CN101835780B - 用于治疗病毒感染诸如肝炎的咪唑并[1,2-a]吡嗪化合物 - Google Patents

用于治疗病毒感染诸如肝炎的咪唑并[1,2-a]吡嗪化合物 Download PDF

Info

Publication number
CN101835780B
CN101835780B CN2008801108961A CN200880110896A CN101835780B CN 101835780 B CN101835780 B CN 101835780B CN 2008801108961 A CN2008801108961 A CN 2008801108961A CN 200880110896 A CN200880110896 A CN 200880110896A CN 101835780 B CN101835780 B CN 101835780B
Authority
CN
China
Prior art keywords
alkyl
substituted
halogen
compounds
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2008801108961A
Other languages
English (en)
Chinese (zh)
Other versions
CN101835780A (zh
Inventor
A·麦克劳德
D·R·米切尔
N·J·帕尔默
C·C·帕尔西
M·D·戈德史密斯
C·J·哈里斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biofocus DPI Ltd
Original Assignee
Biofocus DPI Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biofocus DPI Ltd filed Critical Biofocus DPI Ltd
Publication of CN101835780A publication Critical patent/CN101835780A/zh
Application granted granted Critical
Publication of CN101835780B publication Critical patent/CN101835780B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2008801108961A 2007-08-21 2008-08-20 用于治疗病毒感染诸如肝炎的咪唑并[1,2-a]吡嗪化合物 Expired - Fee Related CN101835780B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0716292.8A GB0716292D0 (en) 2007-08-21 2007-08-21 Imidazopyrazine compounds
GB0716292.8 2007-08-21
PCT/EP2008/060896 WO2009024585A2 (en) 2007-08-21 2008-08-20 Imidazo [1,2-a] pyrazine compounds for treatment of viral infections such as hepatitis

Publications (2)

Publication Number Publication Date
CN101835780A CN101835780A (zh) 2010-09-15
CN101835780B true CN101835780B (zh) 2013-09-18

Family

ID=38566736

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801108961A Expired - Fee Related CN101835780B (zh) 2007-08-21 2008-08-20 用于治疗病毒感染诸如肝炎的咪唑并[1,2-a]吡嗪化合物

Country Status (20)

Country Link
US (1) US8362018B2 (cg-RX-API-DMAC7.html)
EP (2) EP2567960A3 (cg-RX-API-DMAC7.html)
JP (1) JP2010536825A (cg-RX-API-DMAC7.html)
KR (1) KR20100081294A (cg-RX-API-DMAC7.html)
CN (1) CN101835780B (cg-RX-API-DMAC7.html)
AU (1) AU2008290531A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0815717A2 (cg-RX-API-DMAC7.html)
CA (1) CA2707521A1 (cg-RX-API-DMAC7.html)
CY (1) CY1113872T1 (cg-RX-API-DMAC7.html)
DK (1) DK2193131T3 (cg-RX-API-DMAC7.html)
ES (1) ES2404415T3 (cg-RX-API-DMAC7.html)
GB (1) GB0716292D0 (cg-RX-API-DMAC7.html)
HR (1) HRP20130202T1 (cg-RX-API-DMAC7.html)
MX (1) MX2010001733A (cg-RX-API-DMAC7.html)
NZ (1) NZ584108A (cg-RX-API-DMAC7.html)
PL (1) PL2193131T3 (cg-RX-API-DMAC7.html)
PT (1) PT2193131E (cg-RX-API-DMAC7.html)
SI (1) SI2193131T1 (cg-RX-API-DMAC7.html)
WO (1) WO2009024585A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201002009B (cg-RX-API-DMAC7.html)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0716292D0 (en) * 2007-08-21 2007-09-26 Biofocus Dpi Ltd Imidazopyrazine compounds
JP5216912B2 (ja) 2008-04-29 2013-06-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体拮抗薬としてのインダゾール化合物
JP5411927B2 (ja) 2008-05-06 2014-02-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１アンタゴニストとしてのピラゾール化合物
PE20110854A1 (es) 2008-09-26 2011-12-23 Boehringer Ingelheim Int DERIVADOS DE 1-FENIL-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBONILAMINA COMO ANTAGONISTAS DE LOS RECEPTORES CCR1
TW201107329A (en) 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
AP2012006204A0 (en) 2009-10-21 2012-04-30 Boehringer Ingelheim Int Indazole and pyrazolopyridine compounds as CCR1 receptor antagonists.
JP5542214B2 (ja) 2009-10-27 2014-07-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしての複素環化合物
PH12012500778A1 (en) 2009-10-30 2012-11-26 Janssen Pharmaceutica Nv IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
IN2012DN05081A (cg-RX-API-DMAC7.html) * 2009-12-08 2015-10-09 Boehringer Ingelheim Int
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
ES2551407T3 (es) * 2010-03-18 2015-11-18 Bayer Intellectual Property Gmbh Imidazopirazinas
US8871786B2 (en) 2010-04-30 2014-10-28 Boehringer Ingelheim International Gmbh Azaindazole amide compounds as CCR1 receptor antagonists
CN103038235B (zh) 2010-06-01 2015-07-29 拜耳知识产权有限责任公司 取代的咪唑并吡嗪
CA2821829A1 (en) * 2010-12-17 2012-06-21 Bayer Intellectual Property Gmbh Imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
US20140135319A1 (en) 2010-12-17 2014-05-15 Bayer Intellectual Property Gmbh 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
WO2012080228A1 (en) 2010-12-17 2012-06-21 Bayer Pharma Aktiengesellschaft 6-thio-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
WO2012080232A1 (en) * 2010-12-17 2012-06-21 Bayer Pharma Aktiengesellschaft 2-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
US9284317B2 (en) * 2010-12-17 2016-03-15 Bayer Intellectual Property Gmbh Substituted imidazo[1,2-a]pyrazines as MPS-1 inhibitors
US20140187548A1 (en) 2010-12-17 2014-07-03 Bayer Intellectual Property Gmbh 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
US8546442B2 (en) 2010-12-23 2013-10-01 Boehringer Ingelheim International Gmbh Pyrazolopiperidine compounds as CCR1 receptor antagonists
GB201109763D0 (en) * 2011-06-10 2011-07-27 Ucl Business Plc Compounds
JP6115962B2 (ja) 2011-06-27 2017-04-19 ヤンセン ファーマシューティカ エヌ．ベー． １−アリール−４−メチル−［１，２，４］トリアゾロ［４，３−ａ］キノキサリン誘導体
JPWO2013061962A1 (ja) * 2011-10-24 2015-04-02 武田薬品工業株式会社 二環性化合物
WO2014001314A1 (en) 2012-06-26 2014-01-03 Janssen Pharmaceutica Nv Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders
AU2013289284B2 (en) 2012-07-09 2017-03-30 Janssen Pharmaceutica Nv Inhibitors of phosphodiesterase 10 enzyme
WO2016130501A1 (en) 2015-02-09 2016-08-18 Incyte Corporation Aza-heteroaryl compounds as pi3k-gamma inhibitors
BR112017023038A2 (pt) * 2015-04-29 2018-07-03 Janssen Pharmaceutica Nv imidazopirazinas e pirazolopirimidinas e seu uso como moduladores do receptor ampa
BR122023023802A2 (pt) 2015-04-29 2023-12-26 Janssen Pharmaceutica Nv Compostos azabenzimidazóis, seu uso como moduladores do receptor de ampa e composições farmacêuticas que os compreendem
CN107949563B (zh) * 2015-06-24 2020-06-05 库洛维公司 治疗中有用的吡唑并[1,5-a]三嗪-4-胺衍生物
JP6507976B2 (ja) * 2015-09-30 2019-05-08 東レ株式会社 イミダゾール−２−カルボン酸エステル誘導体又はその塩の製造方法
RS63359B1 (sr) 2015-11-06 2022-07-29 Incyte Corp Heterociklična jedinjenja kao inhibitori pi3k-gama
ES2995198T3 (en) 2016-01-05 2025-02-07 Incyte Corp Pyridine compounds as pi3k-gamma inhibitors
HK1250945A1 (zh) * 2016-03-31 2019-01-18 罗马克实验室有限公司 用於治疗病毒性感染的噻唑化物化合物
TW201803871A (zh) 2016-06-24 2018-02-01 英塞特公司 作為ＰＩ３Ｋ-γ抑制劑之雜環化合物
UY37381A (es) 2016-08-30 2018-03-23 Glaxosmithkline Ip No 2 Ltd Compuestos que inhiben proteasas 3c y 3cl y métodos de uso de los mismos
KR102717072B1 (ko) 2017-10-18 2024-10-15 인사이트 코포레이션 Pi3k-감마 저해제로서의 3차 하이드록시기로 치환된 축합된 이미다졸 유도체
JP7133023B2 (ja) 2018-01-17 2022-09-07 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド Ｐｉ４ｋｉｉｉベータ阻害剤
TWI811428B (zh) 2018-08-21 2023-08-11 日商杏林製藥股份有限公司 雙環雜芳香環衍生物
CR20250050A (es) 2018-09-05 2025-03-19 Incyte Corp Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
CN109369545B (zh) * 2018-12-14 2020-04-10 东营曜康医药科技有限公司 2-甲基-5-甲酸吡嗪的合成工艺
US20230014730A1 (en) 2019-09-23 2023-01-19 Nanjing Zhengxiang Pharmaceuticals Co., Ltd. Phosphodiesterase inhibitors and use
WO2021061803A1 (en) 2019-09-23 2021-04-01 Nanjing Zhengxiang Pharmaceuticals Co., Ltd. Phosphodiesterase inhibitors and use
CN115667266A (zh) 2020-06-01 2023-01-31 豪夫迈·罗氏有限公司 新型咪唑并吡嗪衍生物
EP4161930A1 (en) * 2020-06-08 2023-04-12 F. Hoffmann-La Roche AG Novel imidazo-pyrazine derivatives
CN113929633A (zh) * 2021-10-27 2022-01-14 山东大学 一种法匹拉韦的合成方法及其应用
CN113831255B (zh) * 2021-11-25 2022-03-11 山东诚创蓝海医药科技有限公司 一种2-氨基丙二酰胺的制备方法
CN115489188B (zh) * 2022-10-09 2023-08-29 安徽国风新材料股份有限公司 一种家居保护用聚酯薄膜及其制备方法
EP4623911A1 (en) 2024-03-25 2025-10-01 ETH Zurich Pi4kb inhibitors for the treatment of fatty liver disease
EP4623912A1 (en) 2024-03-25 2025-10-01 ETH Zurich A method for defattening a steatotic liver ex vivo

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2607813B1 (fr) * 1986-12-05 1989-03-31 Montpellier I Universite Alkylamino-8 imidazo (1,2-a) pyrazines et derives, leur preparation et leur application en therapeutique
DE19915178A1 (de) 1999-04-03 2000-10-05 Univ Mainz Johannes Gutenberg Hepatitis C Virus Zellkultursystem
DK1296998T3 (da) 2000-05-23 2011-12-12 Univ Washington HCV-varianter
AU2002225895A1 (en) 2000-11-07 2002-05-21 Anadys Pharmaceuticals, Inc. Hepatitis c virus constructs characterized by high efficiency replication
ES2287074T3 (es) 2000-12-22 2007-12-16 Boehringer Ingelheim (Canada) Ltd. Molecula de rna autorreplicante del virus de la hepatitis c.
EP2050822B1 (en) 2001-01-23 2013-07-31 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Hepatitis C virus replicons and replicon enhanced cells
WO2002060492A1 (en) * 2001-01-30 2002-08-08 Cytopia Pty Ltd Methods of inhibiting kinases
JP4799864B2 (ja) 2002-09-23 2011-10-26 シェーリング コーポレイション サイクリン依存性キナーゼインヒビターとしてのイミダゾピラジン
AU2007200401A1 (en) * 2002-09-23 2007-02-22 Schering Corporation Imidazopyrazines as cyclin dependent kinase inhibitors
US7576085B2 (en) * 2002-09-23 2009-08-18 Schering Corporation Imidazopyrazines as cyclin dependent kinase inhibitors
DE602004024658D1 (de) 2003-02-13 2010-01-28 Merck & Co Inc Verfahren zur vermittlung von zellkulturreplikationsaktivität an unterschiedliche hepatitis-c-virus-isolate
AR043002A1 (es) 2003-02-18 2005-07-13 Altana Pharma Ag Imidazopirazinas 6-substituidos
US7186832B2 (en) 2003-02-20 2007-03-06 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
US7157460B2 (en) * 2003-02-20 2007-01-02 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
EP1945216A1 (en) 2005-11-10 2008-07-23 Schering Corporation Methods for inhibiting protein kinases
EP1945644A2 (en) 2005-11-10 2008-07-23 Schering Corporation Imidazopyrazines as protein kinase inhibitors
WO2008030795A2 (en) 2006-09-05 2008-03-13 Boards Of Regents, The University Of Texas System Compositions and methods for inhibition of tyrosine kinases
US8268809B2 (en) * 2006-09-05 2012-09-18 Emory University Kinase inhibitors for preventing or treating pathogen infection and method of use thereof
PE20080931A1 (es) 2006-11-08 2008-07-19 Schering Corp Imidazopirazinas como inhibidores de proteina quinasa
WO2008059373A1 (en) 2006-11-17 2008-05-22 Raqualia Pharma Inc. Imidazo [1, 2-a] pyrazine derivatives and their use as acid pump antagonists
US8243049B2 (en) 2006-12-20 2012-08-14 3M Innovative Properties Company Untethered stylus employing low current power converter
GB0716292D0 (en) * 2007-08-21 2007-09-26 Biofocus Dpi Ltd Imidazopyrazine compounds

Also Published As

Publication number Publication date
DK2193131T3 (da) 2013-04-22
WO2009024585A2 (en) 2009-02-26
NZ584108A (en) 2012-06-29
EP2193131B1 (en) 2013-01-30
BRPI0815717A2 (pt) 2015-02-10
MX2010001733A (es) 2010-07-06
ES2404415T3 (es) 2013-05-27
EP2567960A3 (en) 2013-06-05
ZA201002009B (en) 2010-12-29
US8362018B2 (en) 2013-01-29
GB0716292D0 (en) 2007-09-26
HRP20130202T1 (hr) 2013-04-30
EP2193131A2 (en) 2010-06-09
HK1143810A1 (en) 2011-01-14
WO2009024585A3 (en) 2009-08-06
KR20100081294A (ko) 2010-07-14
PT2193131E (pt) 2013-04-04
US20110166147A1 (en) 2011-07-07
PL2193131T3 (pl) 2013-07-31
AU2008290531A1 (en) 2009-02-26
CN101835780A (zh) 2010-09-15
CA2707521A1 (en) 2009-02-26
SI2193131T1 (sl) 2013-06-28
EP2567960A2 (en) 2013-03-13
JP2010536825A (ja) 2010-12-02
CY1113872T1 (el) 2016-07-27

Similar Documents

Publication Publication Date Title
EP2193131B1 (en) Imidazo[1,2-a]pyrazine compounds for treatment of viral infections such as hepatitis
JP7675777B2 (ja) 免疫調節剤としての複素環式化合物
TWI399380B (zh) 抗病毒化合物
EP3558989B1 (en) Triazolo[1,5-a]pyridine derivatives as immunomodulators
JP7303108B2 (ja) 免疫調節剤としての二環式複素芳香環化合物
CN109641854B (zh) 整合应激通路的调节剂
ES2694829T3 (es) Derivados de benzotriazol trisustituido como inhibidores de dihidroorotato oxigenasa
CA2990145A1 (en) Brk inhibitory compound
WO2011162835A1 (en) Imidazo[1,2-b][1,2,4]triazines as c-met inhibitors
KR20150033645A (ko) 호흡기 합포체 바이러스의 항바이러스제로서의 벤즈이미다졸로 치환된 1,3-디하이드로-2h-벤즈이미다졸-2-온 유도체
EP4006034A1 (en) Condensed imidazole derivatives substituted by tertiary hydroxy groups as pi3k-gamma inhibitors
KR20140059164A (ko) 트라이사이클릭 자이라제 억제제
TW201036612A (en) Antiviral compounds
KR102711244B1 (ko) 할로-알릴아민 화합물 및 그의 용도
KR20110105792A (ko) 페닐피리미돈을 함유하는 화합물, 그 약물 조성물 및 그 제조방법과 용도
EP4320100A1 (en) Deuterated dhodh inhibitors
WO2020076951A1 (en) Pyrimidine and pyrazine hdac1,2 inhibitors
CN103435562B (zh) 6-取代苯并二氮卓-2,4-二酮类化合物及其用途
US20180305364A1 (en) Prodrugs of imidazotriazine compounds as ck2 inhibitors
HK1143810B (en) Imidazo [1,2-a] pyrazine compounds for treatment of viral infections such as hepatitis
HK40075013A (en) Condensed imidazole derivatives substituted by tertiary hydroxy groups as pi3k-gamma inhibitors
BR112020018094A2 (pt) Compostos de aminopirazina diol como inibidores de pi3k-¿
HK40014225A (en) Triazolo[1,5-a]pyridine derivatives as immunomodulators
HK40014225B (en) Triazolo[1,5-a]pyridine derivatives as immunomodulators
HK1189576A (en) Viral polymerase inhibitors

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130918

Termination date: 20140820

EXPY Termination of patent right or utility model