CN101370496B - 作为s1p1/edg1受体促效剂的新型噻吩衍生物 - Google Patents

作为s1p1/edg1受体促效剂的新型噻吩衍生物 Download PDF

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Publication number
CN101370496B
CN101370496B CN2007800022066A CN200780002206A CN101370496B CN 101370496 B CN101370496 B CN 101370496B CN 2007800022066 A CN2007800022066 A CN 2007800022066A CN 200780002206 A CN200780002206 A CN 200780002206A CN 101370496 B CN101370496 B CN 101370496B
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methyl
isobutyl
hydroxy
dimethyl
thiophen
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Expired - Fee Related
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CN101370496A (zh
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马丁·博利
大卫·莱曼
博里斯·马蒂斯
克劳斯·米勒
奥利弗·内勒
比特·斯蒂内
约尔格·韦尔克
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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CN2007800022066A 2006-01-11 2007-01-10 作为s1p1/edg1受体促效剂的新型噻吩衍生物 Expired - Fee Related CN101370496B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IB2006050103 2006-01-11
IBPCT/IB2006/050103 2006-01-11
WOPCT/IB2006/050103 2006-01-11
PCT/IB2007/050070 WO2007080542A1 (en) 2006-01-11 2007-01-10 Novel thiophene derivatives as s1p1/edg1 receptor agonists

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CN101370496A CN101370496A (zh) 2009-02-18
CN101370496B true CN101370496B (zh) 2012-07-04

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US (1) US8003800B2 (enExample)
EP (1) EP1976512B1 (enExample)
JP (1) JP5114430B2 (enExample)
KR (1) KR101382710B1 (enExample)
CN (1) CN101370496B (enExample)
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US8003800B2 (en) 2011-08-23
BRPI0706476A2 (pt) 2011-04-05
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CN101370496A (zh) 2009-02-18
AU2007204121A1 (en) 2007-07-19
CA2635047A1 (en) 2007-07-19
CA2635047C (en) 2014-07-29
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MY154909A (en) 2015-08-28
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RU2008132802A (ru) 2010-02-20
EP1976512B1 (en) 2015-09-30
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AR058956A1 (es) 2008-03-05
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IL192657A0 (en) 2009-02-11
AU2007204121B2 (en) 2012-06-07
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