CN101822630A - Nostoc sphaeroids kutz extractive and application thereof in cosmetics - Google Patents
Nostoc sphaeroids kutz extractive and application thereof in cosmetics Download PDFInfo
- Publication number
- CN101822630A CN101822630A CN 201010131328 CN201010131328A CN101822630A CN 101822630 A CN101822630 A CN 101822630A CN 201010131328 CN201010131328 CN 201010131328 CN 201010131328 A CN201010131328 A CN 201010131328A CN 101822630 A CN101822630 A CN 101822630A
- Authority
- CN
- China
- Prior art keywords
- nostoc
- cosmetics
- sphaeroids kutz
- nostoc sphaeroids
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention relates to a nostoc sphaeroids kutz extractive and application thereof in cosmetics. The preparation method of the extractive comprises the following steps of: sieving pulverized dry bodies of nostoc sphaeroids kutz, adding water in advance for swelling for several hours, or directly using fresh nostoc sphaeroids kutz, adding water for boiling and extracting several times, and then filtering and collecting filtrates; concentrating the filtrates under reduced pressure, and purely settling and centrifuging the filtrates to obtain sediments; and then drying the sediments into the nostoc sphaeroids kutz extractive. The nostoc sphaeroids kutz extractive provided in the invention has the functions of water retention and skin beautification and can play the effect of moisturizing skin after added in the cosmetics.
Description
Technical field
The present invention relates to a kind of plant extract, specifically relate to the extract of Nostoc.The invention still further relates to the purposes of this extract.
Background technology
Nostoc (Nostoc sphaeroids Kutz), it is the wild algae of a kind of fresh water, it is a kind of many cells filamentous cyanobacteria, belong to Cyanophyta (Cyanophyta), Cyanophyceae (Cyanophyceae) together with Nostoc commune (Nostoc commune), deliver vegetables (Nostoc flagelliforme), section is grown Cutleriales (Hormogonales), nostocaceae (Nostocaceae) plant, formal name used at school is for intending ball beads algae (kind), and whole plant is used as medicine.Another name ground also claims beauty's rice, day rosetangle, " water Auricularia " or " field Auricularia ".The green grain circle of its color, exquisitely carved, profile is quite like Margarita, so have another name called Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis).The very thin algal filament of the not branched diameter number that this algae is linked to be by elliptical erythrocyte micron is entwined.All algal filaments all are embedded in the colloid that thick close poly-polysaccharide forms, and form spherical colony not of uniform size.In natural environment, Nostoc is common on the small stream stone of river or in the rice terrace, is blackish green spherical, and it is extremely tight to growing environment and conditional request, and worldwide distributed pole is narrow.
Nostoc mainly contains (1) protein and fatty acid: contain 18 seed amino acids, in eight seed amino acids of needed by human, it contains up to seven kinds, especially the content of lysine and threonine is higher, and kind is more complete, and is rational in infrastructure, meet the mode standard that the FAO/WHO Committee of Experts was recommended in 1973 fully, the dry gross protein is up to about 56%, and it is again a kind of low-fat content food simultaneously, and crude fat content only is 8.11%, based on middle carbochain, contain unsaturated fatty acid, reduce the synthetic of cholesterol, to prevent and treat cardiovascular disease, studies show that, lauric acid in the medium-chain fatty acid, tridecanoic acid, myristic acids etc. all have active anticancer in various degree, and to blood pressure lowering, blood fat reducing content has special effect, simultaneously, also can be used as overweight people and glycosuria patient's meals,, prevent constipation to help digestion.
(2) vitamin: Nostoc is rich in multivitamin, carotenoid and phycobilin, and contain chlorophyll 30.98mg/g, and ascorbic acid, Vitamin C content is high, higher more than 5 times than Fructus Crataegi, higher 15 times than mandarin orange, containing abundant vitamin B group is big characteristics of Nostoc, and vitamin B1, B2 are higher than general Homonemeae, the vitamin E that it is abundant makes Nostoc have aging resistance, antioxidation and anticancer function.Vitamin A content is high especially, and every hectogram contains 387 ius, finds for a long time that in history Nostoc is evident in efficacy to ophthalmics such as nyctalopia, conjunctival congestion swelling, and reason promptly is this.
(3) trace element: Nostoc contains the important element of needed by human such as calcium, potassium, ferrum, zinc, strontium, and its calcium content is higher than general plant, is a kind of fabulous natural rich calcium nutraceutical.
(4) polysaccharide: the Nostoc polyoses content is abundant, and up to 20%, the poly-polysaccharose substance that it is abundant by rare in the plant kingdom, ranks first in the plant of reporting at present.Modern science proves, vegetable polysaccharides is the biomacromolecule that a class has different physiological roles such as defying age, antitumor, blood sugar lowering, anticoagulation and enhancing immunity, its cancer suppressing action especially is subjected to showing great attention to of medical science and food educational circles, and the cancer mechanism that presses down of vegetable polysaccharides is exactly to come from immunocompetence and the antioxidant activity that it improves body usually.
Nostoc has a large amount of historical data to be card as dish and Chinese medicine: beam is gone into " Mingyi Bielu " for the TAO Hong-Jing work, thereafter Compendium of Material Medica, " property of medicine is examined ", " national Chinese herbal medicine compilation " etc., the effect of summing up Nostoc is: QI invigorating makes eye bright, made us son, analgesic relieving inflammation or internal heat, sharp the intestines and stomach, phlegm-fire can be treated, for a long time clothes are prolonged life, and allaying tiredness, restrain, control nyctalopia.The yellow front yard of Song dynasty mountain valley Taoist heavily fortified point writes in " green dish money " poem, is described as delicacy from mountain; Ming Dynasty Wang Xin enrolls " wild herbs spectrum ", back income " agricultural administration book "; The record of Qing Dynasty supplementary Amplifications of the Compendium of Materia Medica that ZHAO Xue-Min is write: " Nostoc is given birth in the Yan Xishan cave, the province of the Yuan Dynasty on the stone, meets heavy rain and washes the cave mouth open; this rice goes out with stream, and natives pull out, when just getting such as little bright Auricularia; be purple green, mixes it with vinegar, and delicious and crisp is edible; the time think thick soup; emerald green lovely just like blue or green spiral shell, the extremely sweet aquatic foods of distinguish the flavor of; sliding crisp and refreshing mouth are gone into vegetables and are advisable; With water logging it, with meat with boiling, make the Auricularia flavor." " Hefeng was the state originally " record: " and Nostoc, produce apart from Zhoucheng (Hefeng was the state originally) over one hundred in, in the paddy field, all living everywhere outside the Pass the big rock.”
Nostoc is as cuisines during the feast, and its color is dark green lovely, its pure and fresh sweet aquatic foods of distinguishing the flavor of, and vegetal pole horn of plenty not only, but also have the more efficient food therapy value, the Nostoc nature and flavor are sweet, light, cold, and the clearing away heat to improve acuity of vision effect is arranged, and can control conjunctival congestion redness, nyctalopia, scald.According to " property of medicine is examined ": " (Nostoc) is clear refreshing analgesic, and phlegm-fire can be treated, and of a specified duration obey prolong life." " national Chinese herbal medicine compilation " record: Nostoc is cold in nature, lightly seasoned, can heat clearing away, convergence, QI invigorating, make eye bright and can treat nyctalopia, proctoptosis and external and can treat diseases such as burn, scald.
Edible and the medicinal use of Nostoc is with a long history, but it does not cause people's attention in the application in beauty and skin care field, especially Nostoc is extracted and is applied in the preparation cosmetic field, and not seeing has any relevant bibliographical information.
A kind of method of extracting polysaccharide from Nostoc is disclosed among the CN200410012922.0. specifically be that fresh Nostoc is ground, the distilled water that adds 8-12 times of weight, fully stir evenly, extracting 20～30min under 1～1.4 pound of pressure in high-pressure sterilizing pot, the centrifugal 5-10min of 12000～15000g, collect supernatant, the freezing in advance dehydrated alcohol to 0～4 ℃ that in supernatant, adds 8～10 times of volumes, leave standstill 10～20min, a large amount of white flocky precipitates will occur separates out, this is the Nostoc polysaccharide, and the centrifugal 5～10min of 12000～15000g collects polysaccharide.
Summary of the invention
The technical problem to be solved in the present invention is to utilize modern technology to prepare nostoc sphaeroids kutz extractive, and be functional component with the nostoc sphaeroids kutz extractive, the cosmetics that preparation has the moisturizing function of preserving moisture for a long time.
Nostoc sphaeroids kutz extractive of the present invention, obtain through following method: get the dried frond of Nostoc, sieve after crushed, add water-soluble bloated a few hours in advance, or directly with the bright Nostoc of tasting with discrimination, adding water boil again extracts for several times, filter and collect filtrate, filtrate concentrates and precipitate with ethanol through concentrating under reduced pressure, the centrifugal precipitate that obtains, the precipitate drying becomes nostoc sphaeroids kutz extractive.
Increase the decolouring step after the above-mentioned in case of necessity collection filtrate step, make the extract decolouring.
As required that the nostoc sphaeroids kutz extractive dry product is soluble in water during use, be configured to certain density Nostoc extracting solution for using.
The present invention also provides a kind of cosmetics, it is characterized in that containing above-mentioned nostoc sphaeroids kutz extractive.
The present invention also provides above-mentioned nostoc sphaeroids kutz extractive to have purposes in the cosmetics of the moisturizing function of preserving moisture in preparation.
With this extract is main functional component, can be made into cosmetics such as facial milk cleanser, cosmetic water, essence, facial film, day cream, late frost, eye cream.
According to embodiments of the invention, cosmetics composition with above-mentioned nostoc sphaeroids kutz extractive preparation is by mass percentage: active component nostoc sphaeroids kutz extractive 0.1～50%, softening agent 0.1～30%, wetting agent 0.1～20%, emulsifying agent 0.1～15%, thickening agent 0.01～10%, stabilizing agent 0.01～5%, essence 0.01～5%, antiseptic 0.1～5%, surplus is a water.
Whether each composition can be included in respectively in the above-mentioned composition classification in the cosmetics of following mask body, and for example, essence 0.30% belongs to above-mentioned spice 0.01-5%.
The preserve moisture composition of facial milk cleanser of described Nostoc is by mass percentage:; The composition of described facial milk cleanser is by mass percentage: active component: nostoc sphaeroids kutz extractive 17.85%; Softening agent: isopropyl palmitate 1.70%, GTCC3.38%; Wetting agent: glycerol 7.10%, 1,3 butylene glycol 3.40%; Emulsifying agent: Arlacel-60 1.70%, Montanov680.20%, Tween-60 2.55%; Thickening agent: octadecanol 1.70%, hexadecanol 2.55%, Acritamer 940 0.05%; Surfactant: sodium N-lauroyl sarcosinate 3.40%; Stabilizing agent: EDTA-Na20.08%; Nertralizer: TEA 0.05%, antiseptic: extremely beautiful II 0.30%; Essence 0.30%, surplus are deionized waters.
The preserve moisture composition of cosmetic water of described Nostoc is by mass percentage: active component: nostoc sphaeroids kutz extractive 12.36%; Wetting agent: glycerol 4.26%, 1,3 butylene glycol 1.70%; Thickening agent: sodium polyacrylate 0.26%; Stabilizing agent: EDTA-Na20.04%; Antiseptic: Geogard Ultra 0.85%, solubilizing agent: HCO-400.024%; Essence 0.05%, surplus are deionized waters.
The preserve moisture composition of essence of described Nostoc is by mass percentage: active component: nostoc sphaeroids kutz extractive 38.67%, allantoin 0.10%; Softening agent: dimethicone 0.68%, squalane 6.5%, vitamin E 0.68%; Wetting agent: glycerol 6.85%, 1,3 butylene glycol 4.56%; Emulsifying agent: Montanov 682.05%, S-1652.05%; Thickening agent: HANSHENGJIAO 0.27%; Stabilizing agent: TT 0.05%, EDTA-Na20.04%; Antiseptic: Geogard Ultra 1.14%; Essence: 0.10%, surplus is a deionized water.
The composition of described Nostoc moisture saver mask is by mass percentage: active component: nostoc sphaeroids kutz extractive 14.32%; Softening agent: vaseline 0.67%, dimethicone 2.02%, squalane 2.33%, NPGC-20.84%, elastic silica gel 0.17%; Wetting agent: 1,3 butylene glycol 1.68%, glycerol 12.76%; Emulsifying agent: Arlacel-60 0.84%, Tween-60 1.26%, thickening agent: hexadecanol 1.68%, Acritamer 940 0.43%, nertralizer: TEA 0.43%; Antiseptic: extremely beautiful II 0.30%; Essence 0.10%, surplus are deionized waters.
The preserve moisture composition of day cream of described Nostoc is by mass percentage: active component: nostoc sphaeroids kutz extractive 22.67%, allantoin 0.10%; Softening agent: squalane 2.27%, dimethicone 1.13%, Vitamin E acetate 0.23%, GTCC4.53%, Semen Myristicae isopropyl ester 2.27% American Avocado Tree oil 4.53%, Jojoba oil 2.27%; Wetting agent: 1,3 butylene glycol 3.40%, EG-73.40%; Emulsifying agent: Arlacel-60 2.27%, Tween-60 3.40%; Thickening agent: octadecanol 5.67%, NS1.13%; Stabilizing agent: EDTA-Na20.06%, antiseptic: extremely beautiful II 0.30%, essence 0.10%, surplus is a deionized water.
The preserve moisture composition of late frost of described Nostoc is by mass percentage: active component: nostoc sphaeroids kutz extractive 22.97%, allantoin 0.10%; Softening agent: dimethicone 2.00%, squalane 5.75%, Vitamin E acetate 0.50%, GTCC5.00%, Semen Myristicae isopropyl ester 8.00%; Wetting agent: 1,3 butylene glycol 5.00%, EG-72.50%; Emulsifying agent: Olivem10003.00%, Oliwax LC 1.00%; Thickening agent: octadecanol 3.00%, HANSHENGJIAO 0.05%; Stabilizing agent: EDTA-Na20.10%, essence 0.10%, antiseptic: extremely beautiful II 0.3%, surplus is a deionized water.
The preserve moisture composition of eye cream of described Nostoc is by mass percentage: active component: nostoc sphaeroids kutz extractive 24.5%, allantoin 0.10%; Softening agent: dimethicone 1%, squalane 3.65%, vaseline 1%, NPGC 1%, elastic silica gel 0.5%; Wetting agent: glycerol 4%, 1,3 butylene glycol 4%; Emulsifying agent: SS1-023%, SS 2%; Thickening agent: hexadecanol 1%, HANSHENGJIAO 0.1%; Stabilizing agent: TT 0.05%, EDTA-Na20.1%; Antiseptic: GermallII0.3%; Essence 0.1%, surplus are deionized waters.
The experiment proved that nostoc sphaeroids kutz extractive provided by the invention has water retaining function, it is added in the cosmetics, can play effect to skin moisture-keeping, beauty treatment.
The specific embodiment
Provide the specific embodiment of the present invention below, but do not mean that limitation of the present invention.
The preparation of embodiment 1 nostoc sphaeroids kutz extractive of the present invention
The dried frond of Nostoc takes by weighing algae powder 20g through pulverizing 60 mesh sieves, expands after 4 hours with 300ml is water-soluble, adds water 1000ml again, places the flask boiling reflux to extract one hour, leaves standstill hypsokinesis and goes out supernatant.Extraction for the second time adds water 500ml, boils 30 minutes.Merge extracted twice liquid and amount to 1500ml, add the 3g decoloration active carbon, 80 ℃ are stirred decolouring 30 minutes, sucking filtration is removed active carbon, gets destaining solution 1350ml, with destaining solution rotary evaporation under 80 ℃ condition, be concentrated into 340ml, cool overnight adds 95% the about 700ml of ethanol while stirring in the concentrated solution, to the alcoholic strength of solution be 74%, white flocculent deposit can appear, the centrifugal supernatant of abandoning, precipitate get nostoc sphaeroids kutz extractive dry product 5.6g 60 ℃ of oven dry.
With the nostoc sphaeroids kutz extractive dry product, add suitable quantity of water, obtain the Nostoc extracting solution, for preparing used for cosmetic with the moisturizing function of preserving moisture.
The embodiment 2 Nostoc facial milk cleanser of preserving moisture
It is as follows to fill a prescription:
A phase: emulsifying agent: Arlacel-60 1.70%, Montanov680.20%; Thickening agent: octadecanol 1.70%, hexadecanol 2.55%; Softening agent: isopropyl palmitate 1.70%, GTCC 3.38%.
B phase: thickening agent: Acritamer 940 0.05%; Wetting agent: glycerol 7.10%, 1,3 butylene glycol 3.40%, emulsifying agent: Tween-60 2.55%; Surfactant: sodium N-lauroyl sarcosinate 3.40%, stabilizing agent: EDTA-Na20.08%; Active component: nostoc sphaeroids kutz extractive 17.85%; Nertralizer: TEA 0.05%.Deionized water 53.69%,
C phase: antiseptic: extremely beautiful II 0.30%.
D phase: essence 0.30%.
Preparation technology is as follows:
Step 1: with A mutually each component add container A, heating is stirred to whole dissolvings, control temperature to 80 ℃.
Step 2: the B phase component is added container B, and heating is stirred to whole dissolvings, control temperature to 80 ℃.
Step 3: while hot quick homogenizing in step 1 solution adding step 2 solution was stirred 2-3 minute, make into Emulsion.
Step 4: reduce to 40 ℃ when the Emulsion temperature, add C phase and D phase component respectively, stir.
Step 5: naturally cool to room temperature.
Step 6: dress flexible pipe.
The embodiment 3 Nostoc cosmetic water of preserving moisture
It is as follows to fill a prescription:
A phase: wetting agent: glycerol 4.26%, 1,3 butylene glycol 1.70%; Thickening agent: sodium polyacrylate 0.26%; Stabilizing agent: EDTA-Na20.04%; Active component: nostoc sphaeroids kutz extractive 12.36%; Deionized water 80.46%.
B phase: antiseptic: Geogard Ultra 0.85%.
C phase: solubilizing agent: HCO-400.024%; Essence 0.05%.
Preparation technology is as follows:
Step 1: get the middle mutually 50g water of A, sodium polyacrylate 0.26g is dissolved in wherein, slight fever stirs, and swelling is complete.
Step 2: other composition outside A dewatered in mutually adds in the sodium polyacrylate solution of step 1, is stirred to dissolving fully.
Step 3: other gets the middle mutually residue 30.1g of A water, and B phase antiseptic Geogard Ultra 0.85g is dissolved in wherein the slight fever stirring and dissolving.
Step 4: the antiseptic solution of step 3 is added in the solution of step 2, stir.
Step 5: merge middle mutually DTH-4080 of C and HCO-40, stir, get the middle mutually 1kg water dilution of A, mix homogeneously.In the adding system, stir.
Step 6: bottling
The embodiment 4 Nostoc essence of preserving moisture
It is as follows to fill a prescription:
A phase: emulsifying agent: Montanov 682.05%; Softening agent: dimethicone 0.68%, squalane 6.5%, vitamin E 0.68%; Stabilizing agent: TT 0.05%.
B phase: wetting agent: glycerol 6.85%, 1,3 butylene glycol 4.56%; Thickening agent: HANSHENGJIAO 0.27%; Stabilizing agent: EDTA-Na20.04%; Emulsifying agent: S-1652.05%; Active component: nostoc sphaeroids kutz extractive 38.67%, allantoin 0.10%; Deionized water 36.26%.
C phase: antiseptic: Geogard Ultra 1.14%.
D phase: essence: DHT-40800.10%.
Preparation technology is as follows:
Step 1: impregnating fluid: get C and be dissolved in mutually in the B phase water, the slight fever stirring and dissolving is (speed is slow slightly) evenly.Standby
Step 2: with A mutually each component add in container A, heating is stirred to whole dissolvings, control temperature to 75 ℃.
Step 3: each component that dewaters the impregnating fluid of step 1 and B outer mutually adds in container B, and heating is stirred to whole dissolvings, control temperature to 75 ℃.
Step 4: under constantly stirring, the solution with step 2 slowly adds in the mixed liquor of step 3 while hot, and homogenizing stirred 2-3 minute fast, made into emulsion.
Step 5: add D phase essence, stir.
Step 6: naturally cool to room temperature.
Step 7: bottling.
Embodiment 5 Nostoc moisture saver mask
It is as follows to fill a prescription:
A phase: emulsifying agent: Arlacel-60 0.84%; Thickening agent: hexadecanol 1.68%; Softening agent: vaseline 0.67%, dimethicone 2.02%, squalane 2.33%, NPGC-20.84%, elastic silica gel 0.17%.
B phase: emulsifying agent: Tween-60 1.26%; Wetting agent: 1,3 butylene glycol 1.68%, glycerol 12.76%; Thickening agent: Acritamer 940 0.43%; Active component: nostoc sphaeroids kutz extractive 14.32%; Nertralizer: TEA 0.43%; Deionized water 60.10%.
C phase: antiseptic: extremely beautiful II 0.30%; Essence 0.10%.
Preparation technology is as follows:
Step 1: each component of A phase is added container A successively, be heated to 75 ℃, stir
Step 2: each component of B phase is added container B successively, be heated to 75 ℃, stir
Step 3: while hot the solution of step 1 is poured in the solution of step 2,5000rpm homogenizing 3 minutes,
Step 4: when temperature is reduced to 40 ℃, add the C phase, stir
Step 5: naturally cool to room temperature.
Step 6: dress flexible pipe.
The embodiment 6 Nostoc day cream of preserving moisture
It is as follows to fill a prescription:
A phase: emulsifying agent: Arlacel-60 2.27%; Thickening agent: octadecanol 5.67%; Softening agent: squalane 2.27%,, dimethicone 1.13%, Vitamin E acetate 0.23%, GTCC 4.53%, Semen Myristicae isopropyl ester 2.27%, American Avocado Tree oil 4.53%, Jojoba oil 2.27%.
B phase: wetting agent: 1,3 butylene glycol 3.40%, EG-73.40%; Emulsifying agent: Tween-60 3.40%; Stabilizing agent: EDTA-Na20.06%; Active component: nostoc sphaeroids kutz extractive 22.67%, allantoin 0.10%; Deionized water 39.41%.
C phase: thickening agent: NS 1.13%, antiseptic: extremely beautiful II 0.30%, essence 0.10%.
D phase: thickening agent: S-3050.86%.
Preparation technology is as follows:
Step 1: with A mutually each component add container A, heating is stirred to whole dissolvings, control temperature to 80 ℃.
Step 2: with B mutually each component add container B, heating is stirred to whole dissolvings, control temperature to 80 ℃.
Step 3: will stir fast in C phase component adding step 1 solution while hot;
Step 4: while hot step 2 solution is added in the mixed liquor of step 3, homogenizer 6500rpm stirs 1min.
Step 5: slowly cool to 40 ℃, add the C phase, stir 10min with 100rpm and mix.
Step 6: naturally cool to room temperature.
Step 7: add the D phase, mix.
Step 8: bottling.
The embodiment 7 Nostoc late frost of preserving moisture
It is as follows to fill a prescription:
A phase: emulsifying agent: Olivem10003.00%, Oliwax LC 1.00%, thickening agent: octadecanol 3.00%, softening agent: dimethicone 2.00%, squalane 5.75%, Vitamin E acetate 0.50%, GTCC 5.00%, Semen Myristicae isopropyl ester 8.00%.
B phase: wetting agent: 1,3 butylene glycol 5.00%, EG-72.50%, stabilizing agent: EDTA-Na20.10%, thickening agent: HANSHENGJIAO 0.05%, active component: nostoc sphaeroids kutz extractive 22.97%, allantoin 0.10%; Deionized water 38.30%.
C phase: essence 0.10%; Antiseptic: extremely beautiful II 0.3%.
Preparation technology is as follows:
Step 1: with A mutually each component add container A, heating is stirred to whole dissolvings, control temperature to 80 ℃.
Step 2: with B mutually each component add container B, heating is stirred to whole dissolvings, control temperature to 80 ℃.
Step 3: the solution with step 1 adds in the solution of step 2 while hot, homogenizing 2-3 minute fast, makes into Emulsion.
Step 4: Emulsion stirs and is cooled to 40 ℃, adds the C phase, mixes.
Step 5: naturally cool to room temperature.
Step 7: bottling.
The embodiment 8 Nostoc eye cream of preserving moisture
It is as follows to fill a prescription:
A phase: emulsifying agent: SSE-023%, SS 2%; Thickening agent: hexadecanol 1%; Softening agent: dimethicone 1%, squalane 3.65%, vaseline 1%, NPGC 1%, elastic silica gel 0.5%; Stabilizing agent: TT 0.05%.
B phase: stabilizing agent: EDTA-Na20.1%; Thickening agent: HANSHENGJIAO 0.1%; Wetting agent: glycerol 4%, 1,3 butylene glycol 4%; Active component: nostoc sphaeroids kutz extractive 24.5%, allantoin 0.10%; Deionized water 54.65%.
C phase: antiseptic: GermallII 0.3%, essence 0.1%.
Preparation technology is as follows:
Step 1: each component of A phase is added container A successively, be heated to 75 ℃, stir
Step 2: each component of B phase is added container B successively, be heated to 75 ℃, stir
Step 3: while hot the solution of step 1 is poured in the solution of step 2,5000rpm homogenizing 3 minutes,
Step 4: when temperature is reduced to 40 ℃, add the C phase, mix
Step 5: naturally cool to room temperature.
Step 6: dress flexible pipe.
The test of embodiment 9 Nostoc moisture saver mask moisture-keeping functions
One, test objective
Measure the moisture-keeping efficacy of testing product by the moisture of skin that different time points is tried the position.
Two, material and method
1. experimenter: healthy women experimenter 30 people, 22～45 years old age, 35.27 ± 7.12 years old mean age.Inclusion criteria: (1) healthy women, 18-45 year, middle dry skin;
(2) this research of voluntary participation, and observe test requirements document;
(3) experimenter has finished Informed Consent Form.
Exclusion standard: (1) is known to some cosmetics, skin care item and other external preparation allergy;
(2) accepted the Hormone Replacement Therapy person;
(3) take medicines such as heavy dose of VitC, beta-carotene, retinoic acid, hormone in nearly January;
Medicines such as nearly external in January hormone, retinoic acid, fruit acid, salicylic acid;
(4) accepted to influence the beauty curing person of test zone;
(5) suffer from some disease, as eczema, skin allergy, physical handicap etc., judgement will influence result of the test according to researcher;
(6) age of sucking or gravid woman;
(7) participate in other clinical researches in the recent period;
(8) any factor that may influence result of the test.
2. instrument and equipment: skin moisture analyzer (Corneometer
) be used for the detection of skin water content.Numerical value is high more, and moisture content of skin is high more.
3. test specimen: press the prepared Nostoc moisture saver mask of embodiment 5
4. method: choose experimenter's forearm and stretch 2 3cm of side * 3cm zone for being tried the position and contrasting the position.The experimenter cleans and is tried position and contrast position, carries out non-wound instrument detecting after sitting quietly 20 minutes.Take by weighing sample 0.03g after the detection and be applied at random and tried the position, and carried out non-wound instrument detecting in back 30 minutes, 1 hour, 2 hours, 4 hours and 6 hours once more in smearing.
5. statistical method: data use SPSS 11.5for windows software kit to add up.Tried the numerical difference between opposite sex between position and the contrast position, tried the opposite sex of numerical difference between between each time point of position and tried the diversity that the position is coated with moisture content of skin Δ behind sample when each position (Δ=point value-each basis, position numerical value) and check with one factor analysis of variance.The horizontal P of the significance of difference＜0.05.
Three, result
1. 30 minutes, 1 hour, 2 hours, 4 hours and 6 hours skin moisture content value see Table 1 after being tried the position basic value and smearing given the test agent.Tried position and contrast position basic value there was no significant difference when not smearing sample.After smearing given the test agent, each time point is tried the position skin moisture content value and is all raise, and comparing with basic value all has significant difference (P＜0.01).Smear behind the sample each time point skin moisture content value and significant difference is all arranged (P＜0.01) with comparing with time point comparing part position.
Table 1 sample and each time point skin moisture content value of contrast position (
)
* show that this is tried between position moisture content of skin and the basic value significant difference to be arranged.▲ show that this is tried between position moisture content of skin and the contrast position moisture content of skin significant difference to be arranged.
2. smear behind the sample 30 minutes with tried position moisture content of skin there was no significant difference in 1 hour and 2 hours, smear behind the sample and to be tried that the position moisture content of skin is higher than 4 hours, 6 hours moisture content of skin in 30 minutes and 1 hour, statistics has significant difference (P＜0.01), 2 hours moisture content of skin are higher than 6 hours after smearing sample, and the two statistics has significant difference (P＜0.01); 4 hours and 6 hours moisture content of skin there was no significant differences.
3. smeared given the test agent 30 minutes, 1 hour, 2 hours, 4 hours and 6 hours, and smeared sample position moisture content of skin Δ value and all be higher than contrast position Δ value (seeing Table 2), statistics all has significant difference (P＜0.01).
Table 2 sample and each time point moisture content of skin Δ value of contrast position (
)
* show that this is tried position moisture content of skin Δ and the variant significance in contrast position
Four, untoward reaction
Smeared behind the given the test agent 30 minutes, 1 hour, 2 hours, 4 hours and skin adverse reactions such as erythema, welt, edema appear in 6 hours no experimenters.
Five, conclusion
1. Nostoc moisture saver mask (091019) is smeared all moistening effect in back 30 minutes, 1 hour, 2 hours, 4 hours and 6 hours.
2. the Nostoc moisture saver mask does not cause in (091019) 6 hour that skin adverse reactions such as erythema, edema, welt appear in the experimenter.
The preserve moisture essence moisture-keeping functions test of embodiment 10 Nostoc
Select healthy women experimenter 30 people, carry out preserve moisture essence moisture-keeping functions test of Nostoc as stated above, test specimen is the essence of preserving moisture according to the Nostoc of embodiment 4 preparations.
One, result of the test
1. 30 minutes, 1 hour, 2 hours, 4 hours and 6 hours skin moisture content value see Table 3 after being tried the position basic value and smearing given the test agent.Tried position and contrast position basic value there was no significant difference when not smearing sample.After smearing given the test agent, each time point is tried the position skin moisture content value and is all raise, and comparing with basic value all has significant difference (P＜0.01).Smear behind the sample each time point skin moisture content value and significant difference is all arranged (P＜0.01) with comparing with time point comparing part position.
Table 3 sample and each time point skin moisture content value of contrast position (
)
* show that this is tried between position moisture content of skin and the basic value significant difference to be arranged.▲ show that this is tried between position moisture content of skin and the contrast position moisture content of skin significant difference to be arranged.
2. smear behind the sample 30 minutes with tried position moisture content of skin there was no significant difference in 1 hour and 2 hours, smear behind the sample and to be tried that the position moisture content of skin is higher than 4 hours, 6 hours moisture content of skin in 30 minutes and 1 hour, statistics has significant difference (P＜0.01), 2 hours moisture content of skin are higher than 6 hours after smearing sample, and the two statistics has significant difference (P＜0.01): 4 hours and 6 hours moisture content of skin there was no significant differences.
3. smeared given the test agent 30 minutes, 1 hour, 2 hours, 4 hours and 6 hours, and smeared sample position moisture content of skin Δ value and all be higher than contrast position Δ value (seeing Table 4), statistics all has significant difference (P＜0.01).
Table 4 sample and each time point moisture content of skin Δ value of contrast position (
)
* show that this is tried position moisture content of skin Δ and the variant significance in contrast position
Two, untoward reaction
Smeared behind the given the test agent 30 minutes, 1 hour, 2 hours, 4 hours and skin adverse reactions such as erythema, welt, edema appear in 6 hours no experimenters.
Three, conclusion
1. the Nostoc essence (091020) of preserving moisture is smeared moistening effect was all arranged in back 30 minutes, 1 hour, 2 hours, 4 hours and 6 hours.
2. the Nostoc essence of preserving moisture does not cause that skin adverse reactions such as erythema, edema, welt appear in the experimenter in (091020) 6 hour.
Claims (10)
1. nostoc sphaeroids kutz extractive, it is characterized in that obtaining: get the dried frond of Nostoc through following method, sieve after crushed, add water-soluble bloated a few hours in advance, or directly with the bright Nostoc of tasting with discrimination, adding water boil extracts for several times, filter and collect filtrate, filtrate concentrates and precipitate with ethanol through concentrating under reduced pressure, the centrifugal precipitate that obtains, the precipitate drying becomes nostoc sphaeroids kutz extractive.
2. nostoc sphaeroids kutz extractive as claimed in claim 1 is characterized in that increasing the decolouring step after the above-mentioned collection filtrate step, makes the extract decolouring.
3. cosmetics is characterized in that containing claim 1 or 2 described nostoc sphaeroids kutz extractives.
4. cosmetics according to claim 3, the composition that it is characterized in that cosmetics is by mass percentage: active component nostoc sphaeroids kutz extractive 0.1～50%, softening agent 0.1～30%, wetting agent 0.1～20%, emulsifying agent 0.1～15%, thickening agent 0.01～10%, stabilizing agent 0.01～5%, spice 0.01～5%, antiseptic 0.1～5%, surplus is a water.
5. cosmetics as claimed in claim 3, it is characterized in that, the composition of described cosmetics is by mass percentage: active component nostoc sphaeroids kutz extractive 0.1～50%, softening agent 0.1～30%, wetting agent 0.1～20%, emulsifying agent 0.1～15%, thickening agent 0.01～10%, stabilizing agent 0.01～5%, spice 0.01～5%, antiseptic 0.1～5%, surplus are deionized waters.
6. cosmetics as claimed in claim 3; it is characterized in that the composition of described facial milk cleanser is by mass percentage: octadecanol 1.70%, hexadecanol 2.55%; Arlacel-60 1.70%; Montanov680.20%, isopropyl palmitate 1.70%, GTCC3.38%; Acritamer 940 0.05%; glycerol 7.10%, 1,3 butylene glycol 3.40%; Tween-60 2.55%; sodium N-lauroyl sarcosinate 3.40%, EDTA-Na20.08%, nostoc sphaeroids kutz extractive 17.85%; TEA 0.05%; extremely beautiful II0.30%, essence 0.30%, surplus is a deionized water.
7. cosmetics as claimed in claim 3, it is characterized in that the composition of described cosmetic water is by mass percentage: glycerol 4.26%, sodium polyacrylate 0.26%, 1,3-butanediol 1.70%, EDTA-Na20.04%, nostoc sphaeroids kutz extractive 12.36%, Geogard Ultra 0.85%, HCO-400.024%, essence 0.05%, surplus is a deionized water.
8. cosmetics as claimed in claim 3, it is characterized in that described cosmetics are essence, its composition is by mass percentage: dimethicone 0.68%, squalane 6.5%, Montanov 682.05%, and TT 0.05%, vitamin E 0.68%, glycerol 6.85%, 1,3 butylene glycol 4.56%, HANSHENGJIAO 0.27%, EDTA-Na20.04%, S-1652.05%, nostoc sphaeroids kutz extractive 38.67%, allantoin 0.10%, Geogard Ultra 1.14%, DHT-4080 0.10%, and surplus is a deionized water.
9. cosmetics as claimed in claim 3, it is characterized in that described cosmetics are facial film, its composition is by mass percentage: Arlacel-60 0.84%, hexadecanol 1.68%, vaseline 0.67%, dimethicone 2.02%, squalane 2.33%, NPGC-20.84%, elastic silica gel 0.17%, Tween-60 1.26%, 1,3 butylene glycol 1.68%, glycerol 12.76%, Acritamer 940 0.43%, nostoc sphaeroids kutz extractive 14.32%, TEA 0.43%, extremely beautiful II 0.30%, essence 0.10%, surplus are deionized waters.
10. claim 1 or 2 described nostoc sphaeroids kutz extractives have purposes in the cosmetics of the moisturizing function of preserving moisture in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010131328 CN101822630A (en) | 2010-03-24 | 2010-03-24 | Nostoc sphaeroids kutz extractive and application thereof in cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010131328 CN101822630A (en) | 2010-03-24 | 2010-03-24 | Nostoc sphaeroids kutz extractive and application thereof in cosmetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101822630A true CN101822630A (en) | 2010-09-08 |
Family
ID=42686936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010131328 Pending CN101822630A (en) | 2010-03-24 | 2010-03-24 | Nostoc sphaeroids kutz extractive and application thereof in cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101822630A (en) |
Cited By (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266361A (en) * | 2011-06-29 | 2011-12-07 | 李俊刚 | Burn skin-grafting paste and preparation method thereof |
| CN102302427A (en) * | 2011-09-23 | 2012-01-04 | 常德炎帝生物技术有限公司 | Production and extraction method of nostoc nourishing and moisturizing material |
| CN103479529A (en) * | 2012-06-12 | 2014-01-01 | 苏州元素集化学工业有限公司 | Surfactant composition and uses thereof |
| CN104031865A (en) * | 2014-06-17 | 2014-09-10 | 常德炎帝生物科技有限公司 | Quick efficient nostoc sphaeroides breeding method |
| CN104173271A (en) * | 2014-09-10 | 2014-12-03 | 山西大学 | Nostoc commune Vauch extract and preparation method and application thereof |
| CN104323342A (en) * | 2014-10-30 | 2015-02-04 | 常德炎帝生物科技有限公司 | Nostoc sphaeroides nutrition powder as well as preparation method and application thereof |
| CN104887754A (en) * | 2015-05-07 | 2015-09-09 | 湖州品创孵化器有限公司 | Traditional Chinese medicine composition with light aging resisting effect |
| CN104940079A (en) * | 2015-07-02 | 2015-09-30 | 湖南炎帝生物工程有限公司 | BB cream containing nostoc sphaeroide extract and preparation method thereof |
| CN104958247A (en) * | 2015-06-30 | 2015-10-07 | 湖南炎帝生物工程有限公司 | Body lotion containing Nostoc sphaeroids extract and preparation method thereof |
| CN104958204A (en) * | 2015-06-18 | 2015-10-07 | 湖南炎帝生物工程有限公司 | Liquid shampoo containing common nostoc extracts and preparation method of liquid shampoo |
| CN105147550A (en) * | 2015-09-09 | 2015-12-16 | 湖南炎帝生物工程有限公司 | Whitening and moisture-preserving mask liquid containing common nostoc extract and preparation method thereof |
| CN106265304A (en) * | 2016-08-24 | 2017-01-04 | 刘艺鹏 | Nostoc moisturizing essence |
| CN106309284A (en) * | 2016-09-29 | 2017-01-11 | 常德炎帝生物科技有限公司 | Nostoc makeup cotton, and preparation method and application thereof |
| CN106333888A (en) * | 2016-08-24 | 2017-01-18 | 登封市科创商务咨询有限公司 | Anti-inflammatory facial cleanser with nostoc sphaeroids kutz |
| CN106333917A (en) * | 2016-10-09 | 2017-01-18 | 上海兰葹生物科技有限公司 | Dendrobium nobile skin regeneration promotion combination essence |
| CN106344420A (en) * | 2016-09-29 | 2017-01-25 | 常德炎帝生物科技有限公司 | Multifunctional common nostoc cotton as well as preparation method and application thereof |
| CN106420593A (en) * | 2016-10-06 | 2017-02-22 | 刘艺鹏 | Nostoc sphaeroides anti-inflammation toner |
| CN106432480A (en) * | 2016-09-07 | 2017-02-22 | 常德炎帝生物科技有限公司 | Extraction method of phycobiliprotein of nostoc sphaeroides kutzing |
| CN106539739A (en) * | 2016-09-29 | 2017-03-29 | 常德炎帝生物科技有限公司 | A kind of nostoc cotton facial mask and preparation method and application |
| CN106749507A (en) * | 2016-11-28 | 2017-05-31 | 湖南炎帝生物工程有限公司 | A kind of nostoc method for extracting protein |
| CN107789306A (en) * | 2017-10-31 | 2018-03-13 | 广州赛莱拉干细胞科技股份有限公司 | A kind of Korean ginseng stem cell extract moistens preserving moisture and protecting skin composition and preparation method thereof |
| CN107951832A (en) * | 2017-12-15 | 2018-04-24 | 广州赛莱拉干细胞科技股份有限公司 | A kind of skin care item of the whitening spot-removing of the extract of stem cell containing rhizoma Gastrodiae |
| CN107961176A (en) * | 2016-10-20 | 2018-04-27 | 申扬阳 | Nostoc moisture retention night cream |
| CN109200010A (en) * | 2018-10-30 | 2019-01-15 | 湖南炎帝生物工程有限公司 | A kind of skin composition and its preparation method and application containing nostoc sphaeroids kutz extractive |
| CN110638739A (en) * | 2019-09-26 | 2020-01-03 | 江苏协合转化医学研究院有限公司 | Preparation method and application of blue-green algae extract |
| CN111407679A (en) * | 2019-03-29 | 2020-07-14 | 张帆 | Moisturizing and repairing mask liquid |
| CN112843097A (en) * | 2019-11-12 | 2021-05-28 | 百岳特生物技术（上海）有限公司 | Use of Nostoc sphaeroids kutz juice for reducing fat and beautifying skin |
| CN114224819A (en) * | 2021-12-27 | 2022-03-25 | 湖南炎帝生物工程有限公司 | Nostoc sphaeroids kutz homogenate extracting solution and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1563099A (en) * | 2004-03-27 | 2005-01-12 | 中国科学院水生生物研究所 | Method for extracting Gexianmi amylose from nostoc |
| CN101647759A (en) * | 2009-09-08 | 2010-02-17 | 武汉大学 | Application of nostoc polysaccharide in nutritional humidity-preserving type cosmetic |
-
2010
- 2010-03-24 CN CN 201010131328 patent/CN101822630A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1563099A (en) * | 2004-03-27 | 2005-01-12 | 中国科学院水生生物研究所 | Method for extracting Gexianmi amylose from nostoc |
| CN101647759A (en) * | 2009-09-08 | 2010-02-17 | 武汉大学 | Application of nostoc polysaccharide in nutritional humidity-preserving type cosmetic |
Non-Patent Citations (2)
| Title |
|---|
| 《食品研究与开发》 20071231 田志环等 葛仙米研究现状及其开发前景 第28卷, 第2期 2 * |
| 《食品科学》 20031231 陈德文等 葛仙米的研究现状及应用前景 第24卷, 第11期 2 * |
Cited By (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266361A (en) * | 2011-06-29 | 2011-12-07 | 李俊刚 | Burn skin-grafting paste and preparation method thereof |
| CN102302427A (en) * | 2011-09-23 | 2012-01-04 | 常德炎帝生物技术有限公司 | Production and extraction method of nostoc nourishing and moisturizing material |
| CN103479529A (en) * | 2012-06-12 | 2014-01-01 | 苏州元素集化学工业有限公司 | Surfactant composition and uses thereof |
| CN104031865A (en) * | 2014-06-17 | 2014-09-10 | 常德炎帝生物科技有限公司 | Quick efficient nostoc sphaeroides breeding method |
| CN104173271A (en) * | 2014-09-10 | 2014-12-03 | 山西大学 | Nostoc commune Vauch extract and preparation method and application thereof |
| CN104323342A (en) * | 2014-10-30 | 2015-02-04 | 常德炎帝生物科技有限公司 | Nostoc sphaeroides nutrition powder as well as preparation method and application thereof |
| CN104323342B (en) * | 2014-10-30 | 2016-02-03 | 常德炎帝生物科技有限公司 | A kind of nostoc nutrient powder, preparation method and application |
| CN104887754A (en) * | 2015-05-07 | 2015-09-09 | 湖州品创孵化器有限公司 | Traditional Chinese medicine composition with light aging resisting effect |
| CN104958204A (en) * | 2015-06-18 | 2015-10-07 | 湖南炎帝生物工程有限公司 | Liquid shampoo containing common nostoc extracts and preparation method of liquid shampoo |
| CN104958247A (en) * | 2015-06-30 | 2015-10-07 | 湖南炎帝生物工程有限公司 | Body lotion containing Nostoc sphaeroids extract and preparation method thereof |
| CN104958247B (en) * | 2015-06-30 | 2018-02-09 | 湖南炎帝生物工程有限公司 | A kind of body lotion containing nostoc sphaeroids kutz extractive and preparation method thereof |
| CN104940079A (en) * | 2015-07-02 | 2015-09-30 | 湖南炎帝生物工程有限公司 | BB cream containing nostoc sphaeroide extract and preparation method thereof |
| CN104940079B (en) * | 2015-07-02 | 2018-03-06 | 湖南炎帝生物工程有限公司 | A kind of BB frosts containing nostoc sphaeroids kutz extractive and preparation method thereof |
| CN105147550A (en) * | 2015-09-09 | 2015-12-16 | 湖南炎帝生物工程有限公司 | Whitening and moisture-preserving mask liquid containing common nostoc extract and preparation method thereof |
| CN105147550B (en) * | 2015-09-09 | 2018-01-23 | 湖南炎帝生物工程有限公司 | A kind of whitening moisturizing face masque liquid containing nostoc sphaeroids kutz extractive and preparation method thereof |
| CN106265304A (en) * | 2016-08-24 | 2017-01-04 | 刘艺鹏 | Nostoc moisturizing essence |
| CN106333888A (en) * | 2016-08-24 | 2017-01-18 | 登封市科创商务咨询有限公司 | Anti-inflammatory facial cleanser with nostoc sphaeroids kutz |
| CN106432480A (en) * | 2016-09-07 | 2017-02-22 | 常德炎帝生物科技有限公司 | Extraction method of phycobiliprotein of nostoc sphaeroides kutzing |
| CN106344420B (en) * | 2016-09-29 | 2019-01-29 | 常德炎帝生物科技有限公司 | A kind of nostoc Multifunctional cotton and the preparation method and application thereof |
| CN106539739B (en) * | 2016-09-29 | 2020-01-17 | 常德炎帝生物科技有限公司 | Nostoc sphaeroids kutz cotton mask and preparation method and application thereof |
| CN106539739A (en) * | 2016-09-29 | 2017-03-29 | 常德炎帝生物科技有限公司 | A kind of nostoc cotton facial mask and preparation method and application |
| CN106344420A (en) * | 2016-09-29 | 2017-01-25 | 常德炎帝生物科技有限公司 | Multifunctional common nostoc cotton as well as preparation method and application thereof |
| CN106309284B (en) * | 2016-09-29 | 2019-09-20 | 常德炎帝生物科技有限公司 | A kind of nostoc cotton pads and the preparation method and application thereof |
| CN106309284A (en) * | 2016-09-29 | 2017-01-11 | 常德炎帝生物科技有限公司 | Nostoc makeup cotton, and preparation method and application thereof |
| CN106420593A (en) * | 2016-10-06 | 2017-02-22 | 刘艺鹏 | Nostoc sphaeroides anti-inflammation toner |
| CN106333917A (en) * | 2016-10-09 | 2017-01-18 | 上海兰葹生物科技有限公司 | Dendrobium nobile skin regeneration promotion combination essence |
| CN107961176A (en) * | 2016-10-20 | 2018-04-27 | 申扬阳 | Nostoc moisture retention night cream |
| CN106749507A (en) * | 2016-11-28 | 2017-05-31 | 湖南炎帝生物工程有限公司 | A kind of nostoc method for extracting protein |
| CN107789306A (en) * | 2017-10-31 | 2018-03-13 | 广州赛莱拉干细胞科技股份有限公司 | A kind of Korean ginseng stem cell extract moistens preserving moisture and protecting skin composition and preparation method thereof |
| CN107951832A (en) * | 2017-12-15 | 2018-04-24 | 广州赛莱拉干细胞科技股份有限公司 | A kind of skin care item of the whitening spot-removing of the extract of stem cell containing rhizoma Gastrodiae |
| CN109200010A (en) * | 2018-10-30 | 2019-01-15 | 湖南炎帝生物工程有限公司 | A kind of skin composition and its preparation method and application containing nostoc sphaeroids kutz extractive |
| CN109200010B (en) * | 2018-10-30 | 2021-10-22 | 湖南炎帝生物工程有限公司 | Skin composition containing nostoc sphaeroides extract and preparation method and application thereof |
| CN111407679B (en) * | 2019-03-29 | 2023-06-09 | 张帆 | Moisturizing and repairing mask liquid |
| CN111407679A (en) * | 2019-03-29 | 2020-07-14 | 张帆 | Moisturizing and repairing mask liquid |
| CN110638739A (en) * | 2019-09-26 | 2020-01-03 | 江苏协合转化医学研究院有限公司 | Preparation method and application of blue-green algae extract |
| CN112843097A (en) * | 2019-11-12 | 2021-05-28 | 百岳特生物技术（上海）有限公司 | Use of Nostoc sphaeroids kutz juice for reducing fat and beautifying skin |
| CN114224819B (en) * | 2021-12-27 | 2023-04-25 | 湖南炎帝生物工程有限公司 | Nostoc sphaeroids kutz homogenate extracting solution and preparation method and application thereof |
| CN114224819A (en) * | 2021-12-27 | 2022-03-25 | 湖南炎帝生物工程有限公司 | Nostoc sphaeroids kutz homogenate extracting solution and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101822630A (en) | Nostoc sphaeroids kutz extractive and application thereof in cosmetics | |
| CN104435775B (en) | A kind of Traditional Chinese medicinal health-care wine and preparation method thereof | |
| CN102302427B (en) | Production and extraction method of nostoc nourishing and moisturizing material | |
| CN104434618B (en) | Have whitening, nti-freckle concurrently and print nine grass green frosts of effect and preparation method thereof | |
| CN105902454B (en) | One kind being used for the regenerated Moringa compound Essence of cell repair | |
| CN110237104A (en) | It is suitable for the health-oriented products composition of adult female, old man and sub-health state crowd | |
| CN101708048B (en) | Health-care food and preparation method thereof | |
| CN105125736A (en) | Composition with effects of protecting liver and improving eyesight and preparation method thereof | |
| CN101869287B (en) | Astragalus and honey soft capsule and preparation method thereof | |
| CN105434857A (en) | Health-care finger citron oral solution for soothing liver, removing blood stasis and fading freckles as well as preparation method of oral solution | |
| CN104586700A (en) | Vitex negundo linn leaf extract and preparation method as well as application thereof | |
| KR20130010250A (en) | Composition for skin wrinkle improvement comprising extracts of honeybush extract or its fermentation solution as an active ingredient | |
| KR20110128384A (en) | The composition material and the manufacturing process for skin-wrinkle, moisture and skin-lightening uses by midam-kyungokko | |
| WO2023125797A1 (en) | Traditional chinese medicine composition and preparation method and application thereof | |
| CN107049866B (en) | Antiallergic plant composition and application thereof | |
| CN114886834B (en) | Whitening essence and preparation method thereof | |
| CN109045081A (en) | The extracting method and diuresis of Erythropalum Scandens Blume | |
| CN104473153A (en) | Beautifying mulberry oral liquid and preparation method thereof | |
| CN110141542B (en) | Allergy-relieving agent containing radix pseudostellariae and preparation method thereof | |
| CN106928376A (en) | The separation method of skunk bush polysaccharide and its application | |
| CN103505398B (en) | Forsythia leaf facial mask | |
| CN106728130A (en) | A kind of Chinese medicine composition and preparation method and its usage for preventing and treating chronic fatigue syndrome | |
| CN102846849B (en) | Traditional Chinese medicine composition for resisting ovarian failure and application thereof | |
| CN105616984A (en) | Crinkle-removing beauty cream containing herba leonurus and preparation method thereof | |
| KR20120096628A (en) | Scrub cosmetic composition containing shiitake |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20100908 |