CN1015106B - 一种口服头孢菌素的结晶性水合物的制备方法 - Google Patents

一种口服头孢菌素的结晶性水合物的制备方法

Info

Publication number
CN1015106B
CN1015106B CN87105009A CN87105009A CN1015106B CN 1015106 B CN1015106 B CN 1015106B CN 87105009 A CN87105009 A CN 87105009A CN 87105009 A CN87105009 A CN 87105009A CN 1015106 B CN1015106 B CN 1015106B
Authority
CN
China
Prior art keywords
method described
water
hydrate
capsule
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN87105009A
Other languages
English (en)
Chinese (zh)
Other versions
CN87105009A (zh
Inventor
滨岛好男
南恭二
河田享三
坂元照男
武田豊彦
铃木裕介
辻川正则
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61156954A external-priority patent/JP2544113B2/ja
Priority claimed from JP21626086A external-priority patent/JPH0717651B2/ja
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to CN91105982A priority Critical patent/CN1036632C/zh
Publication of CN87105009A publication Critical patent/CN87105009A/zh
Publication of CN1015106B publication Critical patent/CN1015106B/zh
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
CN87105009A 1986-07-02 1987-07-02 一种口服头孢菌素的结晶性水合物的制备方法 Expired CN1015106B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN91105982A CN1036632C (zh) 1986-07-02 1987-07-02 含口服头孢菌素结晶性水合物的组合物制法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP156954/86 1986-07-02
JP61156954A JP2544113B2 (ja) 1986-07-02 1986-07-02 安定なカプセル製剤
JP216260/86 1986-09-12
JP21626086A JPH0717651B2 (ja) 1986-09-12 1986-09-12 経口投与用セフアロスポリン水和物結晶

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN91105982A Division CN1036632C (zh) 1986-07-02 1987-07-02 含口服头孢菌素结晶性水合物的组合物制法

Publications (2)

Publication Number Publication Date
CN87105009A CN87105009A (zh) 1988-03-23
CN1015106B true CN1015106B (zh) 1991-12-18

Family

ID=26484565

Family Applications (1)

Application Number Title Priority Date Filing Date
CN87105009A Expired CN1015106B (zh) 1986-07-02 1987-07-02 一种口服头孢菌素的结晶性水合物的制备方法

Country Status (27)

Country Link
US (2) US4812561A (OSRAM)
KR (1) KR950005302B1 (OSRAM)
CN (1) CN1015106B (OSRAM)
AR (1) AR243893A1 (OSRAM)
AT (1) AT392472B (OSRAM)
AU (1) AU594167B2 (OSRAM)
BE (1) BE1001691A4 (OSRAM)
CA (1) CA1283405C (OSRAM)
CH (1) CH672788A5 (OSRAM)
DE (1) DE3721913A1 (OSRAM)
DK (1) DK161080C (OSRAM)
ES (2) ES2004952A6 (OSRAM)
FI (1) FI89052C (OSRAM)
FR (1) FR2601014B1 (OSRAM)
GB (1) GB2192183B (OSRAM)
GR (1) GR871014B (OSRAM)
HK (1) HK47893A (OSRAM)
HU (1) HU200777B (OSRAM)
IE (1) IE59613B1 (OSRAM)
IL (1) IL83059A (OSRAM)
IT (1) IT1211469B (OSRAM)
NL (1) NL193136C (OSRAM)
NO (1) NO170889C (OSRAM)
NZ (1) NZ220764A (OSRAM)
PL (1) PL159180B1 (OSRAM)
RU (1) RU1829932C (OSRAM)
SE (1) SE466257B (OSRAM)

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WO2012018534A2 (en) 2010-07-26 2012-02-09 Schering Corporation Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases
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EP2696681B1 (en) 2011-04-13 2018-10-03 Merck Sharp & Dohme Corp. 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2013033899A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
WO2013033901A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
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CN103948932B (zh) * 2014-04-17 2016-03-16 海南日中天制药有限公司 一种头孢克肟组合物及其制备方法
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Also Published As

Publication number Publication date
HK47893A (en) 1993-05-27
PL159180B1 (pl) 1992-11-30
KR950005302B1 (ko) 1995-05-23
GR871014B (en) 1987-11-02
FR2601014B1 (fr) 1990-09-14
KR880001670A (ko) 1988-04-26
IT1211469B (it) 1989-11-03
CH672788A5 (OSRAM) 1989-12-29
ES2004952A6 (es) 1989-02-16
GB8715064D0 (en) 1987-08-05
PL266567A1 (en) 1988-07-21
DK161080C (da) 1991-11-11
FI872903A0 (fi) 1987-07-01
AU7504087A (en) 1988-01-07
GB2192183B (en) 1990-05-16
ES2008759A6 (es) 1989-08-01
FI89052C (fi) 1993-08-10
IL83059A0 (en) 1987-12-31
BE1001691A4 (fr) 1990-02-13
IE871738L (en) 1988-01-02
SE8702705L (sv) 1988-01-03
HU200777B (en) 1990-08-28
DE3721913A1 (de) 1988-01-07
NL8701507A (nl) 1988-02-01
IE59613B1 (en) 1994-03-09
ATA165887A (de) 1990-09-15
NZ220764A (en) 1989-09-27
AU594167B2 (en) 1990-03-01
NO872729L (no) 1988-01-04
DK336487D0 (da) 1987-06-30
RU1829932C (ru) 1993-07-23
CN87105009A (zh) 1988-03-23
CA1283405C (en) 1991-04-23
FI872903L (fi) 1988-01-03
HUT44257A (en) 1988-02-29
US4812561A (en) 1989-03-14
IT8767566A0 (it) 1987-07-01
FR2601014A1 (fr) 1988-01-08
IL83059A (en) 1992-03-29
NL193136C (nl) 1998-12-04
NO170889C (no) 1992-12-23
SE8702705D0 (sv) 1987-06-30
DK161080B (da) 1991-05-27
US4933443A (en) 1990-06-12
NL193136B (nl) 1998-08-03
FI89052B (fi) 1993-04-30
NO170889B (no) 1992-09-14
NO872729D0 (no) 1987-06-30
AR243893A1 (es) 1993-09-30
GB2192183A (en) 1988-01-06
DK336487A (da) 1988-01-03
AT392472B (de) 1991-04-10
SE466257B (sv) 1992-01-20

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