CN109200010A - A kind of skin composition and its preparation method and application containing nostoc sphaeroids kutz extractive - Google Patents
A kind of skin composition and its preparation method and application containing nostoc sphaeroids kutz extractive Download PDFInfo
- Publication number
- CN109200010A CN109200010A CN201811273890.8A CN201811273890A CN109200010A CN 109200010 A CN109200010 A CN 109200010A CN 201811273890 A CN201811273890 A CN 201811273890A CN 109200010 A CN109200010 A CN 109200010A
- Authority
- CN
- China
- Prior art keywords
- parts
- skin
- sphaeroids kutz
- kutz extractive
- nostoc sphaeroids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000192656 Nostoc Species 0.000 title claims abstract description 136
- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- -1 octyl dodecanol lauroyl glutamate ester Chemical class 0.000 claims abstract description 45
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229940071085 lauroyl glutamate Drugs 0.000 claims abstract description 25
- 230000037394 skin elasticity Effects 0.000 claims abstract description 19
- 230000037307 sensitive skin Effects 0.000 claims abstract description 9
- 208000003251 Pruritus Diseases 0.000 claims abstract description 8
- 230000004888 barrier function Effects 0.000 claims abstract description 5
- 239000013589 supplement Substances 0.000 claims abstract description 5
- 230000037380 skin damage Effects 0.000 claims abstract description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 104
- 239000007864 aqueous solution Substances 0.000 claims description 61
- 239000006260 foam Substances 0.000 claims description 61
- 230000001815 facial effect Effects 0.000 claims description 52
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 45
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 40
- 150000001875 compounds Chemical class 0.000 claims description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 36
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 30
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 28
- 238000004140 cleaning Methods 0.000 claims description 21
- 239000000463 material Substances 0.000 claims description 20
- 239000002994 raw material Substances 0.000 claims description 20
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 20
- HVFAVOFILADWEZ-UHFFFAOYSA-M sodium;2-[2-(dodecanoylamino)ethyl-(2-hydroxyethyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCCN(CCO)CC([O-])=O HVFAVOFILADWEZ-UHFFFAOYSA-M 0.000 claims description 19
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims description 17
- 229930186217 Glycolipid Natural products 0.000 claims description 17
- 150000002148 esters Chemical class 0.000 claims description 17
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 17
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 17
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 17
- 235000010234 sodium benzoate Nutrition 0.000 claims description 17
- 239000004299 sodium benzoate Substances 0.000 claims description 17
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 16
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 16
- 229960005323 phenoxyethanol Drugs 0.000 claims description 16
- 239000000284 extract Substances 0.000 claims description 14
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims description 13
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims description 13
- 239000000467 phytic acid Substances 0.000 claims description 13
- 229940068041 phytic acid Drugs 0.000 claims description 13
- 235000002949 phytic acid Nutrition 0.000 claims description 13
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 12
- 235000021355 Stearic acid Nutrition 0.000 claims description 11
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 11
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 11
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 11
- 239000008117 stearic acid Substances 0.000 claims description 11
- 239000000706 filtrate Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 8
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 7
- 241000195493 Cryptophyta Species 0.000 claims description 6
- 239000005639 Lauric acid Substances 0.000 claims description 6
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims description 6
- 235000007164 Oryza sativa Nutrition 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- 235000009566 rice Nutrition 0.000 claims description 5
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 4
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims description 4
- 230000001376 precipitating effect Effects 0.000 claims description 4
- 241000196324 Embryophyta Species 0.000 claims description 3
- 230000006872 improvement Effects 0.000 claims description 3
- LQIAZOCLNBBZQK-UHFFFAOYSA-N 1-(1,2-Diphosphanylethyl)pyrrolidin-2-one Chemical compound PCC(P)N1CCCC1=O LQIAZOCLNBBZQK-UHFFFAOYSA-N 0.000 claims description 2
- 241000219780 Pueraria Species 0.000 claims description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 244000060011 Cocos nucifera Species 0.000 claims 1
- 235000013162 Cocos nucifera Nutrition 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- HLERILKGMXJNBU-UHFFFAOYSA-N norvaline betaine Chemical compound CCCC(C([O-])=O)[N+](C)(C)C HLERILKGMXJNBU-UHFFFAOYSA-N 0.000 claims 1
- FATBGEAMYMYZAF-KTKRTIGZSA-N oleamide Chemical compound CCCCCCCC\C=C/CCCCCCCC(N)=O FATBGEAMYMYZAF-KTKRTIGZSA-N 0.000 claims 1
- FATBGEAMYMYZAF-UHFFFAOYSA-N oleicacidamide-heptaglycolether Natural products CCCCCCCCC=CCCCCCCCC(N)=O FATBGEAMYMYZAF-UHFFFAOYSA-N 0.000 claims 1
- 230000008439 repair process Effects 0.000 abstract description 3
- 230000007803 itching Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 100
- 210000003491 skin Anatomy 0.000 description 79
- 238000010998 test method Methods 0.000 description 27
- 238000003756 stirring Methods 0.000 description 19
- 238000009826 distribution Methods 0.000 description 16
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 14
- 239000000523 sample Substances 0.000 description 13
- 238000006243 chemical reaction Methods 0.000 description 10
- 238000005259 measurement Methods 0.000 description 10
- 230000002146 bilateral effect Effects 0.000 description 8
- 238000007689 inspection Methods 0.000 description 8
- 238000007619 statistical method Methods 0.000 description 8
- 238000001521 two-tailed test Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 6
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000036074 healthy skin Effects 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 241000209094 Oryza Species 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000003712 anti-aging effect Effects 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229930195712 glutamate Natural products 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- KZRXPHCVIMWWDS-AWEZNQCLSA-N (4S)-4-amino-5-dodecanoyloxy-5-oxopentanoic acid Chemical compound CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O KZRXPHCVIMWWDS-AWEZNQCLSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 206010040830 Skin discomfort Diseases 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 241000863032 Trieres Species 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229960001631 carbomer Drugs 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 239000004973 liquid crystal related substance Substances 0.000 description 2
- 230000008447 perception Effects 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 235000002378 plant sterols Nutrition 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000036572 transepidermal water loss Effects 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- 208000002197 Ehlers-Danlos syndrome Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 244000147568 Laurus nobilis Species 0.000 description 1
- 235000017858 Laurus nobilis Nutrition 0.000 description 1
- 235000019082 Osmanthus Nutrition 0.000 description 1
- 241000333181 Osmanthus Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000220287 Sedum rubrotinctum Species 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000012824 chemical production Methods 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 238000007306 functionalization reaction Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000003827 glycol group Chemical group 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Abstract
The invention discloses a kind of skin compositions containing nostoc sphaeroids kutz extractive, including nostoc sphaeroids kutz extractive and phytosterol/octyl dodecanol lauroyl glutamate ester.Composition of the present invention containing nostoc sphaeroids kutz extractive can supplement skin-nourishing, repair skin damage barrier, keep skin moisture content, improve skin elasticity, cheek glossiness is improved, skin is made to seem more thoroughly net vibrant and improve sensitive skin common tight, dry, the problems such as itching, peeling.The invention also provides the preparation methods of the nostoc sphaeroids kutz extractive.
Description
Technical field
The invention belongs to daily necessities fields, are related to a kind of skin composition and preparation method thereof containing nostoc sphaeroids kutz extractive
And application.
Background technique
As living environment is increasingly serious, modern not only only focuses on health, skin care also gradually by
Pay attention to.The effect of bath product in daily skin care also from the cleaning function on basis extend to solarization after nursing, anti-aging, delay
Pressure, combustion rouge and other effects, demand of the people to bath product also more tends to naturalization, functionalization.
Nostoc contains 18 kinds of amino acid, rich in vitamin B and C and minerals as the unique algae of China.Its
Applying for body-care field is more rare in daily skin-protection product, especially in the bath foam for soothing the skin effect not
Seeing has any relevant document report.
Summary of the invention
The technical problem to be solved in the present invention is to how make effective use of the moisturizing and nourishing of nostoc sphaeroids kutz extractive, mild
The function of releiving, make it is a kind of can mild cleaning skin, the problem of alleviating tight skin, dry, rubescent, itch, to mention
For a kind of skin composition and preparation method thereof containing nostoc sphaeroids kutz extractive.
The invention proposes a kind of skin composition containing nostoc sphaeroids kutz extractive, the composition is extracted comprising nostoc
Object, phytosterol/octyl dodecanol lauroyl glutamate ester, weight ratio are (0.8~1.4): (0.6~1.0).
Preferably, nostoc sphaeroids kutz extractive, phytosterol/octyl dodecanol lauroyl glutamate ester weight in the composition
Amount is than being (1.2~1.4): (0.8~1.0).
It is further preferred that nostoc sphaeroids kutz extractive, phytosterol/octyl dodecanol lauroyl glutamate in the composition
The weight ratio of ester is 1.4:1.0.
In the present invention, the composition also includes sugar ester, is specifically included: nostoc sphaeroids kutz extractive, sugar ester, phytosterol/pungent
Base lauryl alcohol lauroyl glutamate ester, weight ratio are (0.8~1.4): (2.5~4): (0.6~1.0).
Preferably, nostoc sphaeroids kutz extractive, sugar ester, phytosterol/octyl dodecanol lauroyl glutamate in the composition
The weight ratio of ester is (1.2~1.4): (3~4): (0.8~1.0).
It is further preferred that nostoc sphaeroids kutz extractive, sugar ester, phytosterol/octyl dodecanol lauroyl in the composition
The weight ratio of glutamate is 1.4:3:1.0.
The invention also provides the skin compositions containing nostoc sphaeroids kutz extractive to supplement skin-nourishing in preparation, repair
Multiple skin damage barrier keeps skin moisture content, improves skin elasticity, improve skin or cheek glossiness, seen skin
Carry out the application in product that is more thoroughly net vibrant and improving sensitive skin.
The product includes shower cream, facial cleanser, skin care item, cosmetics etc..
Wherein, the sensitive skin of the improvement is to soothe the skin tight, flush, fever, itch, furfur.
Wherein, the supplement skin-nourishing refers to can provide a variety of amino acid, vitamin and other nutritional ingredients for skin,
Auxiliary promotes the formation of skin collagen.
In the present invention, the preparation method of the nostoc sphaeroids kutz extractive the following steps are included:
(1) the dry algae of nostoc is taken, is sieved after crushed, is added water-swellable；
(2) compound extractant is heated 85 DEG C~90 DEG C, is added in nostoc of the above-mentioned steps through being swollen, extracts；
Wherein, the compound extractant includes glycerol, phytic acid and water, the mass fraction percentage of the glycerol, phytic acid and water
Than for (20-50%): (1.0-2.0%): (48-78.5%)；It preferably, is 30%:1.5%:68.5%；
(3) filtrate is filtered and collects, filtrate obtains the nostoc sphaeroids kutz extractive by concentration, precipitating, drying.
In a specific embodiment, the nostoc sphaeroids kutz extractive is prepared by the following method:
(1) the dry algae of nostoc is taken, is sieved after crushed, is added water-swellable 2 hours；
(2) aqueous solution that mass fraction is 1.5% is diluted with water to phytic acid；
(3) aqueous solution of glycerol and phytic acid is mixed by 3:7, after being heated to 85 DEG C, puts into the nostoc being swollen, shake
It swings 30 minutes and extracts；
(4) filtrate is filtered and collects, filtrate is by being concentrated under reduced pressure, and alcohol precipitation obtains sediment, and sediment drying obtains.
The present invention provides a kind of bath foams containing nostoc sphaeroids kutz extractive, wherein the bath foam is type bath foam of releiving；
The bath foam includes the raw material (the raw materials used in the present invention is commercially available to buy) of following parts by weight:
0.8~1.4 part of nostoc sphaeroids kutz extractive, 2.5~4 parts of glycolipid, the aqueous solution 15~21 of Cocoamidopropyl betaine
Part, 4~7 parts of the aqueous solution of Sodium Lauroamphoacetate, phytosterol/octyl dodecanol lauroyl glutamate ester 0.6~1.0
Part, 2~3 parts of glycerol, 0.05~0.07 part of citric acid, 3~5 parts of the aqueous solution of three isostearate of PEG-120 methyl, benzene
0.5~0.8 part of compound of oxyethanol and pungent glycol, 0.07~0.10 part of EDETATE SODIUM, 0.2~0.3 part of sodium benzoate, essence
0.5~1.0 part, add water to 100 parts.
Preferably, the bath foam containing nostoc sphaeroids kutz extractive includes the raw material of following parts by weight: nostoc sphaeroids kutz extractive 1.2
~1.4 parts, 3~4 parts of glycolipid, 16~17 parts of Cocoamidopropyl betaine aqueous solution, Sodium Lauroamphoacetate aqueous solution 5
~7 parts, phytosterol/0.8~1.0 part of octyl dodecanol lauroyl glutamate ester, 2~3 parts of glycerol, citric acid 0.05~0.06
Part, 3~5 parts of three isostearic acid aqueous solution of ester of PEG-120 methyl, the compound 0.6~0.8 of Phenoxyethanol and pungent glycol
Part, 0.2~0.25 part of sodium benzoate, 0.07~0.10 part of EDETATE SODIUM, 0.5~0.8 part of essence, solvent is water.
It is further preferred that the raw material nostoc that the bath foam containing nostoc sphaeroids kutz extractive includes following parts by weight extracts
1.4 parts of object, 3 parts of glycolipid, 17 parts of the aqueous solution of Cocoamidopropyl betaine, 6 parts of the aqueous solution of Sodium Lauroamphoacetate,
Phytosterol/1.0 parts of octyl dodecanol lauroyl glutamate ester, 2 parts of glycerol, 0.06 part of citric acid, PEG-120 methyl three
0.6 part of the compound of 4 parts of the aqueous solution of isostearate, Phenoxyethanol and pungent glycol, 0.25 part of sodium benzoate, EDETATE SODIUM
0.1 part, 0.6 part of essence, add water to 100 parts.
In the present invention, in the aqueous solution of the Cocoamidopropyl betaine mass percentage of active matter be 33%~
36%；It preferably, is 35%.Preferably, the Cocoamidopropyl betaine aqueous solution be Guangzhou be bestowed by heaven company production quotient
The name of an article is the raw material of TC-SHD.
In the present invention, the mass percentage of the aqueous solution of the Sodium Lauroamphoacetate is 47%~53%；It is excellent
Selection of land is 50%.Preferably, the Sodium Lauroamphoacetate aqueous solution is that the trade name of Japanese eastern nation chemical production is
The raw material of OBAZOLIN 662N.
Preferably, the glycolipid is that the trade name of German EVONIK production isONE raw material.
Preferably, the phytosterol/octyl dodecanol lauroyl glutamate ester is the trade name of aginomoto company production
ForThe raw material of PS-203.
In the present invention, the mass percentage of the aqueous solution of three isostearate of PEG-120 methyl is 75%.
Preferably, the aqueous solution of three isostearate of PEG-120 methyl is that the trade name of Japan Oil Co's production isThe raw material of MG-120TIS.
In the present invention, the mass ratio of Phenoxyethanol and pungent glycol is in the compound of the Phenoxyethanol and pungent glycol
65:35.Preferably, the compound of the Phenoxyethanol and pungent glycol is Bristol company of BritainPHG raw material.
Preferably, the sodium benzoate is the powdered sodium benzoate raw material of the big Chemical Group in Tianjin east.
Bath foam of the present invention containing nostoc sphaeroids kutz extractive is nourished using it and is protected by the way that nostoc sphaeroids kutz extractive is added
Excellent function that is wet, mildly releiving, cooperation phytosterol/octyl dodecanol lauroyl glutamate ester promote skin to seek nostoc
The absorption formed point and increase skin moisturization.Select glycolipid, Sodium Lauroamphoacetate as detergent simultaneously, mildly
Clean skin.
The present invention also provides the preparation method of the bath foam containing nostoc sphaeroids kutz extractive, this method includes following step
It is rapid:
(1) water is added in reaction kettle, then be separately added into the EDETATE SODIUM accurately weighed by weight, glycolipid is stirred
It mixes, is heated to 85 DEG C, until all components are completely dispersed uniformly；
(2) glycerol, Sodium Lauroamphoacetate aqueous solution, Cocoamidopropyl betaine are successively added in a kettle
Aqueous solution, three isostearic acid aqueous solution of ester of PEG-120 methyl stir 10 minutes, until being completely dissolved；
(3) nostoc sphaeroids kutz extractive is added by weight, stirring is uniform to being completely dispersed；
(4) 45 DEG C are cooled to, by weight addition phytosterol/octyl dodecanol lauroyl glutamate ester, citric acid, benzene
The compound of oxyethanol and pungent glycol, sodium benzoate, essence stir 15 minutes, until being completely dissolved uniformly.
The present invention also provides a kind of facial cleanser containing nostoc sphaeroids kutz extractive, the raw materials including following parts by weight: nostoc
0.8-1.4 parts of extract, phytosterol/0.6-1.0 parts of octyl dodecanol lauroyl glutamate ester, 3-4.5 parts of lauric acid, Pork and beans
7-9 parts of compound of cool 15-18 parts of acid, stearic acid and palmitinic acid, 15-20 parts of glycerol, gather by 10-14 parts of potassium hydroxide aqueous solution
- 4003-5 parts of ethylene glycol, 0.08-0.15 parts of EDETATE SODIUM, 0.3-0.35 parts of methyl hydroxybenzoate, 0.4-0.8 parts of essence；Wherein, institute
The mass fraction for stating potassium hydroxide aqueous solution is 48%, the quality of stearic acid and palmitinic acid in the compound of stearic acid and palmitinic acid
Ratio is 65:35.
In a specific embodiment, the facial cleanser containing nostoc sphaeroids kutz extractive includes the raw material of following parts by weight: Pueraria lobota
1 part of celestial rice extracts, phytosterol/0.8 part of octyl dodecanol lauroyl glutamate ester, 3 parts of lauric acid, 16 parts of myristic acid,
8 parts of compound of stearic acid and palmitinic acid, 10 parts of potassium hydroxide aqueous solution, 20 parts of glycerol, 5 parts of polyethylene glycol-400, EDTA bis-
0.1 part of sodium, 0.3 part of methyl hydroxybenzoate, 0.5 part of essence.
The present invention also provides a kind of compound extractant, the compound extractant includes glycerol, phytic acid and water, described sweet
The mass fraction percentage of oil, phytic acid and water is (20-50%): (1.0-2.0%): (48-78.5%)；Preferably, it is 30%:
1.5%:68.5%.
The present invention also provides the compound extractants to extract the application in nostoc sphaeroids kutz extractive.
Beneficial effects of the present invention: skin composition of the invention contains nostoc sphaeroids kutz extractive, rich in relatively rich
The nutritional ingredients such as sugar, vitamin, amino acid have the function of moisturizing and nourishing, mildly releive, while utilizing phytosterol/octyl
Lauryl alcohol lauroyl glutamate esters promote nostoc sphaeroids kutz extractive active matter like " the plate liquid crystal structure " of lipid between Skin Cell
Absorption and increase skin moisturization on the skin.The bath foam prepared using the composition adds extremely mild cleaning
Agent, can mild cleaning skin, skin discomfort of releiving, the problems such as alleviating the drying of body after taking a shower, rubescent, itch.
Specific embodiment
Embodiments of the present invention are described in further detail below with reference to embodiment.Following embodiment is for illustrating this
Invention, but cannot be used to limit the scope of the invention.Unless otherwise specified, technological means used in embodiment is this field skill
Conventional means known to art personnel, raw materials used is commercial goods.
In following embodiment, the number of used raw material, what non-specific, concrete illustrated, be parts by weight.
The preparation of embodiment 1-7 nostoc sphaeroids kutz extractive
Parameter Conditions used by the preparation process of the nostoc sphaeroids kutz extractive are as shown in the table:
Extraction demand: light color；Effective substance recovery rate wants high
The parameter and result of 1 embodiment 1-7 of table
Wherein, the preparation process of the nostoc sphaeroids kutz extractive specifically includes:
(1) the dry algae of nostoc is taken, is sieved after crushed, is added water-swellable；
(2) compound extractant is heated to 85 DEG C, is added in nostoc of the above-mentioned steps through being swollen, extracts；
Wherein, the compound extractant includes glycerol, phytic acid and water, the mass fraction percentage of the glycerol, phytic acid and water
Than for 30%:1.5%:68.5%；
(3) filtrate is filtered and collects, filtrate obtains the nostoc sphaeroids kutz extractive by concentration, precipitating, drying.
The preparation of releive type bath foam of the embodiment 8 containing nostoc sphaeroids kutz extractive
Type bath foam of releiving containing nostoc sphaeroids kutz extractive includes the raw material of following parts by weight: Ge Xian prepared by embodiment 1
1.4 parts of rice extracts, 3 parts of glycolipid, 17 parts of the aqueous solution of Cocoamidopropyl betaine, Sodium Lauroamphoacetate it is water-soluble
6 parts of liquid, phytosterol/1.0 parts of octyl dodecanol lauroyl glutamate ester, 2 parts of glycerol, 0.06 part of citric acid, PEG-120 methyl
0.6 part of the compound of 4 parts of the aqueous solution of three isostearate of glucose, Phenoxyethanol and pungent glycol, 0.25 part of sodium benzoate, EDTA
0.1 part of disodium, 0.6 part of essence, add water to 100 parts.
The preparation method of the above-mentioned type bath foam of releiving containing nostoc sphaeroids kutz extractive, method includes the following steps:
(1) water is added in reaction kettle, then be separately added into the EDETATE SODIUM accurately weighed by weight, glycolipid is stirred
It mixes, is heated to 85 DEG C, until all components are completely dispersed uniformly；
(2) glycerol, Sodium Lauroamphoacetate aqueous solution, Cocoamidopropyl betaine are successively added in a kettle
Aqueous solution, three isostearic acid aqueous solution of ester of PEG-120 methyl stir 10 minutes, until being completely dissolved；
(3) nostoc sphaeroids kutz extractive is added by weight, stirring is uniform to being completely dispersed；
(4) 45 DEG C are cooled to, by weight addition phytosterol/octyl dodecanol lauroyl glutamate ester, citric acid, benzene
The compound of oxyethanol and pungent glycol, sodium benzoate, essence stir 15 minutes, until being completely dissolved uniformly.
The preparation of releive type bath foam of the embodiment 9 containing nostoc sphaeroids kutz extractive
Type bath foam of releiving containing nostoc sphaeroids kutz extractive, the raw material including following parts by weight: Ge Xian prepared by embodiment 1
1.2 parts of rice extracts, 4 parts of glycolipid, 20 parts of Cocoamidopropyl betaine aqueous solution, Sodium Lauroamphoacetate aqueous solution 5
Part, phytosterol/0.8 part of octyl dodecanol lauroyl glutamate ester, 3 parts of glycerol, 0.05 part of citric acid, PEG-120 methyl Portugal
Sugared 3 parts of three isostearic acid aqueous solution of ester, 0.6 part of compound of Phenoxyethanol and pungent glycol, 0.30 part of sodium benzoate, EDETATE SODIUM
0.08 part, 0.8 part of essence, add water to 100 parts.
The preparation method of the above-mentioned type bath foam of releiving containing nostoc, method includes the following steps:
(1) water is added in reaction kettle, then be separately added into the EDETATE SODIUM accurately weighed by weight, glycolipid is stirred
It mixes, is heated to 85 DEG C, until all components are completely dispersed uniformly；
(2) glycerol, Sodium Lauroamphoacetate aqueous solution, Cocoamidopropyl betaine are successively added in a kettle
Aqueous solution, three isostearic acid aqueous solution of ester of PEG-120 methyl stir 10 minutes, until being completely dissolved；
(3) nostoc sphaeroids kutz extractive is added by weight, stirring is uniform to being completely dispersed；
(4) 45 DEG C are cooled to, by weight addition phytosterol/octyl dodecanol lauroyl glutamate ester, citric acid, benzene
The compound of oxyethanol and pungent glycol, sodium benzoate, essence stir 15 minutes, until being completely dissolved uniformly.
The preparation of releive type bath foam of the embodiment 10 containing nostoc sphaeroids kutz extractive
Compare with embodiment 8, distinctive points are only that specific formula is as follows in the present embodiment: nostoc prepared by embodiment 1 mentions
Take 0.8 part of object, 2.5 parts of glycolipid, 21 parts of Cocoamidopropyl betaine aqueous solution, 7 parts of Sodium Lauroamphoacetate aqueous solution,
Phytosterol/0.9 part of octyl dodecanol lauroyl glutamate ester, 2.5 parts of glycerol, 0.05 part of citric acid, PEG-120 methyl
0.7 part of compound of three 5 parts of isostearic acid aqueous solution of ester, Phenoxyethanol and pungent glycol, 0.2 part of sodium benzoate, EDETATE SODIUM
0.07 part, 0.5 part of essence, add water to 100 parts.
The preparation of releive type bath foam of the embodiment 11 containing nostoc sphaeroids kutz extractive
Compare with embodiment 9, distinctive points are only that specific formula is as follows in the present embodiment: nostoc prepared by embodiment 1 mentions
Take 1.3 parts of object, 3.5 parts of glycolipid, 19 parts of Cocoamidopropyl betaine aqueous solution, 5 parts of Sodium Lauroamphoacetate aqueous solution,
Phytosterol/0.6 part of octyl dodecanol lauroyl glutamate ester, 2 parts of glycerol, 0.07 part of citric acid, PEG-120 methyl three
3.5 parts of isostearic acid aqueous solution of ester, 0.8 part of compound of Phenoxyethanol and pungent glycol, 0.2 part of sodium benzoate, EDETATE SODIUM 0.1
Part, 1.0 parts of essence, add water to 100 parts.
Facial cleanser of the embodiment 12 containing nostoc sphaeroids kutz extractive
Containing nostoc sphaeroids kutz extractive, phytosterol/octyl dodecanol lauroyl glutamate ester composition facial cleanser, specifically match
Side is as follows: 1 part of nostoc sphaeroids kutz extractive of the preparation of embodiment 1, phytosterol/0.8 part of octyl dodecanol lauroyl glutamate ester, the moon
3 parts of cinnamic acid, 16 parts of myristic acid, 8 parts of compound of stearic acid and palmitinic acid, 10 parts of potassium hydroxide aqueous solution, 20 parts of glycerol, gather
- 4005 parts of ethylene glycol, 0.1 part of EDETATE SODIUM, 0.3 part of methyl hydroxybenzoate, 0.5 part of essence.Wherein, the quality of potassium hydroxide aqueous solution
Score is 48%, and mass ratio is 65:35 in stearic acid and palmitinic acid compound.
Preparation method:
(1) in oily phase pot, the lauric acid accurately weighed by weight, myristic acid, stearic acid and palm are separately added into
The compound of acid, 80 DEG C are heated to being completely dissolved, and are pumped into reaction kettle.
(2) water is added in aqueous phase reactions kettle, then is separately added into the EDETATE SODIUM accurately weighed by weight, potassium hydroxide
Aqueous solution, glycerol, polyethylene glycol-400 are pumped into reaction kettle after 80 DEG C of dissolutions.
(3) 80 DEG C are kept, after mutually 40min is mixed in a kettle in water phase and oil, is separately added into parts by weight nostoc
Extract, methyl hydroxybenzoate stir 15min.
(4) reaction kettle is cooled to 45 DEG C of addition parts by weight phytosterol/octyl dodecanol lauroyl glutamate esters, essence.
(5) it is cooled to 40 DEG C or so while stirring, stops stirring and discharging.
Facial cleanser of the embodiment 13 containing nostoc sphaeroids kutz extractive
Difference with embodiment 12 is that specific formula is as follows: 1.3 parts of nostoc sphaeroids kutz extractive of the preparation of embodiment 1, plant
Sterol/0.6 part of octyl dodecanol lauroyl glutamate ester, 4 parts of lauric acid, 17 parts of myristic acid, stearic acid and palmitinic acid are answered
8.5 parts of object of conjunction, 10 parts of potassium hydroxide aqueous solution, 19 parts of glycerol, 4 parts of polyethylene glycol-400,0.08 part of EDETATE SODIUM, methyl hydroxybenzoate
0.35 part, 0.7 part of essence.
Reference examples 1
Compared with Example 8, distinctive points are only that, nostoc sphaeroids kutz extractive and plant steroid are not included in the formula of the bath foam
Alcohol/octyl dodecanol lauroyl glutamate ester.
The preparation method of the bath foam the following steps are included:
(1) water is added in reaction kettle, then be separately added into the EDETATE SODIUM accurately weighed by weight, glycolipid is stirred
It mixes, is heated to 85 DEG C, until all components are completely dispersed uniformly；
(2) glycerol, Sodium Lauroamphoacetate aqueous solution, Cocoamidopropyl betaine are successively added in a kettle
Aqueous solution, three isostearic acid aqueous solution of ester of PEG-120 methyl, citric acid stir 10 minutes, until being completely dissolved；
(3) 45 DEG C are cooled to, by weight plus compound, sodium benzoate, the essence of Phenoxyethanol and pungent glycol, stirring 15
Minute, until being completely dissolved uniformly.
Reference examples 2
Compared with Example 8, distinctive points are only that, nostoc sphaeroids kutz extractive is not included in the formula of the bath foam.
The preparation method of the bath foam the following steps are included:
(1) water is added in reaction kettle, then be separately added into the EDETATE SODIUM accurately weighed by weight, glycolipid is stirred
It mixes, is heated to 85 DEG C, until all components are completely dispersed uniformly；
(2) glycerol, Sodium Lauroamphoacetate aqueous solution, Cocoamidopropyl betaine are successively added in a kettle
Aqueous solution, three isostearic acid aqueous solution of ester of PEG-120 methyl, citric acid stir 3 minutes, until being completely dissolved；
(3) 45 DEG C are cooled to, by weight addition phytosterol/octyl dodecanol lauroyl glutamate ester, Phenoxyethanol
It with the compound, sodium benzoate, essence of pungent glycol, stirs 15 minutes, until being completely dissolved uniformly.
Reference examples 3
Compared with Example 8, distinctive points are only that, phytosterol/octyl dodecanol is not included in the formula of the bath foam
Lauroyl glutamate ester.
The preparation method of above-mentioned bath foam the following steps are included:
(1) water is added in reaction kettle, then be separately added into the EDETATE SODIUM accurately weighed by weight, glycolipid is stirred
It mixes, is heated to 85 DEG C, until all components are completely dispersed uniformly；
(2) glycerol, Sodium Lauroamphoacetate aqueous solution, Cocoamidopropyl betaine are successively added in a kettle
Aqueous solution, three isostearic acid aqueous solution of ester of PEG-120 methyl, citric acid stir 3 minutes, until being completely dissolved；
(3) nostoc sphaeroids kutz extractive is added by weight, stirring is uniform to being completely dispersed；
(4) 45 DEG C are cooled to, compound, sodium benzoate, the essence of Phenoxyethanol and pungent glycol, stirring are added by weight
15 minutes, until being completely dissolved uniformly.
Reference examples 4: the facial cleanser without containing composition
Compared with embodiment 12, distinctive points are only that, nostoc sphaeroids kutz extractive and plant are not included in the formula of the facial cleanser
Sterol/octyl dodecanol lauroyl glutamate ester.
Reference examples 5: compared with embodiment 12, distinctive points are only that, nostoc is not included in the formula of the facial cleanser and is extracted
Object
Reference examples 6: compared with embodiment 12, distinctive points are only that, phytosterol/pungent is not included in the formula of the facial cleanser
Base lauryl alcohol lauroyl glutamate ester
The type bath foam of releiving containing nostoc sphaeroids kutz extractive of the embodiment of the present invention 8 is tried out, trier is carried out
Following test:
1, percutaneous loss of moist (TEWL) comparison before subject's shin:
Specific test method and data are analyzed as follows:
1.1 tested materials:
A group: the type bath foam of releiving containing nostoc sphaeroids kutz extractive of the embodiment of the present invention 8；The bath foam of reference examples 1
B group: the type bath foam of releiving containing nostoc sphaeroids kutz extractive of the embodiment of the present invention 9；The bath foam of reference examples 2
C group: the type bath foam of releiving containing nostoc sphaeroids kutz extractive of the embodiment of the present invention 10；The bath foam of reference examples 3
D group: the type bath foam of releiving containing nostoc sphaeroids kutz extractive of the embodiment of the present invention 8；Embodiment 11 contains Ge Xian
The type bath foam of releiving of rice extracts
1.2 test methods (illustrate, B group and C group testing experiment method respectively refer to A group, subject's each group by taking A group as an example
Between do not repeat):
1.2.1 23 subjects, Subject characteristics: women, the age 25~55 years old, shower was dried rear skin and is easy to produce
Dry and rubescent or furfur sensitive skin crowd.
1.2.2 recipient site: on front side of double shins, recipient site at label symmetrical two is randomly assigned as trial zone and control
Area, the type bath foam of releiving containing nostoc sphaeroids kutz extractive prepared by the trial zone 5g embodiment of the present invention 8 are cleaned and are rinsed, control
Bath foam prepared by area's reference examples 1 is cleaned and is rinsed, and water used is disposed as 41~43 DEG C during tested, washing time 3
Minute.
1.2.3 test index: the percutaneous loss of moist (TEWL) of skin before measurement subject's shin.
1.2.4 test procedure:
Percutaneous moisture before measuring subject's shin using TewameterTM 210C (Courage+khazaka Germany)
It loses (TEWL), each time test twice and is averaged, and operating ambient temperature is 23~25 DEG C, relative humidity 45%~
65%.Subject sits quietly after 20min, tests (T0) skin TEWL before the use of recipient site sample, then uses by prescribed dose
Tested material, one time a day, 10 minutes test recipient site skin TEWL after drying.During test, the double shin exposures of subject are in
Test mode is placed, and keeps loosening.
Statistical method: it if test data is normal distribution, is examined using t；If test data is Non-Gaussian Distribution, use
Rank sum test, two-tailed test, inspection level α=0.05.
1.2.5 percutaneous loss of moist (TEWL) experimental test result before subject's shin
Percutaneous loss of moist (TEWL) result before 2 subject's shin of table
1.2.6 conclusion (of pressure testing)
By the test of the percutaneous loss of moist (TEWL) to the preceding two sides of subject's shin, as a result, it has been found that, using of the invention real
The test side TEWL value for applying the type bath foam of releiving that a 8-11 contains nostoc sphaeroids kutz extractive is substantially reduced, it was demonstrated that the embodiment of the present invention
There is the type bath foam of releiving that 8-11 contains nostoc sphaeroids kutz extractive reduction moisture of skin to lose, so as to improve dry after skin cleaning
Problem.
2, skin is releived effect assessment
2.1 tested material
The embodiment of the present invention 8 and embodiment 11 are releived bath foam containing the type of releiving of nostoc sphaeroids kutz extractive
2.2 test method
2.2.1 28 subjects, Subject characteristics: women, the age 25~55 years old, average age 43.6 years old, shower was dried
Skin is easy to produce dry and rubescent sensitive skin crowd afterwards.
2.2.2 it test method: is washed one's hair using the embodiment of the present invention 8 containing the type of releiving of nostoc sphaeroids kutz extractive bath foam of releiving
Bath is used continuously 28 days one time a day.Subject tries out 28 days front and backs to bath foam, the tight feeling at skin discomfort position, itch,
Flush, furfur symptom situation of change evaluated.
3 subjects skin's condition susceptible evaluation result of table
2.2.3 test result
From table 3 it is observed that being relaxed using the embodiment of the present invention 8 and embodiment 11 containing the type of releiving of nostoc sphaeroids kutz extractive
After slow bath foam is taken a shower 28 days, the condition responsive of most of subject perception body skins improved (including tight, itch,
Flush, furfur).
3, skin elasticity improvement is evaluated
Specific test method and data are analyzed as follows:
3.1 tested materials:
A group: the type bath foam of releiving containing nostoc sphaeroids kutz extractive of the embodiment of the present invention 8；The bath foam of reference examples 1
B group: the type bath foam of releiving containing nostoc sphaeroids kutz extractive of the embodiment of the present invention 9；The bath foam of reference examples 2
C group: the type bath foam of releiving containing nostoc sphaeroids kutz extractive of the embodiment of the present invention 10；The bath foam of reference examples 3
D group: the type bath foam of releiving containing nostoc sphaeroids kutz extractive of the embodiment of the present invention 8；The bath foam of embodiment 11
3.2 test methods (illustrate, B group and C group testing experiment method respectively refer to A group, subject's each group by taking A group as an example
Between do not repeat):
3.2.1 17 subjects, Subject characteristics: women, the age 25~35 years old, healthy skin crowd.
3.2.2 recipient site: on the inside of both arms, recipient site at label symmetrical two is randomly assigned as trial zone and control
Area, the type bath foam of releiving containing nostoc sphaeroids kutz extractive prepared by the trial zone 3g embodiment of the present invention 8 are cleaned and are rinsed, control
Area is cleaned and is rinsed with bath foam prepared by 3g reference examples 8, and water used is disposed as 41~43 DEG C during tested, washing time
3 minutes.
3.2.3 test index: the elasticity of measurement subject's inboard arm skin.
3.2.4 test procedure
Using skin elasticity tester Cutometer MPA580 (including the subsidiary elasticity of skin elasticity tester MPA580
Test probe, Courage+khazaka Germany).The elasticity number of subject's both arms is measured, each time test 3 times simultaneously takes
Average value, operating ambient temperature are 23~25 DEG C, relative humidity 45%~65%.Subject sits quietly after 20min, tests tested portion
Position sample use before (T0) skin elasticity value, then by prescribed dose use tested material, one time a day, dry after 5 minutes test by
Try area skin elasticity number.During test, the exposure of subject's both arms places in test mode, keeps loosening.
Statistical method: it if test data is normal distribution, is examined using t；If test data is Non-Gaussian Distribution, use
Rank sum test, two-tailed test, inspection level α=0.05.
4 subject's both arms inner elastic value test result of table
3.2.5 test result
From the point of view of the data result of table 4,8-11 of the embodiment of the present invention contains relaxing for nostoc sphaeroids kutz extractive skin composition
Slow type releive bath foam energy significant effective improve skin elasticity value, it was demonstrated that the nostoc sphaeroids kutz extractive in bath foam of the present invention can be skin
Skin provides nutritional ingredient, and auxiliary promotes the formation of skin collagen, so as to improve skin elasticity, to anti aging effect.
Facial cleanser tries out data
Facial cleanser in the present invention in embodiment 12 is tried out, following test has been carried out to trier:
4, the elasticity number comparison of subject's face:
Specific test method and data are analyzed as follows:
4.1 tested materials:
First group: the facial cleanser containing nostoc sphaeroids kutz extractive of the embodiment of the present invention 12；Reference examples 4 do not contain composition
Facial cleanser
Second group: the facial cleanser of the embodiment of the present invention 12；The facial cleanser of reference examples 6
4.2 test method
4.2.1 20 subjects, Subject characteristics: women, the age 25~40 years old, healthy skin crowd.
4.2.2 recipient site: face or so cheek, recipient site at label symmetrical two, be randomly assigned as trial zone and
Check plot, trial zone are cleaned and are rinsed with the facial cleanser containing composition prepared by the 3g embodiment of the present invention 12, check plot 3g
Facial cleanser prepared by reference examples 4 is cleaned and is rinsed, and water used is disposed as 38~40 DEG C, washing time 3 minutes during tested.
4.2.3 test index: the elasticity of measurement two cheek skin of subject.
4.2.4 test procedure
Using skin elasticity tester Cutometer MPA580 (including the subsidiary elasticity of skin elasticity tester MPA580
Test probe, Courage+khazaka Germany).The elasticity number of two cheek of subject is measured, each time test 3 times simultaneously takes
Average value, operating ambient temperature are 23~25 DEG C, relative humidity 45%~65%.Subject sits quietly after 20min, tests tested portion
Then (T0) skin elasticity value before the sample use of position uses tested material by prescribed dose, after 28 days, test recipient site skin bullet
Property value.During test, the exposure of subject's cheeks keeps loosening.
Statistical method: it if test data is normal distribution, is examined using t；If test data is Non-Gaussian Distribution, use
Rank sum test, two-tailed test, inspection level α=0.05.
5 subject's cheeks elasticity number test result of table
4.2.5 test result
Nostoc is added in common soap base facial cleanser from the point of view of the data result of table 5, in the embodiment of the present invention 12 to mention
Object and phytosterol/octyl dodecanol lauroyl glutamate ester composition energy significant effective is taken to improve skin elasticity value, it was demonstrated that this
Nostoc sphaeroids kutz extractive in invention facial cleanser can provide multiple nutritional components for skin, and auxiliary promotes the shape of skin collagen
At so as to improve skin elasticity, to anti aging effect.
5, improve cheek condition susceptible effect assessment
5.1 tested material
First group: the facial cleanser containing nostoc sphaeroids kutz extractive of the embodiment of the present invention 12；Reference examples 4 do not contain composition
Facial cleanser
Second group: the facial cleanser of reference examples 12 of the present invention；The facial cleanser of reference examples 5
Third group: the facial cleanser of reference examples 12 of the present invention；The facial cleanser of reference examples 6
5.2 test method
5.2.1 Subject characteristics: women, the age 25~55 years old, average age 36.8 years old, cheek was easy rubescent after face cleaning
Crowd.
5.2.2 it test method: using the facial cleanser face cleaning of the embodiment of the present invention 12, one time a day, is used continuously 28 days.?
During using facial cleanser, other skin products are unified to be provided, and is used by specified amount.Before subject tries out 28 days to bath foam
Afterwards, situations such as generating heat the flush of cheek after face cleaning records and evaluates.
6 subjects skin's condition susceptible evaluation result of table
5.2.3 test result
As can be seen from Table 6, after using 12 facial cleanser face cleaning of the embodiment of the present invention 28 days, subject perception cheek is no longer
The face cleaning cheek condition responsive of flush, most of subjects is eased.
6, skin shine increases effect assessment
Specific test method and data are analyzed as follows:
6.1 tested materials:
The facial cleanser containing composition of the embodiment of the present invention 12；The facial cleanser without containing composition of reference examples 4；Control
Example 5 is free of the facial cleanser of nostoc sphaeroids kutz extractive；Phytosterol/octyl dodecanol lauroyl glutamate ester is free of in reference examples 6
Facial cleanser
6.2 test method
6.2.1 24 subjects, Subject characteristics: women, the age 25~40 years old, healthy skin crowd.
6.2.2 recipient site: face or so cheek, recipient site at label symmetrical two, be randomly assigned as trial zone and
Check plot, trial zone are cleaned and are rinsed with the facial cleanser containing composition prepared by the 3g embodiment of the present invention 12, check plot 3g
Facial cleanser prepared by reference examples 4 is cleaned and is rinsed, and water used is disposed as 38~40 DEG C, washing time 3 minutes during tested.
6.2.3 test index: the glossiness value added △ L* of measurement two cheek skin of subject.
6.2.4 test procedure
Using skin shine tester (including Skin-Glossymeter GL200 test probe, Courage+
khazaka Germany).The glossiness of two cheek of subject is measured, each time test 3 times is simultaneously averaged, working environment temperature
Degree is 23~25 DEG C, relative humidity 45%~65%.Subject sits quietly after 20min, tests before the use of recipient site sample (T0)
Then glossiness uses tested material by prescribed dose, tests recipient site skin shine after 14 days and 28 days respectively, calculate by
Examination person cheek skin shine value added △ L*.During test, the exposure of subject's cheeks keeps loosening.
Statistical method: it if test data is normal distribution, is examined using t；If test data is Non-Gaussian Distribution, use
Rank sum test, two-tailed test, inspection level α=0.05.
7 subject's cheeks glossiness value added △ L* result of table
6.2.5 test result
It is extracted from nostoc is added from the point of view of the data result of table 7 in the embodiment of the present invention 12 in common soap base facial cleanser
Object and phytosterol/octyl dodecanol lauroyl glutamate ester composition energy significant effective improve cheek glossiness, it was demonstrated that this hair
Nostoc sphaeroids kutz extractive and phytosterol/octyl dodecanol lauroyl glutamate ester composition in bright facial cleanser is washed being added to
After in the milk of face, supplement skin nutrition helps the effective moisturizing of skin, so as to increase the reflecting feel of skin, to make skin more
Add white vibrant.
7, percutaneous loss of moist amount (TEWL) evaluation of cheek is reduced
Specific test method and data are analyzed as follows:
7.1 tested materials:
The facial cleanser containing composition of the embodiment of the present invention 12；The facial cleanser without containing composition of reference examples 4；Control
Example 5 is free of the facial cleanser of nostoc sphaeroids kutz extractive；Phytosterol/octyl dodecanol lauroyl glutamate ester is free of in reference examples 6
Facial cleanser
7.2 test method
7.2.1 21 subjects, Subject characteristics: women the age 25~55 years old, has felt that cheeks are dry after face cleaning
Crowd.
7.2.2 recipient site: cheeks, recipient site at label symmetrical two are randomly assigned as trial zone and check plot, examination
The facial cleanser containing nostoc skin composition for testing the preparation of area's 3g embodiment of the present invention 12 is cleaned and is rinsed, and check plot is used
Facial cleanser without the preparation of nostoc skin composition is cleaned and is rinsed, and water used is disposed as 41~43 during tested
DEG C, washing time 3 minutes.
7.2.3 test index: the percutaneous loss of moist (TEWL) of measurement subject's cheeks.
7.2.4 test procedure:
Using the percutaneous moisture of TewameterTM 210C (Courage+khazaka Germany) measurement subject's cheeks
It loses (TEWL), each time test twice and is averaged, and operating ambient temperature is 23~25 DEG C, relative humidity 45%~
65%.Subject sits quietly after 20min, tests (T0) skin TEWL before the use of recipient site sample, then uses by prescribed dose
Tested material, one time a day, 10 minutes test recipient site skin TEWL after being dried to test same day face cleaning.It is tested during test
The exposure of person's cheeks, keeps loosening.
Statistical method: it if test data is normal distribution, is examined using t；If test data is Non-Gaussian Distribution, use
Rank sum test, two-tailed test, inspection level α=0.05.
Percutaneous loss of moist (TEWL) result of 8 subject's cheek of table
7.2.5 conclusion (of pressure testing)
By table 8 it can be proved that the percutaneous loss of moist of subject's cheek can be reduced with the facial cleanser face cleaning of embodiment 12
Value reflects that the cheek barrier function of subject improves.
In addition, releive type bath foam and embodiment 12- through examining 8-11 of the embodiment of the present invention to contain nostoc sphaeroids kutz extractive
The facial cleanser containing nostoc sphaeroids kutz extractive of 13 preparations meets the requirement of national cosmetic pertinent regulations, sense index (color, perfume (or spice)
Gas, structure) meet national regulation, physical and chemical index (PH, heat-resisting, cold-resistant, centrifugation, viscosity) meets national regulation.
The nostoc sphaeroids kutz extractive that bath foam and facial cleanser of the present invention are especially added with, with moisturizing and nourishing, the function mildly releived
Can, and mild detergent glycolipid and Sodium Lauroamphoacetate are used, while utilizing phytosterol/octyl dodecanol moon
" the plate liquid crystal structure " of osmanthus acyl glutamate promotes the absorption of nostoc sphaeroids kutz extractive active matter and the holding of moisture of skin, energy
Mild cleaning skin is alleviated the sensitive skins problem such as drying, rubescent, itch, furfur of body after taking a shower, while can be mended
Skin-nourishing is filled, skin damage barrier is repaired, improves that skin elasticity, to improve cheek glossiness, skin whiter vibrant etc..
Following data is used to illustrate the effect that the skin composition containing nostoc sphaeroids kutz extractive is used alone.Embodiment A
The range of the claims in the present invention is taken from B, C and D exceed this range, and E and F show that one of which is used alone, and effect is not
It is good.
Specific formula is as follows in embodiment 14-A the present embodiment: 1.4 parts of nostoc sphaeroids kutz extractive of the preparation of embodiment 1, plant
Sterol/0.6 part of octyl dodecanol lauroyl glutamate ester, 0.6 part of carbomer, 0.6 part of triethanolamine, 0.5 part of Phenoxyethanol, hydroxyl
0.1 part of benzene methyl, add water to 100 parts.
In the present embodiment, carbomer and triethanolamine are thickener, help skin composition of the present invention convenient to use,
Without practical skin effect.Phenoxyethanol and methyl hydroxybenzoate are common preservatives.
Embodiment 14-B the present embodiment and the difference of embodiment 14-A be, 0.8 part of nostoc sphaeroids kutz extractive, phytosterol/
1.0 parts of octyl dodecanol lauroyl glutamate ester.
Embodiment 14-C the present embodiment and the difference of embodiment 14-A be, 0.7 part of nostoc sphaeroids kutz extractive, phytosterol/
1.3 parts of octyl dodecanol lauroyl glutamate ester.
Embodiment 14-D the present embodiment and the difference of embodiment 14-A be, 1.4 parts of nostoc sphaeroids kutz extractive, phytosterol/
0.5 part of octyl dodecanol lauroyl glutamate ester.
Embodiment 14-E the present embodiment and the difference of embodiment 14-A be, 1.5 parts of nostoc sphaeroids kutz extractive, phytosterol/
1.2 parts of octyl dodecanol lauroyl glutamate ester.
Embodiment 14-F the present embodiment and the difference of embodiment 14-A are, are free of nostoc sphaeroids kutz extractive.
Embodiment 14-G the present embodiment and the difference of embodiment 14-A are, are free of phytosterol/octyl dodecanol laurel
Acyl glutamate.
Reference examples and the difference of embodiment 14-A are, not comprising the skin combination of the invention containing nostoc sphaeroids kutz extractive
Object.
8 increase the evaluation of facial skin elastic effect
8.1 tested material
First group: embodiment 14-A；Embodiment 14-B
Second group: embodiment 14-C；Embodiment 14-D
Third group: embodiment 14-E；Embodiment 14-F
4th group: embodiment 14-G；Reference examples
8.2 test method
8.2.1 20 subjects, Subject characteristics: women, the age 25~40 years old, healthy skin crowd.
8.2.2 recipient site: bilateral cheek, recipient site at label symmetrical two, after daily face cleaning, in bilateral cheek point
Not Shi Yong the present invention in embodiment 14-A and embodiment 14-B, each 1 time daily morning and evening, be used continuously 28 days, tested period its
He is provided by test side is unified, it is specified that dosage uses face's exterior-applied article.
8.2.3 test index: the elasticity of measurement two cheek skin of subject.
8.2.4 test procedure
Using skin elasticity tester Cutometer MPA580 (including the subsidiary elasticity of skin elasticity tester MPA580
Test probe, Courage+khazaka Germany).The elasticity number of two cheek of subject is measured, each time test 3 times simultaneously takes
Average value, operating ambient temperature are 23~25 DEG C, relative humidity 45%~65%.Subject sits quietly after 20min, tests tested portion
Then (T0) skin elasticity value before the sample use of position uses tested material by prescribed dose, after 28 days, test recipient site skin bullet
Property value.During test, the exposure of subject's cheeks keeps loosening.
Statistical method: it if test data is normal distribution, is examined using t；If test data is Non-Gaussian Distribution, use
Rank sum test, two-tailed test, inspection level α=0.05.
9 subject's cheek elasticity number test result of table
8.2.5 conclusion (of pressure testing)
As can be seen from Table 9, using the gel of 14-A and 14-B, subject's cheek elasticity of skin can be obviously increased.
9, improve the evaluation of cheek sensitizing effect
9.1 tested material
First group: embodiment 14-A；Embodiment 14-B
Second group: embodiment 14-C；Embodiment 14-D
Third group: embodiment 14-E；Embodiment 14-F
4th group: embodiment 14-G；Reference examples
9.2 test method
9.2.1 Subject characteristics: women, the age 25~55 years old, average age 39.2 years old, cheek was easy rubescent after face cleaning
Crowd.
9.2.2 test method: bilateral cheek, recipient site at label symmetrical two, after daily face cleaning, in bilateral cheek point
Not Shi Yong the present invention in embodiment 14-A and embodiment 14-B, each 1 time daily morning and evening, be used continuously 28 days, tested period its
He is provided by test side is unified, it is specified that dosage uses, to the flush hair of cheek after subject's face cleaning after 28 days face's exterior-applied article
Situations such as hot, records and is evaluated.
10 skin sensitivity symptom assessment result of table
9.2.5 conclusion (of pressure testing)
As can be seen from Table 10, using the gel of 14-A and 14-B, the cheek that can be obviously improved very most of subjects is quick
Feel symptom, including flush, fever, decortication.
10, the test of transepidermal water loss rate (TEWL)
10.1 tested materials
First group: embodiment 14-A；Embodiment 14-B
Second group: embodiment 14-C；Embodiment 14-D
Third group: embodiment 14-E；Embodiment 14-F
4th group: embodiment 14-G；Reference examples
10.2 test methods (are illustrated, other group of testing experiment method respectively refers to first group, subject for first group
Do not repeated between each group):
10.2.1 20 subjects, Subject characteristics: women, the age 25~55 years old, facial skin was easy to produce after face cleaning
Dry or rubescent or furfur sensitive skin crowd.
10.2.2 recipient site: bilateral cheek, recipient site at label symmetrical two, after daily face cleaning, in bilateral cheek
Respectively using the embodiment 14-A and embodiment 14-B in the present invention, each 1 time daily morning and evening, it is used continuously 28 days, tested period
Other face's exterior-applied articles are provided by test side is unified, it is specified that dosage uses.
10.2.3 test index: the percutaneous loss of moist (TEWL) of measurement subject's cheeks skin.
10.2.4 test procedure:
Using the percutaneous moisture of TewameterTM 210C (Courage+khazaka Germany) measurement subject's cheeks
It loses (TEWL), each time test twice and is averaged, and operating ambient temperature is 23~25 DEG C, relative humidity 45%~
65%.Subject sits quietly after 20min, tests (T0) skin TEWL before the use of recipient site sample, then dosage in required time
Using tested material, recipient site skin TEWL is tested after 28 days.During test, the exposure of subject's cheeks keeps loosening.
Statistical method: it if test data is normal distribution, is examined using t；If test data is Non-Gaussian Distribution, use
Rank sum test, two-tailed test, inspection level α=0.05.
Percutaneous loss of moist (TEWL) result of 11 subject's cheek of table
10.2.5 conclusion (of pressure testing)
As can be seen from Table 11, using the gel of 14-A and 14-B, subject's cheek skin transepidermal water loss can be substantially reduced
Value.Illustrate effectively repair subject's cheeks skin barrier containing skin composition of the invention.
11, facial skin glossiness test evaluation
11.1 tested materials
First group: embodiment 14-A；Embodiment 14-B
Second group: embodiment 14-C；Embodiment 14-D
Third group: embodiment 14-E；Embodiment 14-F
4th group: embodiment 14-G；Reference examples
11.2 test methods
11.2.1 20 subjects, Subject characteristics: women, the age 25~40 years old, healthy skin crowd.
11.2.2 recipient site: bilateral cheek, recipient site at label symmetrical two, after daily face cleaning, in bilateral cheek
Respectively using the embodiment 14-A and embodiment 14-B in the present invention, each 1 time daily morning and evening, it is used continuously 28 days, tested period
Other face's exterior-applied articles are provided by test side is unified, it is specified that dosage uses.
11.2.3 test index: the elasticity of measurement two cheek skin of subject.
11.2.4 test procedure
Using skin shine tester (including Skin-Glossymeter GL200 test probe, Courage+
khazaka Germany).The glossiness of two cheek of subject is measured, each time test 3 times is simultaneously averaged, working environment temperature
Degree is 23~25 DEG C, relative humidity 45%~65%.Subject sits quietly after 20min, tests before the use of recipient site sample (T0)
Then glossiness uses tested material by prescribed dose, test recipient site skin shine after 28 days respectively, calculates subject's face
Cheek skin shine value added △ L*.During test, the exposure of subject's cheeks keeps loosening.
Statistical method: it if test data is normal distribution, is examined using t；If test data is Non-Gaussian Distribution, use
Rank sum test, two-tailed test, inspection level α=0.05.
12 subject's cheek glossiness value added △ L* result of table
11.2.5 conclusion (of pressure testing)
As can be seen from Table 12, after using 14-A and 14-B gel, cheek skin shine is significantly increased subject,
Subject's skin can be made to seem net vigor.
The above embodiments are only used to illustrate the present invention, rather than limitation of the present invention.Although referring to embodiment to this hair
It is bright to be described in detail, those skilled in the art should understand that, to technical solution of the present invention carry out it is various combination,
Modification or equivalent replacement should all cover and want in right of the invention without departure from the spirit and scope of technical solution of the present invention
It asks in range.
Claims (12)
1. a kind of skin composition containing nostoc sphaeroids kutz extractive, which is characterized in that the composition include nostoc sphaeroids kutz extractive,
Phytosterol/octyl dodecanol lauroyl glutamate ester, weight ratio are (0.8~1.4): (0.6~1.0).
2. as described in claim 1 containing the skin composition of nostoc sphaeroids kutz extractive, which is characterized in that Pueraria lobota in the composition
Celestial rice extracts, phytosterol/octyl dodecanol lauroyl glutamate ester weight ratio are (1.2~1.4): (0.8~1.0).
3. as claimed in claim 1 or 2 containing the skin composition of nostoc sphaeroids kutz extractive, which is characterized in that the nostoc
The extracting method of extract the following steps are included:
(1) the dry algae of nostoc is taken, is sieved after crushed, is added water-swellable；
(2) compound extractant is heated to 85-90 DEG C, is added in nostoc of the above-mentioned steps through being swollen, extracts；
Wherein, the compound extractant includes glycerol, phytic acid and water, and the mass fraction percentage of the glycerol, phytic acid and water is
(20-50%): (1.0-2.0%): (48-78.5%)；
(3) filtrate is filtered and collects, filtrate obtains the nostoc sphaeroids kutz extractive by concentration, precipitating, drying.
4. a kind of bath foam containing nostoc sphaeroids kutz extractive, which is characterized in that the bath foam containing nostoc sphaeroids kutz extractive includes such as
The raw material of lower parts by weight: as described in claim 1 containing the skin composition of nostoc sphaeroids kutz extractive, 2.5~4 parts of glycolipid, coconut palm
15~21 parts of the aqueous solution of oleamide propyl betaine, 4~7 parts of the aqueous solution of Sodium Lauroamphoacetate, 2~3 parts of glycerol,
0.05~0.07 part of citric acid, 3~5 parts of the aqueous solution of three isostearate of PEG-120 methyl, Phenoxyethanol and pungent glycol
0.5~0.8 part of compound, it is 0.2~0.3 part of sodium benzoate, 0.07~0.10 part of EDETATE SODIUM, 0.5~1.0 part of essence, molten
Agent is water.
5. as claimed in claim 4 containing the bath foam of nostoc sphaeroids kutz extractive, which is characterized in that described to contain nostoc sphaeroids kutz extractive
Bath foam include following parts by weight raw material: as claimed in claim 2 containing the skin composition of nostoc sphaeroids kutz extractive, sugar
3~4 parts of rouge, 16~17 parts of Cocoamidopropyl betaine aqueous solution, 5~7 parts of Sodium Lauroamphoacetate aqueous solution, glycerol
2~3 parts, 0.05~0.06 part of citric acid, 3~5 parts of three isostearic acid aqueous solution of ester of PEG-120 methyl, Phenoxyethanol and
0.6~0.8 part of the compound of pungent glycol, 0.2~0.25 part of sodium benzoate, 0.07~0.10 part of EDETATE SODIUM, essence 0.5~
0.8 part, solvent is water.
6. a kind of facial cleanser containing nostoc sphaeroids kutz extractive, which is characterized in that the raw material including following parts by weight: such as claim 1
The skin composition containing nostoc sphaeroids kutz extractive, 3~4.5 parts of lauric acid, 15~18 parts of myristic acid, stearic acid and palm fibre
7~9 parts of the compound of palmitic acid acid, 10~14 parts of potassium hydroxide aqueous solution, 15~20 parts of glycerol, 3~5 parts of polyethylene glycol-400,
0.08~0.15 part of EDETATE SODIUM, 0.3~0.35 part of methyl hydroxybenzoate, 0.4~0.8 part of essence；Wherein, the potassium hydroxide is water-soluble
The mass fraction of liquid is 48%, and the mass ratio of stearic acid and palmitinic acid is 65:35 in the compound of stearic acid and palmitinic acid.
7. as claimed in claim 6 containing the facial cleanser of nostoc sphaeroids kutz extractive, which is characterized in that the original including following parts by weight
Material: 3 parts of lauric acid, 16 parts of myristic acid, stearic as claimed in claim 2 containing the skin composition of nostoc sphaeroids kutz extractive
8 parts of compound of acid and palmitinic acid, 10 parts of potassium hydroxide aqueous solution, 20 parts of glycerol, 5 parts of polyethylene glycol-400, EDETATE SODIUM 0.1
Part, 0.3 part of methyl hydroxybenzoate, 0.5 part of essence.
8. composition as claimed in claim 1 or 2 or as described in claim 4 or 5 containing the bath foam of nostoc sphaeroids kutz extractive
Or the facial cleanser containing nostoc sphaeroids kutz extractive as claimed in claims 6 or 7 the mild cleaning skin of preparation, supplement skin-nourishing,
Skin damage barrier is repaired, skin moisture content is kept, improves skin elasticity, improve skin shine, keep skin whiter
Application in product that is vibrant and improving sensitive skin.
9. application as claimed in claim 8, which is characterized in that the sensitive skin of the improvement is to soothe the skin tight, flush, hair
Heat, itch, furfur.
10. a kind of preparation method of nostoc sphaeroids kutz extractive, which is characterized in that the described method comprises the following steps:
(1) the dry algae of nostoc is taken, is sieved after crushed, is added water-swellable；
(2) compound extractant is heated to 85-90 DEG C, is added in nostoc of the above-mentioned steps through being swollen, extracts；
Wherein, the compound extractant includes glycerol, phytic acid and water, and the mass fraction percentage of the glycerol, phytic acid and water is
(20-50%): (1.0-2.0%): (48-78.5%)；
(3) filtrate is filtered and collects, filtrate obtains the nostoc sphaeroids kutz extractive by concentration, precipitating, drying.
11. a kind of compound extractant, which is characterized in that the compound extractant includes glycerol, phytic acid and water, the glycerol, plant
The mass fraction percentage of acid and water is (20-50%): (1.0-2.0%): (48-78.5%).
12. compound extractant as claimed in claim 11 is preparing the application in nostoc sphaeroids kutz extractive.
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