MX2018014702A - Métodos para predecir el beneficio terapéutico de la terapia con anti-cd19 en pacientes. - Google Patents
Métodos para predecir el beneficio terapéutico de la terapia con anti-cd19 en pacientes.Info
- Publication number
- MX2018014702A MX2018014702A MX2018014702A MX2018014702A MX2018014702A MX 2018014702 A MX2018014702 A MX 2018014702A MX 2018014702 A MX2018014702 A MX 2018014702A MX 2018014702 A MX2018014702 A MX 2018014702A MX 2018014702 A MX2018014702 A MX 2018014702A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- antibody
- level
- biomarker
- subject
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000001225 therapeutic effect Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 abstract 3
- 239000000090 biomarker Substances 0.000 abstract 3
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 abstract 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 abstract 2
- 210000000822 natural killer cell Anatomy 0.000 abstract 2
- 230000002093 peripheral effect Effects 0.000 abstract 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 abstract 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 abstract 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 abstract 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57426—Specifically defined cancers leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente divulgación está dirigida a un método para identificar a un sujeto que tiene leucemia linfocítica crónica (CLL), linfoma no Hodgkin (NHL), linfoma linfocítico pequeño (SLL) o leucemia linfoblástica aguda (ALL) que responde a tratamiento con un anticuerpo anti-CD19, comprendiendo dicho método: a) proporcionar una muestra de sangre obtenida de dicho sujeto antes del tratamiento con dicho anticuerpo anti-CD19, b) determinar el nivel de al menos un biomarcador en dicha muestra seleccionada del grupo que consiste en i) recuento de células NK periféricas, y ii) niveles de expresión de CD16 en células NK periféricas, c) comparar el nivel de dicho al menos un biomarcador en dicha muestra a un nivel de corte predeterminado, en donde los niveles de dicho al menos un biomarcador en o por encima del nivel de corte predeterminado es indicativo de un sujeto que se beneficiaría del tratamiento con un anticuerpo anti-CD19. La presente divulgación también está dirigida a un método para seleccionar un paciente para el tratamiento de acuerdo con lo anterior y al uso de un anticuerpo anti-CD19 para el tratamiento de dicho paciente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16171885 | 2016-05-30 | ||
| PCT/EP2017/063045 WO2017207574A1 (en) | 2016-05-30 | 2017-05-30 | Methods for predicting therapeutic benefit of anti-cd19 therapy in patients |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018014702A true MX2018014702A (es) | 2019-10-02 |
Family
ID=56116221
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018014702A MX2018014702A (es) | 2016-05-30 | 2017-05-30 | Métodos para predecir el beneficio terapéutico de la terapia con anti-cd19 en pacientes. |
| MX2021014963A MX2021014963A (es) | 2016-05-30 | 2018-11-28 | Metodos para predecir el beneficio terapeutico de la terapia con anti-cd19 en pacientes. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021014963A MX2021014963A (es) | 2016-05-30 | 2018-11-28 | Metodos para predecir el beneficio terapeutico de la terapia con anti-cd19 en pacientes. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US20190195879A1 (es) |
| EP (2) | EP3465214B1 (es) |
| JP (2) | JP7066639B2 (es) |
| KR (1) | KR102416144B1 (es) |
| CN (2) | CN109313194B (es) |
| AU (1) | AU2017272608B2 (es) |
| BR (1) | BR112018074603A2 (es) |
| CA (1) | CA3025823A1 (es) |
| CY (1) | CY1124768T1 (es) |
| DK (2) | DK3465214T3 (es) |
| EA (1) | EA201892542A1 (es) |
| ES (1) | ES2878156T3 (es) |
| HR (1) | HRP20210938T1 (es) |
| HU (1) | HUE054860T2 (es) |
| IL (1) | IL263103B2 (es) |
| LT (1) | LT3465214T (es) |
| MA (1) | MA45124B1 (es) |
| MD (1) | MD3465214T2 (es) |
| MX (2) | MX2018014702A (es) |
| PL (1) | PL3465214T3 (es) |
| PT (1) | PT3465214T (es) |
| RS (1) | RS62155B1 (es) |
| SG (2) | SG11201810159TA (es) |
| SI (1) | SI3465214T1 (es) |
| WO (1) | WO2017207574A1 (es) |
| ZA (1) | ZA201808647B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3962943A1 (en) | 2019-05-03 | 2022-03-09 | MorphoSys AG | Anti-cd19 therapy in patients having a limited number of nk cells |
| US20240156863A1 (en) * | 2019-10-31 | 2024-05-16 | Morphosys Ag | Sequential anti-cd19 therapy |
| CA3159534A1 (en) * | 2019-10-31 | 2021-05-06 | Morphosys Ag | Anti-cd19 therapy in combination with lenalidomide for the treatment of leukemia or lymphoma |
| TW202237184A (zh) * | 2020-12-04 | 2022-10-01 | 德商莫菲西斯公司 | 抗cd19組合療法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2388893T3 (es) * | 1998-08-11 | 2012-10-19 | Biogen Idec Inc. | Terapias de combinación para linfomas de células B que comprenden la administración de anticuerpos anti-CD20 |
| WO2002068414A2 (en) | 2001-02-27 | 2002-09-06 | The Governement Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Analogs of thalidomide as potential angiogenesis inhibitors |
| WO2005016326A2 (en) | 2003-07-11 | 2005-02-24 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Analogs of thalidomide as potential angiogenesis inhibitors |
| CA2534639C (en) | 2003-07-31 | 2013-07-30 | Immunomedics, Inc. | Anti-cd19 antibodies |
| US7902338B2 (en) | 2003-07-31 | 2011-03-08 | Immunomedics, Inc. | Anti-CD19 antibodies |
| US8097703B2 (en) | 2005-06-20 | 2012-01-17 | Medarex, Inc. | CD19 antibodies and their uses |
| JP2009521912A (ja) | 2005-12-30 | 2009-06-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 低減された免疫原性を有する抗ｃｄ１９抗体 |
| PL2059536T3 (pl) | 2006-08-14 | 2014-07-31 | Xencor Inc | Zoptymalizowane przeciwciała ukierunkowane na CD19 |
| JP5401314B2 (ja) | 2006-09-08 | 2014-01-29 | メディミューン，エルエルシー | ヒト化抗ｃｄ１９抗体ならびに癌、移植および自己免疫疾患の治療におけるその使用 |
| DE602007013068D1 (de) * | 2006-09-13 | 2011-04-21 | Glycode | Verfahren zur untersuchung der reaktion auf eine behandlung mit einem monoklonalen antikörper |
| WO2008150494A1 (en) | 2007-05-30 | 2008-12-11 | Xencor, Inc. | Methods and compositions for inhibiting cd32b expressing cells |
| CA2702555A1 (en) | 2007-10-19 | 2009-04-23 | Seattle Genetics, Inc. | Cd19 binding agents and uses thereof |
| JP2012518404A (ja) | 2009-02-23 | 2012-08-16 | グレンマーク・ファーマシューティカルズ・エスエー | Ｃｄ１９に結合するヒト化抗体及びその使用 |
| WO2011147834A1 (en) | 2010-05-26 | 2011-12-01 | Roche Glycart Ag | Antibodies against cd19 and uses thereof |
| EP2409993A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC function with improved glycosylation profile |
| EP2409712A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile |
| JP2013543869A (ja) * | 2010-11-15 | 2013-12-09 | メディミューン，エルエルシー | Ｂ細胞リンパ腫のための併用療法 |
| EP2524929A1 (en) | 2011-05-17 | 2012-11-21 | Sanofi | Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms |
| PL2744515T3 (pl) * | 2011-08-16 | 2022-05-30 | Morphosys Ag | Terapia skojarzona przeciwciałem anty-cd19 i iperytem azotowym |
| SI2744826T1 (sl) * | 2011-08-16 | 2022-05-31 | Morphosys Ag | Kombinirana terapija s protitelesom proti CD19 in analogom purina |
| US20140328842A1 (en) * | 2011-12-12 | 2014-11-06 | Pikamab, Inc. | Predicting Responsiveness to Antibody Maintenance Therapy |
| EP3110445A4 (en) * | 2014-02-25 | 2017-09-27 | Immunomedics, Inc. | Humanized rfb4 anti-cd22 antibody |
| EP3157553A4 (en) | 2014-06-16 | 2018-02-28 | Xencor, Inc. | Treatment for chronic lymphocytic leukemia (cll) |
| JP6805137B2 (ja) * | 2014-07-11 | 2020-12-23 | アンセルム（アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル） | 血液学的癌を診断するための方法 |
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2017
- 2017-05-30 WO PCT/EP2017/063045 patent/WO2017207574A1/en unknown
- 2017-05-30 KR KR1020187038026A patent/KR102416144B1/ko active IP Right Grant
- 2017-05-30 MD MDE20190405T patent/MD3465214T2/ro unknown
- 2017-05-30 IL IL263103A patent/IL263103B2/en unknown
- 2017-05-30 PT PT177284841T patent/PT3465214T/pt unknown
- 2017-05-30 ES ES17728484T patent/ES2878156T3/es active Active
- 2017-05-30 SG SG11201810159TA patent/SG11201810159TA/en unknown
- 2017-05-30 SI SI201730823T patent/SI3465214T1/sl unknown
- 2017-05-30 CN CN201780033793.9A patent/CN109313194B/zh active Active
- 2017-05-30 SG SG10201911958SA patent/SG10201911958SA/en unknown
- 2017-05-30 US US16/305,482 patent/US20190195879A1/en not_active Abandoned
- 2017-05-30 RS RS20210893A patent/RS62155B1/sr unknown
- 2017-05-30 BR BR112018074603-7A patent/BR112018074603A2/pt unknown
- 2017-05-30 HU HUE17728484A patent/HUE054860T2/hu unknown
- 2017-05-30 LT LTEP17728484.1T patent/LT3465214T/lt unknown
- 2017-05-30 EP EP17728484.1A patent/EP3465214B1/en active Active
- 2017-05-30 AU AU2017272608A patent/AU2017272608B2/en active Active
- 2017-05-30 DK DK17728484.1T patent/DK3465214T3/da active
- 2017-05-30 CA CA3025823A patent/CA3025823A1/en active Pending
- 2017-05-30 MA MA45124A patent/MA45124B1/fr unknown
- 2017-05-30 PL PL17728484T patent/PL3465214T3/pl unknown
- 2017-05-30 EP EP21170716.1A patent/EP3916392B1/en active Active
- 2017-05-30 CN CN202211271570.5A patent/CN115932265A/zh active Pending
- 2017-05-30 JP JP2018562324A patent/JP7066639B2/ja active Active
- 2017-05-30 DK DK21170716.1T patent/DK3916392T3/da active
- 2017-05-30 EA EA201892542A patent/EA201892542A1/ru unknown
- 2017-05-30 MX MX2018014702A patent/MX2018014702A/es unknown
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2018
- 2018-11-28 MX MX2021014963A patent/MX2021014963A/es unknown
- 2018-12-20 ZA ZA2018/08647A patent/ZA201808647B/en unknown
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2021
- 2021-06-11 HR HRP20210938TT patent/HRP20210938T1/hr unknown
- 2021-07-13 CY CY20211100629T patent/CY1124768T1/el unknown
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2022
- 2022-04-27 JP JP2022072884A patent/JP2022119764A/ja active Pending
- 2022-05-25 US US17/824,266 patent/US20220283166A1/en active Pending
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