JP2009517480A5 - - Google Patents
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- Publication number
- JP2009517480A5 JP2009517480A5 JP2008543418A JP2008543418A JP2009517480A5 JP 2009517480 A5 JP2009517480 A5 JP 2009517480A5 JP 2008543418 A JP2008543418 A JP 2008543418A JP 2008543418 A JP2008543418 A JP 2008543418A JP 2009517480 A5 JP2009517480 A5 JP 2009517480A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- enantiomer
- group
- compounds
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74131505P | 2005-12-01 | 2005-12-01 | |
| US60/741,315 | 2005-12-01 | ||
| US84136606P | 2006-08-30 | 2006-08-30 | |
| US60/841,366 | 2006-08-30 | ||
| PCT/US2006/045673 WO2007064697A1 (en) | 2005-12-01 | 2006-11-30 | Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009517480A JP2009517480A (ja) | 2009-04-30 |
| JP2009517480A5 true JP2009517480A5 (https=) | 2013-01-17 |
| JP5302005B2 JP5302005B2 (ja) | 2013-10-02 |
Family
ID=37776574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008543418A Expired - Fee Related JP5302005B2 (ja) | 2005-12-01 | 2006-11-30 | セロトニン作動性および/またはノルエピネフリン作動性の活性を有する置換フェネチルアミン |
Country Status (18)
| Country | Link |
|---|---|
| US (9) | US7456317B2 (https=) |
| EP (2) | EP2998288B1 (https=) |
| JP (1) | JP5302005B2 (https=) |
| KR (1) | KR101068180B1 (https=) |
| AU (1) | AU2006320655A1 (https=) |
| BR (1) | BRPI0620587A2 (https=) |
| CA (1) | CA2631581C (https=) |
| DK (1) | DK1954669T3 (https=) |
| EA (1) | EA200801488A1 (https=) |
| ES (1) | ES2549079T3 (https=) |
| HU (1) | HUE027865T2 (https=) |
| IL (1) | IL191847A0 (https=) |
| MA (1) | MA30088B1 (https=) |
| NZ (1) | NZ568720A (https=) |
| PL (1) | PL1954669T3 (https=) |
| PT (1) | PT1954669E (https=) |
| SI (1) | SI1954669T1 (https=) |
| WO (1) | WO2007064697A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100076087A1 (en) * | 2005-10-06 | 2010-03-25 | Auspex Pharmaceuticals, Inc. | Methods of reduction of interpatient variability |
| HUE027865T2 (en) | 2005-12-01 | 2016-11-28 | Auspex Pharmaceuticals Inc | Substituted phenyl ethylamines with serotonergic and / or norepinephrine activity |
| US7968874B2 (en) * | 2006-08-31 | 2011-06-28 | Nippon Steel Chemical Co., Ltd. | Organic electroluminescent device material and organic electroluminescent device |
| WO2008140859A1 (en) * | 2007-03-15 | 2008-11-20 | Auspex Pharmaceuticals, Inc. | Deuterated venlafaxines and 0-desmetylvenlafaxines with serotoninergic and / or norepinephrinergic activity |
| WO2009032843A2 (en) * | 2007-09-06 | 2009-03-12 | Auspex Pharmaceuticals, Inc. | Deuterated ethambutols and their use |
| US20110053968A1 (en) | 2009-06-09 | 2011-03-03 | Auspex Pharmaceuticals, Inc. | Aminopyrimidine inhibitors of tyrosine kinase |
| WO2010147830A2 (en) | 2009-06-15 | 2010-12-23 | Auspex Pharmaceuticals, Inc. | Aminothiazole modulators of beta-3-adrenoreceptor |
| EP2483406A2 (en) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products |
| PL3135656T3 (pl) | 2011-06-20 | 2019-07-31 | H. Lundbeck A/S | Deuterowane 1-piperazyno-3-fenyloindany do leczenia schizofrenii |
| US10166183B2 (en) | 2014-02-07 | 2019-01-01 | Auspex Pharmaceuticals, Inc. | Pharmaceutical formulations |
| CN104059030B (zh) | 2014-05-30 | 2016-05-04 | 镇江圣安医药有限公司 | [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途 |
| WO2017079102A1 (en) | 2015-11-03 | 2017-05-11 | Albert Einstein College Of Medicine, Inc. | Use of 13c derivatization reagents for gas or liquid chromatography-mass spectroscopy chemical identification and quantification |
| EP3891134A1 (en) | 2018-12-03 | 2021-10-13 | H. Lundbeck A/S | Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine |
| KR20240096817A (ko) | 2020-05-19 | 2024-06-26 | 사이빈 아이알엘 리미티드 | 중수소화된 트립타민 유도체 및 사용 방법 |
| CN120917022A (zh) | 2023-03-23 | 2025-11-07 | 葛兰素史密斯克莱知识产权(第3号)有限公司 | 氘代p2x3调节剂 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069346A (en) | 1977-02-14 | 1978-01-17 | The Dow Chemical Company | Compositions and methods for anesthetizing an animal using deuterated analogues of halothane and chloroform |
| US4535186A (en) | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
| IE56324B1 (en) * | 1982-12-13 | 1991-06-19 | American Home Prod | Phenethylamine derivatives and intermediates therefor |
| SE9002043D0 (sv) | 1990-06-07 | 1990-06-07 | Astra Ab | Improved method for synthesis |
| US6440457B1 (en) | 1993-05-27 | 2002-08-27 | Alza Corporation | Method of administering antidepressant dosage form |
| PT639374E (pt) | 1993-06-28 | 2002-07-31 | American Home Prod | Novos tratamentos utilizado derivados fenetilo |
| TW344661B (en) | 1993-11-24 | 1998-11-11 | Lilly Co Eli | Pharmaceutical composition for treatment of incontinence |
| CN1087725C (zh) | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US6274171B1 (en) | 1996-03-25 | 2001-08-14 | American Home Products Corporation | Extended release formulation of venlafaxine hydrochloride |
| US20030215507A1 (en) * | 1996-03-25 | 2003-11-20 | Wyeth | Extended release formulation |
| US6884429B2 (en) | 1997-09-05 | 2005-04-26 | Isotechnika International Inc. | Medical devices incorporating deuterated rapamycin for controlled delivery thereof |
| US6342507B1 (en) | 1997-09-05 | 2002-01-29 | Isotechnika, Inc. | Deuterated rapamycin compounds, method and uses thereof |
| EP0991660B8 (en) | 1997-10-08 | 2006-04-05 | Isotechnika,Inc. | DEUTERATED and undeuterated CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS |
| US6579899B1 (en) | 1998-07-16 | 2003-06-17 | Massachusetts Institute Of Technology | Composition for treatment of stress |
| US6333342B1 (en) | 1998-11-04 | 2001-12-25 | Isotechnika, Inc | Methods of pharmacological treatment using S(−) amlodipine |
| US6197828B1 (en) * | 1998-12-01 | 2001-03-06 | Sepracor, Inc. | Derivatives of (+)-venlafaxine and methods of preparing and using the same |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| US6071918A (en) * | 1999-07-21 | 2000-06-06 | Dupont Pharmaceuticals Company | Combination of an opioid antagonist and a selective serotonin reuptake inhibitor for treatment of alcoholism and alcohol dependence |
| WO2001012175A1 (en) | 1999-08-13 | 2001-02-22 | Vela Pharmaceuticals Inc. | Uses compositions for treating or preventing sleep disturbances using very low doses of cyclobenzaprine |
| US20050233459A1 (en) * | 2003-11-26 | 2005-10-20 | Melker Richard J | Marker detection method and apparatus to monitor drug compliance |
| PT1104760E (pt) * | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| EP1134290A3 (en) * | 2000-03-14 | 2004-01-02 | Pfizer Products Inc. | Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors |
| US20020183553A1 (en) * | 2000-10-19 | 2002-12-05 | Ben-Zion Dolitzky | Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof |
| US20050054942A1 (en) | 2002-01-22 | 2005-03-10 | Melker Richard J. | System and method for therapeutic drug monitoring |
| EP1864967A1 (en) * | 2001-02-12 | 2007-12-12 | Wyeth | Method for preparing O-desmethyl-venlafaxine |
| AU2002303427A1 (en) | 2001-04-24 | 2002-11-05 | East Carolina University | Compositions and formulations with a non-glucocorticoid steroid and/or a ubiquinone and kit for treatment of respiratory and lung disease |
| IL146462A (en) | 2001-11-13 | 2015-02-26 | Lycored Bio Ltd | Prolonged-release preparations containing as an active compound and analapaxin hydrochloride |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| EP1729754B1 (en) | 2003-12-12 | 2008-07-02 | Eli Lilly And Company | Selective norepinephrine reuptake inhibitors for the treatment of hot flashes |
| US20050181071A1 (en) | 2004-02-18 | 2005-08-18 | Binder Michael R. | Method for the treatment of clinical depression |
| PT1735296E (pt) * | 2004-04-08 | 2010-02-09 | Aryx Therapeutics | Materiais e métodos para tratamento de distúrbios da coagulação |
| US20050261278A1 (en) | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
| CA2580694A1 (en) | 2004-09-23 | 2006-03-30 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| US20060135443A1 (en) | 2004-10-18 | 2006-06-22 | Bionaut Pharmaceuticals, Inc. | Use of Na*/K*-ATPase inhibitors and antagonists thereof |
| US20080033011A1 (en) * | 2005-07-29 | 2008-02-07 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
| US20100076087A1 (en) | 2005-10-06 | 2010-03-25 | Auspex Pharmaceuticals, Inc. | Methods of reduction of interpatient variability |
| EP1948248A2 (en) * | 2005-11-06 | 2008-07-30 | Katz-Brull, Rachel | Magnetic resonance imaging and spectroscopy means and methods thereof |
| HUE027865T2 (en) * | 2005-12-01 | 2016-11-28 | Auspex Pharmaceuticals Inc | Substituted phenyl ethylamines with serotonergic and / or norepinephrine activity |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| US20090312435A1 (en) * | 2006-08-30 | 2009-12-17 | Auspex Pharmaceuticals, Inc | Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity |
| WO2008140859A1 (en) * | 2007-03-15 | 2008-11-20 | Auspex Pharmaceuticals, Inc. | Deuterated venlafaxines and 0-desmetylvenlafaxines with serotoninergic and / or norepinephrinergic activity |
| WO2008141033A1 (en) | 2007-05-08 | 2008-11-20 | Auspex Pharmaceuticals Inc. | Substituted naphthalenes |
| US20090028873A1 (en) * | 2007-07-27 | 2009-01-29 | Auspex Pharmaceuticals, Inc. | Substituted cyclohexanols |
| US20090069431A1 (en) * | 2007-09-12 | 2009-03-12 | Protia, Llc | Deuterium-enriched milnacipran |
| US20090076162A1 (en) * | 2007-09-17 | 2009-03-19 | Protia, Llc | Deuterium-enriched desvenlafaxine |
| US20100007087A1 (en) * | 2008-07-09 | 2010-01-14 | John Michael Pryke | Six fold game board and method of folding game board |
| WO2010028130A2 (en) | 2008-09-03 | 2010-03-11 | Concert Pharmaceuticals, Inc. | Antidepressant compounds |
-
2006
- 2006-11-30 HU HUE06844628A patent/HUE027865T2/en unknown
- 2006-11-30 NZ NZ568720A patent/NZ568720A/en not_active IP Right Cessation
- 2006-11-30 DK DK06844628.5T patent/DK1954669T3/en active
- 2006-11-30 EA EA200801488A patent/EA200801488A1/ru unknown
- 2006-11-30 EP EP15175770.5A patent/EP2998288B1/en not_active Not-in-force
- 2006-11-30 US US11/565,451 patent/US7456317B2/en active Active
- 2006-11-30 CA CA2631581A patent/CA2631581C/en active Active
- 2006-11-30 EP EP06844628.5A patent/EP1954669B1/en active Active
- 2006-11-30 KR KR1020087015962A patent/KR101068180B1/ko not_active Expired - Fee Related
- 2006-11-30 PL PL06844628T patent/PL1954669T3/pl unknown
- 2006-11-30 ES ES06844628.5T patent/ES2549079T3/es active Active
- 2006-11-30 AU AU2006320655A patent/AU2006320655A1/en not_active Abandoned
- 2006-11-30 PT PT68446285T patent/PT1954669E/pt unknown
- 2006-11-30 WO PCT/US2006/045673 patent/WO2007064697A1/en not_active Ceased
- 2006-11-30 SI SI200631981T patent/SI1954669T1/sl unknown
- 2006-11-30 JP JP2008543418A patent/JP5302005B2/ja not_active Expired - Fee Related
- 2006-11-30 BR BRPI0620587-9A patent/BRPI0620587A2/pt not_active IP Right Cessation
-
2008
- 2008-05-29 IL IL191847A patent/IL191847A0/en unknown
- 2008-06-26 MA MA31078A patent/MA30088B1/fr unknown
- 2008-09-19 US US12/234,236 patent/US9422225B2/en active Active
- 2008-09-19 US US12/234,318 patent/US8138226B2/en active Active
-
2014
- 2014-06-17 US US14/306,396 patent/US9458082B2/en active Active
-
2016
- 2016-07-08 US US15/205,491 patent/US20160318847A1/en not_active Abandoned
- 2016-08-23 US US15/244,575 patent/US20160361275A1/en not_active Abandoned
-
2017
- 2017-05-17 US US15/597,516 patent/US20180085327A1/en not_active Abandoned
-
2018
- 2018-05-09 US US15/975,570 patent/US20180256517A1/en not_active Abandoned
-
2019
- 2019-03-04 US US16/291,126 patent/US20200060995A1/en not_active Abandoned
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