LT3465214T - Anti-cd19 terapijos terapinės naudos pacientams prognozavimo metodai - Google Patents

Anti-cd19 terapijos terapinės naudos pacientams prognozavimo metodai

Info

Publication number
LT3465214T
LT3465214T LTEP17728484.1T LT17728484T LT3465214T LT 3465214 T LT3465214 T LT 3465214T LT 17728484 T LT17728484 T LT 17728484T LT 3465214 T LT3465214 T LT 3465214T
Authority
LT
Lithuania
Prior art keywords
therapy
patients
methods
therapeutic benefit
predicting therapeutic
Prior art date
Application number
LTEP17728484.1T
Other languages
English (en)
Inventor
Jan Endell
Mark Winderlich
Rainer Boxhammer
Original Assignee
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys Ag filed Critical Morphosys Ag
Publication of LT3465214T publication Critical patent/LT3465214T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57426Specifically defined cancers leukemia
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70535Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
LTEP17728484.1T 2016-05-30 2017-05-30 Anti-cd19 terapijos terapinės naudos pacientams prognozavimo metodai LT3465214T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16171885 2016-05-30
PCT/EP2017/063045 WO2017207574A1 (en) 2016-05-30 2017-05-30 Methods for predicting therapeutic benefit of anti-cd19 therapy in patients

Publications (1)

Publication Number Publication Date
LT3465214T true LT3465214T (lt) 2021-10-11

Family

ID=56116221

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP21170716.1T LT3916392T (lt) 2016-05-30 2017-05-30 Pacientų gydymo anti-cd19 terapinės naudos prognozavimo būdai
LTEP17728484.1T LT3465214T (lt) 2016-05-30 2017-05-30 Anti-cd19 terapijos terapinės naudos pacientams prognozavimo metodai

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTEP21170716.1T LT3916392T (lt) 2016-05-30 2017-05-30 Pacientų gydymo anti-cd19 terapinės naudos prognozavimo būdai

Country Status (27)

Country Link
US (2) US20190195879A1 (lt)
EP (2) EP3465214B1 (lt)
JP (2) JP7066639B2 (lt)
KR (1) KR102416144B1 (lt)
CN (2) CN115932265A (lt)
AU (1) AU2017272608B2 (lt)
BR (1) BR112018074603A2 (lt)
CA (1) CA3025823A1 (lt)
CY (1) CY1124768T1 (lt)
DK (2) DK3465214T3 (lt)
EA (1) EA201892542A1 (lt)
ES (1) ES2878156T3 (lt)
FI (1) FI3916392T3 (lt)
HR (1) HRP20210938T1 (lt)
HU (1) HUE054860T2 (lt)
IL (1) IL263103B2 (lt)
LT (2) LT3916392T (lt)
MA (2) MA57021B1 (lt)
MD (1) MD3465214T2 (lt)
MX (2) MX2018014702A (lt)
PL (1) PL3465214T3 (lt)
PT (2) PT3916392T (lt)
RS (2) RS65540B1 (lt)
SG (2) SG11201810159TA (lt)
SI (1) SI3465214T1 (lt)
WO (1) WO2017207574A1 (lt)
ZA (1) ZA201808647B (lt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220242952A1 (en) * 2019-05-03 2022-08-04 Morphosys Ag Anti-cd19 therapy in patients having a limited number of nk cells
TW202131950A (zh) * 2019-10-31 2021-09-01 德商莫菲西斯公司 依序抗cd19療法
AU2020376305A1 (en) * 2019-10-31 2022-05-12 Incyte Corporation Anti-CD19 therapy in combination with lenalidomide for the treatment of leukemia or lymphoma
MX2023006538A (es) * 2020-12-04 2023-08-08 Morphosys Ag Terapia combinada de anticuerpo anti cúmulo de diferenciación 19 (cd19).

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1320044A (zh) 1998-08-11 2001-10-31 Idec药物公司 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法
CA2439410C (en) 2001-02-27 2011-09-06 William D. Figg Analogs of thalidomide as potential angiogenesis inhibitors
WO2005016326A2 (en) 2003-07-11 2005-02-24 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Analogs of thalidomide as potential angiogenesis inhibitors
WO2005012493A2 (en) 2003-07-31 2005-02-10 Immunomedics, Inc. Anti-cd19 antibodies
US7902338B2 (en) 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
EP1899379B1 (en) 2005-06-20 2018-04-11 E. R. Squibb & Sons, L.L.C. Cd19 antibodies and their uses
DK1966245T3 (da) 2005-12-30 2011-07-18 Merck Patent Gmbh Anti-CD19-Antistoffer med reduceret immunogenicitet
AU2007285976B2 (en) 2006-08-14 2011-08-18 Xencor, Inc Optimized antibodies that target CD19
CA2662340C (en) 2006-09-08 2016-08-02 Medimmune, Llc Humanized anti-cd19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
DE602007013068D1 (de) 2006-09-13 2011-04-21 Glycode Verfahren zur untersuchung der reaktion auf eine behandlung mit einem monoklonalen antikörper
LT2176298T (lt) 2007-05-30 2018-04-10 Xencor, Inc. Būdai ir kompozicijos, skirti cd32b ekspresuojančių ląstelių slopinimui
DK2211904T3 (en) 2007-10-19 2016-10-24 Seattle Genetics Inc Cd19-binding agents and uses thereof
BRPI1005984A2 (pt) 2009-02-23 2016-10-04 Glenmark Pharmaceuticals Sa anticorpo humanizado ou fragmento do mesmo que se liga ao cd19 humano, acido nucleico isolado, vetor, célula hospedeira, método para produzir um anticorpo humanizado ou fragmento do mesmo que se liga à cd12 humano, composição, imunoconjugado, uso de um anticorpo humanizado ou fragmento do mesmo, artigo de manufatura e kit
WO2011147834A1 (en) 2010-05-26 2011-12-01 Roche Glycart Ag Antibodies against cd19 and uses thereof
EP2409712A1 (en) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile
EP2409993A1 (en) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anti-CD19 antibody having ADCC function with improved glycosylation profile
US20130330328A1 (en) 2010-11-15 2013-12-12 Medimmune, Llc Combination Therapy For B Cell Lymphomas
EP2524929A1 (en) 2011-05-17 2012-11-21 Sanofi Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms
PL2744515T3 (pl) 2011-08-16 2022-05-30 Morphosys Ag Terapia skojarzona przeciwciałem anty-cd19 i iperytem azotowym
SG10201606788VA (en) * 2011-08-16 2016-09-29 Morphosys Ag Combination therapy with an anti - cd19 antibody and a purine analog
WO2013090478A1 (en) * 2011-12-12 2013-06-20 Pikamab, Inc Predicting responsiveness to antibody maintenance therapy
EP3110445A4 (en) * 2014-02-25 2017-09-27 Immunomedics, Inc. Humanized rfb4 anti-cd22 antibody
WO2015195498A1 (en) * 2014-06-16 2015-12-23 Xencor, Inc. Treatment for chronic lymphocytic leukemia (cll)
JP6805137B2 (ja) * 2014-07-11 2020-12-23 アンセルム(アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル) 血液学的癌を診断するための方法

Also Published As

Publication number Publication date
EA201892542A1 (ru) 2019-06-28
PT3465214T (pt) 2021-06-30
MX2021014963A (es) 2022-02-24
SG11201810159TA (en) 2018-12-28
CN115932265A (zh) 2023-04-07
RS62155B1 (sr) 2021-08-31
JP7511806B2 (ja) 2024-07-08
CN109313194A (zh) 2019-02-05
BR112018074603A2 (pt) 2019-03-19
EP3916392B1 (en) 2024-05-01
AU2017272608A1 (en) 2018-12-06
RS65540B1 (sr) 2024-06-28
IL263103B2 (en) 2023-10-01
ES2878156T3 (es) 2021-11-18
KR102416144B1 (ko) 2022-07-04
CY1124768T1 (el) 2022-11-25
EP3465214B1 (en) 2021-04-28
EP3916392A1 (en) 2021-12-01
MA45124B1 (fr) 2021-05-31
MA45124A (fr) 2017-12-07
JP2022119764A (ja) 2022-08-17
AU2017272608B2 (en) 2023-08-10
JP7066639B2 (ja) 2022-05-13
PT3916392T (pt) 2024-06-04
IL263103A (en) 2018-12-31
ZA201808647B (en) 2021-05-26
IL263103B1 (en) 2023-06-01
HUE054860T2 (hu) 2021-10-28
LT3916392T (lt) 2024-08-26
MX2018014702A (es) 2019-10-02
US20190195879A1 (en) 2019-06-27
PL3465214T3 (pl) 2021-12-20
CN109313194B (zh) 2022-11-04
MA57021B1 (fr) 2024-05-31
DK3465214T3 (da) 2021-05-31
EP3465214A1 (en) 2019-04-10
HRP20210938T1 (hr) 2021-09-03
WO2017207574A1 (en) 2017-12-07
SG10201911958SA (en) 2020-02-27
US20220283166A1 (en) 2022-09-08
MD3465214T2 (ro) 2021-09-30
FI3916392T3 (fi) 2024-06-03
SI3465214T1 (sl) 2021-12-31
CA3025823A1 (en) 2017-12-07
JP2019519770A (ja) 2019-07-11
DK3916392T3 (da) 2024-05-21
KR20190013980A (ko) 2019-02-11

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