CN101406471A - 具有β-内酰胺酶抑制剂活性的新的杂环化合物 - Google Patents

具有β-内酰胺酶抑制剂活性的新的杂环化合物 Download PDF

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Publication number
CN101406471A
CN101406471A CNA2008101667591A CN200810166759A CN101406471A CN 101406471 A CN101406471 A CN 101406471A CN A2008101667591 A CNA2008101667591 A CN A2008101667591A CN 200810166759 A CN200810166759 A CN 200810166759A CN 101406471 A CN101406471 A CN 101406471A
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CN
China
Prior art keywords
oxo
trans
diazabicyclo
octane
sulfooxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CNA2008101667591A
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English (en)
Chinese (zh)
Inventor
J·奥索迪
C·弗罗芒坦
M·兰皮拉斯
D·A·罗兰兹
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Novexel SA
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Aventis Pharma SA
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27619669&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101406471(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of CN101406471A publication Critical patent/CN101406471A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNA2008101667591A 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的新的杂环化合物 Pending CN101406471A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0200951A FR2835186B1 (fr) 2002-01-28 2002-01-28 Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR02/00951 2002-01-28

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB038028786A Division CN100482225C (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的新的杂环化合物

Publications (1)

Publication Number Publication Date
CN101406471A true CN101406471A (zh) 2009-04-15

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ID=27619669

Family Applications (3)

Application Number Title Priority Date Filing Date
CNB038028786A Expired - Lifetime CN100482225C (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的新的杂环化合物
CNB2007100015952A Expired - Lifetime CN100563653C (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的杂环化合物
CNA2008101667591A Pending CN101406471A (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的新的杂环化合物

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CNB038028786A Expired - Lifetime CN100482225C (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的新的杂环化合物
CNB2007100015952A Expired - Lifetime CN100563653C (zh) 2002-01-28 2003-01-27 具有β-内酰胺酶抑制剂活性的杂环化合物

Country Status (44)

Country Link
US (4) US7612087B2 (OSRAM)
EP (2) EP1480644B1 (OSRAM)
JP (1) JP4472346B2 (OSRAM)
KR (1) KR100979079B1 (OSRAM)
CN (3) CN100482225C (OSRAM)
AR (2) AR038234A1 (OSRAM)
AT (1) ATE484281T1 (OSRAM)
AU (1) AU2003214335B2 (OSRAM)
BE (1) BE2016C069I2 (OSRAM)
BR (1) BRPI0307267B8 (OSRAM)
CA (1) CA2474043C (OSRAM)
CL (1) CL2011000009A1 (OSRAM)
CO (1) CO5601014A2 (OSRAM)
CR (2) CR7387A (OSRAM)
CY (3) CY1111061T1 (OSRAM)
DE (1) DE60334527D1 (OSRAM)
DK (2) DK2279737T3 (OSRAM)
EA (1) EA007220B1 (OSRAM)
EC (1) ECSP045193A (OSRAM)
ES (2) ES2401855T3 (OSRAM)
FR (2) FR2835186B1 (OSRAM)
HR (1) HRP20040686B1 (OSRAM)
HU (1) HUS1600055I1 (OSRAM)
IL (1) IL163167A (OSRAM)
JO (1) JO2646B1 (OSRAM)
LT (1) LTC1480644I2 (OSRAM)
MA (1) MA26351A1 (OSRAM)
MX (1) MXPA04006621A (OSRAM)
MY (1) MY140638A (OSRAM)
NL (1) NL300847I2 (OSRAM)
NO (3) NO335195B1 (OSRAM)
NZ (1) NZ533936A (OSRAM)
OA (1) OA12761A (OSRAM)
PE (1) PE20030969A1 (OSRAM)
PL (1) PL220725B1 (OSRAM)
PT (2) PT1480644E (OSRAM)
RS (1) RS52137B (OSRAM)
SI (2) SI2279737T1 (OSRAM)
TN (1) TNSN04137A1 (OSRAM)
TW (1) TWI293071B (OSRAM)
UA (1) UA80271C2 (OSRAM)
UY (1) UY27626A1 (OSRAM)
WO (1) WO2003063864A2 (OSRAM)
ZA (1) ZA200405607B (OSRAM)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103328476A (zh) * 2010-12-22 2013-09-25 明治制果药业株式会社 光学活性二氮杂环辛烷衍生物及其制备方法
CN105859609A (zh) * 2012-05-30 2016-08-17 明治制果药业株式会社 β-内酰胺酶抑制剂及其制备方法
WO2017045510A1 (zh) * 2015-09-16 2017-03-23 山东轩竹医药科技有限公司 β-内酰胺酶抑制剂及其用途
CN116375706A (zh) * 2023-02-22 2023-07-04 时森海(杭州)医药科技有限公司 阿维巴坦钠关键中间体及其制备方法

Families Citing this family (84)

* Cited by examiner, † Cited by third party
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FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
FR2848210B1 (fr) * 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
WO2007063552A1 (en) * 2005-12-02 2007-06-07 Lupin Limited Stable taste masked formulations of cephalosporins
SI1965798T1 (sl) 2005-12-07 2012-01-31 Basilea Pharmaceutica Ag Uporabni monobaktamski antibiotiki
EP2040698A4 (en) * 2006-07-14 2011-08-10 Shionogi & Co OXIM CONNECTIONS AND ITS USE
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ES2422603T3 (es) * 2007-05-31 2013-09-12 Shionogi & Co Compuestos oxiimino y el uso de estos
FR2921060B1 (fr) * 2007-09-14 2012-06-15 Novexel Nouveau procede de preparation d'une piperidine disubsituee et nouveaux intermediaires
SI2231667T1 (sl) * 2008-01-18 2013-12-31 Merck Sharp & Dohme Corp. Beta laktamazni inhibitorji
US20110046101A1 (en) * 2008-03-17 2011-02-24 Dmitrienko Gary I Bate-lactamase inhibitors
FR2930553B1 (fr) * 2008-04-29 2010-05-21 Novexel Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment inhibiteurs de beta-lactamases
JP5501983B2 (ja) * 2008-06-11 2014-05-28 塩野義製薬株式会社 オキシカルバモイル化合物およびその使用
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
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