CN101903403B - Cd19结合剂及其应用 - Google Patents

Cd19结合剂及其应用 Download PDF

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Publication number
CN101903403B
CN101903403B CN200880122233.1A CN200880122233A CN101903403B CN 101903403 B CN101903403 B CN 101903403B CN 200880122233 A CN200880122233 A CN 200880122233A CN 101903403 B CN101903403 B CN 101903403B
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amino acid
antibody
optionally substituted
seq
acid sequence
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CN101903403A (zh
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C·麦克多纳格
C·G·赛弗尼
D·本杰明
P·卡特
H·P·格伯
L·弗朗西斯科
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Seagen Inc
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Seattle Genetics Inc
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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CN200880122233.1A 2007-10-19 2008-10-17 Cd19结合剂及其应用 Active CN101903403B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US98120607P 2007-10-19 2007-10-19
US60/981,206 2007-10-19
US1921408P 2008-01-04 2008-01-04
US61/019,214 2008-01-04
US8016908P 2008-07-11 2008-07-11
US61/080,169 2008-07-11
PCT/US2008/080373 WO2009052431A2 (en) 2007-10-19 2008-10-17 Cd19 binding agents and uses thereof

Publications (2)

Publication Number Publication Date
CN101903403A CN101903403A (zh) 2010-12-01
CN101903403B true CN101903403B (zh) 2016-03-16

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CN200880122233.1A Active CN101903403B (zh) 2007-10-19 2008-10-17 Cd19结合剂及其应用

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EP (1) EP2211904B1 (enExample)
JP (2) JP5727786B2 (enExample)
KR (1) KR101658083B1 (enExample)
CN (1) CN101903403B (enExample)
AU (1) AU2008311815B2 (enExample)
CA (1) CA2702555A1 (enExample)
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PL (1) PL2211904T3 (enExample)
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