ES2545731T3 - Compuestos heterocíclicos - Google Patents
Compuestos heterocíclicos Download PDFInfo
- Publication number
- ES2545731T3 ES2545731T3 ES08874003.0T ES08874003T ES2545731T3 ES 2545731 T3 ES2545731 T3 ES 2545731T3 ES 08874003 T ES08874003 T ES 08874003T ES 2545731 T3 ES2545731 T3 ES 2545731T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- attached
- alkyl
- alkylene
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000002391 heterocyclic compounds Chemical class 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 204
- 125000002947 alkylene group Chemical group 0.000 claims abstract description 59
- 125000003118 aryl group Chemical group 0.000 claims abstract description 51
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 47
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims abstract description 44
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 25
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 24
- 229910003827 NRaRb Inorganic materials 0.000 claims abstract description 12
- 125000001475 halogen functional group Chemical group 0.000 claims abstract 6
- 239000000203 mixture Substances 0.000 claims description 75
- 238000011282 treatment Methods 0.000 claims description 21
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- 125000000217 alkyl group Chemical group 0.000 claims description 11
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- 208000028867 ischemia Diseases 0.000 claims description 11
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 10
- 239000002246 antineoplastic agent Substances 0.000 claims description 7
- 229940127089 cytotoxic agent Drugs 0.000 claims description 7
- 230000006378 damage Effects 0.000 claims description 7
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 6
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- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 10
- DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 10
- JOMNTHCQHJPVAZ-RXMQYKEDSA-N (2r)-2-methylpiperazine Chemical compound C[C@@H]1CNCCN1 JOMNTHCQHJPVAZ-RXMQYKEDSA-N 0.000 description 9
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- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 9
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| US46496 | 2008-04-21 | ||
| PCT/US2008/082202 WO2009131598A1 (en) | 2008-04-21 | 2008-11-03 | Heterocyclic compounds |
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| ES2545731T3 true ES2545731T3 (es) | 2015-09-15 |
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| US9023834B2 (en) * | 2008-11-13 | 2015-05-05 | Taigen Biotechnology Co., Ltd. | Lyophilization formulation |
| CN103204816B (zh) * | 2012-01-16 | 2016-04-27 | 中国人民解放军军事医学科学院毒物药物研究所 | 哌嗪基嘧啶类衍生物及其制备方法和用途 |
| US9522917B2 (en) * | 2012-04-11 | 2016-12-20 | Acerta Pharma B.V. | Bruton's tyrosine kinase inhibitors for hematopoietic mobilization |
| US9862703B2 (en) | 2014-09-22 | 2018-01-09 | National Health Research Institutes | Heterocyclic compounds and use thereof |
| US9375406B2 (en) * | 2014-09-30 | 2016-06-28 | Taigen Biotechnology Co., Ltd. | Substituted pyrimidines for mobilizing cells expressing a type 4 CXC chemokine receptor |
| TWI620748B (zh) | 2016-02-05 | 2018-04-11 | National Health Research Institutes | 氨基噻唑化合物及其用途 |
| RU2756055C2 (ru) * | 2017-01-10 | 2021-09-24 | Нэшнл Хелт Рисерч Инститьютс | Гетероциклические соединения и их применение |
| CN109553604B (zh) * | 2017-09-25 | 2021-08-27 | 盛世泰科生物医药技术(苏州)有限公司 | 4-氨基嘧啶衍生物作cxcr4抑制剂及其应用 |
| CN108794414B (zh) * | 2018-06-22 | 2021-01-01 | 浙江大学 | 芳酰胺基取代的均三嗪类化合物及制备和应用 |
| CN116120195B (zh) * | 2022-12-29 | 2025-02-25 | 长兴宜生药物科技有限公司 | 一种催化制备培哚普利中间体的方法 |
| PL247377B1 (pl) * | 2023-06-29 | 2025-06-23 | Politechnika Krakowska Im Tadeusza Kosciuszki | Nowa pochodna 1,3,5-triazyny i jej zastosowanie |
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| US6029A (en) * | 1849-01-16 | Method of directing the scoops in dredging machines | ||
| US3007A (en) * | 1843-03-21 | Improvement in salt-boilers | ||
| US5034560A (en) | 1990-10-19 | 1991-07-23 | The Standard Oil Company | Synthesis of ethylamines |
| JP3340434B2 (ja) | 1991-07-04 | 2002-11-05 | ダコ アクティーゼルスカブ | ジビニルスルホンに由来する成分を含んで成る水溶性ポリマーベース試薬及び抱合体 |
| US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| IL112795A (en) | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them |
| AU7692996A (en) | 1995-12-01 | 1997-06-27 | Ciba-Geigy Ag | Receptor antagonists |
| TW440563B (en) | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
| WO1997046250A1 (en) | 1996-06-04 | 1997-12-11 | Synaptic Pharmaceutical Corporation | Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5) |
| NO311614B1 (no) * | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
| TW520362B (en) * | 1996-12-05 | 2003-02-11 | Amgen Inc | Substituted pyrimidine compounds and pharmaceutical composition comprising same |
| EP1054871A2 (en) | 1998-04-01 | 2000-11-29 | Du Pont Pharmaceuticals Company | Pyrimidines and triazines as integrin antagonists |
| US6420354B1 (en) | 1998-06-08 | 2002-07-16 | Advanced Medicine, Inc. | Sodium channel drugs and uses |
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| GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
| US6274588B1 (en) | 1999-05-31 | 2001-08-14 | Hoffmann-La Roche Inc. | 4-phenyl-pyrimidine derivatives |
| CA2396693A1 (en) * | 1999-12-28 | 2001-07-05 | Stephen T. Wrobleski | Cytokine, especially tnf-alpha, inhibitors |
| CA2432799C (en) | 2000-12-21 | 2008-08-19 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
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| WO2003026664A1 (en) | 2001-09-26 | 2003-04-03 | Bayer Corporation | 2-phenylamino-4- (5-pyrazolylamino) -pyramidine derivatives as kinase inhibitors, in particular, src kinase inhibitors |
| WO2003028641A2 (en) | 2001-10-01 | 2003-04-10 | Taisho Pharmaceutical Co., Ltd. | Mch receptor antagonists |
| ATE530530T1 (de) | 2002-06-28 | 2011-11-15 | Astellas Pharma Inc | Diaminopyrimidincarbonsäureamidderivat |
| US7759336B2 (en) | 2002-12-10 | 2010-07-20 | Ono Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic compounds and medicinal use thereof |
| EP1590334B1 (en) | 2003-01-30 | 2009-08-19 | Boehringer Ingelheim Pharmaceuticals Inc. | 2,4-diaminopyrimidine derivatives useful as inhibitors of pkc-theta |
| KR100806603B1 (ko) | 2003-09-22 | 2008-02-29 | 에프. 호프만-라 로슈 아게 | 아미노알킬아미드 치환된 사이클로헥실 유도체 |
| KR101258504B1 (ko) * | 2004-03-26 | 2013-04-26 | 메틸진 인코포레이티드 | 히스톤 데아세틸라제의 억제제 |
| EP1751115A4 (en) | 2004-05-23 | 2010-10-20 | Gerard M Housey | THERAMUTEINMODULATOREN |
| JP2006124387A (ja) * | 2004-09-30 | 2006-05-18 | Taisho Pharmaceut Co Ltd | 新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法 |
| WO2006138304A2 (en) | 2005-06-14 | 2006-12-28 | Taigen Biotechnology | Pyrimidine compounds |
| CA2620878A1 (en) | 2005-08-29 | 2007-04-05 | Gerard M. Housey | Theramutein modulators |
| AU2006297089B2 (en) | 2005-09-27 | 2012-05-03 | Irm Llc | Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors |
| WO2007062213A2 (en) | 2005-11-23 | 2007-05-31 | Housey Pharmaceuticals Inc | Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators |
| RU2008140382A (ru) | 2006-03-16 | 2010-04-27 | Новартис АГ (CH) | Гетероциклические органические соединения, например, для лечения меланомы |
| WO2007129195A2 (en) | 2006-05-04 | 2007-11-15 | Pfizer Products Inc. | 4-pyrimidine-5-amino-pyrazole compounds |
| EP2043651A2 (en) * | 2006-07-05 | 2009-04-08 | Exelixis, Inc. | Methods of using igf1r and abl kinase modulators |
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2010
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Also Published As
| Publication number | Publication date |
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| SI2268635T1 (sl) | 2015-10-30 |
| WO2009131598A1 (en) | 2009-10-29 |
| AU2008355098A1 (en) | 2009-10-29 |
| EA019289B1 (ru) | 2014-02-28 |
| PL2268635T3 (pl) | 2015-11-30 |
| EP2268635A1 (en) | 2011-01-05 |
| EP2268635A4 (en) | 2012-02-22 |
| JP2011519360A (ja) | 2011-07-07 |
| CA2720229A1 (en) | 2009-10-29 |
| HUE025179T2 (en) | 2016-02-29 |
| AU2008355098B2 (en) | 2012-11-15 |
| EA201071221A1 (ru) | 2011-08-30 |
| KR101579999B1 (ko) | 2015-12-23 |
| TW200944206A (en) | 2009-11-01 |
| HRP20150932T1 (xx) | 2015-10-09 |
| JP5661607B2 (ja) | 2015-01-28 |
| PT2268635E (pt) | 2015-10-06 |
| NZ588989A (en) | 2012-03-30 |
| CY1116802T1 (el) | 2017-03-15 |
| HK1138269A1 (en) | 2010-08-20 |
| HRP20150932T2 (hr) | 2017-10-20 |
| CN101565404B (zh) | 2012-12-05 |
| ZA201008262B (en) | 2011-07-27 |
| CA2720229C (en) | 2015-02-17 |
| DK2268635T3 (en) | 2015-09-14 |
| US8372849B2 (en) | 2013-02-12 |
| KR20110008085A (ko) | 2011-01-25 |
| TWI444188B (zh) | 2014-07-11 |
| US20090264339A1 (en) | 2009-10-22 |
| EP2268635B1 (en) | 2015-06-10 |
| CN101565404A (zh) | 2009-10-28 |
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