ES2004952A6 - Perfeccionamientos en la fabricacion de capsulas para hidratos cristalinos de cefalosporina - Google Patents

Perfeccionamientos en la fabricacion de capsulas para hidratos cristalinos de cefalosporina

Info

Publication number
ES2004952A6
ES2004952A6 ES8702189A ES8702189A ES2004952A6 ES 2004952 A6 ES2004952 A6 ES 2004952A6 ES 8702189 A ES8702189 A ES 8702189A ES 8702189 A ES8702189 A ES 8702189A ES 2004952 A6 ES2004952 A6 ES 2004952A6
Authority
ES
Spain
Prior art keywords
composition
crystalline hydrate
hydrate
oral cephalosporin
gelatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8702189A
Other languages
English (en)
Inventor
Yoshio Hamashima
Kyoji Minami
Kyozo Kawata
Teruo Sakamoto
Toyohiko Takeda
Yusuke Suzuki
Masanori Tujikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61156954A external-priority patent/JP2544113B2/ja
Priority claimed from JP21626086A external-priority patent/JPH0717651B2/ja
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of ES2004952A6 publication Critical patent/ES2004952A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Abstract

CAPSULAS PARA HIDRATOS CRISTALINOS DE CEFALOSPORINA, DESTINADAS A CONTENER ACIDO 7A-[(Z)-2-(AMINOTIAZOL-4-IL)-4-CARBOXIBUT-2-ENOILAMINO]-3-CEFEM-4- CARBOXILICO, CARACTERIZADAS POR LA DISPOSICION DE UN RECUBRIMIENTO DE ESTANQUEIZACION A BASE DE GELATINA SOBRE LA UNION CIRCUNFERENCIAL ENTRE LA CAPERUZA Y EL CUERPO DE LA CAPSULA.
ES8702189A 1986-07-02 1987-07-02 Perfeccionamientos en la fabricacion de capsulas para hidratos cristalinos de cefalosporina Expired ES2004952A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP61156954A JP2544113B2 (ja) 1986-07-02 1986-07-02 安定なカプセル製剤
JP21626086A JPH0717651B2 (ja) 1986-09-12 1986-09-12 経口投与用セフアロスポリン水和物結晶

Publications (1)

Publication Number Publication Date
ES2004952A6 true ES2004952A6 (es) 1989-02-16

Family

ID=26484565

Family Applications (2)

Application Number Title Priority Date Filing Date
ES8702189A Expired ES2004952A6 (es) 1986-07-02 1987-07-02 Perfeccionamientos en la fabricacion de capsulas para hidratos cristalinos de cefalosporina
ES8703123A Expired ES2008759A6 (es) 1986-07-02 1987-11-02 Procedimiento para la fabricacion de un hidrato del acido 7b -(z)-2-(2-aminotiazol-4-il)-4-carboxibut-2-enoilamino -3- cefem-4-carboxilico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES8703123A Expired ES2008759A6 (es) 1986-07-02 1987-11-02 Procedimiento para la fabricacion de un hidrato del acido 7b -(z)-2-(2-aminotiazol-4-il)-4-carboxibut-2-enoilamino -3- cefem-4-carboxilico.

Country Status (27)

Country Link
US (2) US4812561A (es)
KR (1) KR950005302B1 (es)
CN (1) CN1015106B (es)
AR (1) AR243893A1 (es)
AT (1) AT392472B (es)
AU (1) AU594167B2 (es)
BE (1) BE1001691A4 (es)
CA (1) CA1283405C (es)
CH (1) CH672788A5 (es)
DE (1) DE3721913A1 (es)
DK (1) DK161080C (es)
ES (2) ES2004952A6 (es)
FI (1) FI89052C (es)
FR (1) FR2601014B1 (es)
GB (1) GB2192183B (es)
GR (1) GR871014B (es)
HK (1) HK47893A (es)
HU (1) HU200777B (es)
IE (1) IE59613B1 (es)
IL (1) IL83059A (es)
IT (1) IT1211469B (es)
NL (1) NL193136C (es)
NO (1) NO170889C (es)
NZ (1) NZ220764A (es)
PL (1) PL159180B1 (es)
RU (1) RU1829932C (es)
SE (1) SE466257B (es)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089270A (en) * 1990-05-15 1992-02-18 L. Perrigo Company Capsule-shaped tablet
CZ283428B6 (cs) * 1992-04-30 1998-04-15 Schering Corporation Stabilní hydratovaný suchý práškový cefalosporin vhodný pro orální aplikaci ve formě suspenze
EP2275456B1 (en) * 1998-10-27 2011-10-12 Westlake Longview Corporation Process for the polymerization of olefins.
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) * 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
AT412213B (de) * 2000-05-30 2004-11-25 Sandoz Ag Verfahren zur trocknung von amoxicillin oder amoxicillin-hältigen, oralen, festen pharmazeutischen zusammensetzungen unter verwendung eines gases mit einer definierten gasfeuchte
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
EP1648407A4 (en) * 2003-07-21 2011-08-31 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, CORRESPONDING USE AND FORMULATION
AU2004258949B2 (en) * 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
WO2005009364A2 (en) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
US8758820B2 (en) * 2003-08-11 2014-06-24 Shionogi Inc. Robust pellet
WO2005016278A2 (en) 2003-08-12 2005-02-24 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
WO2005023184A2 (en) * 2003-08-29 2005-03-17 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
JP2007513869A (ja) * 2003-09-15 2007-05-31 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
AU2004308419B2 (en) * 2003-12-24 2011-06-02 Victory Pharma, Inc. Enhanced absorption of modified release dosage forms
JP2008505124A (ja) * 2004-07-02 2008-02-21 アドバンシス ファーマスーティカル コーポレイション パルス送達用錠剤
US20110104109A1 (en) * 2005-07-13 2011-05-05 Frank Bennett Tetracyclic indole derivatives and their use for treating or preventing viral infections
JP5688877B2 (ja) 2005-11-11 2015-03-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌疾患の治療用キナゾリン誘導体
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) * 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
AR062927A1 (es) * 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
AU2007339386B8 (en) * 2006-12-22 2013-12-05 Merck Sharp & Dohme Corp. 4, 5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections
KR20090094154A (ko) 2006-12-22 2009-09-03 쉐링 코포레이션 Ｈｃｖ 및 관련 바이러스 감염을 치료 또는 예방하기 위한 4,5-환 환상 인돌 유도체
CA2674831A1 (en) 2006-12-22 2008-11-13 Schering Corporation 5,6-ring annulated indole derivatives and methods of use thereof
US8404845B2 (en) * 2007-08-29 2013-03-26 Merck Sharp & Dohme Corp. 2,3-substituted azaindole derivatives for treating viral infections
EP2197842B1 (en) * 2007-08-29 2012-05-23 Schering Corporation 2, 3-substituted indole derivatives for treating viral infections
PE20090630A1 (es) 2007-08-29 2009-05-16 Schering Corp Derivados de indol 2-carboxi sustituidos y metodos para su utilizacion
MX2010005355A (es) * 2007-11-16 2010-06-02 Schering Corp Derivados de indol sustituidos con 3-aminosulfonilo y metodos de uso de los mismos.
MX2010005356A (es) * 2007-11-16 2010-05-27 Schering Corp Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos.
CA2727620A1 (en) * 2008-06-13 2009-12-17 Schering Corporation Tricyclic indole derivatives and methods of use thereof
EP2326626B1 (en) 2008-08-20 2013-10-16 Merck Sharp & Dohme Corp. Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
US8697694B2 (en) 2008-08-20 2014-04-15 Merck Sharp & Dohme Corp. Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
EP2326628A1 (en) 2008-08-20 2011-06-01 Schering Corporation Azo-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
CA2734487A1 (en) 2008-08-20 2010-02-25 Southern Research Institute Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
US8980920B2 (en) 2009-05-29 2015-03-17 Merck Sharp & Dohme Corp. Antiviral compounds of three linked aryl moieties to treat diseases such as hepatitis C
LT2451445T (lt) 2009-07-06 2019-06-25 Boehringer Ingelheim International Gmbh Bibw2992, jo druskų ir kietų farmacinių kompozicijų, apimančių šį aktyvųjį ingredientą, džiovinimo būdas
CA2782024A1 (en) 2009-11-25 2011-06-03 Schering Corporation Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases
US20130156731A1 (en) 2009-12-22 2013-06-20 Kevin X. Chen Fused tricyclic compounds and methods of use thereof for the treatment of viral diseas
EP2536410B1 (en) 2010-02-18 2015-09-23 Merck Sharp & Dohme Corp. Substituted pyrimidine derivatives and their use in treating viral infections
JP2013522202A (ja) 2010-03-09 2013-06-13 メルク・シャープ・エンド・ドーム・コーポレイション 縮合三環式シリル化合物およびウイルス疾患の治療のためのその使用方法
WO2011139253A2 (en) 2010-05-04 2011-11-10 Mahmut Bilgic Pharmaceutical compositions comprising ceftibuten
JP2013541499A (ja) 2010-07-26 2013-11-14 メルク・シャープ・エンド・ドーム・コーポレイション 置換されたビフェニレン化合物およびウイルス性疾患の治療のためのその使用方法
WO2012050848A1 (en) 2010-09-29 2012-04-19 Schering Corporation Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases
EP2696681B1 (en) 2011-04-13 2018-10-03 Merck Sharp & Dohme Corp. 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
US9156872B2 (en) 2011-04-13 2015-10-13 Merck Sharp & Dohme Corp. 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2013033899A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
WO2013033901A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
WO2013033900A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
WO2013039876A1 (en) 2011-09-14 2013-03-21 Merck Sharp & Dohme Corp. Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases
WO2013151518A1 (en) * 2012-04-04 2013-10-10 Mahmut Bilgic Capsule formulations comprising ceftibuten
EP2815743A1 (en) 2013-06-21 2014-12-24 Sanovel Ilac Sanayi ve Ticaret A.S. Ceftibuten formulations
EP3063140A4 (en) 2013-10-30 2017-11-08 Merck Sharp & Dohme Corp. Pseudopolymorphs of an hcv ns5a inhibitor and uses thereof
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CN103948932B (zh) * 2014-04-17 2016-03-16 海南日中天制药有限公司 一种头孢克肟组合物及其制备方法
EP3031450A1 (en) 2014-12-12 2016-06-15 Sanovel Ilac Sanayi ve Ticaret A.S. Ceftibuten capsule compositions
EP3454846A4 (en) 2016-05-13 2019-12-11 Aeromics, Inc. CRYSTALS
CN106397455B (zh) * 2016-08-30 2018-08-31 山东罗欣药业集团恒欣药业有限公司 一种抗感染药物头孢布烯晶体化合物及其组合物
CN106397454B (zh) * 2016-08-30 2018-08-24 山东罗欣药业集团股份有限公司 一种抗感染药物头孢布烯晶型化合物及其组合物
CN106432272A (zh) * 2016-09-21 2017-02-22 临沂草之美医药科技有限公司 一种制备治疗外科手术感染的药物头孢布烯晶体化合物的方法
CN106397457A (zh) * 2016-09-21 2017-02-15 临沂草之美医药科技有限公司 一种治疗外科手术感染的药物头孢布烯晶体化合物
CN106432271A (zh) * 2016-09-21 2017-02-22 临沂草之美医药科技有限公司 一种治疗外科手术感染的药物头孢布烯晶体化合物
CN106432270A (zh) * 2016-09-21 2017-02-22 临沂草之美医药科技有限公司 一种制备治疗外科手术感染的药物头孢布烯晶体化合物的方法
WO2023278945A1 (en) * 2021-07-01 2023-01-05 Qpex Biopharma, Inc. Crystalline forms of ceftibuten

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3819620A (en) * 1972-06-01 1974-06-25 Squibb & Sons Inc 7-(d-alpha-amino-1,4-cyclohexadien-1-ylacet-amido)desacetoxycephalosporanic acid dihydrate
JPS5726692A (en) * 1980-07-22 1982-02-12 Fujisawa Pharmaceut Co Ltd Preparation of stable crystal of salt of ceftizoxime
DE3037997A1 (de) * 1980-10-08 1982-05-13 Bayer Ag (beta) -lactamantibiotika, verfahren zu deren herstellung sowie sie enthaltende mittel
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
AU575854B2 (en) * 1983-10-04 1988-08-11 Shionogi & Co., Ltd. 7beta-(carboxyalkenamido) cephalosporins
AU580855B2 (en) * 1985-03-29 1989-02-02 Shionogi & Co., Ltd. Alkeneamidocephalosporin esters

Also Published As

Publication number Publication date
CA1283405C (en) 1991-04-23
RU1829932C (ru) 1993-07-23
FI872903A0 (fi) 1987-07-01
NL193136C (nl) 1998-12-04
ES2008759A6 (es) 1989-08-01
SE8702705L (sv) 1988-01-03
HK47893A (en) 1993-05-27
PL266567A1 (en) 1988-07-21
IL83059A (en) 1992-03-29
CH672788A5 (es) 1989-12-29
IE59613B1 (en) 1994-03-09
BE1001691A4 (fr) 1990-02-13
CN87105009A (zh) 1988-03-23
IT1211469B (it) 1989-11-03
NO170889B (no) 1992-09-14
DE3721913A1 (de) 1988-01-07
NO872729D0 (no) 1987-06-30
HUT44257A (en) 1988-02-29
NO170889C (no) 1992-12-23
FI89052B (fi) 1993-04-30
FI872903A (fi) 1988-01-03
CN1015106B (zh) 1991-12-18
IT8767566A0 (it) 1987-07-01
DK161080B (da) 1991-05-27
AT392472B (de) 1991-04-10
NL193136B (nl) 1998-08-03
GB8715064D0 (en) 1987-08-05
FR2601014B1 (fr) 1990-09-14
KR880001670A (ko) 1988-04-26
NL8701507A (nl) 1988-02-01
GB2192183A (en) 1988-01-06
FR2601014A1 (fr) 1988-01-08
SE466257B (sv) 1992-01-20
AU7504087A (en) 1988-01-07
KR950005302B1 (ko) 1995-05-23
IE871738L (en) 1988-01-02
AU594167B2 (en) 1990-03-01
US4933443A (en) 1990-06-12
GB2192183B (en) 1990-05-16
DK336487A (da) 1988-01-03
FI89052C (fi) 1993-08-10
DK336487D0 (da) 1987-06-30
NZ220764A (en) 1989-09-27
US4812561A (en) 1989-03-14
SE8702705D0 (sv) 1987-06-30
NO872729L (no) 1988-01-04
AR243893A1 (es) 1993-09-30
GR871014B (en) 1987-11-02
PL159180B1 (pl) 1992-11-30
ATA165887A (de) 1990-09-15
HU200777B (en) 1990-08-28
IL83059A0 (en) 1987-12-31
DK161080C (da) 1991-11-11

Similar Documents

Publication Publication Date Title
ES2008759A6 (es) Procedimiento para la fabricacion de un hidrato del acido 7b -(z)-2-(2-aminotiazol-4-il)-4-carboxibut-2-enoilamino -3- cefem-4-carboxilico.
IE44872L (en) Cephadroxil preparation.
ES8702427A1 (es) Un procedimiento para preparar derivados de 1,3-difosfonato
ZA784187B (en) Crystalline form of the sodium salt of an oxime derivative of 7-amino thiazolyl acetamido cephalosporanic acid,process for preparing it and the pharmaceutical compositions containing it
PH25741A (en) Heterocyclic compounds, pharmaceutical composition containing said compound, method of use thereof
IL84409A0 (en) Imidazolidinone derivatives,their preparation and pharmaceutical compositions containing them
DE3568440D1 (en) New (8s)-8-fluoroerythromycin derivatives, the process for the preparation thereof and the pharmaceutical compositions containing them
EP0188254A3 (en) New cephem compounds, processes for preparation thereof and pharmaceutical compositions containing them
IE40671L (en) Antibiotic composition containing a cephalosporin
IL58777A0 (en) Aminothiazole derivatives of 3-cephem-4-carboxylic acid,their preparation and pharmaceutical compositions containing them
IE801095L (en) Preparing pyrenzepine
ATE34661T1 (de) Verbindungen zur verminderung des lipidspiegels.
ES8800140A1 (es) Un procedimiento para preparar un compuesto de n-fenil-trans-4-guanidincometilciclohexanocarboxamida.
JPS57200359A (en) Lysine salt of 5-(p-chlorobenzoyl)-1,4-dimethyl- pyrrole-2-acetic acid, manufacture and medicine containing same
ES8307224A1 (es) Un metodo para preparar derivados de pirazolina.
ES8801287A1 (es) Un procedimiento para producir derivados de ester de cefalosporina.
IL77051A (en) Crystalline form of the monoethanolamine salt of n-(2-pyridyl)-2-methyl-4-hydroxy-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide and pharmaceutical compositions containing it
DE3374005D1 (en) 1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
PT76557B (en) Process for preparing furan derivatives and addition salts thereof and of pharmaceutical compositions containing the same
IL71068A (en) N-(3-trifluoromethylphenyl)-n'-propargyl-piperazine,its preparation and pharmaceutical compositions containing it
ES8104285A1 (es) Un procedimiento para la obtencion de un derivado del acido clarulanico.
ES8306758A1 (es) Un procedimiento para la preparacion de un derivado de beta-lactama.
AU2014488A (en) Crystalline monohydrate of sodium n-(1h-tetrazol-5-yl)-1-phenoxy-4h-quinolizin-4-one-3- carboxamide
ES481936A2 (es) Mejoras introducidas en la patente principal: procedimiento para la obtencion de compuestos oxotio.
ES8202823A1 (es) Procedimiento para preparar derivados de ergolina

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20070703