AU2003214335B2 - Heterocyclic compounds which are active as inhibitors of beta lactamases - Google Patents

Heterocyclic compounds which are active as inhibitors of beta lactamases Download PDF

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Publication number
AU2003214335B2
AU2003214335B2 AU2003214335A AU2003214335A AU2003214335B2 AU 2003214335 B2 AU2003214335 B2 AU 2003214335B2 AU 2003214335 A AU2003214335 A AU 2003214335A AU 2003214335 A AU2003214335 A AU 2003214335A AU 2003214335 B2 AU2003214335 B2 AU 2003214335B2
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Prior art keywords
oxo
trans
octane
diazabicyclo
sulphooxy
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AU2003214335A
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AU2003214335A1 (en
Inventor
Jozsef Aszodi
Claude Fromentin
Maxime Lampilas
David Alan Rowlands
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Pfizer Ireland Pharmaceuticals
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Pfizer Ireland Pharmaceuticals
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Assigned to NOVEXEL reassignment NOVEXEL Request for Assignment Assignors: AVENTIS PHARMA S.A.
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2003214335A 2002-01-28 2003-01-27 Heterocyclic compounds which are active as inhibitors of beta lactamases Active 2028-01-27 AU2003214335B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0200951A FR2835186B1 (fr) 2002-01-28 2002-01-28 Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR02/00951 2002-01-28
PCT/FR2003/000243 WO2003063864A2 (fr) 2002-01-28 2003-01-27 Composes heterocycliques, actifs comme inhibiteurs de beta-lactamases

Publications (2)

Publication Number Publication Date
AU2003214335A1 AU2003214335A1 (en) 2003-09-18
AU2003214335B2 true AU2003214335B2 (en) 2007-04-05

Family

ID=27619669

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003214335A Active 2028-01-27 AU2003214335B2 (en) 2002-01-28 2003-01-27 Heterocyclic compounds which are active as inhibitors of beta lactamases

Country Status (44)

Country Link
US (4) US7612087B2 (OSRAM)
EP (2) EP2279737B1 (OSRAM)
JP (1) JP4472346B2 (OSRAM)
KR (1) KR100979079B1 (OSRAM)
CN (3) CN101406471A (OSRAM)
AR (2) AR038234A1 (OSRAM)
AT (1) ATE484281T1 (OSRAM)
AU (1) AU2003214335B2 (OSRAM)
BE (1) BE2016C069I2 (OSRAM)
BR (1) BRPI0307267B8 (OSRAM)
CA (1) CA2474043C (OSRAM)
CL (1) CL2011000009A1 (OSRAM)
CO (1) CO5601014A2 (OSRAM)
CR (2) CR7387A (OSRAM)
CY (3) CY1111061T1 (OSRAM)
DE (1) DE60334527D1 (OSRAM)
DK (2) DK1480644T3 (OSRAM)
EA (1) EA007220B1 (OSRAM)
EC (1) ECSP045193A (OSRAM)
ES (2) ES2356813T3 (OSRAM)
FR (2) FR2835186B1 (OSRAM)
HR (1) HRP20040686B1 (OSRAM)
HU (1) HUS1600055I1 (OSRAM)
IL (1) IL163167A (OSRAM)
JO (1) JO2646B1 (OSRAM)
LT (1) LTC1480644I2 (OSRAM)
MA (1) MA26351A1 (OSRAM)
MX (1) MXPA04006621A (OSRAM)
MY (1) MY140638A (OSRAM)
NL (1) NL300847I2 (OSRAM)
NO (3) NO335195B1 (OSRAM)
NZ (1) NZ533936A (OSRAM)
OA (1) OA12761A (OSRAM)
PE (1) PE20030969A1 (OSRAM)
PL (1) PL220725B1 (OSRAM)
PT (2) PT2279737E (OSRAM)
RS (1) RS52137B (OSRAM)
SI (2) SI1480644T1 (OSRAM)
TN (1) TNSN04137A1 (OSRAM)
TW (1) TWI293071B (OSRAM)
UA (1) UA80271C2 (OSRAM)
UY (1) UY27626A1 (OSRAM)
WO (1) WO2003063864A2 (OSRAM)
ZA (1) ZA200405607B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017203187B2 (en) * 2010-12-22 2018-07-26 Meiji Seika Pharma Co., Ltd. Optically-active diazabicyclooctane derivative and method for manufacturing same

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* Cited by examiner, † Cited by third party
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FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
US7439253B2 (en) 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
FR2848210B1 (fr) * 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
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