CN101426783B - 作为11-β-羟基甾族化合物脱氢酶1的抑制剂的环己基吡唑-内酰胺衍生物 - Google Patents
作为11-β-羟基甾族化合物脱氢酶1的抑制剂的环己基吡唑-内酰胺衍生物 Download PDFInfo
- Publication number
- CN101426783B CN101426783B CN2007800142829A CN200780014282A CN101426783B CN 101426783 B CN101426783 B CN 101426783B CN 2007800142829 A CN2007800142829 A CN 2007800142829A CN 200780014282 A CN200780014282 A CN 200780014282A CN 101426783 B CN101426783 B CN 101426783B
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- tetrahydro
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- 0 CC1(*)C(*)=CC(*)=C(C[C@](CCN2*)C2=O)C(*)=C1 Chemical compound CC1(*)C(*)=CC(*)=C(C[C@](CCN2*)C2=O)C(*)=C1 0.000 description 11
- MFLQFEHUPJOJOL-UHFFFAOYSA-N CC1Cc2n[nH]cc2CC1 Chemical compound CC1Cc2n[nH]cc2CC1 MFLQFEHUPJOJOL-UHFFFAOYSA-N 0.000 description 2
- LEIPTFSPIDNHEW-SZQRVLIRSA-N CC(C)(C)OC([n]1nc(CCCC2N(CC[C@H]3Cc(c(Cl)cc(O)c4)c4Cl)C3=O)c2c1)=O Chemical compound CC(C)(C)OC([n]1nc(CCCC2N(CC[C@H]3Cc(c(Cl)cc(O)c4)c4Cl)C3=O)c2c1)=O LEIPTFSPIDNHEW-SZQRVLIRSA-N 0.000 description 1
- SPUDMEODCQEKKW-YTJLLHSVSA-N CC(C)(C)OC([n]1ncc2c1CCCC2N(CC[C@H]1Cc(c(Cl)cc(O)c2)c2Cl)C1=O)=O Chemical compound CC(C)(C)OC([n]1ncc2c1CCCC2N(CC[C@H]1Cc(c(Cl)cc(O)c2)c2Cl)C1=O)=O SPUDMEODCQEKKW-YTJLLHSVSA-N 0.000 description 1
- VAYGRAPKORICRV-UHFFFAOYSA-N CC(C)c(cc1)cc2c1[s]cn2 Chemical compound CC(C)c(cc1)cc2c1[s]cn2 VAYGRAPKORICRV-UHFFFAOYSA-N 0.000 description 1
- PNHHYYYKTVHQTI-UHFFFAOYSA-N CC1Cc2c[nH]nc2CC1 Chemical compound CC1Cc2c[nH]nc2CC1 PNHHYYYKTVHQTI-UHFFFAOYSA-N 0.000 description 1
- GLIRZRGFMMGCMG-UHFFFAOYSA-N CC1c2c[nH]nc2CCC1 Chemical compound CC1c2c[nH]nc2CCC1 GLIRZRGFMMGCMG-UHFFFAOYSA-N 0.000 description 1
- AEPIUZZRFHUZAR-PEHGTWAWSA-N CC[C@@H]1C2=CNN(C)C2CCC1 Chemical compound CC[C@@H]1C2=CNN(C)C2CCC1 AEPIUZZRFHUZAR-PEHGTWAWSA-N 0.000 description 1
- SJRJJKPEHAURKC-UHFFFAOYSA-N CN1CCOCC1 Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 1
- XKTNCIKPUXBURO-SCSAIBSYSA-N C[C@H](c1c[nH]nc1)I Chemical compound C[C@H](c1c[nH]nc1)I XKTNCIKPUXBURO-SCSAIBSYSA-N 0.000 description 1
- GLIRZRGFMMGCMG-ZCFIWIBFSA-N C[C@H]1c2c[nH]nc2CCC1 Chemical compound C[C@H]1c2c[nH]nc2CCC1 GLIRZRGFMMGCMG-ZCFIWIBFSA-N 0.000 description 1
- OZAUUUGUHGHZMZ-UHFFFAOYSA-N C[IH]N1CCOCC1 Chemical compound C[IH]N1CCOCC1 OZAUUUGUHGHZMZ-UHFFFAOYSA-N 0.000 description 1
- NAEMNONODDSDIJ-UHFFFAOYSA-N C[n]1nc(CCC(C2)N(CCC3Cc(c(Cl)cc(-c(cc4)ccc4C(OC)=O)c4)c4Cl)C3=O)c2c1 Chemical compound C[n]1nc(CCC(C2)N(CCC3Cc(c(Cl)cc(-c(cc4)ccc4C(OC)=O)c4)c4Cl)C3=O)c2c1 NAEMNONODDSDIJ-UHFFFAOYSA-N 0.000 description 1
- MGHKWBQZEBMFOH-UHFFFAOYSA-N Cc1c(C)[o]nc1C Chemical compound Cc1c(C)[o]nc1C MGHKWBQZEBMFOH-UHFFFAOYSA-N 0.000 description 1
- RRZFDFYIDRCBCQ-UHFFFAOYSA-N Cc1cc2n[o]nc2cc1 Chemical compound Cc1cc2n[o]nc2cc1 RRZFDFYIDRCBCQ-UHFFFAOYSA-N 0.000 description 1
- CPWVROCSIOHZPY-UHFFFAOYSA-N O=C(C(Cc(c(Cl)c1)ccc1Br)CC1)N1C1Cc2n[nH]cc2CC1 Chemical compound O=C(C(Cc(c(Cl)c1)ccc1Br)CC1)N1C1Cc2n[nH]cc2CC1 CPWVROCSIOHZPY-UHFFFAOYSA-N 0.000 description 1
- NKKNXGKONKKSLB-UHFFFAOYSA-N O=C(c(cc1)ccc1-c1cc(Cl)c(CC(CCN2C3Cc4c[nH]nc4CC3)C2=O)c(Cl)c1)N(CC1)CCS1(=O)=O Chemical compound O=C(c(cc1)ccc1-c1cc(Cl)c(CC(CCN2C3Cc4c[nH]nc4CC3)C2=O)c(Cl)c1)N(CC1)CCS1(=O)=O NKKNXGKONKKSLB-UHFFFAOYSA-N 0.000 description 1
- GBZLDIDROONDRN-UHFFFAOYSA-N Oc1ccc(CC(CCN2C3Cc4c[nH]nc4CC3)C2=O)c(Cl)c1 Chemical compound Oc1ccc(CC(CCN2C3Cc4c[nH]nc4CC3)C2=O)c(Cl)c1 GBZLDIDROONDRN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74532006P | 2006-04-21 | 2006-04-21 | |
| US60/745,320 | 2006-04-21 | ||
| PCT/US2007/066069 WO2007124254A2 (en) | 2006-04-21 | 2007-04-05 | Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101426783A CN101426783A (zh) | 2009-05-06 |
| CN101426783B true CN101426783B (zh) | 2013-10-30 |
Family
ID=38595048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800142829A Expired - Fee Related CN101426783B (zh) | 2006-04-21 | 2007-04-05 | 作为11-β-羟基甾族化合物脱氢酶1的抑制剂的环己基吡唑-内酰胺衍生物 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7981918B2 (enExample) |
| EP (1) | EP2029579B1 (enExample) |
| JP (1) | JP5161869B2 (enExample) |
| KR (1) | KR101055576B1 (enExample) |
| CN (1) | CN101426783B (enExample) |
| AR (1) | AR060618A1 (enExample) |
| AU (1) | AU2007240550B2 (enExample) |
| BR (1) | BRPI0710229A2 (enExample) |
| CA (1) | CA2647677C (enExample) |
| CO (1) | CO6140026A2 (enExample) |
| CR (1) | CR10400A (enExample) |
| DO (1) | DOP2007000078A (enExample) |
| EA (1) | EA015675B1 (enExample) |
| EC (1) | ECSP088839A (enExample) |
| ES (1) | ES2533263T3 (enExample) |
| IL (1) | IL194835A (enExample) |
| JO (1) | JO3042B1 (enExample) |
| MA (1) | MA30476B1 (enExample) |
| MX (1) | MX2008013484A (enExample) |
| MY (1) | MY148128A (enExample) |
| NO (1) | NO20084403L (enExample) |
| NZ (1) | NZ571175A (enExample) |
| PE (1) | PE20080362A1 (enExample) |
| SV (1) | SV2008003070A (enExample) |
| TN (1) | TNSN08405A1 (enExample) |
| TW (1) | TWI347321B (enExample) |
| UA (1) | UA95798C2 (enExample) |
| WO (1) | WO2007124254A2 (enExample) |
| ZA (1) | ZA200808686B (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8088776B2 (en) * | 2006-04-21 | 2012-01-03 | Eli Lilly And Company | Biphenyl amide lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| BRPI0710273A2 (pt) | 2006-04-21 | 2011-08-09 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, intermediário |
| ATE472542T1 (de) * | 2006-04-24 | 2010-07-15 | Lilly Co Eli | 11-beta-hydroxysteroid-dehydrogenase-1-hemmer |
| ATE543798T1 (de) | 2006-04-24 | 2012-02-15 | Lilly Co Eli | Cyclohexyl-substituierte pyrrolidinone als hemmer von 11-beta-hydroxysteroiddehydrogenase 1 |
| CA2649650C (en) | 2006-04-24 | 2014-01-14 | Eli Lilly And Company | Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| US7968585B2 (en) | 2006-04-25 | 2011-06-28 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EP2021337B1 (en) | 2006-04-25 | 2010-01-13 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| AU2007244863B2 (en) * | 2006-04-25 | 2012-01-19 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| MX2008013844A (es) * | 2006-04-28 | 2008-11-10 | Lilly Co Eli | Pirrolidinonas substituidas con pieridinilo como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1. |
| US8835426B2 (en) | 2007-02-26 | 2014-09-16 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| KR20110002492A (ko) | 2008-05-01 | 2011-01-07 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
| WO2010011314A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
| US8846668B2 (en) | 2008-07-25 | 2014-09-30 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2729993A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| US8598163B2 (en) * | 2009-02-04 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Derivatives of [1,3]Oxazin-2-one useful for the treatment of metabolic diseases such as lipid disorders |
| JP5679997B2 (ja) | 2009-02-04 | 2015-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| US8507493B2 (en) | 2009-04-20 | 2013-08-13 | Abbvie Inc. | Amide and amidine derivatives and uses thereof |
| UA109255C2 (ru) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
| WO2011011123A1 (en) | 2009-06-11 | 2011-01-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| WO2011002910A1 (en) | 2009-07-01 | 2011-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2496589B1 (en) | 2009-11-05 | 2014-03-05 | Boehringer Ingelheim International GmbH | Novel chiral phosphorus ligands |
| WO2011068927A2 (en) * | 2009-12-04 | 2011-06-09 | Abbott Laboratories | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2576570A1 (en) | 2010-05-26 | 2013-04-10 | Boehringer Ingelheim International GmbH | 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives |
| EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| WO2011161128A1 (en) | 2010-06-25 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| CA2813671A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| JP6020459B2 (ja) * | 2011-10-18 | 2016-11-02 | アステラス製薬株式会社 | 二環式ヘテロ環化合物 |
| AR099936A1 (es) | 2014-04-04 | 2016-08-31 | Sanofi Sa | Heterociclos condensados sustituidos como moduladores de gpr119 para el tratamiento de la diabetes, obesidad, dislipidemia y trastornos relacionados |
| US10858347B2 (en) | 2015-12-31 | 2020-12-08 | Karyopharm Therapeutics Inc. | Multicyclic compounds and uses thereof |
| CN115916766A (zh) | 2021-02-25 | 2023-04-04 | 阿普塔生物治疗公司 | 新型吡唑衍生物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005108361A1 (en) * | 2004-05-07 | 2005-11-17 | Janssen Pharmaceutica N.V. | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| WO2005108360A1 (en) * | 2004-05-07 | 2005-11-17 | Janssen Pharmaceutica N.V. | Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| EP1802623A1 (en) | 2004-10-12 | 2007-07-04 | Novo Nordisk A/S | 11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds |
| WO2006049952A1 (en) | 2004-10-29 | 2006-05-11 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| SG161261A1 (en) | 2004-11-10 | 2010-05-27 | Incyte Corp | Lactam compounds and their use as pharmaceuticals |
| ATE399546T1 (de) * | 2004-12-20 | 2008-07-15 | Lilly Co Eli | Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
| EP1830840B1 (en) * | 2004-12-21 | 2008-07-16 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EP1864971A4 (en) | 2005-03-31 | 2010-02-10 | Takeda Pharmaceutical | PROPHYLACTIC / THERAPEUTIC AGENT AGAINST DIABETES |
| ES2322727B1 (es) | 2005-07-28 | 2010-04-22 | Universidad Del Pais Vasco | Metodo para cuantificar la union receptor acoplado a proteina g (gpcr)-proteina g mediante el empleo de un array de membranas celulares. |
| US7998959B2 (en) | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| US8088776B2 (en) * | 2006-04-21 | 2012-01-03 | Eli Lilly And Company | Biphenyl amide lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| BRPI0710273A2 (pt) * | 2006-04-21 | 2011-08-09 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, intermediário |
| ATE543798T1 (de) | 2006-04-24 | 2012-02-15 | Lilly Co Eli | Cyclohexyl-substituierte pyrrolidinone als hemmer von 11-beta-hydroxysteroiddehydrogenase 1 |
| CA2649650C (en) * | 2006-04-24 | 2014-01-14 | Eli Lilly And Company | Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| ATE472542T1 (de) * | 2006-04-24 | 2010-07-15 | Lilly Co Eli | 11-beta-hydroxysteroid-dehydrogenase-1-hemmer |
| AU2007244863B2 (en) * | 2006-04-25 | 2012-01-19 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| US7968585B2 (en) * | 2006-04-25 | 2011-06-28 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EP2021337B1 (en) | 2006-04-25 | 2010-01-13 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| MX2008013844A (es) | 2006-04-28 | 2008-11-10 | Lilly Co Eli | Pirrolidinonas substituidas con pieridinilo como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1. |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
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2007
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005108361A1 (en) * | 2004-05-07 | 2005-11-17 | Janssen Pharmaceutica N.V. | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| WO2005108360A1 (en) * | 2004-05-07 | 2005-11-17 | Janssen Pharmaceutica N.V. | Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
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