CN1017800B - 三环化合物 - Google Patents

三环化合物

Info

Publication number
CN1017800B
CN1017800B CN87106838A CN87106838A CN1017800B CN 1017800 B CN1017800 B CN 1017800B CN 87106838 A CN87106838 A CN 87106838A CN 87106838 A CN87106838 A CN 87106838A CN 1017800 B CN1017800 B CN 1017800B
Authority
CN
China
Prior art keywords
methyl
fluoro
oxo
dihydro
pyrido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN87106838A
Other languages
English (en)
Chinese (zh)
Other versions
CN87106838A (zh
Inventor
青木雅弘
镰田美也子
大达男
新间信夫
横濑一辉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN87106838A publication Critical patent/CN87106838A/zh
Publication of CN1017800B publication Critical patent/CN1017800B/zh
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN87106838A 1986-09-12 1987-09-12 三环化合物 Expired CN1017800B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP86112619.1 1986-09-12
EP86112619 1986-09-12

Publications (2)

Publication Number Publication Date
CN87106838A CN87106838A (zh) 1988-05-11
CN1017800B true CN1017800B (zh) 1992-08-12

Family

ID=8195410

Family Applications (1)

Application Number Title Priority Date Filing Date
CN87106838A Expired CN1017800B (zh) 1986-09-12 1987-09-12 三环化合物

Country Status (22)

Country Link
JP (3) JPH0696578B2 (sv)
KR (1) KR960002857B1 (sv)
CN (1) CN1017800B (sv)
AT (1) AT389119B (sv)
AU (1) AU602534B2 (sv)
CA (1) CA1336905C (sv)
CZ (1) CZ281195B6 (sv)
DK (1) DK173330B1 (sv)
DZ (1) DZ1124A1 (sv)
FI (1) FI86428C (sv)
HU (1) HU199481B (sv)
IE (1) IE61624B1 (sv)
IL (1) IL83814A (sv)
MC (1) MC1850A1 (sv)
MX (1) MX8302A (sv)
NO (1) NO169125C (sv)
NZ (1) NZ221681A (sv)
PH (1) PH23930A (sv)
PT (1) PT85686B (sv)
SK (1) SK278990B6 (sv)
ZA (1) ZA876636B (sv)
ZW (1) ZW16387A1 (sv)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW16387A1 (en) * 1986-09-12 1988-05-25 Hoffmann La Roche Tricyclic compounds
WO2005111015A1 (ja) 2004-05-13 2005-11-24 Daiichi Pharmaceutical Co., Ltd. 置換ピロリジン誘導体
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
AU2007225088B2 (en) 2006-03-13 2012-09-13 Kyorin Pharmaceutical Co., Ltd Aminoquinolones as GSK-3 inhibitors
JP5426552B2 (ja) 2007-09-11 2014-02-26 杏林製薬株式会社 Ｇｓｋ−３阻害剤としてのシアノアミノキノロン及びテトラゾロアミノキノロン
MX2010002662A (es) 2007-09-12 2010-04-09 Activx Biosciences Inc Aminoquinolonas espirociclicas como inhibidores de gsk-3.
FR2928150A1 (fr) * 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
EP2145891A1 (en) * 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials
EP2406266B1 (en) 2009-03-11 2013-12-25 Kyorin Pharmaceutical Co., Ltd. 7-cycloalkylaminoquinolones as gsk-3 inhibitors
CN107522718B (zh) * 2017-09-14 2019-11-08 浙江国邦药业有限公司 一种马波沙星的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW16387A1 (en) * 1986-09-12 1988-05-25 Hoffmann La Roche Tricyclic compounds

Also Published As

Publication number Publication date
CZ281195B6 (cs) 1996-07-17
PT85686B (pt) 1990-05-31
IL83814A (en) 1991-09-16
SK660487A3 (en) 1998-05-06
AU7811487A (en) 1988-03-17
IE61624B1 (en) 1994-11-16
MX8302A (es) 1993-12-01
NO873816L (no) 1988-03-14
NO169125B (no) 1992-02-03
ZA876636B (en) 1988-07-27
FI86428B (fi) 1992-05-15
JPH07138262A (ja) 1995-05-30
KR960002857B1 (ko) 1996-02-27
JPH07138256A (ja) 1995-05-30
AU602534B2 (en) 1990-10-18
JPH0819120B2 (ja) 1996-02-28
FI873940A (fi) 1988-03-13
DK477287D0 (da) 1987-09-11
DK173330B1 (da) 2000-07-24
JPS63132891A (ja) 1988-06-04
HUT47294A (en) 1989-02-28
CA1336905C (en) 1995-09-05
JPH0696578B2 (ja) 1994-11-30
JPH0826030B2 (ja) 1996-03-13
DZ1124A1 (fr) 2004-09-13
AT389119B (de) 1989-10-25
IE872444L (en) 1988-03-12
MC1850A1 (fr) 1988-09-30
FI873940A0 (fi) 1987-09-11
ATA263887A (de) 1989-03-15
PT85686A (en) 1987-10-01
PH23930A (en) 1990-01-23
FI86428C (sv) 1992-08-25
CN87106838A (zh) 1988-05-11
NO873816D0 (no) 1987-09-11
NO169125C (no) 1992-05-13
ZW16387A1 (en) 1988-05-25
HU199481B (en) 1990-02-28
KR880003954A (ko) 1988-06-01
SK278990B6 (sk) 1998-05-06
DK477287A (da) 1988-03-13
NZ221681A (en) 1990-12-21
CZ660487A3 (en) 1996-04-17

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C13 Decision
GR02 Examined patent application
C14 Grant of patent or utility model
GR01 Patent grant
C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
C17 Cessation of patent right
CX01 Expiry of patent term