CN101675092A - 用于纯化可吸收聚酯的方法和设备 - Google Patents
用于纯化可吸收聚酯的方法和设备 Download PDFInfo
- Publication number
- CN101675092A CN101675092A CN200880014751A CN200880014751A CN101675092A CN 101675092 A CN101675092 A CN 101675092A CN 200880014751 A CN200880014751 A CN 200880014751A CN 200880014751 A CN200880014751 A CN 200880014751A CN 101675092 A CN101675092 A CN 101675092A
- Authority
- CN
- China
- Prior art keywords
- solvent
- polyester
- absorbable polyester
- moisture eliminator
- sieve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000728 polyester Polymers 0.000 title claims abstract description 69
- 238000000034 method Methods 0.000 title claims abstract description 32
- 238000004140 cleaning Methods 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 claims abstract description 72
- 229920000642 polymer Polymers 0.000 claims abstract description 50
- 239000000725 suspension Substances 0.000 claims abstract description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 43
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 21
- 239000000178 monomer Substances 0.000 claims description 17
- 239000000126 substance Substances 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 13
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 12
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 10
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 9
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 9
- 238000004090 dissolution Methods 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 238000010008 shearing Methods 0.000 claims description 9
- 239000002002 slurry Substances 0.000 claims description 9
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 7
- 239000007943 implant Substances 0.000 claims description 7
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 claims description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- 230000005540 biological transmission Effects 0.000 claims description 6
- -1 polyoxyethylene Polymers 0.000 claims description 6
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 5
- 125000000623 heterocyclic group Chemical group 0.000 claims description 5
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 5
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 229910001220 stainless steel Inorganic materials 0.000 claims description 5
- 239000010935 stainless steel Substances 0.000 claims description 5
- 230000005484 gravity Effects 0.000 claims description 4
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims description 4
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 claims description 3
- VPVXHAANQNHFSF-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1 VPVXHAANQNHFSF-UHFFFAOYSA-N 0.000 claims description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 3
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 3
- JBFHTYHTHYHCDJ-UHFFFAOYSA-N gamma-caprolactone Chemical compound CCC1CCC(=O)O1 JBFHTYHTHYHCDJ-UHFFFAOYSA-N 0.000 claims description 3
- 150000005826 halohydrocarbons Chemical class 0.000 claims description 3
- 239000013583 drug formulation Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 18
- 239000007787 solid Substances 0.000 description 8
- 238000000354 decomposition reaction Methods 0.000 description 6
- 238000006460 hydrolysis reaction Methods 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000007062 hydrolysis Effects 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 235000011089 carbon dioxide Nutrition 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000012043 crude product Substances 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 238000006068 polycondensation reaction Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 239000011877 solvent mixture Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 235000019013 Viburnum opulus Nutrition 0.000 description 1
- 244000071378 Viburnum opulus Species 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- JYYOBHFYCIDXHH-UHFFFAOYSA-N carbonic acid;hydrate Chemical compound O.OC(O)=O JYYOBHFYCIDXHH-UHFFFAOYSA-N 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 244000144992 flock Species 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000000710 polymer precipitation Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/88—Post-polymerisation treatment
- C08G63/90—Purification; Drying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D25/00—Filters formed by clamping together several filtering elements or parts of such elements
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L63/00—Compositions of epoxy resins; Compositions of derivatives of epoxy resins
- C08L63/08—Epoxidised polymerised polyenes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polyesters Or Polycarbonates (AREA)
- Developing Agents For Electrophotography (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Extraction Or Liquid Replacement (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Cleaning By Liquid Or Steam (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (22)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007020951A DE102007020951A1 (de) | 2007-05-04 | 2007-05-04 | Verfahren und Vorrichtung zur Reinigung eines resorbierbaren Polyesters |
DE102007020951.9 | 2007-05-04 | ||
PCT/EP2008/055408 WO2008135523A1 (de) | 2007-05-04 | 2008-05-02 | Verfahren und vorrichtung zur reinigung eines resorbierbaren polyesters |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101675092A true CN101675092A (zh) | 2010-03-17 |
CN101675092B CN101675092B (zh) | 2012-01-11 |
Family
ID=39800573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008800147511A Active CN101675092B (zh) | 2007-05-04 | 2008-05-02 | 用于纯化可吸收聚酯的方法和设备 |
Country Status (18)
Country | Link |
---|---|
US (2) | US20100137550A1 (zh) |
EP (2) | EP2246381A3 (zh) |
JP (1) | JP5654342B2 (zh) |
KR (1) | KR20100016203A (zh) |
CN (1) | CN101675092B (zh) |
AR (1) | AR066434A1 (zh) |
AU (1) | AU2008248649A1 (zh) |
BR (1) | BRPI0810713A8 (zh) |
CA (1) | CA2686045A1 (zh) |
DE (1) | DE102007020951A1 (zh) |
ES (1) | ES2627727T3 (zh) |
HK (1) | HK1138027A1 (zh) |
IL (1) | IL201279A (zh) |
MX (1) | MX2009011077A (zh) |
NZ (1) | NZ580827A (zh) |
RU (1) | RU2473577C2 (zh) |
TW (1) | TWI428365B (zh) |
WO (1) | WO2008135523A1 (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103421172A (zh) * | 2012-05-23 | 2013-12-04 | 上海现代药物制剂工程研究中心有限公司 | 一种生物可降解聚酯的纯化工艺 |
CN105492503A (zh) * | 2013-08-29 | 2016-04-13 | 赢创罗姆有限公司 | 粉末形式生物可吸收聚酯的制备方法 |
CN112595033A (zh) * | 2020-12-10 | 2021-04-02 | 万华化学集团股份有限公司 | 一种颜色稳定的聚碳酸酯粉末的制备方法 |
CN112694605A (zh) * | 2020-12-29 | 2021-04-23 | 浙江圣兆药物科技股份有限公司 | 一种聚酯类产品的纯化方法和生产设备 |
CN114058072A (zh) * | 2020-08-07 | 2022-02-18 | Apk股份公司 | 通过集成的滚筒干燥和挤出从聚合物溶液除去溶剂的方法 |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010053242A1 (en) | 2008-11-07 | 2010-05-14 | Samyang Corporation | Highly purified polylactic acid or a derivative thereof, a salt of the same, and purification method thereof |
DE102011014131A1 (de) | 2011-03-15 | 2012-09-20 | Thyssenkrupp Uhde Gmbh | Verfahren zur Trocknung von feuchtem Polymerpulver und dafür geeignete Vorrichtung |
US8735504B2 (en) | 2012-05-02 | 2014-05-27 | Warsaw Orthopedic, Inc. | Methods for preparing polymers having low residual monomer content |
WO2014108191A1 (en) | 2013-01-10 | 2014-07-17 | Evonik Industries Ag | Electronic device unit comprising a polymer coating |
CN103105047B (zh) * | 2013-01-30 | 2014-10-22 | 青岛沃隆花生机械有限公司 | 连续式去水机 |
JP5959728B2 (ja) | 2013-04-11 | 2016-08-02 | 三井化学株式会社 | 乳酸―グリコール酸共重合体の製造法またはその塩の製造法 |
CN106687077B (zh) | 2014-09-07 | 2021-07-27 | 奥西奥有限公司 | 各向异性生物复合材料、包含各向异性生物复合材料的医疗植入物及其治疗方法 |
JP6707537B2 (ja) | 2014-11-14 | 2020-06-10 | レーム・ゲーエムベーハーRoehm GmbH | 粒子の形の生体吸収性ポリエステルの製造方法 |
CA2971990C (en) | 2014-12-26 | 2023-03-28 | Orahn Preiss-Bloom | Continuous-fiber reinforced biocomposite medical implants |
EP3307247A1 (en) | 2015-06-10 | 2018-04-18 | Evonik Röhm GmbH | Process for preparing a powder comprising a human coagulation factor protein and a lactic acid polymer |
WO2018002917A1 (en) * | 2016-06-27 | 2018-01-04 | Ossio Ltd. | Fiber reinforced biocomposite medical implants with high mineral content |
CN111050677B (zh) | 2017-09-07 | 2023-06-20 | 奥西西奥有限公司 | 纤维增强的生物复合材料带螺纹的植入物 |
JP2019167402A (ja) * | 2018-03-22 | 2019-10-03 | 三井化学株式会社 | 乳酸−グリコール酸共重合体を含む粉体の製造方法 |
US11052053B2 (en) | 2018-05-08 | 2021-07-06 | Evonik Operations Gmbh | Nanoparticle comprising a bio-resorbable polyester, a hydrophilic polymer and an acylated human lactoferrin-derived peptide |
DE102019205941A1 (de) * | 2019-04-25 | 2020-10-29 | Robert Bosch Gmbh | Verfahren zur Behandlung mindestens einer Oberfläche eines Polymers |
CN117337168A (zh) | 2021-04-01 | 2024-01-02 | 渤健马萨诸塞州股份有限公司 | 向中枢神经系统的核酸递送 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2164329B (en) * | 1984-09-13 | 1988-05-05 | British Uralite Plc | Hydraulic cement compositions containing fibrous material |
JPS61250025A (ja) * | 1985-04-27 | 1986-11-07 | Mitsubishi Gas Chem Co Inc | 乾燥ポリカ−ボネ−ト固形粒子の製造法 |
DE3708916A1 (de) | 1987-03-19 | 1988-09-29 | Boehringer Ingelheim Kg | Verfahren zur reinigung resorbierbarer polyester |
SU1625876A1 (ru) * | 1988-06-21 | 1991-02-07 | Предприятие П/Я А-7629 | Способ очистки гликолида или лактида от примесей органических кислот |
EP0452111B1 (en) * | 1990-04-13 | 1998-07-15 | Takeda Chemical Industries, Ltd. | Biodegradable high-molecular polymers, production and use thereof |
JP3200706B2 (ja) * | 1990-04-13 | 2001-08-20 | 武田薬品工業株式会社 | 生体内分解型高分子重合物 |
DE4014974A1 (de) | 1990-05-10 | 1991-11-14 | Boehringer Ingelheim Kg | Verfahren zur herstellung von loesungsmittel- und restmonomerenfreien in spritzgiess-, extrusions- und schmelzspinnverfahren einsetzbaren polymeren |
RU2093246C1 (ru) * | 1992-04-02 | 1997-10-20 | Николай Прокофьевич Кохно | Способ разделения грубодисперсных суспензий и устройство для его осуществления |
DE4218268C2 (de) * | 1992-06-03 | 1997-01-16 | Boehringer Ingelheim Kg | Verfahren zur Reinigung bioresorbierbarer Polyester |
DE19800591C2 (de) | 1997-03-21 | 2002-04-25 | Dyneon Gmbh | Verfahren zur Behandlung von Fluorpolymersuspensionen |
US6376643B1 (en) | 2000-11-08 | 2002-04-23 | Invigor Biotechnology Co., Ltd. | Method of polymerization of lactide and polylactide homopolymer thereof |
JP4214183B2 (ja) * | 2003-04-10 | 2009-01-28 | 川口精機株式会社 | スクリュー式脱水機 |
JP4403845B2 (ja) * | 2004-03-22 | 2010-01-27 | 東レ株式会社 | ラクチド含有量が少ないポリ乳酸の製造方法 |
JP2006026563A (ja) * | 2004-07-16 | 2006-02-02 | Fuji Photo Film Co Ltd | 懸濁化学物質を含有した廃液の処理方法及び装置 |
-
2007
- 2007-05-04 DE DE102007020951A patent/DE102007020951A1/de not_active Withdrawn
-
2008
- 2008-05-02 RU RU2009144850/05A patent/RU2473577C2/ru active
- 2008-05-02 AU AU2008248649A patent/AU2008248649A1/en not_active Abandoned
- 2008-05-02 ES ES08749980.2T patent/ES2627727T3/es active Active
- 2008-05-02 BR BRPI0810713A patent/BRPI0810713A8/pt not_active IP Right Cessation
- 2008-05-02 MX MX2009011077A patent/MX2009011077A/es active IP Right Grant
- 2008-05-02 US US12/598,480 patent/US20100137550A1/en not_active Abandoned
- 2008-05-02 JP JP2010506903A patent/JP5654342B2/ja active Active
- 2008-05-02 CN CN2008800147511A patent/CN101675092B/zh active Active
- 2008-05-02 CA CA002686045A patent/CA2686045A1/en not_active Abandoned
- 2008-05-02 KR KR1020097023025A patent/KR20100016203A/ko not_active Application Discontinuation
- 2008-05-02 AR ARP080101884A patent/AR066434A1/es active Pending
- 2008-05-02 TW TW097116376A patent/TWI428365B/zh active
- 2008-05-02 EP EP10173681.7A patent/EP2246381A3/de not_active Withdrawn
- 2008-05-02 WO PCT/EP2008/055408 patent/WO2008135523A1/de active Application Filing
- 2008-05-02 EP EP08749980.2A patent/EP2147036B1/de active Active
- 2008-05-02 NZ NZ580827A patent/NZ580827A/xx unknown
-
2009
- 2009-10-01 IL IL201279A patent/IL201279A/en active IP Right Grant
-
2010
- 2010-05-24 HK HK10105032.7A patent/HK1138027A1/xx unknown
-
2011
- 2011-02-22 US US13/032,198 patent/US9156942B2/en active Active
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103421172A (zh) * | 2012-05-23 | 2013-12-04 | 上海现代药物制剂工程研究中心有限公司 | 一种生物可降解聚酯的纯化工艺 |
CN103421172B (zh) * | 2012-05-23 | 2016-01-20 | 上海现代药物制剂工程研究中心有限公司 | 一种生物可降解聚酯的纯化工艺 |
CN105492503A (zh) * | 2013-08-29 | 2016-04-13 | 赢创罗姆有限公司 | 粉末形式生物可吸收聚酯的制备方法 |
CN105492503B (zh) * | 2013-08-29 | 2018-02-09 | 赢创罗姆有限公司 | 粉末形式生物可吸收聚酯的制备方法 |
CN114058072A (zh) * | 2020-08-07 | 2022-02-18 | Apk股份公司 | 通过集成的滚筒干燥和挤出从聚合物溶液除去溶剂的方法 |
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CN112694605A (zh) * | 2020-12-29 | 2021-04-23 | 浙江圣兆药物科技股份有限公司 | 一种聚酯类产品的纯化方法和生产设备 |
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EP2147036B1 (de) | 2017-03-22 |
RU2473577C2 (ru) | 2013-01-27 |
US20100137550A1 (en) | 2010-06-03 |
NZ580827A (en) | 2012-11-30 |
ES2627727T3 (es) | 2017-07-31 |
AU2008248649A1 (en) | 2008-11-13 |
AR066434A1 (es) | 2009-08-19 |
WO2008135523A1 (de) | 2008-11-13 |
US9156942B2 (en) | 2015-10-13 |
IL201279A (en) | 2013-11-28 |
EP2246381A2 (de) | 2010-11-03 |
KR20100016203A (ko) | 2010-02-12 |
JP5654342B2 (ja) | 2015-01-14 |
TW200909474A (en) | 2009-03-01 |
IL201279A0 (en) | 2010-05-31 |
HK1138027A1 (en) | 2010-08-13 |
BRPI0810713A2 (pt) | 2014-10-21 |
EP2246381A3 (de) | 2017-10-25 |
JP2010526200A (ja) | 2010-07-29 |
US20110288267A2 (en) | 2011-11-24 |
DE102007020951A1 (de) | 2008-11-06 |
EP2147036A1 (de) | 2010-01-27 |
CN101675092B (zh) | 2012-01-11 |
TWI428365B (zh) | 2014-03-01 |
MX2009011077A (es) | 2009-11-02 |
RU2009144850A (ru) | 2011-06-10 |
US20110144301A1 (en) | 2011-06-16 |
CA2686045A1 (en) | 2008-11-13 |
BRPI0810713A8 (pt) | 2016-06-07 |
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