CN101686680B - 作为p2x7调节剂的双环杂芳基化合物及其用途 - Google Patents

作为p2x7调节剂的双环杂芳基化合物及其用途 Download PDF

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CN101686680B
CN101686680B CN200880014110.6A CN200880014110A CN101686680B CN 101686680 B CN101686680 B CN 101686680B CN 200880014110 A CN200880014110 A CN 200880014110A CN 101686680 B CN101686680 B CN 101686680B
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mol
substituted
methyl
disease
oxo
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CN101686680A (zh
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M·G·凯利
J·金凯德
Y·方
Y·曹
C·卡波
S·高鲁加利
Z·王
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Ivotec America Inc
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Reynolds
Ivotec America Inc
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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
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CN200880014110.6A 2007-03-09 2008-03-07 作为p2x7调节剂的双环杂芳基化合物及其用途 Active CN101686680B (zh)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US90604907P 2007-03-09 2007-03-09
US60/906,049 2007-03-09
US91812307P 2007-03-15 2007-03-15
US91826007P 2007-03-15 2007-03-15
US91826107P 2007-03-15 2007-03-15
US91808607P 2007-03-15 2007-03-15
US60/918,086 2007-03-15
US60/918,123 2007-03-15
US60/918,261 2007-03-15
US60/918,260 2007-03-15
US838507P 2007-12-20 2007-12-20
US838607P 2007-12-20 2007-12-20
US837007P 2007-12-20 2007-12-20
US61/008,370 2007-12-20
US61/008,385 2007-12-20
US61/008,386 2007-12-20
US1067208P 2008-01-10 2008-01-10
US61/010,672 2008-01-10
PCT/US2008/003175 WO2008112205A1 (en) 2007-03-09 2008-03-07 Bicycloheteroaryl compounds as p2x7 modulators and uses thereof

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CN101686680A CN101686680A (zh) 2010-03-31
CN101686680B true CN101686680B (zh) 2015-12-09

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US (1) US8093265B2 (OSRAM)
EP (1) EP2124562B1 (OSRAM)
JP (1) JP2010520875A (OSRAM)
CN (1) CN101686680B (OSRAM)
CA (1) CA2680275C (OSRAM)
DK (1) DK2124562T3 (OSRAM)
ES (1) ES2576643T3 (OSRAM)
WO (1) WO2008112205A1 (OSRAM)

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TWI464148B (zh) * 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
JP5306986B2 (ja) * 2006-03-16 2013-10-02 エボテック （ユーエス） インコーポレイテッド Ｐ２ｘ７調節因子としてのビシクロへテロアリール化合物およびその使用
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US8212723B2 (en) * 2008-08-27 2012-07-03 Qualcomm Incorporated Method and apparatus for determining at a predetermined granularity the direction and range of a transmitting mobile device
ES2574840T3 (es) * 2011-07-22 2016-06-22 Actelion Pharmaceuticals Ltd. Derivados de amidas heterocíclicas como antagonistas de receptores p2x7
KR102033190B1 (ko) 2012-01-20 2019-10-16 이도르시아 파마슈티컬스 리미티드 Ｐ２ｘ７ 수용체 길항제로서의 헤테로시클릭 아미드 유도체
EA029644B1 (ru) 2012-12-12 2018-04-30 Идорсиа Фармасьютиклз Лтд Индолкарбоксамидные производные в качестве антагонистов p2xрецепторов
CA2891499C (en) 2012-12-18 2021-07-06 Actelion Pharmaceuticals Ltd Indole carboxamide derivatives as p2x7 receptor antagonists
KR102220847B1 (ko) 2013-01-22 2021-02-26 이도르시아 파마슈티컬스 리미티드 Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
CA2896790C (en) 2013-01-22 2022-05-10 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
AR100724A1 (es) * 2014-06-05 2016-10-26 Merck Patent Gmbh Derivados de quinolina y su uso en enfermedades neurodegenerativas
TWI825637B (zh) 2021-03-31 2023-12-11 美商輝瑞股份有限公司 啶－１，６（２ｈ，７ｈ）－二酮
WO2025057074A1 (en) * 2023-09-13 2025-03-20 Suven Life Sciences Limited N-aryl benzamide derivatives as p2x7 receptor antagonists

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