CN101778865B - 多肽、抗体可变域和拮抗剂 - Google Patents

多肽、抗体可变域和拮抗剂 Download PDF

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Publication number
CN101778865B
CN101778865B CN200880102207.2A CN200880102207A CN101778865B CN 101778865 B CN101778865 B CN 101778865B CN 200880102207 A CN200880102207 A CN 200880102207A CN 101778865 B CN101778865 B CN 101778865B
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protease
polypeptide
polypeptides
dom
variable domain
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Expired - Fee Related
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CN200880102207.2A
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English (en)
Chinese (zh)
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CN101778865A (zh
Inventor
L·耶斯珀斯
M·普佩卡
I·汤林森
C·埃内弗
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Domantis Ltd
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Domantis Ltd
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Priority claimed from GBGB0724331.4A external-priority patent/GB0724331D0/en
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Priority to CN201410440384.9A priority Critical patent/CN104311663B/zh
Publication of CN101778865A publication Critical patent/CN101778865A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
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  • Pulmonology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
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  • Cardiology (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
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CN200880102207.2A 2007-06-06 2008-06-04 多肽、抗体可变域和拮抗剂 Expired - Fee Related CN101778865B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410440384.9A CN104311663B (zh) 2007-06-06 2008-06-04 多肽、抗体可变域和拮抗剂

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US93363207P 2007-06-06 2007-06-06
US60/933632 2007-06-06
GBGB0724331.4A GB0724331D0 (en) 2007-12-13 2007-12-13 Compositions for pulmonary delivery
GB0724331.4 2007-12-13
PCT/GB2008/050405 WO2008149148A2 (en) 2007-06-06 2008-06-04 Polypeptides, antibody variable domains and antagonists

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CN201410440384.9A Division CN104311663B (zh) 2007-06-06 2008-06-04 多肽、抗体可变域和拮抗剂

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CN101778865A CN101778865A (zh) 2010-07-14
CN101778865B true CN101778865B (zh) 2016-11-09

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CN200880019060A Pending CN101802004A (zh) 2007-06-06 2008-06-04 多肽、抗体可变域和拮抗剂
CN2008801020043A Pending CN101883788A (zh) 2007-06-06 2008-06-04 多肽，抗体可变结构域&拮抗剂
CN200880102207.2A Expired - Fee Related CN101778865B (zh) 2007-06-06 2008-06-04 多肽、抗体可变域和拮抗剂
CN201410440384.9A Expired - Fee Related CN104311663B (zh) 2007-06-06 2008-06-04 多肽、抗体可变域和拮抗剂

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CN200880019060A Pending CN101802004A (zh) 2007-06-06 2008-06-04 多肽、抗体可变域和拮抗剂
CN2008801020043A Pending CN101883788A (zh) 2007-06-06 2008-06-04 多肽，抗体可变结构域&拮抗剂

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JP (3) JP5444215B2 (cg-RX-API-DMAC7.html)
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JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
DK1888641T3 (da) 2005-05-18 2012-04-23 Ablynx Nv Serumalbuminbindende proteiner
DE102005023617A1 (de) 2005-05-21 2006-11-23 Aspre Ag Verfahren zum Mischen von Farben in einem Display
GB0724331D0 (en) 2007-12-13 2008-01-23 Domantis Ltd Compositions for pulmonary delivery
JP2010528647A (ja) * 2007-06-06 2010-08-26 ドマンティス リミテッド ポリペプチド、抗体可変ドメインおよびアンタゴニスト
CA2688434A1 (en) 2007-06-06 2008-12-11 Domantis Limited Polypeptides, antibody variable domains and antagonists
TW200938222A (en) * 2007-12-13 2009-09-16 Glaxo Group Ltd Compositions for pulmonary delivery
JP2011516603A (ja) 2008-04-17 2011-05-26 アブリンクス エン．ヴェー． 血清タンパク質と結合することが可能なペプチド、並びにこれを含む化合物、構築物及びポリペプチド
SI3722310T1 (sl) 2008-06-25 2025-01-31 Novartis Ag Stabilna in topna protitelesa, ki zavirajo vegf
US8268314B2 (en) 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
CA2744055A1 (en) * 2008-11-26 2010-06-03 Glaxo Group Limited Polypeptides, antibody variable domains & antagonists
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