ATE419536T1 - Biospezifische kontrastmittel - Google Patents
Biospezifische kontrastmittelInfo
- Publication number
- ATE419536T1 ATE419536T1 AT03711417T AT03711417T ATE419536T1 AT E419536 T1 ATE419536 T1 AT E419536T1 AT 03711417 T AT03711417 T AT 03711417T AT 03711417 T AT03711417 T AT 03711417T AT E419536 T1 ATE419536 T1 AT E419536T1
- Authority
- AT
- Austria
- Prior art keywords
- sample
- condition
- quantum dots
- metallic nanoparticles
- contrast agents
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/416—Evaluating particular organs or parts of the immune or lymphatic systems the spleen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0065—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
- A61K49/0067—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle quantum dots, fluorescent nanocrystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/587—Nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36192402P | 2002-03-05 | 2002-03-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE419536T1 true ATE419536T1 (de) | 2009-01-15 |
Family
ID=27805093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03711417T ATE419536T1 (de) | 2002-03-05 | 2003-03-05 | Biospezifische kontrastmittel |
Country Status (7)
Country | Link |
---|---|
US (2) | US20040023415A1 (de) |
EP (1) | EP1487343B1 (de) |
AT (1) | ATE419536T1 (de) |
AU (1) | AU2003213729A1 (de) |
CA (1) | CA2478083A1 (de) |
DE (1) | DE60325564D1 (de) |
WO (1) | WO2003075765A1 (de) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8614169B2 (en) * | 2001-12-04 | 2013-12-24 | Wayne State University | Neoepitope detection of disease using protein arrays |
US7964536B2 (en) * | 2001-12-04 | 2011-06-21 | Wayne State University | Neoepitope detection of disease using protein arrays |
US20040023415A1 (en) * | 2002-03-05 | 2004-02-05 | Konstantin Sokolov | Biospecific contrast agents |
JP2006508095A (ja) | 2002-05-07 | 2006-03-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 粒子の生物活性化 |
US8020433B2 (en) * | 2003-03-25 | 2011-09-20 | Tearlab Research, Inc. | Systems and methods for a sample fluid collection device |
US7810380B2 (en) * | 2003-03-25 | 2010-10-12 | Tearlab Research, Inc. | Systems and methods for collecting tear film and measuring tear film osmolarity |
US6965434B2 (en) * | 2002-09-13 | 2005-11-15 | Centre National De La Recherche Scientifiques (C.N.R.S.) | Method and device for photothermal imaging tiny metal particles immersed in a given medium |
US7623908B2 (en) * | 2003-01-24 | 2009-11-24 | The Board Of Trustees Of The University Of Illinois | Nonlinear interferometric vibrational imaging |
JP4787938B2 (ja) * | 2003-03-28 | 2011-10-05 | ザ・プロウボウスト・フェロウズ・ファウンデーション・スカラーズ・アンド・ザ・アザー・メンバーズ・オブ・ボード・オブ・ザ・カレッジ・オブ・ザ・ホリー・アンド・アンデバイデッド・トリニティ・オブ・クイーン | 銀ナノ粒子を用いた検体検出用センサ |
US20050250094A1 (en) * | 2003-05-30 | 2005-11-10 | Nanosphere, Inc. | Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes |
US20050176029A1 (en) * | 2003-10-20 | 2005-08-11 | The Regents Of The University Of California | Nanoscale transduction systems for detecting molecular interactions |
AU2003285133A1 (en) * | 2003-11-05 | 2005-06-24 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Biofunctionalized quantum dots for biological imaging |
US7610074B2 (en) * | 2004-01-08 | 2009-10-27 | The Board Of Trustees Of The University Of Illinois | Multi-functional plasmon-resonant contrast agents for optical coherence tomography |
DE102004013052A1 (de) * | 2004-03-10 | 2005-09-29 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Charakterisierung von technischen Oberflächen |
US20050220714A1 (en) * | 2004-04-01 | 2005-10-06 | Susan Kauzlarich | Agents for use in magnetic resonance and optical imaging |
US8128908B2 (en) * | 2004-04-30 | 2012-03-06 | University Of Florida Research Foundation, Inc. | Nanoparticles and their use for multifunctional bioimaging |
US7943396B2 (en) | 2004-06-22 | 2011-05-17 | The Regents Of The University Of California | Peptide-coated nanoparticles with graded shell compositions |
WO2006005065A2 (en) * | 2004-06-30 | 2006-01-12 | University Of South Florida | Luminescence characterization of quantum dots conjugated with biomarkers for early cancer detection |
US20060057627A1 (en) * | 2004-09-08 | 2006-03-16 | Board Of Regents, The University Of Texas System | Selection scheme for enzymatic function |
CA2520670A1 (en) * | 2004-09-23 | 2006-03-23 | National Research Council Of Canada | Nanocrystal coated surfaces |
US20080093550A1 (en) * | 2004-11-12 | 2008-04-24 | Seoul National University Industry Foundation | Method For Adhering Nanostructures to End of Probe of Microscope and Microscope Having Probe Made By the Same Method |
US8346346B1 (en) | 2005-01-24 | 2013-01-01 | The Board Of Trustees Of The Leland Stanford Junior University | Optical analysis system and approach therefor |
US7307774B1 (en) | 2005-01-24 | 2007-12-11 | The Board Of Trustees Of The Leland Standford Junior University | Micro-optical analysis system and approach therefor |
US8788021B1 (en) | 2005-01-24 | 2014-07-22 | The Board Of Trustees Of The Leland Stanford Junior Univerity | Live being optical analysis system and approach |
US7586618B2 (en) | 2005-02-28 | 2009-09-08 | The Board Of Trustees Of The University Of Illinois | Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering |
US7725169B2 (en) * | 2005-04-15 | 2010-05-25 | The Board Of Trustees Of The University Of Illinois | Contrast enhanced spectroscopic optical coherence tomography |
US8355776B2 (en) | 2005-05-27 | 2013-01-15 | Board Of Regents, The University Of Texas System | Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus |
US8454511B2 (en) | 2005-05-27 | 2013-06-04 | Board Of Regents, The University Of Texas System | Magneto-motive ultrasound detection of magnetic nanoparticles |
US7801590B2 (en) * | 2005-05-27 | 2010-09-21 | Board Of Regents, The University Of Texas System | Optical coherence tomographic detection of cells and killing of the same |
CA2609965A1 (en) * | 2005-05-27 | 2006-11-30 | Board Of Regents, The University Of Texas System | Optical coherence tomographic detection of cells and compositions |
US20080206152A1 (en) | 2005-06-07 | 2008-08-28 | Koninklijke Philips Electronics, N.V. | In Vivo Expression Profiling |
WO2007006039A2 (en) * | 2005-07-05 | 2007-01-11 | The Board Of Regents Of The University Of Texas System | Depth-resolved spectroscopy method and apparatus |
JP2007023058A (ja) * | 2005-07-12 | 2007-02-01 | Fujifilm Holdings Corp | 金属酸化物又は金属硫化物ナノ粒子蛍光体を用いる癌検出方法 |
US7787129B2 (en) | 2006-01-31 | 2010-08-31 | The Board Of Trustees Of The University Of Illinois | Method and apparatus for measurement of optical properties in tissue |
US7951776B2 (en) | 2006-09-01 | 2011-05-31 | American Type Culture Collection | Methods for treatment of type 1 diabetes |
EP2060916A4 (de) * | 2006-09-14 | 2010-09-22 | Konica Minolta Med & Graphic | Fluoreszenz-halbleitermikropartikelanordnung, fluoreszenzmarkierungsmittelanordnung für eine biologische substanz und biologisches bildgebungsverfahren sowie analyseverfahren für biologische substanzen mit verwendung der anordnungen |
US8026108B1 (en) * | 2006-10-19 | 2011-09-27 | The University Of Central Florida Research Foundation, Inc. | Detection of biotargets using bioreceptor functionalized nanoparticles |
US7654716B1 (en) | 2006-11-10 | 2010-02-02 | Doheny Eye Institute | Enhanced visualization illumination system |
EP2092297A4 (de) | 2006-11-21 | 2018-01-17 | California Institute of Technology | Nanoröhrchen für harmonische zweitbildgebung und verfahren zu ihrer verwendung |
US8426152B2 (en) * | 2007-01-03 | 2013-04-23 | Lamdagen Corporation | Enzymatic assay for LSPR |
GB0701444D0 (en) * | 2007-01-25 | 2007-03-07 | Iti Scotland Ltd | Detecting analytes |
WO2008101019A2 (en) * | 2007-02-13 | 2008-08-21 | Board Of Regents, The University Of Texas System | Molecular specific photoacoustic imaging |
EP2129964A4 (de) * | 2007-02-28 | 2013-11-06 | Doheny Eye Inst | Tragbares beleuchtungssystem |
CN101679022A (zh) * | 2007-04-02 | 2010-03-24 | 爱默蕾大学 | 使用表面增强拉曼纳米粒子标记物的体内肿瘤靶向和光谱检测 |
AU2008296733B2 (en) | 2007-08-08 | 2013-07-11 | The Board Of Regents Of The University Of Texas System | VEGFR-1/NRP-1 targeting peptides |
US20110052572A1 (en) * | 2007-08-15 | 2011-03-03 | Yeda Research And Development Co. Ltd | Regulators of mmp-9 and uses therof |
US8238942B2 (en) * | 2007-11-21 | 2012-08-07 | Trapeze Networks, Inc. | Wireless station location detection |
US8983580B2 (en) | 2008-01-18 | 2015-03-17 | The Board Of Trustees Of The University Of Illinois | Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors |
US8115934B2 (en) | 2008-01-18 | 2012-02-14 | The Board Of Trustees Of The University Of Illinois | Device and method for imaging the ear using optical coherence tomography |
US7751057B2 (en) | 2008-01-18 | 2010-07-06 | The Board Of Trustees Of The University Of Illinois | Magnetomotive optical coherence tomography |
US8488863B2 (en) * | 2008-11-06 | 2013-07-16 | Los Alamos National Security, Llc | Combinational pixel-by-pixel and object-level classifying, segmenting, and agglomerating in performing quantitative image analysis that distinguishes between healthy non-cancerous and cancerous cell nuclei and delineates nuclear, cytoplasm, and stromal material objects from stained biological tissue materials |
WO2010090844A2 (en) * | 2009-01-21 | 2010-08-12 | California Institute Of Technology | Multipurpose analysis using second harmonic generating nanoprobes |
WO2010099543A2 (en) * | 2009-02-27 | 2010-09-02 | Inter-Med, Inc. | Compositions and methods for detecting oral neoplasm |
WO2011041701A2 (en) * | 2009-10-02 | 2011-04-07 | The Brigham And Women's Hospital, Inc. | Inplantable contrast agents and methods |
EP3372206A1 (de) | 2010-05-13 | 2018-09-12 | Doheny Eye Institute | Autonome beleuchtete infusionskanülensysteme und vorrichtungen |
US9448173B2 (en) | 2011-03-08 | 2016-09-20 | The Board Of Trustees Of The University Of Illinois | Dye-conjugated dendrimers |
EP2715354A4 (de) | 2011-05-27 | 2015-04-29 | Univ Drexel | Klare randbestimmung während einer krebschirurgie |
US9155497B1 (en) | 2011-06-02 | 2015-10-13 | Stc.Unm | Compact biosensor of matrix metalloproteinase with cadmium free quantum dots |
US20140302491A1 (en) * | 2011-10-28 | 2014-10-09 | The Board Of Trustees Of The Leland Stanford Junior University | Ex Vivo Culture, Proliferation and Expansion of Primary Tissue Organoids |
WO2013078410A1 (en) | 2011-11-21 | 2013-05-30 | California Institute Of Technology | Functionalization of and use of functionalized second harmonic generating nanoprobes |
US8984733B2 (en) | 2013-02-05 | 2015-03-24 | Artventive Medical Group, Inc. | Bodily lumen occlusion |
JP6568802B2 (ja) * | 2013-02-20 | 2019-08-28 | コーネル ユニバーシティCornell University | 多層蛍光性ナノ粒子及びその製造並びに使用方法 |
US9636116B2 (en) | 2013-06-14 | 2017-05-02 | Artventive Medical Group, Inc. | Implantable luminal devices |
US10149968B2 (en) * | 2013-06-14 | 2018-12-11 | Artventive Medical Group, Inc. | Catheter-assisted tumor treatment |
US9092691B1 (en) * | 2014-07-18 | 2015-07-28 | Median Technologies | System for computing quantitative biomarkers of texture features in tomographic images |
CA2959073A1 (en) | 2014-09-23 | 2016-03-31 | Tearlab Research, Inc. | Systems and methods for integration of microfluidic tear collection and lateral flow analysis of analytes of interest |
US10830639B2 (en) | 2014-09-25 | 2020-11-10 | Northwestern University | Devices, methods, and systems relating to super resolution imaging |
US10588564B2 (en) * | 2014-09-30 | 2020-03-17 | Moein Health, LLC | Method and kit for diagnosing and treating neoplastic tissue |
WO2016105769A1 (en) * | 2014-12-23 | 2016-06-30 | Boston Scientific Scimed, Inc. | Marker for detection and confirmation of peripheral lung nodules |
TWI608076B (zh) * | 2015-03-04 | 2017-12-11 | 納諾柯技術有限公司 | 以金屬硫醇聚合物穩定化的量子點 |
US10845312B2 (en) | 2015-07-22 | 2020-11-24 | The Board Of Regents Of The University Of Texas System | Label-free detection of sialic acid using surface-enhanced Raman scattering microscopy |
US10813644B2 (en) | 2016-04-01 | 2020-10-27 | Artventive Medical Group, Inc. | Occlusive implant and delivery system |
US11180735B2 (en) | 2016-10-28 | 2021-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods to preserve tumor-stromal interactions in culture and therapeutic predictive applications thereof |
US10634890B1 (en) | 2018-10-26 | 2020-04-28 | General Electric Company | Miniaturized microscope for phase contrast and multicolor fluorescence imaging |
CA3127027A1 (en) * | 2019-01-17 | 2020-07-23 | University Health Network | Tissue phantoms |
AU2020395181A1 (en) * | 2019-12-05 | 2022-06-30 | Imaginab, Inc. | Methods of imaging using multiple imaging agents |
WO2023137542A1 (en) * | 2022-01-19 | 2023-07-27 | University Of Ottawa | Compositions with metal nanoparticles, their methods of manufacture and their uses |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
GB8331514D0 (en) * | 1983-11-25 | 1984-01-04 | Janssen Pharmaceutica Nv | Visualization method |
US4752569A (en) * | 1984-06-21 | 1988-06-21 | The Regents Of The University Of California | Sialylated Lewisx epitope, antibodies and diagnosis |
GB8426467D0 (en) | 1984-10-19 | 1984-11-28 | Technology Licence Co Ltd | Monoclonal antibodies |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
WO1990006718A1 (en) * | 1988-12-21 | 1990-06-28 | Massachusetts Institute Of Technology | A method for laser induced fluorescence of tissue |
EP0739904A1 (de) | 1989-06-29 | 1996-10-30 | Medarex, Inc. | Bispezifische Reagenzien für die AIDS-Therapie |
US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
KR970002255B1 (ko) | 1990-06-11 | 1997-02-26 | 넥스스타 파아마슈티컬드, 인크. | 핵산 리간드 |
WO1992005285A1 (en) | 1990-09-21 | 1992-04-02 | Fred Hutchinson Cancer Research Center | Protein sequence-specific oligonucleotide sequences |
CA2104698A1 (en) | 1991-02-21 | 1992-08-22 | John J. Toole | Aptamers specific for biomolecules and methods of making |
US5840867A (en) | 1991-02-21 | 1998-11-24 | Gilead Sciences, Inc. | Aptamer analogs specific for biomolecules |
EP0586505A1 (de) | 1991-05-14 | 1994-03-16 | Repligen Corporation | Heterokonjugat-antikörper zur behandlung von hiv-infektionen |
US5582981A (en) | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
US5217594A (en) * | 1992-01-15 | 1993-06-08 | Enzyme Technology Research Group, Inc. | Convenient determination of trace lead in whole blood and other fluids |
US5756291A (en) * | 1992-08-21 | 1998-05-26 | Gilead Sciences, Inc. | Aptamers specific for biomolecules and methods of making |
US5421339A (en) * | 1993-05-12 | 1995-06-06 | Board Of Regents, The University Of Texas System | Diagnosis of dysplasia using laser induced fluoroescence |
US6159445A (en) * | 1994-07-20 | 2000-12-12 | Nycomed Imaging As | Light imaging contrast agents |
US5681702A (en) | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
US5631146A (en) * | 1995-01-19 | 1997-05-20 | The General Hospital Corporation | DNA aptamers and catalysts that bind adenosine or adenosine-5'-phosphates and methods for isolation thereof |
US5991653A (en) * | 1995-03-14 | 1999-11-23 | Board Of Regents, The University Of Texas System | Near-infrared raman spectroscopy for in vitro and in vivo detection of cervical precancers |
US6258576B1 (en) | 1996-06-19 | 2001-07-10 | Board Of Regents, The University Of Texas System | Diagnostic method and apparatus for cervical squamous intraepithelial lesions in vitro and in vivo using fluorescence spectroscopy |
US5697373A (en) * | 1995-03-14 | 1997-12-16 | Board Of Regents, The University Of Texas System | Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies |
US5699795A (en) | 1995-03-31 | 1997-12-23 | Board Of Regents, The University Of Texas System | Optical probe for the detection of cervical neoplasia using fluorescence spectroscopy and apparatus incorporating same |
US5612540A (en) * | 1995-03-31 | 1997-03-18 | Board Of Regents, The University Of Texas Systems | Optical method for the detection of cervical neoplasias using fluorescence spectroscopy |
US6111095A (en) | 1995-06-07 | 2000-08-29 | Merck & Co., Inc. | Capped synthetic RNA, analogs, and aptamers |
DE19543750C2 (de) * | 1995-11-24 | 1997-10-23 | Crinos Industria Farmaco | Cathepsin G inhibierende Aptamere |
EP0882224A4 (de) * | 1996-02-22 | 1999-06-09 | Dexall Biochemical Labs Inc | Flüssigphaseimmunoassay mit nicht eingefangenem substrat |
US5750411A (en) * | 1996-06-03 | 1998-05-12 | Bayer Corporation | Sol particle decay protection immunoassay |
US5792613A (en) * | 1996-06-12 | 1998-08-11 | The Curators Of The University Of Missouri | Method for obtaining RNA aptamers based on shape selection |
US5842995A (en) | 1996-06-28 | 1998-12-01 | Board Of Regents, The Univerisity Of Texas System | Spectroscopic probe for in vivo measurement of raman signals |
US6135965A (en) | 1996-12-02 | 2000-10-24 | Board Of Regents, The University Of Texas System | Spectroscopic detection of cervical pre-cancer using radial basis function networks |
US5939021A (en) * | 1997-01-23 | 1999-08-17 | Hansen; W. Peter | Homogeneous binding assay |
US5929985A (en) * | 1997-03-18 | 1999-07-27 | Sandia Corporation | Multispectral imaging probe |
US5920399A (en) * | 1997-03-18 | 1999-07-06 | Sandia Corporation | Multispectral imaging method and apparatus |
US6275726B1 (en) * | 1997-05-15 | 2001-08-14 | Board Of Regents, The University Of Texas System | Methods of enhanced light transmission through turbid biological media |
EP1071473B1 (de) * | 1997-10-20 | 2007-10-10 | Board Of Regents, The University Of Texas System | Essigsäure als signalverbesserendes kontrastmittel in der fluoreszenzspektroscopie |
US6087102A (en) * | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
US6699724B1 (en) * | 1998-03-11 | 2004-03-02 | Wm. Marsh Rice University | Metal nanoshells for biosensing applications |
DE59913716D1 (de) * | 1998-10-29 | 2006-09-07 | Dakocytomation Denmark As | Nachweis von säure-resistenten mikroorganismen im stuhl |
US6251616B1 (en) * | 1999-01-14 | 2001-06-26 | Biocrystal Ltd. | Methods and assay kits for detecting altered mononuclear cell phenotype related to a pro-tumor immune response |
US6465180B1 (en) * | 1999-03-17 | 2002-10-15 | The Regents Of The University Of California | Detection of premalignant melanocytes |
US20010055764A1 (en) * | 1999-05-07 | 2001-12-27 | Empedocles Stephen A. | Microarray methods utilizing semiconductor nanocrystals |
US6680377B1 (en) * | 1999-05-14 | 2004-01-20 | Brandeis University | Nucleic acid-based detection |
EP1226153B1 (de) * | 1999-10-26 | 2010-03-03 | University of Utah Research Foundation | Fluoreszierende cobalamine und deren verwendung |
US20040023415A1 (en) * | 2002-03-05 | 2004-02-05 | Konstantin Sokolov | Biospecific contrast agents |
-
2003
- 2003-03-05 US US10/382,136 patent/US20040023415A1/en not_active Abandoned
- 2003-03-05 WO PCT/US2003/006730 patent/WO2003075765A1/en not_active Application Discontinuation
- 2003-03-05 AU AU2003213729A patent/AU2003213729A1/en not_active Abandoned
- 2003-03-05 CA CA002478083A patent/CA2478083A1/en not_active Abandoned
- 2003-03-05 DE DE60325564T patent/DE60325564D1/de not_active Expired - Lifetime
- 2003-03-05 AT AT03711417T patent/ATE419536T1/de not_active IP Right Cessation
- 2003-03-05 EP EP03711417A patent/EP1487343B1/de not_active Expired - Lifetime
-
2007
- 2007-10-23 US US11/877,476 patent/US20090068108A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2478083A1 (en) | 2003-09-18 |
WO2003075765A1 (en) | 2003-09-18 |
DE60325564D1 (de) | 2009-02-12 |
US20090068108A1 (en) | 2009-03-12 |
US20040023415A1 (en) | 2004-02-05 |
AU2003213729A1 (en) | 2003-09-22 |
EP1487343A1 (de) | 2004-12-22 |
EP1487343B1 (de) | 2008-12-31 |
EP1487343A4 (de) | 2007-03-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE419536T1 (de) | Biospezifische kontrastmittel | |
Jayanthi et al. | Recent advances in biosensor development for the detection of cancer biomarkers | |
Fedele | Diagnostic aids in the screening of oral cancer | |
WO2005020803A3 (en) | Raman imaging and sensing apparatus employing nanoantennas | |
Rahman et al. | Evaluation of a low-cost, portable imaging system for early detection of oral cancer | |
SG144722A1 (en) | Method and apparatus for detecting and imaging the presence of biological materials | |
Huang et al. | Gold nanoparticle based platforms for circulating cancer marker detection | |
Lutz et al. | Raman nanoparticle probes for antibody-based protein detection in tissues | |
Wu et al. | How nanoparticles transform single molecule measurements into quantitative sensors | |
WO2007056523A3 (en) | Methods for diagnosing and monitoring the progression of cancer | |
Poh et al. | Squamous cell carcinoma and precursor lesions: diagnosis and screening in a technical era | |
EP1917528A4 (de) | Biomarker und verfahren zur bestimmung der empfindlichkeit gegenüber modulatoren des egf(epidermal growth factor)-rezeptors | |
WO2007109881A8 (en) | Biomarkers useful for diagnosing prostate cancer, and methods thereof | |
EP1498722A3 (de) | Ramansonde und ihre Anwendung in einer Vorrichtung zur Messung von Ramanspektren | |
CN113167791A (zh) | 作为通用增强剂的超亮荧光纳米构建体 | |
WO2006014576A3 (en) | Fluorescent lifetime biological detection and imaging using water-stable semiconductor nanocrystals | |
Baeten et al. | Molecular imaging of oral premalignant and malignant lesions using fluorescently labeled lectins | |
Mahfoud et al. | Detection of ErbB2: nanotechnological solutions for clinical diagnostics | |
Tukimin et al. | Polarized light-based cancer cell detection techniques: a review | |
Chakraborty et al. | Nano‐diagnostics as an emerging platform for oral cancer detection: Current and emerging trends | |
Liu et al. | Development of microfluidic platform capable of high-throughput absolute quantification of single-cell multiple intracellular proteins from tumor cell lines and patient tumor samples | |
KR20110039170A (ko) | 나노 스페이서를 이용한 광학 센서 및 광학 센서를 이용한 검출 방법 | |
WO2006007064A3 (en) | System and method for spectroscopy and imaging | |
Seekell et al. | Feasibility study of brain tumor delineation using immunolabeled gold nanorods | |
WO2004096971A3 (de) | Verfahren zur schnellen bestimmung von qualitäten/qualitätsänderungen beliebiger systeme |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |