CN101679409B - 双环杂环衍生化合物、其医药组合物和其用途 - Google Patents

双环杂环衍生化合物、其医药组合物和其用途 Download PDF

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Publication number
CN101679409B
CN101679409B CN200780047742.8A CN200780047742A CN101679409B CN 101679409 B CN101679409 B CN 101679409B CN 200780047742 A CN200780047742 A CN 200780047742A CN 101679409 B CN101679409 B CN 101679409B
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China
Prior art keywords
phenyl
pyridin
group
base
imidazo
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Expired - Fee Related
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CN200780047742.8A
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English (en)
Chinese (zh)
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CN101679409A (zh
Inventor
瓦雷奥·伯蒂尼
基伯特·俄白·苯菘
欧文·卡拉格汉
马日拉·格拉斯阿·卡尔
莫尔·斯图阿特·空各日乌
阿德热安·利安姆·吉尔
莎乐特·马里·各热夫斯-琼斯
安竺·马丁
克斯托弗·威廉·姆热
娆吉狄浦·卡尔·尼基价
麦克·阿里斯塔·欧布赖恩
安竺·俳克
果登·萨克斯提
里查德·大为·忒勒
爱玛·魏克斯塔夫
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Astex Therapeutics Ltd
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Astex Therapeutics Ltd
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Priority claimed from GB0625827A external-priority patent/GB0625827D0/en
Priority claimed from GB0719998A external-priority patent/GB0719998D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of CN101679409A publication Critical patent/CN101679409A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Enzymes And Modification Thereof (AREA)
CN200780047742.8A 2006-12-22 2007-12-21 双环杂环衍生化合物、其医药组合物和其用途 Expired - Fee Related CN101679409B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US87153806P 2006-12-22 2006-12-22
US60/871,538 2006-12-22
GB0625827A GB0625827D0 (en) 2006-12-22 2006-12-22 New compounds
GB0625827.1 2006-12-22
US97958207P 2007-10-12 2007-10-12
GB0719998A GB0719998D0 (en) 2007-10-12 2007-10-12 New compounds
US60/979,582 2007-10-12
GB0719998.7 2007-10-12
PCT/GB2007/004960 WO2008078100A2 (en) 2006-12-22 2007-12-21 Tricyclic amine derivatives as protein tyrosine kinase inhibitors

Publications (2)

Publication Number Publication Date
CN101679409A CN101679409A (zh) 2010-03-24
CN101679409B true CN101679409B (zh) 2014-11-26

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US (1) US8513276B2 (cg-RX-API-DMAC7.html)
EP (1) EP2121687B1 (cg-RX-API-DMAC7.html)
JP (1) JP5442449B2 (cg-RX-API-DMAC7.html)
CN (1) CN101679409B (cg-RX-API-DMAC7.html)
AU (1) AU2007337895C1 (cg-RX-API-DMAC7.html)
CA (1) CA2672213C (cg-RX-API-DMAC7.html)
CY (1) CY1117319T1 (cg-RX-API-DMAC7.html)
HR (1) HRP20151398T1 (cg-RX-API-DMAC7.html)
MX (1) MX2009006704A (cg-RX-API-DMAC7.html)
NO (1) NO342865B1 (cg-RX-API-DMAC7.html)
PL (1) PL2121687T3 (cg-RX-API-DMAC7.html)
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