CN101223157B - 合成杂环化合物的方法 - Google Patents

合成杂环化合物的方法 Download PDF

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Publication number
CN101223157B
CN101223157B CN2006800259861A CN200680025986A CN101223157B CN 101223157 B CN101223157 B CN 101223157B CN 2006800259861 A CN2006800259861 A CN 2006800259861A CN 200680025986 A CN200680025986 A CN 200680025986A CN 101223157 B CN101223157 B CN 101223157B
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compound
formula
approximately
solvent
unsubstituted
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Expired - Fee Related
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English (en)
Chinese (zh)
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CN101223157A (zh
Inventor
G·卡尔文
E·哈尔渥德
D·里克曼
S·朱
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN2006800259861A 2005-05-17 2006-05-17 合成杂环化合物的方法 Expired - Fee Related CN101223157B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68189305P 2005-05-17 2005-05-17
US60/681,893 2005-05-17
PCT/US2006/019349 WO2006125130A1 (en) 2005-05-17 2006-05-17 Methods for synthesizing heterocyclic compounds

Publications (2)

Publication Number Publication Date
CN101223157A CN101223157A (zh) 2008-07-16
CN101223157B true CN101223157B (zh) 2013-03-06

Family

ID=37431595

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800259861A Expired - Fee Related CN101223157B (zh) 2005-05-17 2006-05-17 合成杂环化合物的方法

Country Status (15)

Country Link
US (1) US8222413B2 (https=)
EP (2) EP1888556B1 (https=)
JP (2) JP5545925B2 (https=)
KR (1) KR101324863B1 (https=)
CN (1) CN101223157B (https=)
AT (1) ATE530533T1 (https=)
AU (1) AU2006247062A1 (https=)
BR (1) BRPI0610355A2 (https=)
CA (1) CA2608087C (https=)
ES (1) ES2376347T3 (https=)
MX (1) MX2007014381A (https=)
PL (1) PL1888556T3 (https=)
PT (1) PT1888556E (https=)
RU (1) RU2437878C2 (https=)
WO (1) WO2006125130A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5545925B2 (ja) * 2005-05-17 2014-07-09 ノバルティス アーゲー ヘテロ環化合物の合成方法
JP5541454B2 (ja) * 2009-09-16 2014-07-09 Ｊｓｒ株式会社 液晶配向剤および液晶表示素子
KR102087662B1 (ko) 2018-06-20 2020-03-11 강원대학교산학협력단 4-[[4-[3-(사이클로프로필메톡시)-4-(디플루오로메톡시)페닐]-2-티아졸릴]아미노]페놀 화합물을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물
KR102087661B1 (ko) 2018-07-27 2020-03-11 강원대학교산학협력단 Ｇｅｂｒ―７ｂ 화합물을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020165218A1 (en) * 2000-09-01 2002-11-07 James Halbrook Materials and methods to potentiate cancer treatment

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Also Published As

Publication number Publication date
BRPI0610355A2 (pt) 2010-06-15
EP2465857B1 (en) 2014-06-04
JP2014012682A (ja) 2014-01-23
EP1888556A4 (en) 2009-12-02
MX2007014381A (es) 2008-02-06
JP2008540675A (ja) 2008-11-20
EP1888556B1 (en) 2011-10-26
CN101223157A (zh) 2008-07-16
KR101324863B1 (ko) 2013-11-01
ATE530533T1 (de) 2011-11-15
EP2465857A1 (en) 2012-06-20
KR20080026106A (ko) 2008-03-24
WO2006125130A1 (en) 2006-11-23
EP1888556A1 (en) 2008-02-20
RU2007146394A (ru) 2009-06-27
PL1888556T3 (pl) 2012-03-30
US8222413B2 (en) 2012-07-17
AU2006247062A1 (en) 2006-11-23
PT1888556E (pt) 2012-02-03
CA2608087A1 (en) 2006-11-23
JP5545925B2 (ja) 2014-07-09
US20110046376A1 (en) 2011-02-24
ES2376347T3 (es) 2012-03-13
CA2608087C (en) 2013-12-10
RU2437878C2 (ru) 2011-12-27

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