CN101248192A - 皮肤老化标记物及其利用技术 - Google Patents
皮肤老化标记物及其利用技术 Download PDFInfo
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- CN101248192A CN101248192A CNA2006800310618A CN200680031061A CN101248192A CN 101248192 A CN101248192 A CN 101248192A CN A2006800310618 A CNA2006800310618 A CN A2006800310618A CN 200680031061 A CN200680031061 A CN 200680031061A CN 101248192 A CN101248192 A CN 101248192A
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Abstract
Description
斑点编号 | MW(kDa)/pl | 经鉴定的蛋白质 |
7912,22,22121,23,219,220,222206,207208209210,211212213214217218223226227228229230 | 15/8.013/8.218/7.212/7.245/7.241/7.539/7.5541/7.230/6.728/6.829/6.628/5.425/5.133/8.031/4.830/4.314/7.314/5.212/5.0 | 妊娠特异性β-1糖蛋白2前纤维蛋白 *胱抑素Mβ-2微球蛋白 *纤溶酶原激活剂抑制剂-1(PAI-1) *烯醇化酶-1天冬氨酸氨基转移酶 *鳞状细胞癌抗原1(SCCA 1)磷酸甘油酸变位酶1Peroxiredotoxin6 *异戊烯基焦磷酸(IPP)异构酶1(IPP 1) *ER-localized typel transmembrane adaptor precursor *谷胱甘肽硫-转移酶整合素偶联激酶(ILK) *激肽释放酶7 *Rho GDP解离抑制因子(Rho-GDI)凝血酶敏感蛋白1 *T细胞抗原受体a *胱抑素A |
斑点编号 | Mr kDa/pl | 经鉴定的蛋白质 |
182431323335363942,59516264,686780869094100105125,128,129,241136140143145152160161163168172176,178 | 10/7.413/5.714/4.123/8.624/8.424/8.229/8.636/9.026/7.322/7.123/5.626/5.329/4.826/6.130/6.332/5.734/4.520/3.040/4.834/8.238/6.334/6.844/8.341/8.345/5.553/4.848/4.350/4.265/7.659/7.554/7.5 | 磷酸甘油酸变位酶1脂肪酸结合蛋白5(FABP 5)肌动蛋白相关蛋白2/3复合体5 *蛋白酶体亚基b5 *过氧化物酶1 *蛋白酶体亚基b1 *蛋白酶体亚基a7 *线粒体脱氢酶 *磷酸丙糖异构化酶(Tim)锰超氧化物岐化酶蛋白酶体亚基b3 *热休克蛋27(HSP 27)蛋白酶体亚基b7 *蛋白酶体亚基a6 *嘌呤核苷磷酸化酶δ3,5-δ2,4-二烯酰辅酶A *L-乳酸脱氢酶B *Similar to tubulin b5 *Maspin膜连蛋白A2膜连蛋白I胞质苹果酸脱氢酶 *磷酸甘油酸激酶1果糖-二磷酸醛缩酶A *腺苷高半胱氨酸酶 *胞质非特异二肽酶 *肌动蛋白相关蛋白3 *谷胱甘肽合成酶 *转酮酶 *丙酮酸激酶,M1同工酶 *尿苷三磷酸-葡萄糖-1-磷酸尿苷转移酶2 * |
177183184185186187188,235189191193195196197199200,201204239242 | 56/7.496/6.872/5.976/5.860/3.662/3.470/3.685/4.855/3.177/3.695/3.4100/4.5110/3.6115/4.266/5.2150/3.337/5.228/3.8 | 腺苷酸环化酶相关蛋白1(CAP 1) *延伸因子2 *膜突蛋白 *埃兹蛋白泛素羧基末端水解酶14 *角蛋白9 *热休克蛋白70(HSP 70)凝溶胶蛋白微管蛋白a6酰基氨基酸释放酶 *过渡型内质网腺苷三磷酸酶 *辅肌动蛋白,a1 *穹隆体主蛋白 *Vinculin isoform VCL *角蛋白1 *白三烯A4水解酶 *60S酸性核糖体蛋白P0 *胱冬肽酶14 * |
蛋白质的分类 | 蛋白质名 | 表达变化(第五代/第二代) | |
CM | CL | ||
蛋白酶蛋白酶抑制剂 | 激肽释放酶7纤溶酶原激活剂抑制剂-1尿激酶型纤溶酶原激活物蛋白裂解酶 | ↓(0.1)↓(0.1)↓(0.1)↓(0.4) | NDND↓(0.3)↓(0.2) |
HSP | 葡萄糖调节蛋白94热休克蛋白70热休克蛋白90 | ↑(22.0)↑(12.4)↑(19.2) | →→→ |
半乳糖凝集素 | 半乳糖凝集素-1半乳糖凝集素-3 | ↑(20.0)↑(2.2) | NDND |
半乳糖凝集素-7胰岛素生长因子结合蛋白-3 | ↑(7.9)↑(3.4) | NDND | |
细胞骨架 | 烯醇化酶-1膜连蛋白II埃兹蛋白/膜突蛋白/根蛋白凝溶胶蛋白 | ↑(6.1)↑(12.6)↑(10.6)→ | →→↑(2.3) |
角蛋白 | 角蛋白3角蛋白5角蛋白7角蛋白8角蛋白10角蛋白13角蛋白14角蛋白15角蛋白16角蛋白17角蛋白18角蛋白19角蛋白20 | NDNDNDNDNDNDNDNDNDNDNDNDND | →→↓(0.2)↑(4.0)↑(3.1)↑(2.4)↑(5.0)↑(2.4)→↑(3.1)↑(2.0)↑(2.2) |
其他 | β2-微球蛋白 | ↑[*] | ↑(3.5) |
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WO2007023808A1 (ja) | 2007-03-01 |
JP2012189602A (ja) | 2012-10-04 |
JP2014149299A (ja) | 2014-08-21 |
JPWO2007023808A1 (ja) | 2009-02-26 |
KR101318521B1 (ko) | 2013-10-16 |
JP2013174608A (ja) | 2013-09-05 |
US20090305242A1 (en) | 2009-12-10 |
JP5596742B2 (ja) | 2014-09-24 |
CN101248192B (zh) | 2013-02-20 |
JP5362219B2 (ja) | 2013-12-11 |
KR20080057233A (ko) | 2008-06-24 |
JP5663054B2 (ja) | 2015-02-04 |
HK1114883A1 (en) | 2008-11-14 |
US7972788B2 (en) | 2011-07-05 |
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