 Univ Hong Kong Chinese Detection of genetic or molecular aberrations associated with cancer
US9193997B2 (en) 2010-12-15 2015-11-24 The Board Of Trustees Of The Leland Stanford Junior University Measuring and monitoring of cell clonality
DK2652155T3 (en) 2010-12-16 2017-02-13 Gigagen Inc Methods for Massive Parallel Analysis of Nucleic Acids in Single Cells
US20120183969A1 (en) * 2011-01-14 2012-07-19 Jian Han Immunodiversity Assessment Method and Its Use
CA3097861A1 (en) 2011-01-21 2012-07-26 Labrador Diagnostics Llc Systems and methods for sample use maximization
BR112013020220B1 (pt) 2011-02-09 2020-03-17 Natera, Inc. Método para determinar o estado de ploidia de um cromossomo em um feto em gestação
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
ES2729945T3 (es) * 2011-05-31 2019-11-07 Biogen Ma Inc Procedimiento para valorar el riesgo de LMP
US20140235474A1 (en) 2011-06-24 2014-08-21 Sequenom, Inc. Methods and processes for non invasive assessment of a genetic variation
WO2013016226A1 (en) * 2011-07-22 2013-01-31 Metamark Genetics, Inc. Quality control method for digital pathology
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
WO2013044234A1 (en) 2011-09-22 2013-03-28 ImmuMetrix, LLC Detection of isotype profiles as signatures for disease
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2850785C (en) 2011-10-06 2022-12-13 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2768982A4 (en) 2011-10-21 2015-06-03 Adaptive Biotechnologies Corp QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS
US20140336059A1 (en) * 2011-12-05 2014-11-13 Sequenta, Inc. Clonotypes as biometric specimen tags
WO2013086462A1 (en) * 2011-12-09 2013-06-13 Sequenta, Inc. Method of measuring immune activation
AU2012347460B2 (en) 2011-12-09 2017-05-25 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
EP3269820A1 (en) * 2011-12-22 2018-01-17 Ibis Biosciences, Inc. Kit for the amplification of a sequence from a ribonucleic acid
CN103184216B (zh) * 2011-12-27 2015-03-18 深圳华大基因科技有限公司 用于扩增免疫球蛋白重链cdr3编码序列的引物组合物及其用途
US9823246B2 (en) 2011-12-28 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Fluorescence enhancing plasmonic nanoscopic gold films and assays based thereon
CA2861856C (en) 2012-01-20 2020-06-02 Sequenom, Inc. Diagnostic processes that factor experimental conditions
US20150038346A1 (en) * 2012-03-05 2015-02-05 Sequenta, Inc. Monitoring immune responsiveness to cancer vaccination
JP6302847B2 (ja) * 2012-03-05 2018-03-28 アダプティヴ バイオテクノロジーズ コーポレーション 頻度が一致したサブユニットからの、対をなす免疫受容体鎖の決定
CA2869481A1 (en) * 2012-04-13 2013-10-17 Sequenta, Inc. Detection and quantitation of sample contamination in immune repertoire analysis
ES2711156T3 (es) 2012-05-08 2019-04-30 Adaptive Biotechnologies Corp Método para medir y calibrar el sesgo de amplificación en reacciones de PCR multiplexadas
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
SG11201407888RA (en) * 2012-06-11 2014-12-30 Sequenta Inc Method of sequence determination using sequence tags
WO2013188772A1 (en) * 2012-06-14 2013-12-19 Gigagen, Inc. Methods for antibody and cell therapeutic discovery
CA2876209A1 (en) * 2012-06-15 2013-12-19 Adaptive Biotechnologies Corporation Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
WO2013190086A1 (en) * 2012-06-21 2013-12-27 Philip Morris Products S.A. Systems and methods for generating biomarker signatures
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20150167084A1 (en) * 2012-07-03 2015-06-18 Sloan Kettering Institute For Cancer Research Quantitative Assessment of Human T-Cell Repertoire Recovery After Allogeneic Hematopoietic Stem Cell Transplantation
JP2015523087A (ja) * 2012-07-24 2015-08-13 シーケンタ インコーポレイテッド 配列タグを用いる単一細胞分析
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
AU2013302756C1 (en) 2012-08-14 2018-05-17 10X Genomics, Inc. Microcapsule compositions and methods
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
WO2014038622A1 (ja) * 2012-09-05 2014-03-13 国立大学法人大阪大学 自己免疫疾患のバイオマーカー
EP2904111B1 (en) * 2012-10-01 2017-12-06 Adaptive Biotechnologies Corporation Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
UA118441C2 (uk) 2012-10-08 2019-01-25 Протена Біосаєнсиз Лімітед Антитіло, що розпізнає альфа-синуклеїн
DK3511423T4 (da) 2012-10-17 2024-07-29 Spatial Transcriptomics Ab Fremgangsmåder og produkt til optimering af lokaliseret eller rumlig detektion af genekspression i en vævsprøve
KR101525584B1 (ko) 2012-12-03 2015-06-03 주식회사 케이티 바이오 데이터 검증 방법 및 이를 위한 장치
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
EP2931828B1 (en) 2012-12-14 2018-01-31 3M Innovative Properties Company Method of making packaged viscoelastic compositions by polymerizing ethylenically-unsaturated materials using ionizing radiation
EP2931757B1 (en) 2012-12-14 2020-04-01 3M Innovative Properties Company Method of polymerizing ethylenically-unsaturated materials using ionizing radiation
US20150320799A1 (en) 2012-12-20 2015-11-12 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
EP2746405B1 (en) * 2012-12-23 2015-11-04 HS Diagnomics GmbH Methods and primer sets for high throughput PCR sequencing
EP2946345B1 (en) 2013-01-17 2024-04-03 Personalis, Inc. Methods and systems for genetic analysis
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9909180B2 (en) 2013-02-04 2018-03-06 The Board Of Trustees Of The Leland Stanford Junior University Measurement and comparison of immune diversity by high-throughput sequencing
US20160034637A1 (en) * 2013-02-11 2016-02-04 Cb Biotechnologies, Inc. Method for evaluating an immunorepertoire
WO2014164362A1 (en) 2013-03-09 2014-10-09 Harry Stylli Methods of detecting prostate cancer
EP2965077B1 (en) 2013-03-09 2022-07-13 Harry Stylli Methods of detecting cancer
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
SG11201507261WA (en) 2013-03-15 2015-10-29 Theranos Inc Nucleic acid amplification
DK2970958T3 (en) 2013-03-15 2018-02-19 Lineage Biosciences Inc METHODS FOR SEQUENCING THE IMMUN REPERTOIR
WO2014145291A1 (en) 2013-03-15 2014-09-18 Theranos, Inc. Nucleic acid amplification
SG11201507272RA (en) * 2013-03-15 2015-10-29 Theranos Inc Nuclei acid amplification
US10450595B2 (en) * 2013-03-15 2019-10-22 Theranos Ip Company, Llc Nucleic acid amplification
SG11201506991VA (en) * 2013-03-15 2015-10-29 Adaptive Biotechnologies Corp Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
US10119134B2 (en) 2013-03-15 2018-11-06 Abvitro Llc Single cell bar-coding for antibody discovery
EP4187543A1 (en) 2013-04-03 2023-05-31 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CN111383715B (zh) * 2013-04-17 2024-09-10 先锋国际良种公司 用于在基因组中表征dna序列组成的方法
WO2014190286A2 (en) 2013-05-24 2014-11-27 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3011051B1 (en) 2013-06-21 2019-01-30 Sequenom, Inc. Method for non-invasive assessment of genetic variations
EP4234716A3 (en) 2013-06-25 2023-12-06 Prognosys Biosciences, Inc. Methods for determining spatial patterns of biological targets in a sample
US9708657B2 (en) * 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
US9951131B2 (en) 2013-07-12 2018-04-24 Prothena Biosciences Limited Antibodies that recognize IAPP
US9850302B2 (en) 2013-07-12 2017-12-26 Prothena Biosciences Limited Antibodies that recognize IAPP
EP4567682A3 (en) 2013-08-30 2025-09-03 Personalis, Inc. Methods for genomic analysis
BR112016004955B1 (pt) 2013-09-06 2021-10-26 Labrador Diagnostics Llc Dispositivos, sistemas, métodos e conjuntos para receber cotonete
SG11201601611WA (en) 2013-09-06 2016-04-28 Theranos Inc Systems and methods for detecting infectious diseases
GB2535066A (en) 2013-10-03 2016-08-10 Personalis Inc Methods for analyzing genotypes
BR112016007401B1 (pt) 2013-10-04 2023-04-11 Sequenom, Inc. Método para determinar a presença ou ausência de uma aneuploidia cromossômica em uma amostra
EP3495496B1 (en) 2013-10-07 2020-11-25 Sequenom, Inc. Methods and processes for non-invasive assessment of chromosome alterations
AU2014337063A1 (en) * 2013-10-18 2016-05-19 Adaptive Biotechnologies Corp. Predicting patient responsiveness to immune checkpoint inhibitors
JP6220222B2 (ja) * 2013-10-28 2017-10-25 シスメックス株式会社 関節リウマチの診断を補助するための方法、システム及びコンピュータプログラム製品
CN106103711A (zh) * 2013-11-21 2016-11-09 组库创世纪株式会社 T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用
US20170292149A1 (en) 2014-03-05 2017-10-12 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
WO2015138746A1 (en) * 2014-03-12 2015-09-17 The Board Of Trustees Of The Leland Stanford Junior University Monitoring immunocompetance using immune repertoire sequencing
HUE043288T2 (hu) * 2014-03-14 2019-08-28 Caredx Inc Eljárások immunszuppresszív terápiák monitorozására transzplantátum recipiensben
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
WO2015155694A1 (en) 2014-04-08 2015-10-15 Prothena Biosciences Limited Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
EP3134541B1 (en) 2014-04-21 2020-08-19 Natera, Inc. Detecting copy number variations (cnv) of chromosomal segments in cancer
US10202640B2 (en) 2014-05-07 2019-02-12 The Board Of Trustees Of The Leland Stanford Junior University Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
CN113249435B (zh) * 2014-06-26 2024-09-03 10X基因组学有限公司 分析来自单个细胞或细胞群体的核酸的方法
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
WO2016019042A1 (en) 2014-07-30 2016-02-04 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP4428251A3 (en) 2014-09-11 2024-12-18 Immunis.AI, Inc. Methods of detecting prostate cancer
SG10201911069WA (en) 2014-09-15 2020-01-30 Abvitro Llc High-throughput nucleotide library sequencing
WO2016069886A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corporation Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
EP4026913A1 (en) 2014-10-30 2022-07-13 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
EP3215846B1 (en) 2014-11-05 2020-03-11 Nirmidas Biotech, Inc. Metal composites for enhanced imaging
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
CA2968543C (en) 2014-11-25 2024-04-02 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
WO2016138122A1 (en) 2015-02-24 2016-09-01 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing
WO2016144776A1 (en) * 2015-03-06 2016-09-15 Cb Biotechnologies, Inc. Method for measuring a change in an individual's immunorepertoire
WO2016161273A1 (en) 2015-04-01 2016-10-06 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
EP4119677B1 (en) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
CA2983937A1 (en) 2015-04-27 2016-11-03 Abvitro Llc Methods of sequencing, determining, pairing, and validating therapeutic agents and disease specific antigens
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
US9422547B1 (en) 2015-06-09 2016-08-23 Gigagen, Inc. Recombinant fusion proteins and libraries from immune cell repertoires
JP6576129B2 (ja) * 2015-07-06 2019-09-18 キヤノン株式会社 通信装置、通信方法およびプログラム
WO2017013170A1 (en) 2015-07-22 2017-01-26 F. Hoffmann-La Roche Ag Identification of antigen epitopes and immune sequences recognizing the antigens
US10539564B2 (en) 2015-07-22 2020-01-21 Roche Sequencing Solutions, Inc. Identification of antigen epitopes and immune sequences recognizing the antigens
CN108348167B (zh) * 2015-09-09 2022-06-03 普梭梅根公司 用于脑-颅面健康相关病症的源自微生物群系的诊断及治疗方法和系统
US20190136298A1 (en) * 2015-09-09 2019-05-09 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for eczema
WO2017132438A1 (en) * 2016-01-29 2017-08-03 The Johns Hopkins University Bottleneck sequencing
US20200299761A1 (en) * 2016-03-23 2020-09-24 The Methodist Hospital System Pre-transplant tcr clonality assessment to predict post-liver transplant survival
JP7282521B2 (ja) 2016-04-08 2023-05-29 パーデュー・リサーチ・ファウンデイション Car t細胞療法のための方法および組成物
RU2760913C2 (ru) 2016-04-15 2021-12-01 Натера, Инк. Способы выявления рака легкого
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
CN109790203A (zh) 2016-06-20 2019-05-21 健康之语公司 自身免疫疾病的诊断和治疗方法
WO2017223116A2 (en) 2016-06-20 2017-12-28 Healthtell Inc. Methods for differential diagnosis of autoimmune diseases
EP3491560A1 (en) 2016-07-27 2019-06-05 Sequenom, Inc. Genetic copy number alteration classifications
CN113151423B (zh) 2016-08-05 2024-09-10 生物辐射实验室股份有限公司 第二链引导
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
CN110168370A (zh) 2016-11-11 2019-08-23 健康之语公司 用于鉴定候选生物标志物的方法
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CN110168105B (zh) * 2016-12-09 2024-05-24 瑞泽恩制药公司 用于对t细胞受体进行测序的系统和方法及其用途
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2018136562A2 (en) 2017-01-17 2018-07-26 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
CA3207879A1 (en) 2017-01-24 2018-08-02 Sequenom, Inc. Methods and processes for assessment of genetic variations
EP3579870A4 (en) 2017-02-07 2020-12-30 Seattle Children's Hospital (DBA Seattle Children's Research Institute) PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS
WO2018160622A1 (en) 2017-02-28 2018-09-07 Endocyte, Inc. Compositions and methods for car t cell therapy
US10822662B2 (en) 2017-03-06 2020-11-03 Karkinos Precision Oncology LLC Diagnostic methods for identifying T-cell lymphoma and leukemia by high-throughput TCR-β sequencing
EP3596233B1 (en) 2017-03-17 2022-05-18 Sequenom, Inc. Methods and processes for assessment of genetic mosaicism
CN108728903A (zh) * 2017-04-21 2018-11-02 深圳市乐土精准医疗科技有限公司 基于高通量测序用于地中海贫血大样本筛查的建库方法
US20180315510A1 (en) * 2017-04-27 2018-11-01 Koninklijke Philips N.V. Use of clinical knowledge to improve use of next generation sequencing
US11754552B2 (en) * 2017-06-09 2023-09-12 The Regents Of The University Of California Use of immune repertoire diversity for predicting transplant rejection
CA3067637A1 (en) 2017-06-20 2018-12-27 The Medical College Of Wisconsin, Inc. Assessing transplant complication risk with total cell-free dna
US10636512B2 (en) 2017-07-14 2020-04-28 Cofactor Genomics, Inc. Immuno-oncology applications using next generation sequencing
EP3431610A1 (en) 2017-07-19 2019-01-23 Noscendo GmbH Methods and devices for nucleic acid-based real-time determination of disease states
CN111727262A (zh) 2017-07-25 2020-09-29 加州理工学院 胞啃介导的表位发现
WO2019046817A1 (en) 2017-09-01 2019-03-07 Life Technologies Corporation COMPOSITIONS AND METHODS FOR IMMUNOLOGICAL REPERTOIRE SEQUENCING
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
AU2019209432A1 (en) 2018-01-22 2020-08-06 Seattle Children's Hospital (dba Seattle Children's Research Institute) Methods of use for CAR T cells
CN111936518A (zh) 2018-02-06 2020-11-13 西雅图儿童医院(Dba西雅图儿童研究所) 对fl-ple标记的肿瘤表现出最佳的t细胞功能的荧光素特异性car
SG11202007686VA (en) 2018-02-12 2020-09-29 10X Genomics Inc Methods characterizing multiple analytes from individual cells or cell populations
WO2019165237A1 (en) 2018-02-23 2019-08-29 Endocyte, Inc. Sequencing method for car t cell therapy
US20190287649A1 (en) * 2018-03-13 2019-09-19 Grail, Inc. Method and system for selecting, managing, and analyzing data of high dimensionality
JP7455757B2 (ja) 2018-04-13 2024-03-26 フリーノーム・ホールディングス・インコーポレイテッド 生体試料の多検体アッセイのための機械学習実装
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
CA3099424A1 (en) * 2018-05-07 2019-11-14 Id Genomics, Inc. Methods and tools for determining clonal relatedness and predicting clonal traits
WO2019217758A1 (en) 2018-05-10 2019-11-14 10X Genomics, Inc. Methods and systems for molecular library generation
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US11211148B2 (en) 2018-06-28 2021-12-28 International Business Machines Corporation Time-series phylogenetic tumor evolution trees
US11189361B2 (en) 2018-06-28 2021-11-30 International Business Machines Corporation Functional analysis of time-series phylogenetic tumor evolution tree
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
EP3824103A1 (en) 2018-07-18 2021-05-26 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
US11894139B1 (en) * 2018-12-03 2024-02-06 Patientslikeme Llc Disease spectrum classification
KR20210104779A (ko) 2018-12-13 2021-08-25 디엔에이 스크립트 세포 및 생체분자 상의 직접 올리고뉴클레오타이드 합성
CN109593758B (zh) * 2018-12-26 2021-11-26 山东艾克韦生物技术有限公司 多重引物组及利用该引物组基于高通量测序构建人类b细胞免疫组库的方法
CN109554440A (zh) * 2018-12-26 2019-04-02 山东艾克韦生物技术有限公司 多重引物组及利用该引物组基于高通量测序构建人类t细胞免疫组库的方法
EP3941491A4 (en) 2019-03-21 2023-03-29 Gigamune, Inc. ENGINEERED CELLS EXPRESSING ANTIVIRAL T-CELL RECEPTORS AND METHODS OF USE
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
EP3976820A1 (en) 2019-05-30 2022-04-06 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
NZ773619A (en) 2019-05-31 2025-07-25 Freenome Holdings Inc Methods and systems for high-depth sequencing of methylated nucleic acid
WO2020247263A1 (en) 2019-06-06 2020-12-10 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
EP4010902A4 (en) * 2019-08-05 2023-08-23 Tata Consultancy Services Limited MULTIPLE SCLEROSIS RISK ASSESSMENT SYSTEM AND METHOD
JP6761093B1 (ja) * 2019-09-12 2020-09-23 積水メディカル株式会社 リアルタイムpcrによる核酸検出方法
EP4055610A4 (en) 2019-11-05 2023-11-29 Personalis, Inc. ESTIMATION OF TUMOR PURITY FROM SINGLE SAMPLES
CN111081334B (zh) * 2019-12-18 2023-04-18 鲁东大学 一种基于风险因素概率组合分析的慢性疾病早期预警方法
KR20220130756A (ko) * 2020-01-22 2022-09-27 라이프 테크놀로지스 코포레이션 자가면역 질환과 면역결핍 장애의 면역 레퍼토리 바이오마커
US12449419B1 (en) 2020-02-12 2025-10-21 10X Genomics, Inc. Methods for detecting binding of peptide-MHC monomers to T cells
CA3178302A1 (en) 2020-03-31 2021-10-07 Freenome Holdings, Inc. Methods and systems for detecting colorectal cancer via nucleic acid methylation analysis
EP4150118A1 (en) * 2020-05-14 2023-03-22 Becton Dickinson and Company Primers for immune repertoire profiling
EP4025692A2 (en) 2020-06-02 2022-07-13 10X Genomics, Inc. Nucleic acid library methods
WO2021247568A1 (en) 2020-06-02 2021-12-09 10X Genomics, Inc. Spatial trancriptomics for antigen-receptors
ES2981265T3 (es) 2020-06-08 2024-10-08 10X Genomics Inc Métodos para determinar un margen quirúrgico y métodos de uso del mismo
CA3188431A1 (en) 2020-08-07 2022-02-10 Carsten LINNEMANN Methods to enrich genetically engineered t cells
GB202013141D0 (en) * 2020-08-21 2020-10-07 Univ College Cardiff Consultants Ltd A screening method for the detection of DNA damage
WO2022076237A1 (en) 2020-10-05 2022-04-14 Freenome Holdings, Inc. Markers for the early detection of colon cell proliferative disorders
CA3202255A1 (en) 2020-12-21 2022-06-30 Hayley WARSINSKE Markers for the early detection of colon cell proliferative disorders
KR20230160885A (ko) 2021-03-24 2023-11-24 제넨테크, 인크. T 림프구에서 효율적인 tcr 유전자 편집
EP4358855A4 (en) * 2021-06-25 2025-04-30 Sunnybrook Research Institute Systems and methods for characterizing intra-tumor regions on quantitative ultrasound parametric images to predict cancer response to chemotherapy at pre-treatment
CN113792099B (zh) * 2021-08-12 2023-08-25 上海熙业信息科技有限公司 一种基于历史效用表剪枝的数据流高效用项集挖掘系统
CN113822170B (zh) * 2021-08-31 2024-02-06 西安理工大学 身体非静止状态的手部震颤识别方法
EP4413580A4 (en) 2021-10-05 2025-08-13 Personalis Inc PERSONALIZED TESTS FOR PERSONALIZED CANCER MONITORING
JP2024543827A (ja) * 2021-11-11 2024-11-26 ザ ジェネラル ホスピタル コーポレイション 筋萎縮性側索硬化症のステージおよび進行を画定するための方法
EP4499877A2 (en) * 2022-03-25 2025-02-05 Freenome Holdings, Inc. Tcr/bcr profiling for cell-free nucleic acid detection of cancer
WO2024129539A1 (en) * 2022-12-14 2024-06-20 Solventum Intellectual Properties Company Clinical data analysis
AU2024228388A1 (en) 2023-02-27 2025-10-02 Adaptive Biotechnologies Corp. Therapeutic t cell receptors targeting kras g12d
CN116469473B (zh) * 2023-06-15 2023-09-22 北京智因东方转化医学研究中心有限公司 T细胞亚型鉴定的模型训练方法、装置、设备及存储介质
US20250297318A1 (en) * 2024-03-25 2025-09-25 Milaboratories Inc. Dna-based adaptome profiling for minimal residual disease quantification in lymphoid malignancies

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046706A1 (en) * 1996-06-03 1997-12-11 University Of Alberta Methods for detection of rearranged dna

Family Cites Families (338)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3270960A (en) 1964-09-11 1966-09-06 Sperry Rand Corp Fluid sensor
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
DE3211263A1 (de) 1981-03-31 1983-01-27 Otsuka Pharmaceutical Co. Ltd., Tokyo Human-interferon verwandte peptide, antigene und antikoerper, sowie verfahren zu deren herstellung
DE3238353A1 (de) 1982-10-15 1984-04-19 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Verfahren zur simultanen quantitativen bestimmung der blutzellen und reagenz hierfuer
US5189147A (en) 1984-06-13 1993-02-23 Massachusetts Institute Of Technology Meterodimeric T lymphocyte receptor antibody
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DE3541033A1 (de) 1985-11-19 1987-05-21 Boehringer Mannheim Gmbh Verfahren zur quantifizierung von zellpopulationen bzw. subpopulationen sowie hierfuer geeignetes reagenz
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4942124A (en) 1987-08-11 1990-07-17 President And Fellows Of Harvard College Multiplex sequencing
US5149625A (en) 1987-08-11 1992-09-22 President And Fellows Of Harvard College Multiplex analysis of DNA
US5667967A (en) 1990-05-01 1997-09-16 The Board Of Trustees Of The Leland Stanford Junior University T-cell receptor varible transcripts as disease related markers
US5506126A (en) 1988-02-25 1996-04-09 The General Hospital Corporation Rapid immunoselection cloning method
US5168038A (en) 1988-06-17 1992-12-01 The Board Of Trustees Of The Leland Stanford Junior University In situ transcription in cells and tissues
WO1990004648A1 (en) * 1988-10-20 1990-05-03 Alexander Alan Morley Method for diagnosis of monoclonality in leukaemia and lymphoma
US5075217A (en) 1989-04-21 1991-12-24 Marshfield Clinic Length polymorphisms in (dC-dA)n ·(dG-dT)n sequences
US5231012A (en) 1989-06-28 1993-07-27 Schering Corporation Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10)
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5336598A (en) 1989-11-15 1994-08-09 National Jewish Center For Immunology And Respiratory Medicine Method for diagnosing a superantigen caused pathologial condition via assay of T-cells
US5298396A (en) 1989-11-15 1994-03-29 National Jewish Center For Immunology And Respiratory Medicine Method for identifying T cells disease involved in autoimmune disease
US6054034A (en) 1990-02-28 2000-04-25 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US6916605B1 (en) 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
WO1992002551A1 (en) 1990-08-02 1992-02-20 B.R. Centre Limited Methods for the production of proteins with a desired function
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
IE76732B1 (en) 1990-08-07 1997-11-05 Becton Dickinson Co One step test for absolute counts
US5699798A (en) 1990-08-10 1997-12-23 University Of Washington Method for optically imaging solid tumor tissue
US5635354A (en) * 1991-01-09 1997-06-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for describing the repertoires of antibodies (Ab) and of T-cell receptors (TcR) of an individual's immune system
US5364759B2 (en) 1991-01-31 1999-07-20 Baylor College Medicine Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats
CA2079881C (fr) 1991-02-12 2007-11-06 Thierry Hercend Sequences nucleotidiques codant pour des regions variables de chaines .beta. des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques
JP3080178B2 (ja) 1991-02-18 2000-08-21 東洋紡績株式会社 核酸配列の増幅方法およびそのための試薬キット
US6091000A (en) * 1991-03-15 2000-07-18 Duke University SCID mouse engrafted with human synovium tissue
JP3266311B2 (ja) 1991-05-02 2002-03-18 生化学工業株式会社 新規ポリペプチドおよびこれを用いる抗hiv剤
US5674679A (en) 1991-09-27 1997-10-07 Amersham Life Science, Inc. DNA cycle sequencing
US5981179A (en) 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
US5213960A (en) 1992-03-09 1993-05-25 Tanox Biosystems, Inc. Methods for selecting low frequency antigen-specific single B lymphocytes
US5256542A (en) 1992-03-09 1993-10-26 Tanox Biosystems, Inc. Selecting low frequency antigen-specific single B lymphocytes with correction for background noise
US5837447A (en) * 1992-04-15 1998-11-17 Blood Center Research Foundation, Inc., The Monitoring an immune response by analysis of amplified immunoglobulin or T-cell-receptor nucleic acid
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5981176A (en) 1992-06-17 1999-11-09 City Of Hope Method of detecting and discriminating between nucleic acid sequences
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
EP0753060A4 (en) * 1994-04-18 1999-11-24 New York Society PRESERVED T CELL RECEPTOR SEQUENCES
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US6090592A (en) 1994-08-03 2000-07-18 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid on supports
FR2724182B1 (fr) * 1994-09-02 1996-12-13 Pasteur Institut Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5776737A (en) 1994-12-22 1998-07-07 Visible Genetics Inc. Method and composition for internal identification of samples
US6919434B1 (en) 1995-02-20 2005-07-19 Sankyo Co., Ltd. Monoclonal antibodies that bind OCIF
US5698396A (en) * 1995-06-07 1997-12-16 Ludwig Institute For Cancer Research Method for identifying auto-immunoreactive substances from a subject
AU7437996A (en) 1995-10-11 1997-04-30 Leonard Adleman Large scale dna sequencing by position sensitive hybridization
WO1997013877A1 (en) 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Measurement of gene expression profiles in toxicity determination
US6087096A (en) 1995-11-13 2000-07-11 Dau; Peter C. Method of intrafamily fragment analysis of the T cell receptor α and β chain CDR3 regions
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
KR19990087749A (ko) * 1996-03-13 1999-12-27 시오노 요시히코 류마티스성 관절염에 특이적인 인간 티 세포 클론
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
AU726501B2 (en) 1996-06-04 2000-11-09 University Of Utah Research Foundation Monitoring hybridization during PCR
WO1998001738A2 (en) * 1996-06-20 1998-01-15 Cornell Research Foundation, Inc. Identification of abnormalities in the expression of t and b cell antigen receptors as disease indicators
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
ATE347103T1 (de) * 1996-09-06 2006-12-15 Ortho Mcneil Pharm Inc Reinigung von antigenspezifischen t-zellen
WO1998015644A2 (en) 1996-09-27 1998-04-16 The Chinese University Of Hong Kong Parallel polynucleotide sequencing method
GB9626815D0 (en) * 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
ATE364718T1 (de) 1997-04-01 2007-07-15 Solexa Ltd Verfahren zur vervielfältigung von nukleinsäure
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
DK1801214T3 (da) 1997-07-07 2011-01-24 Medical Res Council In vitro sorteringsfremgangsmåde
US7572582B2 (en) 1997-09-12 2009-08-11 Exiqon A/S Oligonucleotide analogues
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US6008002A (en) 1997-09-29 1999-12-28 Bodey; Bela Immunomagnetic detection and isolation of cancer cells
CA2306126A1 (en) 1997-10-15 1999-04-22 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
EP1025265A1 (en) 1997-10-23 2000-08-09 Exact Laboratories, Inc. Methods for detecting contamination in molecular diagnostics using pcr
US7351578B2 (en) 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
EP1062515B1 (en) 1998-02-12 2009-11-25 Immunivest Corporation Methods and reagents for the rapid and efficient isolation of circulating cancer cells
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
DE19833738A1 (de) 1998-07-27 2000-02-03 Michael Giesing Verfahren zur Isolierung von Krebszellen aus zellhaltigen Körperflüssigkeiten sowie Sets zur Durchführung dieses Verfahrens
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
DE19844931C1 (de) 1998-09-30 2000-06-15 Stefan Seeger Verfahren zur DNS- oder RNS-Sequenzierung
US6541608B1 (en) 1999-02-23 2003-04-01 Baylor College Of Medicine T cell receptor Vβ-Dβ-Jβ sequence and methods for its detection
US6307024B1 (en) 1999-03-09 2001-10-23 Zymogenetics, Inc. Cytokine zalpha11 Ligand
US6300070B1 (en) 1999-06-04 2001-10-09 Mosaic Technologies, Inc. Solid phase methods for amplifying multiple nucleic acids
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US20040209314A1 (en) 1999-09-06 2004-10-21 Institut National De La Sante Et De La Recherche Medicale France Means for detection and purification of CD8+ T lymphocyte populations specific to peptides presented in the context of HLA
US6235483B1 (en) 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
US20040033490A1 (en) 2000-03-31 2004-02-19 Laird Peter W. Epigenetic sequences for esophageal adenocarcinoma
AUPQ687600A0 (en) 2000-04-13 2000-05-11 Flinders Technologies Pty Ltd A method of detection
US20030207300A1 (en) 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US6596492B2 (en) 2000-07-11 2003-07-22 Colorado State University Research Foundation PCR materials and methods useful to detect canine and feline lymphoid malignancies
US7567870B1 (en) * 2000-07-31 2009-07-28 Institute For Systems Biology Multiparameter analysis for predictive medicine
US6939451B2 (en) 2000-09-19 2005-09-06 Aclara Biosciences, Inc. Microfluidic chip having integrated electrodes
US6858412B2 (en) 2000-10-24 2005-02-22 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic DNA
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
US7148040B2 (en) 2001-02-20 2006-12-12 University Of Georgia Research Foundation, Inc. Method of rapid production of hybridomas expressing monoclonal antibodies on the cell surface
US7265208B2 (en) 2001-05-01 2007-09-04 The Regents Of The University Of California Fusion molecules and treatment of IgE-mediated allergic diseases
EP1395114A2 (en) 2001-05-24 2004-03-10 Guard Inc., Methods for selecting and producing animals having a predicted level of immune response
US20050260570A1 (en) 2001-05-29 2005-11-24 Mao Jen-I Sequencing by proxy
US6720144B1 (en) 2001-06-21 2004-04-13 Quest Diagnostics Detection of clonal T-cell receptor-γ gene rearrangement by PCR/temporal temperature gradient gel electrophoresis (TTGE)
US7112423B2 (en) 2001-07-15 2006-09-26 Keck Graduate Institute Nucleic acid amplification using nicking agents
WO2003020983A1 (en) 2001-08-30 2003-03-13 Virginia Commonwealth University Allele specific pcr for genotyping
AU2002322518A1 (en) 2001-08-31 2003-03-18 Rosetta Inpharmactis Llc Methods for preparing nucleic acid samples
JP4317940B2 (ja) 2001-08-31 2009-08-19 イミュノコア・リミテッド 物質
AU2002341752B2 (en) * 2001-09-19 2008-04-03 Alexion Pharmaceuticals, Inc. Engineered templates and their use in single primer amplification
US6964850B2 (en) * 2001-11-09 2005-11-15 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
GB2382137A (en) 2001-11-20 2003-05-21 Mats Gullberg Nucleic acid enrichment
GB0128153D0 (en) * 2001-11-23 2002-01-16 Bayer Ag Profiling of the immune gene repertoire
WO2003052101A1 (en) 2001-12-14 2003-06-26 Rosetta Inpharmatics, Inc. Sample tracking using molecular barcodes
GB0130267D0 (en) 2001-12-19 2002-02-06 Neutec Pharma Plc Focussed antibody technology
WO2003059155A2 (en) 2002-01-09 2003-07-24 Maxx Genetech Co. Ltd Method of detecting t-cell proliferation for diagnosis of diseases by gene array
AUPS028002A0 (en) 2002-02-01 2002-02-28 Ausman Engineering And Associates Pty Ltd A bearing assembly
US7157274B2 (en) 2002-06-24 2007-01-02 Cytonome, Inc. Method and apparatus for sorting particles
AU2003299503A1 (en) 2002-05-16 2004-06-15 Vanderbilt University Method for predicting autoimmune diseases
AU2003247129A1 (en) 2002-07-01 2004-01-19 Centre National De La Recherche Scientifique (Cnrs) System, method, device, and computer program product for extraction, gathering, manipulation, and analysis of peak data from an automated sequencer
AU2003281336A1 (en) * 2002-07-03 2004-01-23 Institute For Scientific Research, Inc. Compositions and methods for the detection of human t cell receptor variable family gene expression
US20040115216A1 (en) 2002-07-12 2004-06-17 The Johns Hopkins University Reagents and methods for engaging unique clonotypic lymphocyte receptors
EP1552010B1 (en) 2002-07-19 2010-06-09 Althea Technologies, Inc. Strategies for gene expression analysis
US7157228B2 (en) 2002-09-09 2007-01-02 Bioarray Solutions Ltd. Genetic analysis and authentication
US7459273B2 (en) 2002-10-04 2008-12-02 Affymetrix, Inc. Methods for genotyping selected polymorphism
EP1597557A4 (en) 2002-10-11 2008-06-11 Univ California PROCESS FOR THE DIAGNOSIS AND FORECAST OF MULTIPLE SCLEROSIS
EP2460889B1 (en) * 2002-10-11 2013-11-20 Erasmus Universiteit Rotterdam Nucleic acid amplification primers for PCR-based clonality studies of BCL2-IGH rearrangements
US20060147925A1 (en) 2002-11-13 2006-07-06 Morley Alexander A Method of detection
US20060134704A1 (en) * 2002-11-14 2006-06-22 Atsushi Muraguchi Microwell array chip for detecting antigen-specific lymphocytes, method of detecting and method of manufacturing antigen-specific lymphocytes, and method of cloning antigen-specific lymphocyte antigen receptor genes
WO2004053104A2 (en) 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. 5’ cpg nucleic acids and methods of use
WO2004063706A2 (en) 2003-01-08 2004-07-29 Maxx Genetech Co., Ltd. Method of detecting over-expression of t-cell receptor genes by real-time pcr
CA2513535C (en) 2003-01-29 2012-06-12 454 Corporation Bead emulsion nucleic acid amplification
GB0304068D0 (en) 2003-02-22 2003-03-26 Avidex Ltd Substances
WO2004096985A2 (en) 2003-04-24 2004-11-11 Mayo Foundation For Medical Education And Research Methods for assessing biologic diversity
AU2003902299A0 (en) 2003-05-13 2003-05-29 Flinders Medical Centre A method of analysing a marker nucleic acid molecule
WO2005020784A2 (en) * 2003-05-23 2005-03-10 Mount Sinai School Of Medicine Of New York University Surrogate cell gene expression signatures for evaluating the physical state of a subject
US20050010030A1 (en) 2003-07-02 2005-01-13 Zang Jingwu Z. T cell receptor CDR3 sequence and methods for detecting and treating rheumatoid arthritis
WO2005010145A2 (en) 2003-07-05 2005-02-03 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
US20060228350A1 (en) 2003-08-18 2006-10-12 Medimmune, Inc. Framework-shuffling of antibodies
US20050048498A1 (en) 2003-08-29 2005-03-03 Applera Corporation Compositions, methods, and kits for assembling probes
WO2005026686A2 (en) 2003-09-09 2005-03-24 Compass Genetics, Llc Multiplexed analytical platform
TWI333977B (en) 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
FR2863274B1 (fr) * 2003-12-05 2012-11-16 Commissariat Energie Atomique Procede d'evaluation quantitative d'un rearrangement ou d'une recombinaison genetique ciblee d'un individu et ses applications.
WO2005053603A2 (en) 2003-12-08 2005-06-16 Yeda Research And Development Co. Ltd. Antigen receptor variable region typing
US20070160994A1 (en) 2003-12-15 2007-07-12 Institut Pasteur Repertoire determination of a lymphocyte b population
US20080166718A1 (en) 2003-12-15 2008-07-10 Institut Pasteur Repertoire determination of a lymphocyte B population
EP1544308B1 (en) 2003-12-15 2009-01-28 Institut Pasteur Repertoire determination of a lymphocyte B population
EP1721014B1 (en) 2004-02-18 2013-07-17 Trustees Of Boston University Method for detecting and quantifying rare mutations/polymorphisms
US20060046258A1 (en) * 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
WO2005084134A2 (en) 2004-03-04 2005-09-15 Dena Leshkowitz Quantifying and profiling antibody and t cell receptor gene expression
JP4480423B2 (ja) * 2004-03-08 2010-06-16 独立行政法人科学技術振興機構 免疫細胞クローンの拡大の有無の判定方法
DE102004016437A1 (de) * 2004-04-04 2005-10-20 Oligene Gmbh Verfahren zur Erkennung von Signaturen in komplexen Genexpressionsprofilen
WO2005111242A2 (en) 2004-05-10 2005-11-24 Parallele Bioscience, Inc. Digital profiling of polynucleotide populations
JP2007536939A (ja) 2004-05-14 2007-12-20 アモークス インコーポレーティッド 免疫細胞バイオセンサーおよびその使用方法
EP1598429A1 (en) 2004-05-19 2005-11-23 Amplion Ltd. Detection of amplicon contamination during PCR exhibiting two different annealing temperatures
GB0412973D0 (en) 2004-06-10 2004-07-14 Celltech R&D Ltd Identification of antibody producing cells
US20060020397A1 (en) 2004-07-21 2006-01-26 Kermani Bahram G Methods for nucleic acid and polypeptide similarity search employing content addressable memories
WO2006014869A1 (en) 2004-07-26 2006-02-09 Parallele Bioscience, Inc. Simultaneous analysis of multiple genomes
US7820382B2 (en) * 2004-08-03 2010-10-26 Bauer A Robert Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the donor and in the recipient and their associated conditions related and unrelated to the organ transplantation
US20060094018A1 (en) * 2004-08-03 2006-05-04 Bauer A R Jr Discovery and a method for the early detection of pancreatic cancer and other disease conditions
US7476724B2 (en) 2004-08-05 2009-01-13 Genentech, Inc. Humanized anti-cmet antibodies
CA2576702C (en) 2004-08-11 2016-10-04 Albert Einstein College Of Medicine Of Yeshiva University Isolation, gene expression, and chemotherapeutic resistance of motile cancer cells
CA2580412A1 (en) * 2004-09-13 2006-03-23 Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services Compositions comprising t cell receptors and methods of use thereof
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
EP1812563B1 (en) 2004-10-29 2013-04-10 Benaroya Research Institute at Virginia Mason Methods of generating antigen-specific cd4+cd25+ regulatory t cells, compositions and methods of use
US7966988B2 (en) 2005-01-11 2011-06-28 Exxonmobil Research And Engineering Company Method for controlling soot induced lubricant viscosity increase
US8029783B2 (en) 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
FR2881436B1 (fr) * 2005-02-03 2007-04-27 Commissariat Energie Atomique Procede de determination de la diversite des lymphocytes t dans un echantillon biologique
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US20080280774A1 (en) * 2005-02-16 2008-11-13 Wyeth Methods and Systems for Diagnosis, Prognosis and Selection of Treatment of Leukemia
US7537894B2 (en) 2005-03-02 2009-05-26 The University Of Chicago Methods and kits for monitoring Barrett's metaplasia
WO2006099164A2 (en) 2005-03-10 2006-09-21 Applera Corporation Methods for multiplex amplification
US20060211030A1 (en) 2005-03-16 2006-09-21 Sydney Brenner Methods and compositions for assay readouts on multiple analytical platforms
JP2008538496A (ja) 2005-04-12 2008-10-30 454 ライフ サイエンシーズ コーポレイション ウルトラディープ配列決定を用いて配列変異体を決定するための方法
WO2006116155A2 (en) 2005-04-21 2006-11-02 The Regents Of The University Of California A method for diagnosis and prognosis of multiple sclerosis subtypes
US20060263789A1 (en) 2005-05-19 2006-11-23 Robert Kincaid Unique identifiers for indicating properties associated with entities to which they are attached, and methods for using
US7208795B2 (en) 2005-05-24 2007-04-24 Atmel Corporation Low-cost, low-voltage single-layer polycrystalline EEPROM memory cell integration into BiCMOS technology
US8426146B2 (en) 2005-06-03 2013-04-23 University of Pittsburgh—of the Commonwealth System of Higher Education Multiparameteric method for assessing immune system status
US20090264299A1 (en) 2006-02-24 2009-10-22 Complete Genomics, Inc. High throughput genome sequencing on DNA arrays
EP1907571B1 (en) 2005-06-15 2017-04-26 Complete Genomics Inc. Nucleic acid analysis by random mixtures of non-overlapping fragments
WO2007008759A2 (en) 2005-07-07 2007-01-18 Hematologics, Inc. Methods for detecting and confirming minimal disease in a cancer patient
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
US7993821B2 (en) 2005-08-11 2011-08-09 University Of Washington Methods and apparatus for the isolation and enrichment of circulating tumor cells
GB0521521D0 (en) 2005-10-21 2005-11-30 Medical Res Council Diagnostic methods and kits
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
US20070105165A1 (en) 2005-11-04 2007-05-10 Charles Goolsby Composite profiles of cell antigens and target signal transduction proteins for analysis and clinical management of hematologic cancers
US7375211B2 (en) * 2005-11-18 2008-05-20 Kou Zhong C Method for detection and quantification of T-cell receptor Vβ repertoire
US8137936B2 (en) 2005-11-29 2012-03-20 Macevicz Stephen C Selected amplification of polynucleotides
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
US7544473B2 (en) 2006-01-23 2009-06-09 Population Genetics Technologies Ltd. Nucleic acid analysis using sequence tokens
KR20080113223A (ko) * 2006-03-06 2008-12-29 심포젠 에이/에스 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체
ES2546848T3 (es) 2006-03-10 2015-09-29 Epigenomics Ag Un método para identificar una muestra biológica para el análisis de la metilación
WO2007114693A2 (en) * 2006-04-04 2007-10-11 Keygene N.V. High throughput detection of molecular markers based on aflp and high throughput sequencing
US20100323401A1 (en) 2006-05-11 2010-12-23 Lewis George K General method for generating human antibody responses in vitro
WO2007136518A2 (en) * 2006-05-17 2007-11-29 Torrey Pines Institute For Molecular Studies Treatment of autoimmune disorders
WO2007139584A2 (en) 2006-05-25 2007-12-06 Institute For Advanced Study Methods for identifying sequence motifs, and applications thereof
US7833716B2 (en) 2006-06-06 2010-11-16 Gen-Probe Incorporated Tagged oligonucleotides and their use in nucleic acid amplification methods
CN101915957B (zh) 2006-06-12 2012-12-12 加利福尼亚太平洋生物科学公司 实施分析反应的基材
US20100027896A1 (en) 2006-06-28 2010-02-04 Amir Geva Automated application interaction using a virtual operator
CA2656525A1 (en) * 2006-06-30 2008-01-10 Applera Corporation Reversible terminator nucleotides and methods of use
WO2008108803A2 (en) 2006-07-13 2008-09-12 Amaox, Ltd. Immune cell biosensors and methods of using same
US8394590B2 (en) 2006-08-02 2013-03-12 California Institute Of Technology Capture agents and related methods and systems for detecting and/or sorting targets
US20080274904A1 (en) * 2006-08-10 2008-11-06 Niall Anthony Gormley Method of target enrichment
WO2008026927A2 (en) * 2006-08-30 2008-03-06 Academisch Medisch Centrum Process for displaying t- and b-cell receptor repertoires
WO2008039694A2 (en) 2006-09-26 2008-04-03 St. Jude Children's Research Hospital Methods and compositions for monitoring t cell receptor diversity
WO2008039818A2 (en) 2006-09-26 2008-04-03 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Modified t cell receptors and related materials and methods
JP5026047B2 (ja) * 2006-10-18 2012-09-12 株式会社膠原病研究所 自己免疫疾患の発症に関わる自己応答性t細胞またはt細胞受容体の同定方法、およびその利用
EP2102367A2 (en) * 2006-11-09 2009-09-23 XDX, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US7862999B2 (en) 2007-01-17 2011-01-04 Affymetrix, Inc. Multiplex targeted amplification using flap nuclease
MX2009008908A (es) 2007-03-01 2009-08-28 Symphogen As Metodo para clonacion de anticuerpos analogos.
WO2008147879A1 (en) 2007-05-22 2008-12-04 Ryan Golhar Automated method and device for dna isolation, sequence determination, and identification
CA2689356A1 (en) 2007-06-01 2008-12-11 454 Life Sciences Corporation System and meth0d for identification of individual samples from a multiplex mixture
WO2009015296A1 (en) 2007-07-24 2009-01-29 The Regents Of The University Of California Microfabricated dropley generator
JP2010534474A (ja) 2007-07-26 2010-11-11 パシフィック バイオサイエンシーズ オブ カリフォルニア, インコーポレイテッド 分子冗長配列決定
ITRM20070429A1 (it) 2007-08-06 2009-02-07 Uni Cattolica Del Sacro Cuor E Mezzi per la diagnosi la prevenzione e la cura dell'artrite reumatoide.
JP5547071B2 (ja) 2007-08-09 2014-07-09 セルラ・インコーポレイテッド 関連付け多パラメーター単一細胞測定および残留する生物学的材料の回収のための方法および装置
US8268564B2 (en) 2007-09-26 2012-09-18 President And Fellows Of Harvard College Methods and applications for stitched DNA barcodes
US7960116B2 (en) 2007-09-28 2011-06-14 Pacific Biosciences Of California, Inc. Nucleic acid sequencing methods and systems
WO2009045898A2 (en) 2007-09-28 2009-04-09 Mayo Foundation For Medical Education And Research Assessing t cell repertoires
BRPI0820707A2 (pt) 2007-11-07 2015-06-16 Genentech Inc Métodos e composição para avaliar a responsividade do linfoma de células b para o tratamento com anticorpos anti-cd40
WO2009070767A2 (en) 2007-11-28 2009-06-04 Whitehead Institute For Biomedical Research Systemic instigation systems to study tumor growth or metastasis
EP2062982A1 (fr) * 2007-11-26 2009-05-27 ImmunID Procédé d'étude de la diversité combinatoire V(D)J
CN101225441B (zh) 2007-12-05 2010-12-01 浙江大学 一种检测克隆特异性t淋巴细胞tcr bv cdr3基因组成的方法
US20100021894A1 (en) * 2007-12-20 2010-01-28 Northwestern University Nanoparticle-Based Colorimetric Detection Of Cysteine
US8621502B2 (en) 2007-12-21 2013-12-31 Microsoft Corporation Obtaining user reactions to video
US11051733B2 (en) 2008-01-18 2021-07-06 Wake Forest University Health Sciences Isolating and purifying cells for therapy
US7767400B2 (en) * 2008-02-03 2010-08-03 Helicos Biosciences Corporation Paired-end reads in sequencing by synthesis
EP2088205A1 (en) 2008-02-11 2009-08-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) PSMB10: A diagnosis marker and therapeutic target of chronic rejection.
EP2088432A1 (en) 2008-02-11 2009-08-12 MorphoSys AG Methods for identification of an antibody or a target
CA2717030A1 (en) 2008-02-28 2009-09-03 The Ohio State University Research Foundation Microrna signatures associated with cytogenetics and prognosis in acute myeloid leukemia (aml) and uses thereof
WO2009108860A2 (en) 2008-02-28 2009-09-03 The Ohio University Rasearch Foundation Microrna-based methods and compositions for the diagnosis, pronosis and treatment of prostate related disorders
US20090226975A1 (en) * 2008-03-10 2009-09-10 Illumina, Inc. Constant cluster seeding
TW200938840A (en) 2008-03-12 2009-09-16 Emo Biomedicine Corp A method for in vitro study of immune modulation using pig blood cell
EP2100970B1 (en) * 2008-03-13 2017-05-10 National Institute of Immunology Ig genes specific oligonucleotides and uses thereof
CN102084001B (zh) 2008-03-28 2015-03-18 加利福尼亚太平洋生物科学股份有限公司 用于核酸测序的组合物和方法
EP2107040B1 (en) 2008-03-31 2011-10-26 Sony Deutschland Gmbh A method of fabricating a membrane having a tapered pore
CN102066578B (zh) * 2008-04-16 2016-07-06 哈森阿尔法生物技术研究院 用于评价和比较免疫组库的方法
US8911948B2 (en) 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
EP2277049A4 (en) 2008-05-09 2012-05-30 Univ Duke AUTOANTIKÖRPER FOR THE PROOF AND THE TREATMENT OF CANCER
US9068181B2 (en) 2008-05-23 2015-06-30 The General Hospital Corporation Microfluidic droplet encapsulation
DE102008025656B4 (de) 2008-05-28 2016-07-28 Genxpro Gmbh Verfahren zur quantitativen Analyse von Nukleinsäuren, Marker dafür und deren Verwendung
DK2297333T3 (en) 2008-05-30 2015-04-07 Massachusetts Inst Technology Method for spatial separation and for screening cells
WO2009151628A2 (en) 2008-06-12 2009-12-17 Gov't Of The Usa, As Represented By The Secretary, Department Of Health Human Services Monitoring tcr-b to determine hiv therapy and disease progression
MX2010014556A (es) 2008-06-25 2011-07-28 Baylor Res Inst Firma transcripcional de sangre por infeccion de mycobacterium tuberculosis.
US8394583B2 (en) 2008-07-24 2013-03-12 The Board Of Regents Of The University Of Texas System VH4 codon signature for multiple sclerosis
KR20110036638A (ko) * 2008-07-25 2011-04-07 리차드 더블유. 와그너 단백질 스크리닝 방법
CN102405402A (zh) 2008-09-23 2012-04-04 阔达生命有限公司 基于液滴的测定系统
US9156010B2 (en) * 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8699361B2 (en) 2008-09-30 2014-04-15 Qualcomm Incorporated Out-of-synchronization handling method and apparatus
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8546128B2 (en) 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
WO2010051416A1 (en) 2008-10-31 2010-05-06 Qualcomm Incorporated Using magnetometer with a positioning system
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
GB2483810B (en) 2008-11-07 2012-09-05 Sequenta Inc Methods for correlating clonotypes with diseases in a population
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US20140234835A1 (en) 2008-11-07 2014-08-21 Sequenta, Inc. Rare clonotypes and uses thereof
US8691510B2 (en) * 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
US20110105343A1 (en) 2008-11-21 2011-05-05 Emory University Systems Biology Approach Predicts Immunogenicity of Vaccines
US8367330B2 (en) 2008-12-22 2013-02-05 Quest Diagnostics Investments Incorporated Methods for detecting TCR-gamma gene rearrangement
CA2750155A1 (en) 2008-12-30 2010-07-08 Centocor Ortho Biotech Inc. Serum markers predicting clinical response to anti-tnf.alpha. antibodiesin patients with ankylosing spondylitis
PT2387627E (pt) 2009-01-15 2016-06-03 Adaptive Biotechnologies Corp Determinação do perfil de imunidade adaptativa e métodos de geração de anticorpos monoclonais
US9329170B2 (en) * 2009-01-20 2016-05-03 The Board Of Trustees Of The Leland Stanford Junior University Single cell gene expression for diagnosis, prognosis and identification of drug targets
US20100323348A1 (en) 2009-01-31 2010-12-23 The Regents Of The University Of Colorado, A Body Corporate Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
JP2012531202A (ja) 2009-06-25 2012-12-10 フレッド ハチンソン キャンサー リサーチ センター 適応免疫を測定する方法
US20120058902A1 (en) 2009-06-25 2012-03-08 Livingston Robert J Method of measuring adaptive immunity
EP2278513A1 (en) * 2009-07-15 2011-01-26 Nagravision SA Method for preventing the use of a cloned user unit communicating with a server
US8497071B2 (en) 2009-06-29 2013-07-30 California Institute Of Technology Isolation of unknown rearranged T-cell receptors from single cells
EP2480683B1 (en) 2009-09-22 2017-11-29 Roche Diagnostics GmbH Determination of kir haplotypes by amplification of exons
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US8545248B2 (en) 2010-01-07 2013-10-01 Life Technologies Corporation System to control fluid flow based on a leak detected by a sensor
KR101323827B1 (ko) 2010-01-08 2013-10-31 키스트 유럽 에프게엠베하 강직성척추염 진단용 프라이머 및 이를 이용한 강직성 척추염 진단 방법
GB201000375D0 (en) * 2010-01-09 2010-02-24 Univ Cardiff T Cell clonotypes
WO2011106738A2 (en) 2010-02-25 2011-09-01 Fred Hutchinson Cancer Research Center Use of tcr clonotypes as biomarkers for disease
EP2367000A1 (en) 2010-03-04 2011-09-21 Charité Universitätsmedizin Berlin High throughput analysis of T-cell receptor repertoires
EP3456847B1 (en) 2010-05-06 2024-12-25 Adaptive Biotechnologies Corporation Monitoring solid transplant rejection using clonotype profiles
CA2796822C (en) 2010-05-07 2021-10-05 The Board Of Trustees Of The Leland Standford Junior University Measurement and comparison of immune diversity by high-throughput sequencing
US20130123120A1 (en) 2010-05-18 2013-05-16 Natera, Inc. Highly Multiplex PCR Methods and Compositions
EP2580353B1 (en) 2010-06-11 2015-07-29 Life Technologies Corporation Alternative nucleotide flows in sequencing-by-synthesis methods
ES2690753T3 (es) 2010-09-21 2018-11-22 Agilent Technologies, Inc. Aumento de la confianza en las identificaciones de alelos con el recuento molecular
EP2622103B2 (en) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Sandwich assays in droplets
DK2625320T3 (da) 2010-10-08 2019-07-01 Harvard College High-throughput enkeltcellestregkodning
EP2625295B1 (en) 2010-10-08 2019-03-13 President and Fellows of Harvard College High-throughput immune sequencing
US8753816B2 (en) 2010-10-26 2014-06-17 Illumina, Inc. Sequencing methods
CA2821299C (en) 2010-11-05 2019-02-12 Frank J. Steemers Linking sequence reads using paired code tags
US9193997B2 (en) 2010-12-15 2015-11-24 The Board Of Trustees Of The Leland Stanford Junior University Measuring and monitoring of cell clonality
DK2652155T3 (en) 2010-12-16 2017-02-13 Gigagen Inc Methods for Massive Parallel Analysis of Nucleic Acids in Single Cells
US9594870B2 (en) 2010-12-29 2017-03-14 Life Technologies Corporation Time-warped background signal for sequencing-by-synthesis operations
US10146906B2 (en) 2010-12-30 2018-12-04 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US8759036B2 (en) 2011-03-21 2014-06-24 Affymetrix, Inc. Methods for synthesizing pools of probes
DK3246416T3 (da) 2011-04-15 2024-09-02 Univ Johns Hopkins Sikkert sekventeringssystem
EP3421591B1 (en) 2011-04-28 2023-09-27 The Board of Trustees of the Leland Stanford Junior University Identification of polynucleotides associated with a sample
MX360823B (es) 2011-05-24 2018-11-16 Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh Vacunas individualizadas para el cancer.
WO2013033721A1 (en) 2011-09-02 2013-03-07 Atreca, Inc. Dna barcodes for multiplexed sequencing
WO2013036459A2 (en) 2011-09-09 2013-03-14 Sequenta, Inc. Sequence-based measures of immune response
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
WO2013055595A1 (en) 2011-10-11 2013-04-18 Sequenta, Inc. Determining responsiveness of autoimmune patients to dmard treatment
EP2768982A4 (en) 2011-10-21 2015-06-03 Adaptive Biotechnologies Corp QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS
ES2619713T3 (es) 2011-11-04 2017-06-26 Adaptive Biotechnologies Corporation Clonotipos de receptores de células T compartidos entre pacientes con espondilitis anquilosante
US20140336059A1 (en) 2011-12-05 2014-11-13 Sequenta, Inc. Clonotypes as biometric specimen tags
WO2013086462A1 (en) 2011-12-09 2013-06-13 Sequenta, Inc. Method of measuring immune activation
AU2012347460B2 (en) 2011-12-09 2017-05-25 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
WO2013090390A2 (en) 2011-12-13 2013-06-20 Sequenta, Inc. Method of measuring immune activation
EP2794925A4 (en) 2011-12-20 2015-09-30 Sequenta Inc MONITORING THE TRANSFORMATION OF FOLLICULAR LYMPHOMA IN DIFFUSED LYMPHOMA WITH LARGE B CELLS BY ANALYSIS OF THE IMMUNE REPERTOIRE
WO2013112655A1 (en) 2012-01-24 2013-08-01 Gigagen, Inc. Method for correction of bias in multiplexed amplification
US11177020B2 (en) 2012-02-27 2021-11-16 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
WO2013131074A1 (en) 2012-03-02 2013-09-06 Diogenix, Inc. Methods and reagents for evaluating autoimmune disease and determining antibody repertoire
JP6302847B2 (ja) 2012-03-05 2018-03-28 アダプティヴ バイオテクノロジーズ コーポレーション 頻度が一致したサブユニットからの、対をなす免疫受容体鎖の決定
US20150038346A1 (en) 2012-03-05 2015-02-05 Sequenta, Inc. Monitoring immune responsiveness to cancer vaccination
WO2013134302A1 (en) 2012-03-05 2013-09-12 Sequenta, Inc. Monitoring immune responsiveness to cancer vaccination
CA2869481A1 (en) 2012-04-13 2013-10-17 Sequenta, Inc. Detection and quantitation of sample contamination in immune repertoire analysis
WO2013158936A1 (en) 2012-04-20 2013-10-24 Sequenta, Inc Monitoring immunoglobulin heavy chain evolution in b-cell acute lymphoblastic leukemia
ES2711156T3 (es) 2012-05-08 2019-04-30 Adaptive Biotechnologies Corp Método para medir y calibrar el sesgo de amplificación en reacciones de PCR multiplexadas
US20150247201A1 (en) 2012-05-31 2015-09-03 Malek Faham Predicting relapse of chronic lymphocytic leukemia patients treated by allogeneic stem cell transplantation
US20130324422A1 (en) 2012-06-04 2013-12-05 Sequenta, Inc. Detecting disease-correlated clonotypes from fixed samples
SG11201407888RA (en) 2012-06-11 2014-12-30 Sequenta Inc Method of sequence determination using sequence tags
CA2876209A1 (en) 2012-06-15 2013-12-19 Adaptive Biotechnologies Corporation Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
JP2015523087A (ja) 2012-07-24 2015-08-13 シーケンタ インコーポレイテッド 配列タグを用いる単一細胞分析
JP2015524282A (ja) 2012-08-10 2015-08-24 シーケンタ インコーポレイテッド 配列タグを用いた高感度突然変異検出
CA2884246C (en) 2012-09-24 2023-11-07 Cb Biotechnologies, Inc. Multiplex pyrosequencing using non-interfering noise-canceling polynucleotide identification tags
AU2013331135A1 (en) 2012-10-19 2015-05-07 Adaptive Biotechnologies Corp. Monitoring diffuse large B-cell lymphoma from peripheral blood samples
EP2909344A4 (en) 2012-10-19 2016-06-29 Adaptive Biotechnologies Corp SURVEILLANCE OF CLONOTYPES IN PROLIFERATIVE DISORDERS OF PLASMOCYTES IN PERIPHERAL BLOOD
AU2013335021A1 (en) 2012-10-22 2015-05-07 Adaptive Biotechnologies Corp. Monitoring mantle cell lymphoma clonotypes in peripheral blood after immunotransplant
WO2014130685A1 (en) 2013-02-22 2014-08-28 Sequenta, Inc. Rare clonotypes and uses thereof
US20140255944A1 (en) 2013-03-08 2014-09-11 Sequenta, Inc. Monitoring treatment-resistant clones in lymphoid and myeloid neoplasms by relative levels of evolved clonotypes
US20140255929A1 (en) 2013-03-11 2014-09-11 Sequenta, Inc. Mosaic tags for labeling templates in large-scale amplifications
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
US20160186260A1 (en) 2013-07-26 2016-06-30 Sequenta, Llc Cancer vaccination with antigen evolution
AU2014337063A1 (en) 2013-10-18 2016-05-19 Adaptive Biotechnologies Corp. Predicting patient responsiveness to immune checkpoint inhibitors
US20150218656A1 (en) 2014-02-03 2015-08-06 Adaptive Biotechnologies Corp. Methods for detection and diagnosis of a lymphoid malignancy using high throughput sequencing
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
WO2016069886A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corporation Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046706A1 (en) * 1996-06-03 1997-12-11 University Of Alberta Methods for detection of rearranged dna

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A novel approach for the analysis of T-cell reconstitution by using a T-cell receptor b-based oligonucleotide microarry in hematopoietic stem cell transplantation;Chen Xiaohua;《Experimental Hematology》;20071231;第35卷;831-841 *
Activated Memory B Cell Subsets Correlate With Disease Activity in Systemic Lupus Erythematosus;Annett M. Jacobi;《ARTHRITIS & RHEUMATISM》;20080630;第58卷(第6期);1762-1773 *

Also Published As

Publication number Publication date
US20120135409A1 (en) 2012-05-31
US20190062848A1 (en) 2019-02-28
GB2467704B (en) 2011-08-24
GB201120209D0 (en) 2012-01-04
GB201209668D0 (en) 2012-07-18
US10246752B2 (en) 2019-04-02
CA2742380A1 (en) 2010-05-14
EP4335932A3 (en) 2024-06-26
ES2453066T3 (es) 2014-04-03
US11001895B2 (en) 2021-05-11
US20100151471A1 (en) 2010-06-17
GB2488700A (en) 2012-09-05
US20130267427A1 (en) 2013-10-10
CN104195227A (zh) 2014-12-10
US20110207617A1 (en) 2011-08-25
US20160230236A1 (en) 2016-08-11
US9347099B2 (en) 2016-05-24
CA2742380C (en) 2018-05-29
US9228232B2 (en) 2016-01-05
US20210310076A1 (en) 2021-10-07
GB201105068D0 (en) 2011-05-11
GB2483810B (en) 2012-09-05
US20140342367A1 (en) 2014-11-20
EP2719774B8 (en) 2020-04-22
US20190169698A1 (en) 2019-06-06
CN104195227B (zh) 2017-04-12
GB201009641D0 (en) 2010-07-21
US20160201133A1 (en) 2016-07-14
US11021757B2 (en) 2021-06-01
GB2467704A (en) 2010-08-11
JP2012508011A (ja) 2012-04-05
AU2009311588A1 (en) 2010-05-14
US20130005584A1 (en) 2013-01-03
AU2009311588B2 (en) 2016-07-28
GB2483810A (en) 2012-03-21
GB2488700B (en) 2013-05-29
US20130017957A1 (en) 2013-01-17
US20180112278A1 (en) 2018-04-26
GB2497007A (en) 2013-05-29
WO2010053587A3 (en) 2010-08-19
JP6112577B2 (ja) 2017-04-12
US20180080090A1 (en) 2018-03-22
US9217176B2 (en) 2015-12-22
EP4335932A2 (en) 2024-03-13
EP3699296A1 (en) 2020-08-26
US10865453B2 (en) 2020-12-15
GB201300533D0 (en) 2013-02-27
US10760133B2 (en) 2020-09-01
EP2719774B1 (en) 2020-03-18
EP2364368A2 (en) 2011-09-14
US20190100810A1 (en) 2019-04-04
JP5798926B2 (ja) 2015-10-21
EP2719774A1 (en) 2014-04-16
GB2497007B (en) 2013-08-07
US8795970B2 (en) 2014-08-05
JP2016039800A (ja) 2016-03-24
US20130344066A1 (en) 2013-12-26
US8236503B2 (en) 2012-08-07
CN102272327A (zh) 2011-12-07
EP2364368B1 (en) 2014-01-15
GB2477439B (en) 2012-02-15
US8507205B2 (en) 2013-08-13
ES2781754T3 (es) 2020-09-07
US10266901B2 (en) 2019-04-23
WO2010053587A2 (en) 2010-05-14
SG195652A1 (en) 2013-12-30
GB2477439A (en) 2011-08-03

Similar Documents

Publication Publication Date Title
CN102272327B (zh) 通过序列分析监测状况的方法
JP6533272B2 (ja) クロノタイププロファイルを用いた健康状態および疾患状態のモニタリング
US9416420B2 (en) Monitoring health and disease status using clonotype profiles
HK40035877A (en) Methods of monitoring conditions by sequence analysis

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20160330

Address after: Washington State

Patentee after: ADAPTIVE BIOTECHNOLOGIES Corp.

Address before: California, USA

Patentee before: Sequenta, Inc.

Effective date of registration: 20160330

Address after: California, USA

Patentee after: SEQUENTA, Inc.

Address before: California, USA

Patentee before: SEQUENTA, Inc.