TWI347316B - Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto - Google Patents
Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates theretoInfo
- Publication number
- TWI347316B TWI347316B TW093133900A TW93133900A TWI347316B TW I347316 B TWI347316 B TW I347316B TW 093133900 A TW093133900 A TW 093133900A TW 93133900 A TW93133900 A TW 93133900A TW I347316 B TWI347316 B TW I347316B
- Authority
- TW
- Taiwan
- Prior art keywords
- intermediates
- processes
- hexane derivatives
- preparing bicyclo
- bicyclo
- Prior art date
Links
- JAPMJSVZDUYFKL-UHFFFAOYSA-N bicyclo[3.1.0]hexane Chemical class C1CCC2CC21 JAPMJSVZDUYFKL-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/08—Saturated compounds having a carboxyl group bound to a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Epoxy Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51839103P | 2003-11-07 | 2003-11-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200530178A TW200530178A (en) | 2005-09-16 |
| TWI347316B true TWI347316B (en) | 2011-08-21 |
Family
ID=34590258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093133900A TWI347316B (en) | 2003-11-07 | 2004-11-05 | Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7786314B2 (enExample) |
| EP (1) | EP1689727A4 (enExample) |
| JP (1) | JP4742239B2 (enExample) |
| KR (1) | KR101204145B1 (enExample) |
| CN (2) | CN100475800C (enExample) |
| AU (1) | AU2004289652B8 (enExample) |
| CA (1) | CA2544560C (enExample) |
| RU (1) | RU2388747C2 (enExample) |
| TW (1) | TWI347316B (enExample) |
| WO (1) | WO2005047215A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5309680B2 (ja) * | 2008-05-09 | 2013-10-09 | 大正製薬株式会社 | フッ素化エステル化合物の製造方法及びその中間体 |
| WO2009142184A1 (ja) * | 2008-05-21 | 2009-11-26 | 大正製薬株式会社 | 酵素を用いたビシクロ［３．１．０］ヘキサン誘導体の製造方法 |
| US8742161B2 (en) * | 2009-11-18 | 2014-06-03 | Taisho Pharmaceutical Co., Ltd | Process for producing optically active bicyclo [3.1.0] hexane derivative using enzyme |
| CN112074505B (zh) | 2018-03-08 | 2024-04-05 | 因赛特公司 | 作为PI3K-γ抑制剂的氨基吡嗪二醇化合物 |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2152925C1 (ru) * | 1994-08-12 | 2000-07-20 | Эли Лилли Энд Компани | Производные аминобицикло[3.1.0]гексан-2,6-дикарбоновой кислоты и фармацевтическая композиция |
| US5661184A (en) | 1994-08-12 | 1997-08-26 | Eli Lilly And Company | Psychiatric agents |
| ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
| JP2000072731A (ja) * | 1998-08-31 | 2000-03-07 | Taisho Pharmaceut Co Ltd | ４−置換−２−アミノビシクロ［３．１．０］ヘキサン−２，６−ジカルボン酸誘導体及び製薬用組成物 |
| JP4194715B2 (ja) * | 1998-08-31 | 2008-12-10 | 大正製薬株式会社 | ６−フルオロビシクロ［３．１．０］ヘキサン誘導体 |
| CN1247527C (zh) * | 1998-08-31 | 2006-03-29 | 大正制药株式会社 | 6－氟双环[3.1.0]己烷衍生物 |
| PE20001236A1 (es) | 1998-11-13 | 2000-11-10 | Lilly Co Eli | Moduladores del receptor de aminoacidos excitadores |
| US6479674B1 (en) * | 1999-03-25 | 2002-11-12 | Taisho Pharmaceutical Co., Ltd. | Carboxylic acid derivatives and process for producing same |
| AU6785501A (en) | 2000-06-28 | 2002-01-08 | Taisho Pharmaceutical Co Ltd | Intermediate and process for producing fluorinated carboxylic acid derivative from the same |
| CA2441127A1 (en) * | 2001-03-14 | 2002-09-19 | Taisho Pharmaceutical Co., Ltd. | Process for producing bicyclocarboxylic acid derivative |
-
2004
- 2004-11-03 US US10/578,476 patent/US7786314B2/en not_active Expired - Fee Related
- 2004-11-03 CN CNB2004800381879A patent/CN100475800C/zh not_active Expired - Fee Related
- 2004-11-03 CA CA2544560A patent/CA2544560C/en not_active Expired - Fee Related
- 2004-11-03 WO PCT/US2004/036574 patent/WO2005047215A2/en not_active Ceased
- 2004-11-03 CN CN2009100086868A patent/CN101654410B/zh not_active Expired - Fee Related
- 2004-11-03 EP EP04800646A patent/EP1689727A4/en not_active Withdrawn
- 2004-11-03 AU AU2004289652A patent/AU2004289652B8/en not_active Ceased
- 2004-11-03 KR KR1020067011065A patent/KR101204145B1/ko not_active Expired - Fee Related
- 2004-11-03 JP JP2006538449A patent/JP4742239B2/ja not_active Expired - Fee Related
- 2004-11-03 RU RU2006119924/04A patent/RU2388747C2/ru not_active IP Right Cessation
- 2004-11-05 TW TW093133900A patent/TWI347316B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1689727A2 (en) | 2006-08-16 |
| US20070112030A1 (en) | 2007-05-17 |
| CA2544560C (en) | 2014-01-07 |
| JP4742239B2 (ja) | 2011-08-10 |
| CA2544560A1 (en) | 2005-05-26 |
| HK1096971A1 (en) | 2007-06-15 |
| RU2006119924A (ru) | 2007-12-27 |
| EP1689727A4 (en) | 2008-12-31 |
| TW200530178A (en) | 2005-09-16 |
| KR101204145B1 (ko) | 2012-11-22 |
| WO2005047215A2 (en) | 2005-05-26 |
| CN100475800C (zh) | 2009-04-08 |
| JP2007513070A (ja) | 2007-05-24 |
| CN101654410B (zh) | 2013-03-06 |
| CN1898224A (zh) | 2007-01-17 |
| AU2004289652B8 (en) | 2011-01-20 |
| CN101654410A (zh) | 2010-02-24 |
| US7786314B2 (en) | 2010-08-31 |
| AU2004289652A1 (en) | 2005-05-26 |
| KR20060131771A (ko) | 2006-12-20 |
| HK1139124A1 (en) | 2010-09-10 |
| AU2004289652B2 (en) | 2010-09-16 |
| RU2388747C2 (ru) | 2010-05-10 |
| WO2005047215A3 (en) | 2005-07-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2002359923A1 (en) | 6-fluorobicyclo[3.1.0]hexane derivatives | |
| IL166235A (en) | H-1-pyrolidine-4,2-deion spirocyclic annihilated conjugates in cisal alkoxies for use as pesticides, their preparation and intermediates | |
| HRP20050328A2 (en) | Process for the preparation of (s,s)-cis-2-benzhyd | |
| MXPA03008630A (es) | Derivados de arilisoxazolinas, procedimientos para su preparacion y su utilizacion como agentes plaguicidas. | |
| AU2003265589A1 (en) | Process for the preparation of 1,1,1,2,2-pentafluoroethane | |
| AU2003275675A1 (en) | Process for producing hexahydrofurofuranol derivative, intermediate thereof and process for producing the same | |
| AU2002242996A1 (en) | Spiroisoquinoline compounds, methods for their preparation and intermediates | |
| EP1561434A4 (en) | BITE ATTACHMENT, BIT AND MANUFACTURING PROCESS THEREFOR | |
| AU2003269949A1 (en) | Substituted 1,4-pyrazine derivatives | |
| ZA200407361B (en) | Acyl-3-carboxyphenylurea derivatives, method for production and use thereof. | |
| TWI347316B (en) | Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto | |
| AU2003289176A1 (en) | 1,3-benzothiazinone derivatives, process for producing the same and use thereof | |
| IL174596A0 (en) | Preparation of 3-azabicyclo[3.1.0] hexane derivatives | |
| IL174415A0 (en) | Process for preparing an azabicyclo[3.1.0] hexane compound | |
| AU2003300262A1 (en) | Phthalimidylazo dyes, processes for the preparation thereof and the use thereof | |
| EG23417A (en) | Process for the preparation 7 a-methylsteroids. | |
| ZA200505352B (en) | Novel substituted 2,3-benzodiazepine derivatives | |
| ZA200702070B (en) | Process for preparing substituted 8-azablcyclo[3.2.1] octan-3-ols | |
| IL174975A0 (en) | 2-phenyl-benzofuran derivatives, method for the production thereof and their use | |
| AU2003254781A1 (en) | Aminosalicylamide derivative, process for producing the same and agri-horticultural pesticide | |
| AU2003289546A1 (en) | Process for preparing simvastatin. | |
| AU2003245818A1 (en) | 2,4-dialkyl-branched aldehydes and derivatives produced therefrom | |
| MXPA03007550A (es) | Derivados coloporosidos, proceso para su preparacion y su uso. | |
| AU2003269482A1 (en) | Process for the manufacture of 2,1,3-benzoxadiazole-4-carboxaldehyde | |
| AU2003264894A1 (en) | Novel method for preparing alpha-glycosylceramides, novel alpha-glycosylceramide derivatives and their uses |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |