CN101365432A - 二肽基肽酶-4抑制剂与二甲双胍的组合的药物组合物 - Google Patents
二肽基肽酶-4抑制剂与二甲双胍的组合的药物组合物 Download PDFInfo
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- CN101365432A CN101365432A CNA2006800471037A CN200680047103A CN101365432A CN 101365432 A CN101365432 A CN 101365432A CN A2006800471037 A CNA2006800471037 A CN A2006800471037A CN 200680047103 A CN200680047103 A CN 200680047103A CN 101365432 A CN101365432 A CN 101365432A
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
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- 238000009097 single-agent therapy Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
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- 229940082004 sodium laurate Drugs 0.000 description 1
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- 239000008279 sol Substances 0.000 description 1
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- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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Abstract
Description
西他列汀磷酸盐一水合物 | 128.5mg* |
二甲双胍盐酸盐 | 1000mg |
聚乙烯吡咯烷酮 | 91.0mg |
月桂基硫酸钠(SLS) | 6.50mg |
微晶纤维素(Avicel PH-102) | 48mg |
硬脂富马酸钠 | 26mg |
净化水** | 667mg |
西他列汀磷酸盐一水合物 | 128.5mg* |
二甲双胍盐酸盐 | 500mg |
聚乙烯吡咯烷酮 | 53.8mg |
月桂基硫酸钠(SLS) | 3.84mg |
微晶纤维素(Avicel PH-102) | 66.5mg |
硬脂富马酸钠 | 15.4mg |
净化水** | 394mg |
Claims (21)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US75095405P | 2005-12-16 | 2005-12-16 | |
US60/750,954 | 2005-12-16 | ||
PCT/US2006/047380 WO2007078726A2 (en) | 2005-12-16 | 2006-12-12 | Pharmaceutical compositions of combinations of dipeptidyl peptidase-4 inhibitors with metformin |
Publications (2)
Publication Number | Publication Date |
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CN101365432A true CN101365432A (zh) | 2009-02-11 |
CN101365432B CN101365432B (zh) | 2011-06-22 |
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Application Number | Title | Priority Date | Filing Date |
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CN2006800471037A Active CN101365432B (zh) | 2005-12-16 | 2006-12-12 | 二肽基肽酶-4抑制剂与二甲双胍的组合的药物组合物 |
Country Status (7)
Country | Link |
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US (1) | US8414921B2 (zh) |
EP (1) | EP1962827A4 (zh) |
JP (2) | JP5165582B2 (zh) |
CN (1) | CN101365432B (zh) |
AU (1) | AU2006333151B2 (zh) |
CA (1) | CA2633167A1 (zh) |
WO (1) | WO2007078726A2 (zh) |
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Also Published As
Publication number | Publication date |
---|---|
EP1962827A4 (en) | 2011-02-16 |
EP1962827A2 (en) | 2008-09-03 |
WO2007078726A2 (en) | 2007-07-12 |
JP5165582B2 (ja) | 2013-03-21 |
AU2006333151B2 (en) | 2010-03-04 |
JP5779566B2 (ja) | 2015-09-16 |
US20090105265A1 (en) | 2009-04-23 |
AU2006333151A1 (en) | 2007-07-12 |
JP2013047260A (ja) | 2013-03-07 |
WO2007078726A3 (en) | 2008-06-12 |
CA2633167A1 (en) | 2007-07-12 |
US8414921B2 (en) | 2013-04-09 |
CN101365432B (zh) | 2011-06-22 |
JP2009519934A (ja) | 2009-05-21 |
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Effective date of registration: 20121031 Address after: New jersey, USA Patentee after: SCHERING Corp. Address before: New jersey, USA Patentee before: MERCK SHARP & DOHME Corp. |
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