CN101565404B - 杂环化合物 - Google Patents
杂环化合物 Download PDFInfo
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- CN101565404B CN101565404B CN2008101796944A CN200810179694A CN101565404B CN 101565404 B CN101565404 B CN 101565404B CN 2008101796944 A CN2008101796944 A CN 2008101796944A CN 200810179694 A CN200810179694 A CN 200810179694A CN 101565404 B CN101565404 B CN 101565404B
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- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US4649608P | 2008-04-21 | 2008-04-21 | |
| US61/046,496 | 2008-04-21 |
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| CN101565404A CN101565404A (zh) | 2009-10-28 |
| CN101565404B true CN101565404B (zh) | 2012-12-05 |
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| WO2010056847A2 (en) * | 2008-11-13 | 2010-05-20 | Taigen Biotechnology Co., Ltd. | Lyophilization formulation |
| CN103204816B (zh) * | 2012-01-16 | 2016-04-27 | 中国人民解放军军事医学科学院毒物药物研究所 | 哌嗪基嘧啶类衍生物及其制备方法和用途 |
| EP2836214B1 (en) * | 2012-04-11 | 2018-06-27 | Acerta Pharma B.V. | Bruton's tyrosine kinase inhibitors for hematopoietic mobilization |
| WO2016048861A2 (en) | 2014-09-22 | 2016-03-31 | National Health Research Institutes | Heterocyclic compounds and use thereof |
| US9375406B2 (en) * | 2014-09-30 | 2016-06-28 | Taigen Biotechnology Co., Ltd. | Substituted pyrimidines for mobilizing cells expressing a type 4 CXC chemokine receptor |
| TWI620748B (zh) | 2016-02-05 | 2018-04-11 | National Health Research Institutes | 氨基噻唑化合物及其用途 |
| WO2018132326A1 (en) * | 2017-01-10 | 2018-07-19 | National Health Research Institutes | Heterocyclic compounds and use thereof |
| CN109553604B (zh) * | 2017-09-25 | 2021-08-27 | 盛世泰科生物医药技术(苏州)有限公司 | 4-氨基嘧啶衍生物作cxcr4抑制剂及其应用 |
| CN108794414B (zh) * | 2018-06-22 | 2021-01-01 | 浙江大学 | 芳酰胺基取代的均三嗪类化合物及制备和应用 |
| CN116120195B (zh) * | 2022-12-29 | 2025-02-25 | 长兴宜生药物科技有限公司 | 一种催化制备培哚普利中间体的方法 |
| PL247377B1 (pl) * | 2023-06-29 | 2025-06-23 | Politechnika Krakowska Im Tadeusza Kosciuszki | Nowa pochodna 1,3,5-triazyny i jej zastosowanie |
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Patent Citations (2)
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| CN1180698A (zh) * | 1996-10-01 | 1998-05-06 | 詹森药业有限公司 | 取代的二氨基－1,3,5－三嗪衍生物 |
| WO2006138304A2 (en) * | 2005-06-14 | 2006-12-28 | Taigen Biotechnology | Pyrimidine compounds |
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| EP2268635B1 (en) | 2015-06-10 |
| EP2268635A4 (en) | 2012-02-22 |
| KR101579999B1 (ko) | 2015-12-23 |
| AU2008355098A1 (en) | 2009-10-29 |
| CY1116802T1 (el) | 2017-03-15 |
| EA019289B1 (ru) | 2014-02-28 |
| DK2268635T3 (en) | 2015-09-14 |
| JP5661607B2 (ja) | 2015-01-28 |
| WO2009131598A1 (en) | 2009-10-29 |
| EA201071221A1 (ru) | 2011-08-30 |
| PL2268635T3 (pl) | 2015-11-30 |
| HRP20150932T2 (hr) | 2017-10-20 |
| AU2008355098B2 (en) | 2012-11-15 |
| JP2011519360A (ja) | 2011-07-07 |
| CA2720229C (en) | 2015-02-17 |
| TWI444188B (zh) | 2014-07-11 |
| US20090264339A1 (en) | 2009-10-22 |
| KR20110008085A (ko) | 2011-01-25 |
| HRP20150932T1 (xx) | 2015-10-09 |
| NZ588989A (en) | 2012-03-30 |
| US8372849B2 (en) | 2013-02-12 |
| ZA201008262B (en) | 2011-07-27 |
| CN101565404A (zh) | 2009-10-28 |
| SI2268635T1 (sl) | 2015-10-30 |
| HK1138269A1 (en) | 2010-08-20 |
| TW200944206A (en) | 2009-11-01 |
| ES2545731T3 (es) | 2015-09-15 |
| PT2268635E (pt) | 2015-10-06 |
| CA2720229A1 (en) | 2009-10-29 |
| EP2268635A1 (en) | 2011-01-05 |
| HUE025179T2 (en) | 2016-02-29 |
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