CN102264755A - 靶向vegfr-1/nrp-1的肽 - Google Patents

靶向vegfr-1/nrp-1的肽 Download PDF

Info

Publication number
CN102264755A
CN102264755A CN2008801105643A CN200880110564A CN102264755A CN 102264755 A CN102264755 A CN 102264755A CN 2008801105643 A CN2008801105643 A CN 2008801105643A CN 200880110564 A CN200880110564 A CN 200880110564A CN 102264755 A CN102264755 A CN 102264755A
Authority
CN
China
Prior art keywords
peptide
cancer
albumen
isolating
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2008801105643A
Other languages
English (en)
Chinese (zh)
Inventor
R·帕斯奎利尼
W·阿拉普
R·乔尔达诺
M·卡尔多-维拉
A·P·瓦伦特
F·塞尼维瓦拉塞尔达德埃尔梅达
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade Federal do Rio de Janeiro UFRJ
University of Texas at Austin
Original Assignee
Universidade Federal do Rio de Janeiro UFRJ
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade Federal do Rio de Janeiro UFRJ, University of Texas at Austin filed Critical Universidade Federal do Rio de Janeiro UFRJ
Publication of CN102264755A publication Critical patent/CN102264755A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Nanotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Cardiology (AREA)
CN2008801105643A 2007-08-08 2008-08-08 靶向vegfr-1/nrp-1的肽 Pending CN102264755A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95475007P 2007-08-08 2007-08-08
US60/954,750 2007-08-08
PCT/US2008/072675 WO2009032477A2 (en) 2007-08-08 2008-08-08 Vegfr-1/nrp-1 targeting peptides

Publications (1)

Publication Number Publication Date
CN102264755A true CN102264755A (zh) 2011-11-30

Family

ID=40429628

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801105643A Pending CN102264755A (zh) 2007-08-08 2008-08-08 靶向vegfr-1/nrp-1的肽

Country Status (8)

Country Link
US (1) US20120028880A1 (enExample)
EP (1) EP2283028A2 (enExample)
JP (1) JP5548616B2 (enExample)
CN (1) CN102264755A (enExample)
AU (1) AU2008296733B2 (enExample)
CA (1) CA2695960A1 (enExample)
RU (1) RU2488592C2 (enExample)
WO (1) WO2009032477A2 (enExample)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102746380A (zh) * 2012-07-25 2012-10-24 中国药科大学 血管生成抑制剂多肽在制备治疗肿瘤及类风湿性关节炎药物中的应用
CN104045718A (zh) * 2014-07-08 2014-09-17 南京安吉生物科技有限公司 多功能融合多肽及其制备方法和应用
CN104774246A (zh) * 2014-03-21 2015-07-15 中山大学附属肿瘤医院 Nrp-1特异性肿瘤靶向多肽及其应用
CN104974227A (zh) * 2014-04-04 2015-10-14 中国科学院苏州纳米技术与纳米仿生研究所 阳离子双亲性膜靶向α-螺旋多肽及其应用
CN105237637A (zh) * 2015-11-10 2016-01-13 厦门大学 抗人神经纤毛蛋白1的单域抗体及其制备方法
CN109966495A (zh) * 2017-12-28 2019-07-05 义慧科技(深圳)有限公司 一种预防和/或治疗脂肪代谢症的药物及vegfr1抑制剂在该药物中的应用
CN109966494A (zh) * 2017-12-28 2019-07-05 义慧科技(深圳)有限公司 一种预防和/或治疗糖尿病的药物及vegfr1抑制剂在该药物中的应用
CN111018952A (zh) * 2019-12-23 2020-04-17 哈尔滨医科大学 一种具有双重功效的抗肿瘤多肽及其应用
CN112409455A (zh) * 2020-11-12 2021-02-26 国家纳米科学中心 一种用于治疗脉络膜新生血管的多肽纳米材料及其制备方法和应用
CN112996528A (zh) * 2018-09-11 2021-06-18 安必圣有限责任公司 肽及其医学用途
CN116254237A (zh) * 2022-12-20 2023-06-13 中山大学中山眼科中心 一种降低眼压的表达nrp1的重组腺相关病毒的构建方法及其应用
CN119978068A (zh) * 2025-04-15 2025-05-13 浙江大学 一种神经纤毛蛋白nrp-1亲和肽及其用途

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101870734B (zh) * 2010-05-25 2012-06-20 北京大学 一种抑制新生血管生成的融合多肽及其编码基因与应用
CU23950B1 (es) * 2011-03-21 2013-10-29 Ct De Ingeniería Genética Y Biotecnología Péptidos cíclicos con actividad antineoplásica y antiangiogénica
SG187271A1 (en) * 2011-07-07 2013-02-28 Agency Science Tech & Res Anti-amyloidogenic, alpha-helix breaking ultra-small peptide therapeutic
WO2013134249A1 (en) * 2012-03-08 2013-09-12 Ablaris Therapeutics Inc. Adipose tissue targeted peptides
EP2897974B1 (en) * 2012-09-20 2018-03-28 Mackay Memorial Hospital Use of pedf-derived polypeptides for treating osteoarthritis
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
WO2015085147A1 (en) 2013-12-05 2015-06-11 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
CA2932798C (en) * 2013-12-06 2022-09-20 The Broad Institute, Inc. Formulations for neoplasia vaccines
EP3082853A2 (en) 2013-12-20 2016-10-26 The Broad Institute, Inc. Combination therapy with neoantigen vaccine
EP3108255B1 (en) * 2014-02-18 2020-08-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of diseases mediated by the nrp-1/obr complex signaling pathway
ES3049406T3 (en) 2014-12-19 2025-12-16 Broad Inst Inc Methods for profiling the t-cell-receptor repertoire
EP3234193B1 (en) 2014-12-19 2020-07-15 Massachusetts Institute of Technology Molecular biomarkers for cancer immunotherapy
WO2016123163A2 (en) 2015-01-27 2016-08-04 Kardiatonos, Inc. Biomarkers of vascular disease
RU2708375C2 (ru) * 2015-03-02 2019-12-06 Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Иллинойс Пептиды для ингибирования ангиогенеза
CN108025048B (zh) 2015-05-20 2022-10-25 博德研究所 共有的新抗原
KR102216566B1 (ko) 2016-07-05 2021-02-17 (주) 아이벤트러스 종양 혈관형성을 억제하는 vegf 딥 블로커를 포함하는 암 치료용 조성물 및 이의 제조방법
US11549149B2 (en) 2017-01-24 2023-01-10 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003086450A1 (es) * 2002-04-15 2003-10-23 Centro De Ingenieria Genetica Y Biotecnologia Inmunoterapia activa antiangiogenica.

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4957939A (en) 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4472509A (en) 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US5206347A (en) 1985-08-06 1993-04-27 La Jolla Cancer Research Foundation Isolation and use of receptors binding to a peptide column
JP3407072B2 (ja) 1991-02-14 2003-05-19 バクスター、インターナショナル、インコーポレイテッド リポソームへの認識物質の結合
US5603872A (en) 1991-02-14 1997-02-18 Baxter International Inc. Method of binding recognizing substances to liposomes
US5329028A (en) 1992-08-05 1994-07-12 Genentech, Inc. Carbohydrate-directed cross-linking reagents
US5789542A (en) * 1994-04-22 1998-08-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Amphipathic peptides
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US6339069B1 (en) * 1996-10-15 2002-01-15 Elan Pharmaceuticalstechnologies, Inc. Peptide-lipid conjugates, liposomes and lipsomal drug delivery
RU2142134C1 (ru) * 1997-06-11 1999-11-27 Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии им.Пастера Тест-система для обнаружения антител к ядерному белку вируса гепатита с класса igm
DE10154458B4 (de) * 2001-11-08 2009-10-29 Universität Leipzig Peptide zur Analyse von Gluten in Lebensmitteln und anderen Substanzgemischen und deren Verwendung
ATE419536T1 (de) 2002-03-05 2009-01-15 Univ Texas Biospezifische kontrastmittel
US20030194704A1 (en) * 2002-04-03 2003-10-16 Penn Sharron Gaynor Human genome-derived single exon nucleic acid probes useful for gene expression analysis two
WO2004084950A2 (en) * 2003-03-24 2004-10-07 Case Western Reserve University Cell targeting methods and compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003086450A1 (es) * 2002-04-15 2003-10-23 Centro De Ingenieria Genetica Y Biotecnologia Inmunoterapia activa antiangiogenica.

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GIORADNO R J ET AL: "Biopanning and rapid analysis of selective interactive ligands", 《NATURAL MEDICINE》 *
GIORDABI ET.AL: "Structural basis for the interaction of a vascular endothelial growth factor mimic peptide motif and its correspoding receptors", 《CHEMISTRY AND BIOLOGY,CURRENT BIOLOGY》 *
GIORDANO RICARDO J ET.AL: "From combinatorial peptide selection ro drug prototype(I):Targeting the vascular endothelial growth factor receptor pathway", 《PNAS》 *
PODDA E ET.AL: "Dual mode of action of Bac7, a proline-rich antibacterial peptide", 《BIOCHIM BIOPHYS ACTA》 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102746380A (zh) * 2012-07-25 2012-10-24 中国药科大学 血管生成抑制剂多肽在制备治疗肿瘤及类风湿性关节炎药物中的应用
CN104774246A (zh) * 2014-03-21 2015-07-15 中山大学附属肿瘤医院 Nrp-1特异性肿瘤靶向多肽及其应用
CN104774246B (zh) * 2014-03-21 2018-05-04 中山大学附属肿瘤医院 Nrp-1特异性肿瘤靶向多肽及其应用
CN104974227B (zh) * 2014-04-04 2019-04-23 中国科学院苏州纳米技术与纳米仿生研究所 阳离子双亲性膜靶向α-螺旋多肽及其应用
CN104974227A (zh) * 2014-04-04 2015-10-14 中国科学院苏州纳米技术与纳米仿生研究所 阳离子双亲性膜靶向α-螺旋多肽及其应用
CN104045718A (zh) * 2014-07-08 2014-09-17 南京安吉生物科技有限公司 多功能融合多肽及其制备方法和应用
CN104045718B (zh) * 2014-07-08 2016-08-17 南京安吉生物科技有限公司 多功能融合多肽及其制备方法和应用
CN105237637A (zh) * 2015-11-10 2016-01-13 厦门大学 抗人神经纤毛蛋白1的单域抗体及其制备方法
CN105237637B (zh) * 2015-11-10 2018-10-30 厦门大学 抗人神经纤毛蛋白1的单域抗体及其制备方法
CN109966495A (zh) * 2017-12-28 2019-07-05 义慧科技(深圳)有限公司 一种预防和/或治疗脂肪代谢症的药物及vegfr1抑制剂在该药物中的应用
CN109966494A (zh) * 2017-12-28 2019-07-05 义慧科技(深圳)有限公司 一种预防和/或治疗糖尿病的药物及vegfr1抑制剂在该药物中的应用
CN112996528A (zh) * 2018-09-11 2021-06-18 安必圣有限责任公司 肽及其医学用途
CN111018952A (zh) * 2019-12-23 2020-04-17 哈尔滨医科大学 一种具有双重功效的抗肿瘤多肽及其应用
CN111018952B (zh) * 2019-12-23 2021-09-07 哈尔滨医科大学 一种具有双重功效的抗肿瘤多肽及其应用
CN112409455A (zh) * 2020-11-12 2021-02-26 国家纳米科学中心 一种用于治疗脉络膜新生血管的多肽纳米材料及其制备方法和应用
CN116254237A (zh) * 2022-12-20 2023-06-13 中山大学中山眼科中心 一种降低眼压的表达nrp1的重组腺相关病毒的构建方法及其应用
CN116254237B (zh) * 2022-12-20 2024-02-20 中山大学中山眼科中心 一种降低眼压的表达nrp1的重组腺相关病毒的构建方法及其应用
CN119978068A (zh) * 2025-04-15 2025-05-13 浙江大学 一种神经纤毛蛋白nrp-1亲和肽及其用途
CN119978068B (zh) * 2025-04-15 2025-07-15 浙江大学 一种神经纤毛蛋白nrp-1亲和肽及其用途

Also Published As

Publication number Publication date
AU2008296733B2 (en) 2013-07-11
EP2283028A2 (en) 2011-02-16
RU2488592C2 (ru) 2013-07-27
JP5548616B2 (ja) 2014-07-16
JP2011504458A (ja) 2011-02-10
WO2009032477A3 (en) 2011-01-13
WO2009032477A8 (en) 2009-06-04
RU2010108499A (ru) 2011-09-20
AU2008296733A1 (en) 2009-03-12
US20120028880A1 (en) 2012-02-02
CA2695960A1 (en) 2009-03-12
WO2009032477A2 (en) 2009-03-12

Similar Documents

Publication Publication Date Title
RU2488592C2 (ru) Пептиды направленного действия на vegfr-1/nrp-1
JP2011504458A5 (enExample)
JP4949844B2 (ja) エリスロポエチン受容体に結合する新規ペプチド
JP4266028B2 (ja) エリスロポエチン受容体に結合する新規ペプチド
US20110282029A1 (en) Novel peptides that bind to the erythropoietin receptor
JP2007530440A (ja) 新規ポリ（エチレングリコール）修飾化合物およびその用途
JP2011525491A (ja) Ｃｒｋｌ標的化ペプチド
US20130237476A1 (en) Adipose tissue targeted peptides
WO2018219301A1 (zh) 一种PDGFRβ靶向性肿瘤坏死因子相关凋亡诱导配体变异体及其制备方法和用途
CN104119444B (zh) 抗肿瘤融合蛋白及其制备方法和用途
HK1164344A (en) Vegfr-1/nrp-1 targeting peptides
US20090005292A1 (en) Novel Peptides that Bind to the Erythropoietin Receptor
WO2013149237A1 (en) Targeting intracellular organelle zip codes with functional homing ligands from cell-internalizing phage combinatorial libraries
JP2009191056A (ja) 合成ペプチドをベースとするｅｐｏレセプターアゴニストを用いた抗エリスロポエチン抗体に媒介された障害の治療

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1164344

Country of ref document: HK

C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20111130

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1164344

Country of ref document: HK