CN101316852A - 丝氨酸蛋白酶的抑制剂 - Google Patents

丝氨酸蛋白酶的抑制剂 Download PDF

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Publication number
CN101316852A
CN101316852A CNA2006800390595A CN200680039059A CN101316852A CN 101316852 A CN101316852 A CN 101316852A CN A2006800390595 A CNA2006800390595 A CN A2006800390595A CN 200680039059 A CN200680039059 A CN 200680039059A CN 101316852 A CN101316852 A CN 101316852A
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CN
China
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aliphatic group
group
compound
base
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Pending
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CNA2006800390595A
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English (en)
Chinese (zh)
Inventor
K·M·科特雷尔
J·马克斯威尔
Q·唐
A·-L·格里洛
A·勒蒂兰
E·佩罗拉
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of CN101316852A publication Critical patent/CN101316852A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNA2006800390595A 2005-08-26 2006-08-28 丝氨酸蛋白酶的抑制剂 Pending CN101316852A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71153005P 2005-08-26 2005-08-26
US60/711,530 2005-08-26

Publications (1)

Publication Number Publication Date
CN101316852A true CN101316852A (zh) 2008-12-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800390595A Pending CN101316852A (zh) 2005-08-26 2006-08-28 丝氨酸蛋白酶的抑制剂

Country Status (21)

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US (2) US7985762B2 (US08039623-20111018-C00020.png)
EP (3) EP2364984A1 (US08039623-20111018-C00020.png)
JP (1) JP5394063B2 (US08039623-20111018-C00020.png)
KR (1) KR20080041715A (US08039623-20111018-C00020.png)
CN (1) CN101316852A (US08039623-20111018-C00020.png)
AR (1) AR055395A1 (US08039623-20111018-C00020.png)
AT (1) ATE530554T1 (US08039623-20111018-C00020.png)
AU (1) AU2006282771B2 (US08039623-20111018-C00020.png)
BR (1) BRPI0615223A2 (US08039623-20111018-C00020.png)
CA (1) CA2620621A1 (US08039623-20111018-C00020.png)
EA (1) EA200800670A1 (US08039623-20111018-C00020.png)
EC (1) ECSP088258A (US08039623-20111018-C00020.png)
ES (1) ES2374943T3 (US08039623-20111018-C00020.png)
GE (1) GEP20115280B (US08039623-20111018-C00020.png)
IL (1) IL189668A0 (US08039623-20111018-C00020.png)
MX (1) MX2008002606A (US08039623-20111018-C00020.png)
NO (1) NO20081467L (US08039623-20111018-C00020.png)
NZ (1) NZ566197A (US08039623-20111018-C00020.png)
TW (1) TW200730533A (US08039623-20111018-C00020.png)
WO (1) WO2007025307A2 (US08039623-20111018-C00020.png)
ZA (1) ZA200801793B (US08039623-20111018-C00020.png)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103304571A (zh) * 2012-03-06 2013-09-18 上海昀怡健康管理咨询有限公司 螺环化合物、其制备方法、中间体、药物组合物和应用
CN104718211A (zh) * 2012-08-08 2015-06-17 默沙东公司 Hcv ns3蛋白酶抑制剂
CN107954990A (zh) * 2017-11-14 2018-04-24 安徽诺全药业有限公司 一种雷迪帕维的制备方法
CN109563033A (zh) * 2016-06-21 2019-04-02 奥瑞恩眼科有限责任公司 脂族脯氨酰胺衍生物

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MY148123A (en) * 2003-09-05 2013-02-28 Vertex Pharma Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
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CN101494979A (zh) 2006-03-20 2009-07-29 沃泰克斯药物股份有限公司 药物组合物
ATE481089T1 (de) * 2006-05-31 2010-10-15 Vertex Pharma Orale formulierungen mit kontrollierter freisetzung eines interleukin-1-beta-converting- enzyme inhibitors

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CN103304571A (zh) * 2012-03-06 2013-09-18 上海昀怡健康管理咨询有限公司 螺环化合物、其制备方法、中间体、药物组合物和应用
CN103304571B (zh) * 2012-03-06 2018-02-16 凯惠科技发展(上海)有限公司 螺环化合物、其制备方法、中间体、药物组合物和应用
CN104718211A (zh) * 2012-08-08 2015-06-17 默沙东公司 Hcv ns3蛋白酶抑制剂
CN109563033A (zh) * 2016-06-21 2019-04-02 奥瑞恩眼科有限责任公司 脂族脯氨酰胺衍生物
CN109563033B (zh) * 2016-06-21 2023-04-04 奥瑞恩眼科有限责任公司 脂族脯氨酰胺衍生物
CN107954990A (zh) * 2017-11-14 2018-04-24 安徽诺全药业有限公司 一种雷迪帕维的制备方法

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EA200800670A1 (ru) 2009-12-30
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US20070179167A1 (en) 2007-08-02
BRPI0615223A2 (pt) 2009-07-14
KR20080041715A (ko) 2008-05-13
AR055395A1 (es) 2007-08-22
AU2006282771A1 (en) 2007-03-01
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