CO6311077A2 - Derivados de 1-(4-hidroxi-fenil)-1h-indol como ligandos novedosos de receptor de estrógeno - Google Patents

Derivados de 1-(4-hidroxi-fenil)-1h-indol como ligandos novedosos de receptor de estrógeno

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Publication number
CO6311077A2
CO6311077A2 CO10142504A CO10142504A CO6311077A2 CO 6311077 A2 CO6311077 A2 CO 6311077A2 CO 10142504 A CO10142504 A CO 10142504A CO 10142504 A CO10142504 A CO 10142504A CO 6311077 A2 CO6311077 A2 CO 6311077A2
Authority
CO
Colombia
Prior art keywords
sterrogen
novedos
indol
hydroxy
phenyl
Prior art date
Application number
CO10142504A
Other languages
English (en)
Inventor
Patrik P Rhonnstad
Elisabet Kallin
Theresa Apelqvist
Mattias Wennerstal
Aiping Cheng
Original Assignee
Karobio Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0806944A external-priority patent/GB0806944D0/en
Priority claimed from GB0823367A external-priority patent/GB0823367D0/en
Application filed by Karobio Ab filed Critical Karobio Ab
Publication of CO6311077A2 publication Critical patent/CO6311077A2/es

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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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Abstract

La invención proporciona un compuesto de la fórmula (I) o un éster, amida, carbamato, solvato o sal del mismo farmacéuticamente aceptable, incluyendo una sal de tal éster, amida o carbamato, y un solvato de tal éster, amida, carbamato o sal. La invención proporciona también el uso de tales compuestos en el tratamiento o profilaxis de una condición asociada con una enfermedad o trastorno asociados con actividad de receptor de estrógeno, en donde R1, R2, R3, R4, R5 y R6 son como se definen en la especificación.
CO10142504A 2008-04-16 2010-11-12 Derivados de 1-(4-hidroxi-fenil)-1h-indol como ligandos novedosos de receptor de estrógeno CO6311077A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0806944A GB0806944D0 (en) 2008-04-16 2008-04-16 Novel estrogen receptor ligands
GB0823367A GB0823367D0 (en) 2008-12-22 2008-12-22 Novel Estrogen Receptor Ligands

Publications (1)

Publication Number Publication Date
CO6311077A2 true CO6311077A2 (es) 2011-08-22

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CO10142504A CO6311077A2 (es) 2008-04-16 2010-11-12 Derivados de 1-(4-hidroxi-fenil)-1h-indol como ligandos novedosos de receptor de estrógeno

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US (2) US8367665B2 (es)
EP (1) EP2276732B1 (es)
JP (1) JP5635493B2 (es)
KR (2) KR20160067981A (es)
CN (1) CN102066323B (es)
AU (1) AU2009237657B2 (es)
BR (1) BRPI0910656A2 (es)
CA (1) CA2720215C (es)
CO (1) CO6311077A2 (es)
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DK (1) DK2276732T3 (es)
EC (1) ECSP10010601A (es)
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Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201124404A (en) 2009-10-07 2011-07-16 Karobio Ab Novel estrogen receptor ligands
CN102648183B (zh) 2009-10-07 2015-12-02 卡罗生物股份公司 作为雌激素受体配体的取代吡唑
KR20120117905A (ko) 2010-01-28 2012-10-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 프로테아좀 활성을 향상시키는 조성물 및 방법
CA2789757A1 (en) * 2010-02-17 2011-08-25 Janssen Pharmaceutica Nv Aminothiazolones as estrogen related receptor-alpha modulators
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