CN102066323A - 新的雌激素受体配体 - Google Patents
新的雌激素受体配体 Download PDFInfo
- Publication number
- CN102066323A CN102066323A CN2009801227522A CN200980122752A CN102066323A CN 102066323 A CN102066323 A CN 102066323A CN 2009801227522 A CN2009801227522 A CN 2009801227522A CN 200980122752 A CN200980122752 A CN 200980122752A CN 102066323 A CN102066323 A CN 102066323A
- Authority
- CN
- China
- Prior art keywords
- phenyl
- indoles
- hydroxyl
- nitrile
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *[n]1c(I)c(C(O)=O)c2ccccc12 Chemical compound *[n]1c(I)c(C(O)=O)c2ccccc12 0.000 description 2
- DWEVILIUNQTWAA-UHFFFAOYSA-N Cc(cc1)ccc1-[n](c1cccc(F)c11)c(Br)c1C#N Chemical compound Cc(cc1)ccc1-[n](c1cccc(F)c11)c(Br)c1C#N DWEVILIUNQTWAA-UHFFFAOYSA-N 0.000 description 2
- YSJZRHGVBFKFDQ-VGQHJLIWSA-N C/C=C\C(\[n](c1ccccc11)c(Br)c1C#N)=C/C Chemical compound C/C=C\C(\[n](c1ccccc11)c(Br)c1C#N)=C/C YSJZRHGVBFKFDQ-VGQHJLIWSA-N 0.000 description 1
- NMGSDTSOSIPXTN-UHFFFAOYSA-N C1CC=C=CC1 Chemical compound C1CC=C=CC1 NMGSDTSOSIPXTN-UHFFFAOYSA-N 0.000 description 1
- LIRNFFOEIAGXKB-YWEYNIOJSA-N CC/C=C\c([n](c1c2cccc1)-c(cc1)ccc1OC)c2C#N Chemical compound CC/C=C\c([n](c1c2cccc1)-c(cc1)ccc1OC)c2C#N LIRNFFOEIAGXKB-YWEYNIOJSA-N 0.000 description 1
- BUFVNKRYVPNWLH-CLTKARDFSA-N CC/C=C\c([n](c1ccccc11)-c(cc2)ccc2O)c1C#N Chemical compound CC/C=C\c([n](c1ccccc11)-c(cc2)ccc2O)c1C#N BUFVNKRYVPNWLH-CLTKARDFSA-N 0.000 description 1
- LSCKLDPIKXNKRP-UHFFFAOYSA-N CCCC[Sn](CCCC)(CCCC)c([n](c1ccccc11)-c(cc2)ccc2OC)c1C#N Chemical compound CCCC[Sn](CCCC)(CCCC)c([n](c1ccccc11)-c(cc2)ccc2OC)c1C#N LSCKLDPIKXNKRP-UHFFFAOYSA-N 0.000 description 1
- FPQOHIFQSRBYMX-UHFFFAOYSA-N COc(cc1)ccc1-[n](c1ccccc11)c(Br)c1C#N Chemical compound COc(cc1)ccc1-[n](c1ccccc11)c(Br)c1C#N FPQOHIFQSRBYMX-UHFFFAOYSA-N 0.000 description 1
- YALPVEPCSMXDQL-UHFFFAOYSA-N Cc1n[o]c(C)c1-c([n](c1c2cccc1)-c(cc1)ccc1O)c2Cl Chemical compound Cc1n[o]c(C)c1-c([n](c1c2cccc1)-c(cc1)ccc1O)c2Cl YALPVEPCSMXDQL-UHFFFAOYSA-N 0.000 description 1
- YVDJIZONSPBKDD-UHFFFAOYSA-N Cc1n[o]c(C)c1-c([n](c1c2cccc1)-c(cc1)ccc1OC)c2Cl Chemical compound Cc1n[o]c(C)c1-c([n](c1c2cccc1)-c(cc1)ccc1OC)c2Cl YVDJIZONSPBKDD-UHFFFAOYSA-N 0.000 description 1
- BRFCWNIYWUHTBY-UHFFFAOYSA-N Cc1n[o]c(C)c1-c1cc(cccc2)c2[n]1-c(cc1)ccc1OC Chemical compound Cc1n[o]c(C)c1-c1cc(cccc2)c2[n]1-c(cc1)ccc1OC BRFCWNIYWUHTBY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Transplantation (AREA)
Abstract
Description
Claims (25)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0806944A GB0806944D0 (en) | 2008-04-16 | 2008-04-16 | Novel estrogen receptor ligands |
GB0806944.5 | 2008-04-16 | ||
GB0823367.8 | 2008-12-22 | ||
GB0823367A GB0823367D0 (en) | 2008-12-22 | 2008-12-22 | Novel Estrogen Receptor Ligands |
PCT/EP2009/054521 WO2009127686A1 (en) | 2008-04-16 | 2009-04-16 | Novel estrogen receptor ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102066323A true CN102066323A (zh) | 2011-05-18 |
CN102066323B CN102066323B (zh) | 2015-05-13 |
Family
ID=40673672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200980122752.2A Expired - Fee Related CN102066323B (zh) | 2008-04-16 | 2009-04-16 | 新的雌激素受体配体 |
Country Status (25)
Country | Link |
---|---|
US (2) | US8367665B2 (zh) |
EP (1) | EP2276732B1 (zh) |
JP (1) | JP5635493B2 (zh) |
KR (2) | KR20160067981A (zh) |
CN (1) | CN102066323B (zh) |
AU (1) | AU2009237657B2 (zh) |
BR (1) | BRPI0910656A2 (zh) |
CA (1) | CA2720215C (zh) |
CO (1) | CO6311077A2 (zh) |
CY (1) | CY1116741T1 (zh) |
DK (1) | DK2276732T3 (zh) |
EC (1) | ECSP10010601A (zh) |
ES (1) | ES2543599T3 (zh) |
HR (1) | HRP20150864T1 (zh) |
HU (1) | HUE025471T2 (zh) |
IL (1) | IL208392A (zh) |
MX (1) | MX2010011408A (zh) |
NZ (1) | NZ588121A (zh) |
PL (1) | PL2276732T3 (zh) |
PT (1) | PT2276732E (zh) |
RS (1) | RS54165B1 (zh) |
RU (1) | RU2492164C2 (zh) |
SI (1) | SI2276732T1 (zh) |
WO (1) | WO2009127686A1 (zh) |
ZA (1) | ZA201007255B (zh) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201124404A (en) | 2009-10-07 | 2011-07-16 | Karobio Ab | Novel estrogen receptor ligands |
JP5735518B2 (ja) | 2009-10-07 | 2015-06-17 | カロ バイオ アクチェブラーグ | エストロゲン受容体リガンドとしての置換ピラゾール |
AU2011210765A1 (en) | 2010-01-28 | 2012-09-13 | President And Fellows Of Harvard College | Compositions and methods for enhancing proteasome activity |
MX2012009529A (es) * | 2010-02-17 | 2013-01-14 | Janssen Pharmaceutica Nv | Aminotiazolonas como moduladores de receptores alfa relacionados con el estrógeno. |
CN102917707A (zh) * | 2010-05-06 | 2013-02-06 | 默沙东公司 | 可用作faah调节剂的氮杂吲哚衍生物 |
GB201105979D0 (en) * | 2011-04-07 | 2011-05-18 | Karobio Ab | Novel estrogen receptor ligands |
ES2724531T3 (es) | 2011-05-12 | 2019-09-11 | Proteostasis Therapeutics Inc | Reguladores de proteostasis |
GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2014116228A1 (en) | 2013-01-25 | 2014-07-31 | President And Fellows Of Harvard College | Usp14 inhibitors for treating or preventing viral infections |
WO2015073528A1 (en) | 2013-11-12 | 2015-05-21 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
CA2931313C (en) | 2013-11-21 | 2022-04-05 | Marquette University | Substituted (4'-hydroxyphenyl)cycloalkane compounds and uses thereof as selective agonists of the estrogen receptor beta isoform |
AU2014359178A1 (en) | 2013-12-05 | 2016-07-21 | Karo Pharma Ab | Estrogen receptor beta agonists for use in treating mesothelioma |
EP3782616B1 (en) | 2014-09-02 | 2023-11-01 | The Regents of The University of California | Estrogen receptor ligand treatment for neurodegenerative diseases |
GB201417456D0 (en) * | 2014-10-02 | 2014-11-19 | Karobio Ab | Treatment of cancer |
WO2016097036A1 (en) * | 2014-12-17 | 2016-06-23 | Karo Bio Ab | Estrogen receptor ligand for use in treating melanoma |
EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
MA45918A (fr) | 2016-08-15 | 2019-06-19 | Bayer Ag | Dérivés hétérocycliques bicycliques condensés utilisés comme pesticides |
US11624095B2 (en) | 2017-09-27 | 2023-04-11 | Case Western Reserve University | Method of quantifying HIV reservoirs by induced transcription based sequencing |
CN111741958A (zh) | 2018-02-21 | 2020-10-02 | 拜耳公司 | 作为害虫防治剂的稠合双环杂环衍生物 |
EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THERE |
WO2021203023A1 (en) * | 2020-04-03 | 2021-10-07 | Vertex Pharmaceuticals Incorporated | Indole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd) |
CN115916749A (zh) * | 2020-04-03 | 2023-04-04 | 弗特克斯药品有限公司 | 作为α-1抗胰蛋白酶调节剂的取代的5-羟基吲哚化合物 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4056624A (en) * | 1976-05-14 | 1977-11-01 | American Hoechst Corporation | Method of treating dermal inflammation |
WO1996003375A1 (de) * | 1994-07-27 | 1996-02-08 | Schering Aktiengesellschaft | 2-phenylindole als antiestrogene arzneimittel |
CN1867329A (zh) * | 2003-08-12 | 2006-11-22 | 惠氏公司 | 作为雌激素药剂的(4-羟基苯基)-1h-吲哚-3-甲醛肟衍生物 |
JP2008195642A (ja) * | 2007-02-13 | 2008-08-28 | Asahi Kasei Corp | インドール誘導体 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3799943A (en) * | 1971-06-23 | 1974-03-26 | Sterling Drug Inc | 1,2-diphenylindoles |
US3878225A (en) * | 1973-03-01 | 1975-04-15 | Hoechst Co American | Condensed pyrroles bearing an N-phenyl substituent |
SK281737B6 (sk) | 1996-04-19 | 2001-07-10 | American Home Products Corporation | 2-fenylindolové zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie |
BR9911040A (pt) | 1998-05-15 | 2001-02-13 | American Home Prod | 2-fenil-1-[4-(2-aminoetóxi)-benzil]-indol em combinação com estrogêneos |
AU4831899A (en) | 1998-06-30 | 2000-01-17 | Eli Lilly And Company | 5-HT1F agonists |
JP2002538141A (ja) | 1999-03-04 | 2002-11-12 | ワイス | エストロゲン剤としてのn−置換ベンゾイルインドール |
EP1175419B1 (en) | 1999-04-02 | 2003-05-28 | Bristol-Myers Squibb Pharma Company | Aryl sulfonyls as factor xa inhibitors |
US20030220377A1 (en) * | 2002-05-08 | 2003-11-27 | Richard Chesworth | Indole compounds and their use as estrogen agonists/antagonists |
JP2006510673A (ja) * | 2002-12-10 | 2006-03-30 | ワイス | プラスミノゲンアクティベータインヒビター1(pai−1)のインヒビターとしての、アリール、アリールオキシ、および、アルキルオキシ置換1h−インドール−3−イルグリオキシル酸誘導体 |
US7250440B2 (en) * | 2003-08-12 | 2007-07-31 | Wyeth | (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents |
US7868037B2 (en) * | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
EP1771169A1 (en) | 2004-07-14 | 2007-04-11 | PTC Therapeutics, Inc. | Methods for treating hepatitis c |
US7772271B2 (en) * | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7781478B2 (en) * | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
AR056690A1 (es) * | 2005-10-14 | 2007-10-17 | Athersys Inc | Derivados de indol como inhibidores de indol como inhibidores del receptor 3 de histamina para el tartamiento de trastornos del sueno y cognitivos obesidad y otros trastornos de snc |
US20090326018A1 (en) | 2006-10-13 | 2009-12-31 | Henrik Jernstedt | 2-Phenyl indene derivatives useful as estrogen receptor ligands |
JP2009105642A (ja) | 2007-10-23 | 2009-05-14 | Canon Inc | データ再生装置及びそのデータ通信方法、データ再生システム、並びにプログラム |
US8126781B2 (en) * | 2009-02-06 | 2012-02-28 | Cross Loop, Inc. | Real-time collaborative selection of service providers |
-
2009
- 2009-04-16 RS RS20150525A patent/RS54165B1/en unknown
- 2009-04-16 JP JP2011504464A patent/JP5635493B2/ja not_active Expired - Fee Related
- 2009-04-16 KR KR1020167014182A patent/KR20160067981A/ko not_active Application Discontinuation
- 2009-04-16 HU HUE09731606A patent/HUE025471T2/hu unknown
- 2009-04-16 ES ES09731606.1T patent/ES2543599T3/es active Active
- 2009-04-16 BR BRPI0910656A patent/BRPI0910656A2/pt not_active IP Right Cessation
- 2009-04-16 NZ NZ588121A patent/NZ588121A/xx not_active IP Right Cessation
- 2009-04-16 KR KR1020107025586A patent/KR101653229B1/ko active IP Right Grant
- 2009-04-16 PT PT97316061T patent/PT2276732E/pt unknown
- 2009-04-16 CA CA2720215A patent/CA2720215C/en not_active Expired - Fee Related
- 2009-04-16 MX MX2010011408A patent/MX2010011408A/es active IP Right Grant
- 2009-04-16 PL PL09731606T patent/PL2276732T3/pl unknown
- 2009-04-16 SI SI200931250T patent/SI2276732T1/sl unknown
- 2009-04-16 DK DK09731606.1T patent/DK2276732T3/en active
- 2009-04-16 EP EP20090731606 patent/EP2276732B1/en active Active
- 2009-04-16 AU AU2009237657A patent/AU2009237657B2/en not_active Ceased
- 2009-04-16 US US12/736,438 patent/US8367665B2/en active Active
- 2009-04-16 RU RU2010146485/04A patent/RU2492164C2/ru active
- 2009-04-16 WO PCT/EP2009/054521 patent/WO2009127686A1/en active Application Filing
- 2009-04-16 CN CN200980122752.2A patent/CN102066323B/zh not_active Expired - Fee Related
-
2010
- 2010-10-03 IL IL208392A patent/IL208392A/en not_active IP Right Cessation
- 2010-10-11 ZA ZA2010/07255A patent/ZA201007255B/en unknown
- 2010-11-10 EC EC2010010601A patent/ECSP10010601A/es unknown
- 2010-11-12 CO CO10142504A patent/CO6311077A2/es not_active Application Discontinuation
-
2013
- 2013-01-11 US US13/739,124 patent/US8653072B2/en not_active Expired - Fee Related
-
2015
- 2015-08-12 HR HRP20150864TT patent/HRP20150864T1/hr unknown
- 2015-08-18 CY CY20151100719T patent/CY1116741T1/el unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4056624A (en) * | 1976-05-14 | 1977-11-01 | American Hoechst Corporation | Method of treating dermal inflammation |
WO1996003375A1 (de) * | 1994-07-27 | 1996-02-08 | Schering Aktiengesellschaft | 2-phenylindole als antiestrogene arzneimittel |
CN1867329A (zh) * | 2003-08-12 | 2006-11-22 | 惠氏公司 | 作为雌激素药剂的(4-羟基苯基)-1h-吲哚-3-甲醛肟衍生物 |
JP2008195642A (ja) * | 2007-02-13 | 2008-08-28 | Asahi Kasei Corp | インドール誘導体 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102066323B (zh) | 新的雌激素受体配体 | |
CN102271682B (zh) | 用于治疗疼痛的p2x3受体拮抗剂 | |
JP5735518B2 (ja) | エストロゲン受容体リガンドとしての置換ピラゾール | |
WO2011042474A1 (en) | Novel estrogen receptor ligands | |
CN102791688B (zh) | 雌激素受体配体 | |
CN102216268A (zh) | 新的雌激素受体配体 | |
CN101998852A (zh) | 新的雌激素受体配体 | |
JP6223336B2 (ja) | 新規なエストロゲン受容体リガンド | |
CN101506181A (zh) | 三环化合物及其制药用途 | |
WO2012136772A1 (en) | Fused pyrrole derivates as estrogen receptor ligands | |
CN102532073A (zh) | 作为选择性雌激素受体调节剂的乙烯衍生物 | |
TWI699366B (zh) | 治療或預防癌症的化合物 | |
CN104812753A (zh) | 作为Syk抑制剂的取代吡啶并吡嗪类化合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: Stockholm Patentee after: Caro Pharmaceutical Co.,Ltd. Address before: Swedish hedinger Patentee before: KARO BIO AB |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20171031 Address after: uppsala Patentee after: Oswald MIA pharmaceutical Co. Address before: Stockholm Patentee before: Caro Pharmaceutical Co.,Ltd. |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150513 |