AR246969A1 - Un procedimiento para la preparacion de derivados racemicos u opticamente activos de pirido¡1,2-a¿pirazina. - Google Patents

Un procedimiento para la preparacion de derivados racemicos u opticamente activos de pirido¡1,2-a¿pirazina.

Info

Publication number
AR246969A1
AR246969A1 AR90315971A AR31597190A AR246969A1 AR 246969 A1 AR246969 A1 AR 246969A1 AR 90315971 A AR90315971 A AR 90315971A AR 31597190 A AR31597190 A AR 31597190A AR 246969 A1 AR246969 A1 AR 246969A1
Authority
AR
Argentina
Prior art keywords
formula
derivatives
optically active
racemic
preparation
Prior art date
Application number
AR90315971A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of AR246969A1 publication Critical patent/AR246969A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PREPARACION DE DERIVADOS RACEMICOS U OPTICAMENTE ACTIVOS DE PIRIDO¡1,2- A¿PIRAZINA DE FORMULA (I) O UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE DEL MISMO, DONDE X ES N O CH; Y ES FORMULA (II); Z ES FORMULA (III) O -Y1(CH2)(N) SUSTITUIDO EN UN ATOMO DE CARBONO CON HASTA DOS GRUPOS METILO; N ES 1 O 2 E Y1 ES CH2, NH O NCH3; OBTENIDO POR HACER REACCIONAR UN COMPUESTO RACEMICO U OPTICAMENTE ACTIVO DE FORMULA (VII), DONDE X ES N O CH; Y4 ES HO-, RSO2O- O H2N- Y R ES ALQUILO, FENILO O TOLILO; (A) CUANDO Y4 ES HO-, CON UN COMPUESTO YH, EN PRESENCIA DE UN REACTIVO COPULANTE QUE ES AZODICARBOXILATO DE DIETILO Y TRIFENILFOSFINA; (B) CUANDO Y4 ES RSO2O-, CON UN ANION DE FORMULA Y(-), FORMADO POR LA ACCION DE UNA BASE SOBRE UN COMPUESTO YH O (C) CUANDO Y4 ES H2N- E Y ESUNA IMIDA, CON UN ANHIDRIDO DE FORMULA (IV).
AR90315971A 1989-01-23 1990-01-19 Un procedimiento para la preparacion de derivados racemicos u opticamente activos de pirido¡1,2-a¿pirazina. AR246969A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1989/000275 WO1990008148A1 (en) 1989-01-23 1989-01-23 Bis-aza-bicyclic anxiolytic agents
PCT/US1989/003811 WO1990008144A1 (en) 1989-01-23 1989-09-01 Bis-aza-bicyclic anxiolytic agents

Publications (1)

Publication Number Publication Date
AR246969A1 true AR246969A1 (es) 1994-10-31

Family

ID=22214801

Family Applications (1)

Application Number Title Priority Date Filing Date
AR90315971A AR246969A1 (es) 1989-01-23 1990-01-19 Un procedimiento para la preparacion de derivados racemicos u opticamente activos de pirido¡1,2-a¿pirazina.

Country Status (38)

Country Link
US (1) US5122525A (es)
EP (1) EP0380217B1 (es)
JP (1) JPH0643427B2 (es)
KR (1) KR910009289B1 (es)
CN (1) CN1022186C (es)
AP (1) AP128A (es)
AR (1) AR246969A1 (es)
AT (1) ATE82574T1 (es)
AU (1) AU614214B2 (es)
BA (1) BA98302A (es)
BG (1) BG51046A3 (es)
CA (1) CA2008108C (es)
CZ (1) CZ277698B6 (es)
DD (1) DD291560A5 (es)
DE (1) DE69000467T2 (es)
DK (1) DK0380217T3 (es)
EG (1) EG19306A (es)
ES (1) ES2053094T3 (es)
FI (1) FI95381C (es)
GR (1) GR3006925T3 (es)
HU (1) HU215154B (es)
IE (1) IE62670B1 (es)
IL (1) IL93073A (es)
IS (1) IS1667B (es)
MA (1) MA21735A1 (es)
MX (1) MX19222A (es)
MY (1) MY104861A (es)
NO (1) NO175978C (es)
NZ (1) NZ232168A (es)
OA (1) OA10041A (es)
PL (1) PL163836B1 (es)
PT (1) PT92919B (es)
RO (1) RO110142B1 (es)
RU (1) RU2015977C1 (es)
SK (1) SK279339B6 (es)
WO (2) WO1990008148A1 (es)
YU (1) YU47554B (es)
ZA (1) ZA90430B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents
WO1992000075A1 (en) * 1990-06-29 1992-01-09 Pfizer Inc. Pyridopyrazine derivatives for treating substance abuse and addiction
EP0569387B1 (en) * 1991-01-31 1995-04-05 Pfizer Inc. Resolution of trans-2-(2-pyrimidinyl)-7-(hydroxymethyl)octahydro-2h-pyrido 1,2-a]pyrazine
US5157034A (en) * 1991-02-27 1992-10-20 Pfizer Inc. Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
CA2101252C (en) * 1991-02-27 1998-02-17 Frank J. Urban Process for preparing trans-piperidine-2,5- dicarboxylates
US5185449A (en) * 1991-02-27 1993-02-09 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
US5311195A (en) * 1991-08-30 1994-05-10 Etak, Inc. Combined relative and absolute positioning method and apparatus
US5565453A (en) * 1991-09-25 1996-10-15 Pfizer Inc. Neuroleptic 2-substituted perhydro-1-h-pyrido[1,2-a]pyrazines
US5719286A (en) * 1992-06-16 1998-02-17 Pfizer Inc. Process and intermediates for bis-aza-bicyclic anxiolytic agents
WO1994006794A1 (en) * 1992-09-24 1994-03-31 National Institutes Of Health Aralkyl diazabicycloalkane derivatives for cns disorders
IL104506A (en) * 1993-01-25 1997-11-20 Israel State Fast changing heating- cooling device and method, particularly for cryogenic and/or surgical use
US5637713A (en) * 1993-08-20 1997-06-10 Pfizer Inc. Process for preparing trans-piperidine-2,5-dicarboxylates
US5455350A (en) * 1993-10-13 1995-10-03 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
IL107460A (en) * 1993-11-01 1999-06-20 Israel State Controlled cryogenic contact system
US6231833B1 (en) 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
WO1996010571A1 (en) * 1994-09-30 1996-04-11 Pfizer Inc. 2,7-SUBSTITUTED OCTAHYDRO-1H-PYRIDO[1,2-a]PYRAZINE DERIVATIVES
WO1996010570A1 (en) * 1994-09-30 1996-04-11 Pfizer Inc. NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
DE69615404T2 (de) * 1995-12-21 2002-06-06 Pfizer 2,7-SUBSTITUIERTE OCTAHYDROPYRROLO(1,2-a)PYRAZINDERIVATE
CA2259496A1 (en) * 1996-07-01 1998-01-08 Philip Dietrich Hammen Preparation of (7s,trans)-2-(2-pyrimidinyl)-7-(hydroxymethyl)octahydro-2h-pyrido[1,2-a]pyrazine
PA8469101A1 (es) * 1998-04-09 2000-09-29 Pfizer Prod Inc Ligandos azabiciclicos de receptores 5ht1
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
HN1999000146A (es) * 1998-09-21 2000-11-11 Pfizer Prod Inc Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
US20020016334A1 (en) * 2000-07-31 2002-02-07 Coe Jotham Wadsworth Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
US6670476B2 (en) 2000-11-29 2003-12-30 Pfizer Inc. Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
JP3910627B2 (ja) * 2003-03-12 2007-04-25 ファイザー・プロダクツ・インク ピリジルオキシメチルおよびベンゾイソオキサゾールのアザビシクロ環の誘導体
US7834014B2 (en) 2003-04-09 2010-11-16 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
ES2347152T3 (es) * 2003-11-26 2010-10-26 Pfizer Products Inc. Derivados de aminopirazol como inhibidores de gsk-3.
US20070219201A1 (en) * 2004-05-27 2007-09-20 Warner-Lambert Company Llc Combination of atomoxetine and a 5ht1a receptor agonist for treating adhd and other disorders
US7658206B2 (en) 2006-12-05 2010-02-09 Kohler Co. Plumbing valve with stick control handle

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US3388128A (en) * 1965-09-03 1968-06-11 Allan R. Day Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
US4339579A (en) * 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
US4400511A (en) * 1982-05-07 1983-08-23 American Home Products Corporation 2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
US4414389A (en) * 1982-05-25 1983-11-08 American Home Products Corporation 4-Substituted-piperidino carboxamides
US4517187A (en) * 1982-10-18 1985-05-14 Pennwalt Corporation 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3409440A1 (de) * 1984-03-15 1985-09-26 Bayer Ag, 5090 Leverkusen Imidazo(1,5-a)pyridyl-methan- und imidazo(1,5-b)pyridazinylmethan-derivate, ihre herstellung und sie enthaltende aufzeichnungsmaterialien
IT1204803B (it) * 1986-02-17 1989-03-10 Acraf Composto farmacologicamente attivo e composizioni farmaceutiche che lo contengono,procedimento per prepararlo e intermedio utile in detto procedimento
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
JP2668259B2 (ja) * 1988-02-18 1997-10-27 塩野義製薬株式会社 複素環化合物および抗潰瘍剤
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents

Also Published As

Publication number Publication date
CA2008108A1 (en) 1990-07-23
BA98302A (bs) 2001-09-14
US5122525A (en) 1992-06-16
FI95381C (fi) 1996-01-25
BG51046A3 (en) 1993-01-15
OA10041A (en) 1996-10-14
PT92919A (pt) 1990-07-31
ZA90430B (en) 1991-08-28
GR3006925T3 (es) 1993-06-30
EP0380217B1 (en) 1992-11-19
ATE82574T1 (de) 1992-12-15
KR900011774A (ko) 1990-08-02
IS3529A7 (is) 1990-07-24
FI913510A0 (fi) 1991-07-22
MA21735A1 (fr) 1990-10-01
CN1022186C (zh) 1993-09-22
MX19222A (es) 1993-12-01
IE62670B1 (en) 1995-03-08
AU4867990A (en) 1990-07-26
RO110142B1 (ro) 1995-10-30
KR910009289B1 (ko) 1991-11-09
RU2015977C1 (ru) 1994-07-15
YU47554B (sh) 1995-10-03
CA2008108C (en) 1995-08-08
EG19306A (en) 1995-01-31
EP0380217A1 (en) 1990-08-01
MY104861A (en) 1994-06-30
HUT63163A (en) 1993-07-28
JPH0643427B2 (ja) 1994-06-08
IL93073A (en) 1994-05-30
WO1990008148A1 (en) 1990-07-26
CS29990A3 (en) 1992-11-18
DE69000467T2 (de) 1993-04-01
HU215154B (hu) 2000-09-28
AU614214B2 (en) 1991-08-22
YU11190A (sh) 1993-05-28
NO912863D0 (no) 1991-07-22
AP128A (en) 1991-03-20
PL163836B1 (pl) 1994-05-31
FI95381B (fi) 1995-10-13
WO1990008144A1 (en) 1990-07-26
DE69000467D1 (de) 1992-12-24
IE900225L (en) 1990-07-23
DK0380217T3 (da) 1992-12-14
SK279339B6 (sk) 1998-10-07
CZ277698B6 (en) 1993-03-17
AP9000158A0 (en) 1990-01-31
CN1044464A (zh) 1990-08-08
NO175978B (no) 1994-10-03
NZ232168A (en) 1991-08-27
IS1667B (is) 1997-11-14
NO912863L (no) 1991-07-22
NO175978C (no) 1995-01-11
PT92919B (pt) 1995-12-29
JPH02233681A (ja) 1990-09-17
DD291560A5 (de) 1991-07-04
ES2053094T3 (es) 1994-07-16

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