CN101654410B - 二环[3.1.0]己烷衍生物的制备方法及其中间体 - Google Patents

二环[3.1.0]己烷衍生物的制备方法及其中间体 Download PDF

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Publication number
CN101654410B
CN101654410B CN2009100086868A CN200910008686A CN101654410B CN 101654410 B CN101654410 B CN 101654410B CN 2009100086868 A CN2009100086868 A CN 2009100086868A CN 200910008686 A CN200910008686 A CN 200910008686A CN 101654410 B CN101654410 B CN 101654410B
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compound
molecular formula
solution
formula
nmr
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Chinese (zh)
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CN101654410A (zh
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F·W·哈特纳
L·塔恩
安田修祥
吉川直树
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Taisho Pharmaceutical Co Ltd
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Taisho Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/08—Saturated compounds having a carboxyl group bound to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2009100086868A 2003-11-07 2004-11-03 二环[3.1.0]己烷衍生物的制备方法及其中间体 Expired - Fee Related CN101654410B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51839103P 2003-11-07 2003-11-07
US60/518,391 2003-11-07

Related Parent Applications (1)

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CNB2004800381879A Division CN100475800C (zh) 2003-11-07 2004-11-03 二环[3.1.0]己烷衍生物的制备方法及其中间体

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CN101654410A CN101654410A (zh) 2010-02-24
CN101654410B true CN101654410B (zh) 2013-03-06

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CNB2004800381879A Expired - Fee Related CN100475800C (zh) 2003-11-07 2004-11-03 二环[3.1.0]己烷衍生物的制备方法及其中间体
CN2009100086868A Expired - Fee Related CN101654410B (zh) 2003-11-07 2004-11-03 二环[3.1.0]己烷衍生物的制备方法及其中间体

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CNB2004800381879A Expired - Fee Related CN100475800C (zh) 2003-11-07 2004-11-03 二环[3.1.0]己烷衍生物的制备方法及其中间体

Country Status (10)

Country Link
US (1) US7786314B2 (enExample)
EP (1) EP1689727A4 (enExample)
JP (1) JP4742239B2 (enExample)
KR (1) KR101204145B1 (enExample)
CN (2) CN100475800C (enExample)
AU (1) AU2004289652B8 (enExample)
CA (1) CA2544560C (enExample)
RU (1) RU2388747C2 (enExample)
TW (1) TWI347316B (enExample)
WO (1) WO2005047215A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5309680B2 (ja) * 2008-05-09 2013-10-09 大正製薬株式会社 フッ素化エステル化合物の製造方法及びその中間体
WO2009142184A1 (ja) * 2008-05-21 2009-11-26 大正製薬株式会社 酵素を用いたビシクロ［３．１．０］ヘキサン誘導体の製造方法
US8742161B2 (en) * 2009-11-18 2014-06-03 Taisho Pharmaceutical Co., Ltd Process for producing optically active bicyclo [3.1.0] hexane derivative using enzyme
CN112074505B (zh) 2018-03-08 2024-04-05 因赛特公司 作为PI3K-γ抑制剂的氨基吡嗪二醇化合物
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6160009A (en) * 1997-05-14 2000-12-12 Eli Lilly And Company Excitatory amino acid receptor modulators
US6333428B1 (en) * 1998-08-31 2001-12-25 Taisho Pharmaceutical Co., Ltd. 6-fluorobicyclo[3.1.0]hexane derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2152925C1 (ru) * 1994-08-12 2000-07-20 Эли Лилли Энд Компани Производные аминобицикло[3.1.0]гексан-2,6-дикарбоновой кислоты и фармацевтическая композиция
US5661184A (en) 1994-08-12 1997-08-26 Eli Lilly And Company Psychiatric agents
JP2000072731A (ja) * 1998-08-31 2000-03-07 Taisho Pharmaceut Co Ltd ４−置換−２−アミノビシクロ［３．１．０］ヘキサン−２，６−ジカルボン酸誘導体及び製薬用組成物
JP4194715B2 (ja) * 1998-08-31 2008-12-10 大正製薬株式会社 ６−フルオロビシクロ［３．１．０］ヘキサン誘導体
PE20001236A1 (es) 1998-11-13 2000-11-10 Lilly Co Eli Moduladores del receptor de aminoacidos excitadores
US6479674B1 (en) * 1999-03-25 2002-11-12 Taisho Pharmaceutical Co., Ltd. Carboxylic acid derivatives and process for producing same
AU6785501A (en) 2000-06-28 2002-01-08 Taisho Pharmaceutical Co Ltd Intermediate and process for producing fluorinated carboxylic acid derivative from the same
CA2441127A1 (en) * 2001-03-14 2002-09-19 Taisho Pharmaceutical Co., Ltd. Process for producing bicyclocarboxylic acid derivative

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6160009A (en) * 1997-05-14 2000-12-12 Eli Lilly And Company Excitatory amino acid receptor modulators
US6333428B1 (en) * 1998-08-31 2001-12-25 Taisho Pharmaceutical Co., Ltd. 6-fluorobicyclo[3.1.0]hexane derivatives

Also Published As

Publication number Publication date
EP1689727A2 (en) 2006-08-16
US20070112030A1 (en) 2007-05-17
CA2544560C (en) 2014-01-07
JP4742239B2 (ja) 2011-08-10
CA2544560A1 (en) 2005-05-26
HK1096971A1 (en) 2007-06-15
RU2006119924A (ru) 2007-12-27
EP1689727A4 (en) 2008-12-31
TW200530178A (en) 2005-09-16
KR101204145B1 (ko) 2012-11-22
WO2005047215A2 (en) 2005-05-26
CN100475800C (zh) 2009-04-08
JP2007513070A (ja) 2007-05-24
CN1898224A (zh) 2007-01-17
AU2004289652B8 (en) 2011-01-20
CN101654410A (zh) 2010-02-24
TWI347316B (en) 2011-08-21
US7786314B2 (en) 2010-08-31
AU2004289652A1 (en) 2005-05-26
KR20060131771A (ko) 2006-12-20
HK1139124A1 (en) 2010-09-10
AU2004289652B2 (en) 2010-09-16
RU2388747C2 (ru) 2010-05-10
WO2005047215A3 (en) 2005-07-14

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