CN101657450B - 噁唑烷酮抗生素衍生物 - Google Patents

噁唑烷酮抗生素衍生物 Download PDF

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Publication number
CN101657450B
CN101657450B CN200880011810.XA CN200880011810A CN101657450B CN 101657450 B CN101657450 B CN 101657450B CN 200880011810 A CN200880011810 A CN 200880011810A CN 101657450 B CN101657450 B CN 101657450B
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CN
China
Prior art keywords
methoxy
oxo
benzo
oxazolidin
naphthyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200880011810.XA
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English (en)
Chinese (zh)
Other versions
CN101657450A (zh
Inventor
马库斯·盖得
克里斯蒂安·哈伯舒兰
乔治·吕迪
吉恩-菲利普·苏里维特
科内丽亚·扎姆布朗恩·埃科林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aidu West Pharmaceutical Co Ltd
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of CN101657450A publication Critical patent/CN101657450A/zh
Application granted granted Critical
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Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880011810.XA 2007-04-11 2008-04-10 噁唑烷酮抗生素衍生物 Expired - Fee Related CN101657450B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
IBPCT/IB2007/051292 2007-04-11
WOPCT/IB2007/051292 2007-04-11
IB2007051292 2007-04-11
IBPCT/IB2008/050746 2008-02-29
IB2008050746 2008-02-29
WOPCT/IB2008/050746 2008-02-29
PCT/IB2008/051356 WO2008126024A2 (en) 2007-04-11 2008-04-10 Oxazolidinone antibiotic derivatives

Publications (2)

Publication Number Publication Date
CN101657450A CN101657450A (zh) 2010-02-24
CN101657450B true CN101657450B (zh) 2014-04-23

Family

ID=39722506

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880011810.XA Expired - Fee Related CN101657450B (zh) 2007-04-11 2008-04-10 噁唑烷酮抗生素衍生物

Country Status (16)

Country Link
US (1) US8114867B2 (cg-RX-API-DMAC7.html)
EP (1) EP2146987B1 (cg-RX-API-DMAC7.html)
JP (1) JP5363457B2 (cg-RX-API-DMAC7.html)
KR (1) KR101563752B1 (cg-RX-API-DMAC7.html)
CN (1) CN101657450B (cg-RX-API-DMAC7.html)
AR (1) AR066012A1 (cg-RX-API-DMAC7.html)
AU (1) AU2008238894B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0809667A2 (cg-RX-API-DMAC7.html)
CA (1) CA2679069C (cg-RX-API-DMAC7.html)
CL (1) CL2008001003A1 (cg-RX-API-DMAC7.html)
ES (1) ES2560870T3 (cg-RX-API-DMAC7.html)
MX (1) MX2009010641A (cg-RX-API-DMAC7.html)
PL (1) PL2146987T3 (cg-RX-API-DMAC7.html)
RU (1) RU2506263C2 (cg-RX-API-DMAC7.html)
TW (1) TWI415614B (cg-RX-API-DMAC7.html)
WO (1) WO2008126024A2 (cg-RX-API-DMAC7.html)

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US8349828B2 (en) 2008-02-20 2013-01-08 Actelion Pharmaceuticals Ltd. Azatricyclic antibiotic compounds
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EP2346862B1 (en) * 2008-10-10 2012-09-12 Actelion Pharmaceuticals Ltd. 2-benzothiophenyl-and 2-naphthyl-0xaz0lidin0nes and their azaisostere analogues as antibacterial agents
NZ593891A (en) 2008-12-12 2013-05-31 Actelion Pharmaceuticals Ltd 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives
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TW201309689A (zh) 2011-02-07 2013-03-01 Daiichi Sankyo Co Ltd 含胺基之吡咯啶酮衍生物
EP2742042A1 (en) 2011-08-11 2014-06-18 Actelion Pharmaceuticals Ltd. Quinazoline-2,4-dione derivatives
MX344529B (es) * 2011-11-08 2016-12-19 Actelion Pharmaceuticals Ltd Derivados antibioticos de 2 - oxo -oxazolidin - 3, 5 -diilo.
EP2785721A1 (en) 2011-11-30 2014-10-08 Actelion Pharmaceuticals Ltd. 3,7-disubstituted octahydro-2h-pyrido[4,3-e][1,3]oxazin-2-one antibiotics
WO2014024056A1 (en) 2012-08-06 2014-02-13 Daiichi Sankyo Company, Limited Pyrrolidine derivatives with antibacterial properties
MX349214B (es) * 2012-08-17 2017-07-18 Basf Se Proceso para la fabricacion de benzoxazinonas.
HK1221459A1 (zh) * 2013-04-16 2017-06-02 Idorsia Pharmaceuticals Ltd 抗菌双芳香族衍生物
AR102256A1 (es) * 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
EP3414246A1 (en) * 2016-02-08 2018-12-19 Redx Pharma PLC Antibacterial compounds
GB201602235D0 (en) * 2016-02-08 2016-03-23 Redx Pharma Plc Antibacterial compounds
US10487093B2 (en) 2016-02-08 2019-11-26 Redx Pharma Plc Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds
GB2550437B (en) 2016-05-20 2021-06-23 Bugworks Res Inc Heterocyclic compounds useful as anti-bacterial agents and method for production
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
DK3634968T3 (da) * 2017-06-08 2023-05-01 Bugworks Res Inc Heterocykliske forbindelser, der kan anvendes som antibakterielle midler, og fremgangsmåde til fremstilling heraf
JP7390728B2 (ja) * 2017-11-29 2023-12-04 バグワークス・リサーチ・インコーポレイテッド 抗菌複素環式化合物及びそれらの合成
HUE061835T2 (hu) 2018-03-28 2023-08-28 Bugworks Res Inc Oxazolidinon antibiotikus vegyületek és eljárás azok elõállítására
CN117532894B (zh) * 2023-12-05 2024-06-14 东莞美泰电子有限公司 一种用于保护零件的pu皮革热压贴皮工艺

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WO2002096907A1 (en) * 2001-05-25 2002-12-05 Smithkline Beecham P.L.C. Bicyclic nitrogen-containing heterocyclic derivatives for use as antibacterials
WO2004035569A2 (de) * 2002-10-10 2004-04-29 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue verbindungen mit antibakterieller aktivität
WO2004050036A2 (en) * 2002-12-04 2004-06-17 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
WO2004089947A2 (de) * 2003-04-08 2004-10-21 Morphochem Ag Neue verbindungen mit antibakterieller aktivität
WO2006010831A1 (fr) * 2004-06-29 2006-02-02 Novexel Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
US20070060558A1 (en) * 2004-07-30 2007-03-15 Palumed S.A. Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents

Also Published As

Publication number Publication date
KR20090130112A (ko) 2009-12-17
US20100137290A1 (en) 2010-06-03
TWI415614B (zh) 2013-11-21
BRPI0809667A2 (pt) 2014-10-07
AU2008238894A1 (en) 2008-10-23
PL2146987T3 (pl) 2016-05-31
CA2679069A1 (en) 2008-10-23
AU2008238894B2 (en) 2013-06-20
TW200843780A (en) 2008-11-16
JP5363457B2 (ja) 2013-12-11
RU2009141310A (ru) 2011-05-20
ES2560870T3 (es) 2016-02-23
CN101657450A (zh) 2010-02-24
WO2008126024A3 (en) 2008-12-04
CL2008001003A1 (es) 2008-10-17
CA2679069C (en) 2016-06-07
KR101563752B1 (ko) 2015-10-27
WO2008126024A2 (en) 2008-10-23
EP2146987B1 (en) 2015-12-02
US8114867B2 (en) 2012-02-14
AR066012A1 (es) 2009-07-15
MX2009010641A (es) 2009-10-23
RU2506263C2 (ru) 2014-02-10
EP2146987A2 (en) 2010-01-27
JP2010523645A (ja) 2010-07-15

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Effective date of registration: 20171113

Address after: Swiss A Skei Weil

Patentee after: Aidu West Pharmaceutical Co. Ltd.

Address before: Swiss A Schriewer

Patentee before: Actelion Pharmaceuticals Ltd.

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20140423

Termination date: 20190410