CN101448800A - 作为大麻素受体配体的新型化合物及其用途 - Google Patents
作为大麻素受体配体的新型化合物及其用途 Download PDFInfo
- Publication number
- CN101448800A CN101448800A CNA2007800186013A CN200780018601A CN101448800A CN 101448800 A CN101448800 A CN 101448800A CN A2007800186013 A CNA2007800186013 A CN A2007800186013A CN 200780018601 A CN200780018601 A CN 200780018601A CN 101448800 A CN101448800 A CN 101448800A
- Authority
- CN
- China
- Prior art keywords
- methane amide
- thiazoles
- fork base
- diamantane
- methoxy ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80961506P | 2006-05-31 | 2006-05-31 | |
US60/809,615 | 2006-05-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101448800A true CN101448800A (zh) | 2009-06-03 |
Family
ID=38645597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2007800186013A Pending CN101448800A (zh) | 2006-05-31 | 2007-05-31 | 作为大麻素受体配体的新型化合物及其用途 |
Country Status (8)
Country | Link |
---|---|
US (3) | US7875639B2 (es) |
EP (1) | EP2024349B1 (es) |
JP (1) | JP2009538933A (es) |
CN (1) | CN101448800A (es) |
CA (1) | CA2647598A1 (es) |
ES (1) | ES2645995T3 (es) |
MX (1) | MX2008015214A (es) |
WO (1) | WO2007140439A2 (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109574856A (zh) * | 2018-12-07 | 2019-04-05 | 无锡福祈制药有限公司 | 一种新的金刚乙胺类似物及其合成方法 |
CN110172067A (zh) * | 2019-04-11 | 2019-08-27 | 河南科技大学第一附属医院 | 一种具有杀菌活性的噻唑类药物分子及其制备方法 |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8841334B2 (en) * | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
JP2009538931A (ja) * | 2006-05-31 | 2009-11-12 | アボット・ラボラトリーズ | カンナビノイド受容体リガンドとしてのチアゾール化合物およびそれの使用 |
EP2024349B1 (en) * | 2006-05-31 | 2017-08-02 | AbbVie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
US8481574B2 (en) | 2006-10-12 | 2013-07-09 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
US8158663B2 (en) | 2006-12-22 | 2012-04-17 | Abbott Laboratories | Compounds as cannabinoid receptor ligands and uses thereof |
EP2142522A1 (en) | 2007-03-28 | 2010-01-13 | Abbott Laboratories | 1, 3-thiazol-2 (3h) -ylidene compounds as cannabinoid receptor ligands |
US7872033B2 (en) | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
MX2009012374A (es) * | 2007-05-18 | 2009-12-01 | Abbott Lab | Compuestos novedosos como ligandos del receptor de canabinoides. |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US9193713B2 (en) | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
MX2010005649A (es) * | 2007-11-21 | 2010-08-18 | Abbott Lab | Compuestos novedosos como ligandos del receptor canabinoide y sus usos. |
WO2009114566A1 (en) | 2008-03-11 | 2009-09-17 | Abbott Laboratories | Novel compounds as cannabinoid receptor ligands |
US8173687B2 (en) * | 2008-08-15 | 2012-05-08 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
US8846730B2 (en) | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
EP2334646A2 (en) | 2008-09-16 | 2011-06-22 | Abbott Laboratories | Substituted benzamides as cannabinoid receptor ligands |
PA8854001A1 (es) * | 2008-12-16 | 2010-07-27 | Abbott Lab | Compuestos novedosos como ligandos de receptores de canabinoides |
WO2011090935A1 (en) | 2010-01-19 | 2011-07-28 | Merck Sharp & Dohme Corp. | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS |
EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
MY173280A (en) | 2012-12-21 | 2020-01-10 | Janssen Sciences Ireland Uc | Antibacterial compounds |
WO2015012210A1 (ja) * | 2013-07-23 | 2015-01-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ縮合環化合物 |
US10653681B2 (en) | 2016-03-16 | 2020-05-19 | Recurium Ip Holdings, Llc | Analgesic compounds |
Family Cites Families (119)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1522361A1 (de) | 1966-03-08 | 1969-07-24 | Agfa Gevaert Ag | Sensibilisierung lichtempfindlicher Polymerer |
US3557142A (en) | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
DE1772867A1 (de) | 1968-07-15 | 1971-06-16 | Agfa Gevaert Ag | Sensibilisierung von Schichten aus lichtvernetzbaren Polymeren |
JPS5089367A (es) | 1973-12-14 | 1975-07-17 | ||
JPS57171986A (en) | 1981-04-14 | 1982-10-22 | Taiho Yakuhin Kogyo Kk | Heterocylic ring compound containing sulfur |
DE3333450A1 (de) | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | Trihalogenmethylgruppen enthaltende carbonylmethylenheterocyclen, verfahren zu ihrer herstellung und lichtempfindliches gemisch, das diese verbindungen enthaelt |
US4885295A (en) | 1984-08-06 | 1989-12-05 | Sterling Drug Inc. | Method of use of 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indoles |
US4978664A (en) | 1984-08-06 | 1990-12-18 | Sterling Drug Inc. | 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indole pharmaceutical compositions |
DE3533331A1 (de) | 1985-09-18 | 1987-03-26 | Heumann Ludwig & Co Gmbh | Pyridothiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE3807381A1 (de) | 1988-03-07 | 1989-09-21 | Hoechst Ag | 4,6-bis-trichlormethyl-s-triazin-2-ylgruppen enthaltende heterocyclische verbindungen, verfahren zu ihrer herstellung und lichtempfindliches gemisch, das diese verbindung enthaelt |
TW205041B (es) | 1989-08-07 | 1993-05-01 | Fujisawa Pharmaceutical Co | |
DE4021439A1 (de) | 1989-12-14 | 1991-06-20 | Bayer Ag | 2-iminopyridin-derivate |
US6559186B1 (en) | 1990-02-26 | 2003-05-06 | Arc 1, Inc. | Compositions and methods of treatment of sympathetically maintained pain |
US5013837A (en) | 1990-03-08 | 1991-05-07 | Sterling Drug Inc. | 3-Arylcarbonyl-1H-indole-containing compounds |
US4973587A (en) | 1990-03-08 | 1990-11-27 | Sterling Drug Inc. | 3-arylcarbonyl-1-aminoalkyl-1H-indole-containing antiglaucoma method |
WO1992015564A1 (en) | 1991-03-11 | 1992-09-17 | Nippon Soda Co., Ltd. | Novel heterocyclic compound |
BR9306011A (pt) | 1992-03-03 | 1997-10-21 | Idemitsu Kosan Co | Derivados de pirazol |
EP0568096B1 (en) | 1992-04-30 | 1998-07-29 | Hodogaya Chemical Co., Ltd. | Benzothiazole derivative and agricultural and horticultural fingicide composition containing the same |
US5654322A (en) | 1992-08-11 | 1997-08-05 | Wakunaga Seiyaku Kabushiki Kaisha | Biphenylmethane derivatives and pharmaceuticals containing the same |
WO1994022821A1 (en) | 1993-04-05 | 1994-10-13 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives as testosterone 5 alpha-reductase inhibitors |
US5395836A (en) | 1993-04-07 | 1995-03-07 | Kyowa Hakko Kogyo Co., Ltd. | 8-tricycloalkyl xanthine derivatives |
JPH06345736A (ja) | 1993-06-14 | 1994-12-20 | Tokuyama Soda Co Ltd | ウレタン化合物を製造する方法 |
MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
AU2641295A (en) | 1994-05-17 | 1995-12-05 | Dowelanco | N-(5-isothiazolyl)amide pesticides |
ES2340142T3 (es) | 1994-07-08 | 2010-05-31 | Ev3 Inc. | Sistema para llevar a cabo un procedimiento intravascular. |
FR2735774B1 (fr) | 1995-06-21 | 1997-09-12 | Sanofi Sa | Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant |
EP1019385B1 (en) | 1995-09-15 | 2004-01-14 | PHARMACIA & UPJOHN COMPANY | Aminoaryl oxazolidinone n-oxides |
CA2283925A1 (en) * | 1997-03-24 | 1998-10-01 | Basf Aktiengesellschaft | Thiazolimine derivatives |
US20030220234A1 (en) | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
US6323214B1 (en) * | 1997-10-29 | 2001-11-27 | Medco Research, Inc | Allosteric adenosine receptor modulators |
US6358992B1 (en) | 1998-11-25 | 2002-03-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with indole derivatives |
CA2370265A1 (en) | 1999-04-20 | 2000-10-26 | Syngenta Limited | Pesticidal indazole or benzotriazole derivatives |
DE19928033A1 (de) | 1999-06-18 | 2000-12-21 | Basf Ag | Verwendung von cyclischen Enaminen als Lichtschutzmittel |
FR2796643B1 (fr) * | 1999-07-22 | 2005-04-29 | Sod Conseils Rech Applic | Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique |
GB9918037D0 (en) | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
DE60011100T2 (de) | 1999-08-27 | 2005-06-16 | Abbott Laboratories, Abbott Park | Als cox-hemmer verwendbare sulfonylphenylpyrazol-verbindungen |
CN1247553C (zh) | 1999-09-14 | 2006-03-29 | 盐野义制药株式会社 | 2-亚氨基-1,3-噻嗪衍生物 |
AU1095101A (en) | 1999-10-18 | 2001-04-30 | University Of Connecticut, The | Cannabimimetic indole derivatives |
GB0002034D0 (en) | 2000-01-28 | 2000-03-22 | Zeneca Ltd | Chemical compounds |
GB0002032D0 (en) | 2000-01-28 | 2000-03-22 | Zeneca Ltd | Chemical compounds |
GB0006289D0 (en) * | 2000-03-15 | 2000-05-03 | Smithkline Beecham Plc | New use |
GB0010437D0 (en) | 2000-04-28 | 2000-06-14 | Darwin Discovery Ltd | Process |
EP1300401B1 (en) | 2000-06-30 | 2009-12-09 | Dainippon Sumitomo Pharma Co., Ltd. | Thiazole derivatives for use as antiinflammatories |
US6369052B1 (en) * | 2000-08-07 | 2002-04-09 | Georgetown University | Combination of huperzine and nicotinic compounds as a neuroprotective agent |
FR2816938B1 (fr) | 2000-11-22 | 2003-01-03 | Sanofi Synthelabo | Derives de 3-aroylindole, leur procede de preparation et les compositions pharmaceutiques en contenant |
EP1363632B1 (en) | 2001-01-29 | 2010-08-25 | The University of Connecticut | Receptor selective cannabimimetic aminoalkylindoles |
US20030008807A1 (en) | 2001-06-14 | 2003-01-09 | The Regents Of The University Of California | Novel signaling pathway for the production of inflammatory pain and neuropathy |
US7949668B2 (en) | 2001-08-20 | 2011-05-24 | Pardalis, Inc. | Common point authoring system for the complex sharing of hierarchically authored data objects in a distribution chain |
US20040259912A1 (en) | 2001-09-28 | 2004-12-23 | Takahiro Matsumoto | Benzine derivatives, process for preparing the same and use thereof |
US7183288B2 (en) * | 2001-11-01 | 2007-02-27 | Herwig Josephus Margareta Janssen, legal representative | Amide derivatives as glycogen synthase kinase 3-β inhibitors |
US6727247B2 (en) * | 2001-12-10 | 2004-04-27 | Hoffman-La Roche Inc. | Substituted benzothiazole amide derivatives |
WO2003057693A1 (fr) * | 2001-12-28 | 2003-07-17 | Sumitomo Pharmaceuticals Co., Ltd. | Composes cycliques a 5 chainons |
IL165217A0 (en) * | 2002-05-16 | 2005-12-18 | Bayer Cropscience Gmbh | Pesticidal pyridinecarboxamide derivatives |
JP3902523B2 (ja) | 2002-08-05 | 2007-04-11 | 富士フイルム株式会社 | 光情報記録媒体および情報記録方法 |
US20040077617A1 (en) * | 2002-10-22 | 2004-04-22 | Bennani Youssef L. | Fused cycloalkyl amides and acids and their therapeutic applications |
FR2847899B1 (fr) | 2002-11-29 | 2006-04-28 | Sanofi Synthelabo | Derives d'indole-3-carboxamide, leur preparation et leur application en therapeutique |
US7390670B2 (en) | 2003-02-20 | 2008-06-24 | Lumigen, Inc. | Signalling compounds and methods for detecting hydrogen peroxide |
US20040259887A1 (en) | 2003-06-18 | 2004-12-23 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
US20070105908A1 (en) | 2003-06-27 | 2007-05-10 | Dainippon Sumitomo Pharma Co., Ltd. | Thiazolimine compound and oxazolimine compound |
WO2005023818A2 (en) | 2003-09-10 | 2005-03-17 | Gpc Biotech Ag | Heterobicyclic compounds as pharmaceutically active agents |
CN100509808C (zh) * | 2003-12-08 | 2009-07-08 | 霍夫曼-拉罗奇有限公司 | 新型噻唑衍生物 |
GB0402357D0 (en) | 2004-02-03 | 2004-03-10 | Glaxo Group Ltd | Novel compounds |
US7307163B2 (en) | 2004-04-19 | 2007-12-11 | Symed Labs Limited | Process for the preparation of linezolid and related compounds |
SE0401342D0 (sv) | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds |
SE0401345D0 (sv) | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine as scaffold |
US7429661B2 (en) | 2004-07-20 | 2008-09-30 | Symed Labs Limited | Intermediates for linezolid and related compounds |
WO2006039164A2 (en) | 2004-09-29 | 2006-04-13 | Amr Technology, Inc. | Novel cyclosporin analogues and their pharmaceutical uses |
US20080312435A1 (en) * | 2004-11-15 | 2008-12-18 | Taisho Pharmaceutical Co., Ltd. | Imine Compound |
EP1833824B1 (en) | 2004-12-21 | 2016-08-03 | AbbVie Inc. | 3-cycloalkylcarbonyl indoles as cannabinoid receptor ligands |
FR2880023B1 (fr) | 2004-12-23 | 2007-02-23 | Sanofi Aventis Sa | Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique |
US7759337B2 (en) | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
TW200700387A (en) | 2005-03-21 | 2007-01-01 | Akzo Nobel Nv | 1-benzylindole-2-carboxamide derivatives |
US7674912B2 (en) | 2005-04-25 | 2010-03-09 | H. Lundbeck A/S | Pro-drugs of N-thiazol-2-yl-benzamide derivatives |
US20070155738A1 (en) | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
TW200716636A (en) | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Heterocyclic spiro-compounds |
US7514068B2 (en) | 2005-09-14 | 2009-04-07 | Concert Pharmaceuticals Inc. | Biphenyl-pyrazolecarboxamide compounds |
US7872006B2 (en) | 2005-10-21 | 2011-01-18 | Mitsubishi Tanabe Pharma Corporation | Pyrazole compounds having cannabinoid receptor (CB1) antagonizing activity |
AR057987A1 (es) | 2005-11-24 | 2008-01-09 | Astrazeneca Ab | Compuestos agonistas de cb1 (receptor cannabinoide) |
US8841334B2 (en) | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
JP2009538931A (ja) | 2006-05-31 | 2009-11-12 | アボット・ラボラトリーズ | カンナビノイド受容体リガンドとしてのチアゾール化合物およびそれの使用 |
EP2024349B1 (en) * | 2006-05-31 | 2017-08-02 | AbbVie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
CA2659762A1 (en) | 2006-06-27 | 2008-01-03 | Abbott Laboratories | Thiazoline and oxazoline derivatives and their methods of use |
CN101547910A (zh) | 2006-07-28 | 2009-09-30 | 合成纤维有限公司 | 结晶埃罗替尼 |
WO2008028094A1 (en) | 2006-08-31 | 2008-03-06 | Abbott Laboratories | Compounds as cb2 cannabinoid receptor ligands |
WO2008028093A1 (en) | 2006-08-31 | 2008-03-06 | Abbott Laboratories | Compounds as cb2 cannabinoid receptor ligands |
US8481574B2 (en) | 2006-10-12 | 2013-07-09 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
US8796267B2 (en) | 2006-10-23 | 2014-08-05 | Concert Pharmaceuticals, Inc. | Oxazolidinone derivatives and methods of use |
US9763894B2 (en) | 2006-12-05 | 2017-09-19 | Virginia Commonwealth University | Inflammation therapy |
TW200831092A (en) | 2006-12-21 | 2008-08-01 | Astrazeneca Ab | Therapeutic agents |
US8158663B2 (en) | 2006-12-22 | 2012-04-17 | Abbott Laboratories | Compounds as cannabinoid receptor ligands and uses thereof |
EP2121641B1 (en) | 2007-02-15 | 2014-09-24 | F. Hoffmann-La Roche AG | 2-aminooxazolines as taar1 ligands |
EP2142522A1 (en) | 2007-03-28 | 2010-01-13 | Abbott Laboratories | 1, 3-thiazol-2 (3h) -ylidene compounds as cannabinoid receptor ligands |
US7872033B2 (en) | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
US8501794B2 (en) | 2007-04-17 | 2013-08-06 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
KR20100105802A (ko) | 2007-04-19 | 2010-09-29 | 콘서트 파마슈티컬즈, 인크. | 중수소화된 모르폴리닐 화합물 |
MX2009012374A (es) | 2007-05-18 | 2009-12-01 | Abbott Lab | Compuestos novedosos como ligandos del receptor de canabinoides. |
US7531685B2 (en) | 2007-06-01 | 2009-05-12 | Protia, Llc | Deuterium-enriched oxybutynin |
US8338623B2 (en) | 2007-07-09 | 2012-12-25 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
US20090131485A1 (en) | 2007-09-10 | 2009-05-21 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
US20090118238A1 (en) | 2007-09-17 | 2009-05-07 | Protia, Llc | Deuterium-enriched alendronate |
US20090082471A1 (en) | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched fingolimod |
US20090088416A1 (en) | 2007-09-26 | 2009-04-02 | Protia, Llc | Deuterium-enriched lapaquistat |
EP2209774A1 (en) | 2007-10-02 | 2010-07-28 | Concert Pharmaceuticals Inc. | Pyrimidinedione derivatives |
US9193713B2 (en) | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
US20090105338A1 (en) | 2007-10-18 | 2009-04-23 | Protia, Llc | Deuterium-enriched gabexate mesylate |
WO2009051782A1 (en) | 2007-10-18 | 2009-04-23 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
US8044071B2 (en) | 2007-10-18 | 2011-10-25 | Abbott Laboratories | Method for reducing side effects of CB2 receptor agonist therapy using a combination of a selective CB2 receptor agonist and a selective CB1 receptor antagonist |
WO2009055006A1 (en) | 2007-10-26 | 2009-04-30 | Concert Pharmaceuticals, Inc. | Deuterated darunavir |
MX2010005649A (es) | 2007-11-21 | 2010-08-18 | Abbott Lab | Compuestos novedosos como ligandos del receptor canabinoide y sus usos. |
WO2009114566A1 (en) | 2008-03-11 | 2009-09-17 | Abbott Laboratories | Novel compounds as cannabinoid receptor ligands |
US8173687B2 (en) | 2008-08-15 | 2012-05-08 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
US8846730B2 (en) | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
EP2334646A2 (en) | 2008-09-16 | 2011-06-22 | Abbott Laboratories | Substituted benzamides as cannabinoid receptor ligands |
WO2010054024A2 (en) | 2008-11-04 | 2010-05-14 | Abbott Laboratories | Novel compounds as cannabinoid receptor ligands |
PA8854001A1 (es) | 2008-12-16 | 2010-07-27 | Abbott Lab | Compuestos novedosos como ligandos de receptores de canabinoides |
CA2756178A1 (en) | 2009-03-27 | 2010-09-30 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
US8236822B2 (en) | 2009-03-27 | 2012-08-07 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
WO2010111573A1 (en) | 2009-03-27 | 2010-09-30 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
US8586596B2 (en) | 2010-06-15 | 2013-11-19 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
-
2007
- 2007-05-31 EP EP07797908.6A patent/EP2024349B1/en active Active
- 2007-05-31 ES ES07797908.6T patent/ES2645995T3/es active Active
- 2007-05-31 MX MX2008015214A patent/MX2008015214A/es active IP Right Grant
- 2007-05-31 US US11/755,884 patent/US7875639B2/en not_active Expired - Fee Related
- 2007-05-31 WO PCT/US2007/070029 patent/WO2007140439A2/en active Application Filing
- 2007-05-31 JP JP2009513447A patent/JP2009538933A/ja active Pending
- 2007-05-31 CA CA 2647598 patent/CA2647598A1/en not_active Abandoned
- 2007-05-31 CN CNA2007800186013A patent/CN101448800A/zh active Pending
-
2010
- 2010-12-16 US US12/970,480 patent/US9006275B2/en not_active Expired - Fee Related
-
2015
- 2015-02-20 US US14/628,131 patent/US20150231141A1/en not_active Abandoned
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109574856A (zh) * | 2018-12-07 | 2019-04-05 | 无锡福祈制药有限公司 | 一种新的金刚乙胺类似物及其合成方法 |
CN110172067A (zh) * | 2019-04-11 | 2019-08-27 | 河南科技大学第一附属医院 | 一种具有杀菌活性的噻唑类药物分子及其制备方法 |
CN110172067B (zh) * | 2019-04-11 | 2021-06-15 | 河南科技大学第一附属医院 | 一种具有杀菌活性的噻唑类药物分子及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
ES2645995T3 (es) | 2017-12-11 |
US20080064699A1 (en) | 2008-03-13 |
US7875639B2 (en) | 2011-01-25 |
US20150231141A1 (en) | 2015-08-20 |
MX2008015214A (es) | 2008-12-12 |
WO2007140439A2 (en) | 2007-12-06 |
JP2009538933A (ja) | 2009-11-12 |
CA2647598A1 (en) | 2007-12-06 |
EP2024349B1 (en) | 2017-08-02 |
US20110086855A1 (en) | 2011-04-14 |
WO2007140439A3 (en) | 2008-01-24 |
US9006275B2 (en) | 2015-04-14 |
EP2024349A2 (en) | 2009-02-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101448800A (zh) | 作为大麻素受体配体的新型化合物及其用途 | |
CN101454302A (zh) | 用作大麻素受体配位体的噻唑化合物及其用途 | |
TWI291465B (en) | Heterocyclic dihydropyrimidine compounds | |
CN105121432B (zh) | 作为激酶抑制剂的杂环酰胺 | |
CN102822165B (zh) | 芳基甲氧基异吲哚啉衍生物和包括其的组合物及它们的使用方法 | |
CN102083312B (zh) | 苯磺酰胺噻唑和噁唑化合物 | |
CN101765593A (zh) | 用作大麻素受体配体的2-亚氨基异噻唑衍生物 | |
JP6624594B2 (ja) | 炎症性、代謝性、腫瘍性および自己免疫疾患の処置に有用なピリミジンの任意選択により縮合されているヘテロシクリル置換誘導体 | |
CN101263107A (zh) | 作为二肽基肽酶-iv(dpp-iv)抑制剂的药物组合物 | |
CN101925300A (zh) | 作为大麻素受体配体的新化合物和其用途 | |
CN101743223A (zh) | 用作大麻素受体配体的新化合物 | |
CN104220422B (zh) | Ep1受体配体 | |
CN102036984A (zh) | 作为大麻素受体配体的新化合物 | |
CA2677296A1 (en) | Therapeutic agents | |
CN102666489B (zh) | 鞘氨醇激酶抑制剂 | |
CN101711253A (zh) | 用作大麻素受体配体的新化合物 | |
CN101573357A (zh) | 吲哚化合物 | |
CN101636155A (zh) | 二酰甘油o-酰基转移酶1型酶的抑制剂 | |
JP2023513272A (ja) | ヘテロ環glp-1アゴニスト | |
ES2685923T3 (es) | Composición medicinal para mejorar la función cerebral | |
CN101820868A (zh) | 作为大麻素受体配体的新化合物 | |
JPWO2008091021A1 (ja) | ヘテロシクリデン−n−(アリール)アセトアミド誘導体 | |
CN102448957A (zh) | 作为大麻素受体配体的化合物 | |
CN102123993A (zh) | 作为大麻素受体配体的亚胺衍生物 | |
CN1972913A (zh) | 四氢吡喃基环戊基四氢吡啶并吡啶趋化因子受体活性调节剂 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C12 | Rejection of a patent application after its publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20090603 |