CN1022186C - 二氮杂双环化合物的制备方法 - Google Patents

二氮杂双环化合物的制备方法 Download PDF

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Publication number
CN1022186C
CN1022186C CN90100291A CN90100291A CN1022186C CN 1022186 C CN1022186 C CN 1022186C CN 90100291 A CN90100291 A CN 90100291A CN 90100291 A CN90100291 A CN 90100291A CN 1022186 C CN1022186 C CN 1022186C
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China
Prior art keywords
formula
nmr
hrms
preparation
tlc
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Expired - Fee Related
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CN90100291A
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English (en)
Chinese (zh)
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CN1044464A (zh
Inventor
基沙·安姆拉特拉尔·迪沙伊
吉恩·迈克尔·布赖特
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Pfizer Corp SRL
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Pfizer Corp SRL
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Publication of CN1044464A publication Critical patent/CN1044464A/zh
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Publication of CN1022186C publication Critical patent/CN1022186C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CN90100291A 1989-01-23 1990-01-22 二氮杂双环化合物的制备方法 Expired - Fee Related CN1022186C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/US1989/000275 WO1990008148A1 (en) 1989-01-23 1989-01-23 Bis-aza-bicyclic anxiolytic agents
USPCT/US89/00275 1989-01-23
USPCT/US89/03811 1989-09-01
PCT/US1989/003811 WO1990008144A1 (en) 1989-01-23 1989-09-01 Bis-aza-bicyclic anxiolytic agents

Publications (2)

Publication Number Publication Date
CN1044464A CN1044464A (zh) 1990-08-08
CN1022186C true CN1022186C (zh) 1993-09-22

Family

ID=22214801

Family Applications (1)

Application Number Title Priority Date Filing Date
CN90100291A Expired - Fee Related CN1022186C (zh) 1989-01-23 1990-01-22 二氮杂双环化合物的制备方法

Country Status (38)

Country Link
US (1) US5122525A (cg-RX-API-DMAC7.html)
EP (1) EP0380217B1 (cg-RX-API-DMAC7.html)
JP (1) JPH0643427B2 (cg-RX-API-DMAC7.html)
KR (1) KR910009289B1 (cg-RX-API-DMAC7.html)
CN (1) CN1022186C (cg-RX-API-DMAC7.html)
AP (1) AP128A (cg-RX-API-DMAC7.html)
AR (1) AR246969A1 (cg-RX-API-DMAC7.html)
AT (1) ATE82574T1 (cg-RX-API-DMAC7.html)
AU (1) AU614214B2 (cg-RX-API-DMAC7.html)
BA (1) BA98302A (cg-RX-API-DMAC7.html)
BG (1) BG51046A3 (cg-RX-API-DMAC7.html)
CA (1) CA2008108C (cg-RX-API-DMAC7.html)
CZ (1) CZ277698B6 (cg-RX-API-DMAC7.html)
DD (1) DD291560A5 (cg-RX-API-DMAC7.html)
DE (1) DE69000467T2 (cg-RX-API-DMAC7.html)
DK (1) DK0380217T3 (cg-RX-API-DMAC7.html)
EG (1) EG19306A (cg-RX-API-DMAC7.html)
ES (1) ES2053094T3 (cg-RX-API-DMAC7.html)
FI (1) FI95381C (cg-RX-API-DMAC7.html)
GR (1) GR3006925T3 (cg-RX-API-DMAC7.html)
HU (1) HU215154B (cg-RX-API-DMAC7.html)
IE (1) IE62670B1 (cg-RX-API-DMAC7.html)
IL (1) IL93073A (cg-RX-API-DMAC7.html)
IS (1) IS1667B (cg-RX-API-DMAC7.html)
MA (1) MA21735A1 (cg-RX-API-DMAC7.html)
MX (1) MX19222A (cg-RX-API-DMAC7.html)
MY (1) MY104861A (cg-RX-API-DMAC7.html)
NO (1) NO175978C (cg-RX-API-DMAC7.html)
NZ (1) NZ232168A (cg-RX-API-DMAC7.html)
OA (1) OA10041A (cg-RX-API-DMAC7.html)
PL (1) PL163836B1 (cg-RX-API-DMAC7.html)
PT (1) PT92919B (cg-RX-API-DMAC7.html)
RO (1) RO110142B1 (cg-RX-API-DMAC7.html)
RU (1) RU2015977C1 (cg-RX-API-DMAC7.html)
SK (1) SK279339B6 (cg-RX-API-DMAC7.html)
WO (2) WO1990008148A1 (cg-RX-API-DMAC7.html)
YU (1) YU47554B (cg-RX-API-DMAC7.html)
ZA (1) ZA90430B (cg-RX-API-DMAC7.html)

Families Citing this family (29)

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WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents
WO1992000075A1 (en) * 1990-06-29 1992-01-09 Pfizer Inc. Pyridopyrazine derivatives for treating substance abuse and addiction
CA2099563C (en) * 1991-01-31 1998-09-29 Charles W. Murtiashaw Preparation of (7s, trans)-2-(2-pyrimidinyl)-7-(hydroxymethyl) octahydro-2h-pyrido[1,2-a]pyrazine
US5157034A (en) * 1991-02-27 1992-10-20 Pfizer Inc. Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
US5326874A (en) * 1991-02-27 1994-07-05 Pfizer Inc. Process for preparing trans-piperidine-2,5-dicarboxylates
US5185449A (en) * 1991-02-27 1993-02-09 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
US5311195A (en) * 1991-08-30 1994-05-10 Etak, Inc. Combined relative and absolute positioning method and apparatus
EP0607163B1 (en) * 1991-09-25 1996-12-11 Pfizer Inc. NEUROLEPTIC 2-SUBSTITUTED PERHYDRO-1-H-PYRIDO[1,2-a]PYRAZINES
WO1993025552A1 (en) * 1992-06-16 1993-12-23 Pfizer Inc. Process and intermediates for bis-aza-bicyclic anxiolytic agents
WO1994006794A1 (en) * 1992-09-24 1994-03-31 National Institutes Of Health Aralkyl diazabicycloalkane derivatives for cns disorders
IL104506A (en) * 1993-01-25 1997-11-20 Israel State Fast changing heating- cooling device and method, particularly for cryogenic and/or surgical use
US5637713A (en) * 1993-08-20 1997-06-10 Pfizer Inc. Process for preparing trans-piperidine-2,5-dicarboxylates
US5455350A (en) * 1993-10-13 1995-10-03 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
IL107460A (en) * 1993-11-01 1999-06-20 Israel State Controlled cryogenic contact system
CA2200959C (en) * 1994-09-30 2000-05-23 Kishor A. Desai 2,7-substituted octahydro-1h-pyrido[1,2-a]pyrazine derivatives
WO1996010570A1 (en) * 1994-09-30 1996-04-11 Pfizer Inc. NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
US6231833B1 (en) 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
NZ320537A (en) * 1995-12-21 1999-03-29 Pfizer 2,7-substituted octahydro-pyrrolo(1,2-a)pyrazine derivatives
AU2974497A (en) * 1996-07-01 1998-01-21 Pfizer Inc. Preparation of (7S,trans)-2-(2-pyrimidinyl)-7- (hydrooxymethyl)octahydro-2H-pyrido(1,2-a)pyrazine
PA8469101A1 (es) * 1998-04-09 2000-09-29 Pfizer Prod Inc Ligandos azabiciclicos de receptores 5ht1
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
HN1999000146A (es) * 1998-09-21 2000-11-11 Pfizer Prod Inc Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
US20020016334A1 (en) * 2000-07-31 2002-02-07 Coe Jotham Wadsworth Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
US6670476B2 (en) 2000-11-29 2003-12-30 Pfizer Inc. Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
AP2005003390A0 (en) * 2003-03-12 2005-09-30 Pfizer Prod Inc Pyridyloxymethyl and benzisoxazole azabicyclic derivatives.
WO2004092173A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
ATE473967T1 (de) * 2003-11-26 2010-07-15 Pfizer Prod Inc Aminopyrazolderivate als gsk-3-inhibitoren
WO2005115396A2 (en) * 2004-05-27 2005-12-08 Warner-Lambert Company Llc Combination of atomoxetine and a 5t1a receptor agonist for treating adhd and other disorders
US7658206B2 (en) 2006-12-05 2010-02-09 Kohler Co. Plumbing valve with stick control handle

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US3388128A (en) * 1965-09-03 1968-06-11 Allan R. Day Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
US4339579A (en) * 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
US4400511A (en) * 1982-05-07 1983-08-23 American Home Products Corporation 2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
US4414389A (en) * 1982-05-25 1983-11-08 American Home Products Corporation 4-Substituted-piperidino carboxamides
US4517187A (en) * 1982-10-18 1985-05-14 Pennwalt Corporation 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3409440A1 (de) * 1984-03-15 1985-09-26 Bayer Ag, 5090 Leverkusen Imidazo(1,5-a)pyridyl-methan- und imidazo(1,5-b)pyridazinylmethan-derivate, ihre herstellung und sie enthaltende aufzeichnungsmaterialien
IT1204803B (it) * 1986-02-17 1989-03-10 Acraf Composto farmacologicamente attivo e composizioni farmaceutiche che lo contengono,procedimento per prepararlo e intermedio utile in detto procedimento
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
JP2668259B2 (ja) * 1988-02-18 1997-10-27 塩野義製薬株式会社 複素環化合物および抗潰瘍剤
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents

Also Published As

Publication number Publication date
AP128A (en) 1991-03-20
AU614214B2 (en) 1991-08-22
AU4867990A (en) 1990-07-26
MA21735A1 (fr) 1990-10-01
BG51046A3 (bg) 1993-01-15
WO1990008144A1 (en) 1990-07-26
US5122525A (en) 1992-06-16
YU47554B (sh) 1995-10-03
FI95381C (fi) 1996-01-25
HUT63163A (en) 1993-07-28
KR900011774A (ko) 1990-08-02
JPH0643427B2 (ja) 1994-06-08
NO912863L (no) 1991-07-22
NZ232168A (en) 1991-08-27
NO175978B (no) 1994-10-03
IS1667B (is) 1997-11-14
CZ277698B6 (en) 1993-03-17
NO175978C (no) 1995-01-11
RU2015977C1 (ru) 1994-07-15
BA98302A (bs) 2001-09-14
OA10041A (en) 1996-10-14
FI913510A0 (fi) 1991-07-22
EP0380217B1 (en) 1992-11-19
CS29990A3 (en) 1992-11-18
PT92919B (pt) 1995-12-29
FI95381B (fi) 1995-10-13
PT92919A (pt) 1990-07-31
IE900225L (en) 1990-07-23
SK279339B6 (sk) 1998-10-07
CA2008108C (en) 1995-08-08
DK0380217T3 (da) 1992-12-14
WO1990008148A1 (en) 1990-07-26
DE69000467T2 (de) 1993-04-01
DE69000467D1 (de) 1992-12-24
IL93073A (en) 1994-05-30
AR246969A1 (es) 1994-10-31
RO110142B1 (ro) 1995-10-30
GR3006925T3 (cg-RX-API-DMAC7.html) 1993-06-30
MY104861A (en) 1994-06-30
CA2008108A1 (en) 1990-07-23
KR910009289B1 (ko) 1991-11-09
IE62670B1 (en) 1995-03-08
CN1044464A (zh) 1990-08-08
IS3529A7 (is) 1990-07-24
EG19306A (en) 1995-01-31
ES2053094T3 (es) 1994-07-16
HU215154B (hu) 2000-09-28
MX19222A (es) 1993-12-01
NO912863D0 (no) 1991-07-22
ATE82574T1 (de) 1992-12-15
DD291560A5 (de) 1991-07-04
PL163836B1 (pl) 1994-05-31
ZA90430B (en) 1991-08-28
EP0380217A1 (en) 1990-08-01
JPH02233681A (ja) 1990-09-17
AP9000158A0 (en) 1990-01-31
YU11190A (sh) 1993-05-28

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C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee