CN101309917B - 具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂 - Google Patents

具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂 Download PDF

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Publication number
CN101309917B
CN101309917B CN2006800426099A CN200680042609A CN101309917B CN 101309917 B CN101309917 B CN 101309917B CN 2006800426099 A CN2006800426099 A CN 2006800426099A CN 200680042609 A CN200680042609 A CN 200680042609A CN 101309917 B CN101309917 B CN 101309917B
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compound
enantiomorph
weight
mixture
deuterium
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Chinese (zh)
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CN101309917A (zh
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托马斯·甘特
赛博·萨莎
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Auspex Pharmaceuticals Inc
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Auspex Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN2006800426099A 2005-10-06 2006-10-04 具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂 Active CN101309917B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72416005P 2005-10-06 2005-10-06
US60/724,160 2005-10-06
US74131605P 2005-12-01 2005-12-01
US60/741,316 2005-12-01
PCT/US2006/038819 WO2007041630A1 (en) 2005-10-06 2006-10-04 Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties

Publications (2)

Publication Number Publication Date
CN101309917A CN101309917A (zh) 2008-11-19
CN101309917B true CN101309917B (zh) 2013-09-11

Family

ID=37603090

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800426099A Active CN101309917B (zh) 2005-10-06 2006-10-04 具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂

Country Status (9)

Country Link
US (3) US7598273B2 (https=)
EP (1) EP1934201A1 (https=)
JP (1) JP2009511481A (https=)
CN (1) CN101309917B (https=)
AU (1) AU2006299424A1 (https=)
BR (1) BRPI0617987A2 (https=)
CA (1) CA2624179A1 (https=)
IL (1) IL190331A0 (https=)
WO (1) WO2007041630A1 (https=)

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