ATE530533T1 - Verfahren zur synthese heterocyclischer verbindungen - Google Patents
Verfahren zur synthese heterocyclischer verbindungenInfo
- Publication number
- ATE530533T1 ATE530533T1 AT06760144T AT06760144T ATE530533T1 AT E530533 T1 ATE530533 T1 AT E530533T1 AT 06760144 T AT06760144 T AT 06760144T AT 06760144 T AT06760144 T AT 06760144T AT E530533 T1 ATE530533 T1 AT E530533T1
- Authority
- AT
- Austria
- Prior art keywords
- solvent
- synthesis
- heterocyclic compounds
- nitroaniline
- methylpiperazine
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000002904 solvent Substances 0.000 abstract 3
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 abstract 2
- ZCWXYZBQDNFULS-UHFFFAOYSA-N 5-chloro-2-nitroaniline Chemical compound NC1=CC(Cl)=CC=C1[N+]([O-])=O ZCWXYZBQDNFULS-UHFFFAOYSA-N 0.000 abstract 2
- 238000009835 boiling Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68189305P | 2005-05-17 | 2005-05-17 | |
| PCT/US2006/019349 WO2006125130A1 (en) | 2005-05-17 | 2006-05-17 | Methods for synthesizing heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE530533T1 true ATE530533T1 (de) | 2011-11-15 |
Family
ID=37431595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06760144T ATE530533T1 (de) | 2005-05-17 | 2006-05-17 | Verfahren zur synthese heterocyclischer verbindungen |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8222413B2 (https=) |
| EP (2) | EP2465857B1 (https=) |
| JP (2) | JP5545925B2 (https=) |
| KR (1) | KR101324863B1 (https=) |
| CN (1) | CN101223157B (https=) |
| AT (1) | ATE530533T1 (https=) |
| AU (1) | AU2006247062A1 (https=) |
| BR (1) | BRPI0610355A2 (https=) |
| CA (1) | CA2608087C (https=) |
| ES (1) | ES2376347T3 (https=) |
| MX (1) | MX2007014381A (https=) |
| PL (1) | PL1888556T3 (https=) |
| PT (1) | PT1888556E (https=) |
| RU (1) | RU2437878C2 (https=) |
| WO (1) | WO2006125130A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2465857B1 (en) * | 2005-05-17 | 2014-06-04 | Novartis AG | Methods for synthesizing heterocyclic compounds |
| JP5541454B2 (ja) * | 2009-09-16 | 2014-07-09 | Ｊｓｒ株式会社 | 液晶配向剤および液晶表示素子 |
| KR102087662B1 (ko) | 2018-06-20 | 2020-03-11 | 강원대학교산학협력단 | 4-[[4-[3-(사이클로프로필메톡시)-4-(디플루오로메톡시)페닐]-2-티아졸릴]아미노]페놀 화합물을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물 |
| KR102087661B1 (ko) | 2018-07-27 | 2020-03-11 | 강원대학교산학협력단 | Ｇｅｂｒ―７ｂ 화합물을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물 |
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| DE3248043A1 (de) | 1982-12-24 | 1984-06-28 | Bayer Ag, 5090 Leverkusen | Fluorogene phosphorsaeureester, verfahren zu deren herstellung sowie verfahren und mittel zum nachweis und zur fluorometrischen bestimmung von phosphaten |
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| GB8709448D0 (en) | 1987-04-21 | 1987-05-28 | Pfizer Ltd | Heterobicyclic quinoline derivatives |
| DE3932953A1 (de) | 1989-10-03 | 1991-04-11 | Boehringer Mannheim Gmbh | Neue 2-bicyclo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| GB9107742D0 (en) | 1991-04-11 | 1991-05-29 | Rhone Poulenc Agriculture | New compositions of matter |
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| SG64322A1 (en) | 1991-05-10 | 1999-04-27 | Rhone Poulenc Rorer Int | Bis mono and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase |
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| WO2004087153A2 (en) | 2003-03-28 | 2004-10-14 | Chiron Corporation | Use of organic compounds for immunopotentiation |
| US20050209247A1 (en) * | 2003-11-07 | 2005-09-22 | Chiron Corporation | Pharmaceutically acceptable salts of quinolinone compounds having improved pharmaceutical properties |
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| EP2465857B1 (en) * | 2005-05-17 | 2014-06-04 | Novartis AG | Methods for synthesizing heterocyclic compounds |
-
2006
- 2006-05-17 EP EP11186414.6A patent/EP2465857B1/en active Active
- 2006-05-17 PL PL06760144T patent/PL1888556T3/pl unknown
- 2006-05-17 CN CN2006800259861A patent/CN101223157B/zh not_active Expired - Fee Related
- 2006-05-17 KR KR1020077029274A patent/KR101324863B1/ko not_active Expired - Fee Related
- 2006-05-17 ES ES06760144T patent/ES2376347T3/es active Active
- 2006-05-17 CA CA2608087A patent/CA2608087C/en not_active Expired - Fee Related
- 2006-05-17 MX MX2007014381A patent/MX2007014381A/es active IP Right Grant
- 2006-05-17 PT PT06760144T patent/PT1888556E/pt unknown
- 2006-05-17 EP EP06760144A patent/EP1888556B1/en active Active
- 2006-05-17 JP JP2008512523A patent/JP5545925B2/ja not_active Expired - Fee Related
- 2006-05-17 BR BRPI0610355-3A patent/BRPI0610355A2/pt not_active IP Right Cessation
- 2006-05-17 US US11/920,078 patent/US8222413B2/en not_active Expired - Fee Related
- 2006-05-17 AT AT06760144T patent/ATE530533T1/de active
- 2006-05-17 AU AU2006247062A patent/AU2006247062A1/en not_active Abandoned
- 2006-05-17 RU RU2007146394/04A patent/RU2437878C2/ru not_active IP Right Cessation
- 2006-05-17 WO PCT/US2006/019349 patent/WO2006125130A1/en not_active Ceased
-
2013
- 2013-08-08 JP JP2013164660A patent/JP2014012682A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008540675A (ja) | 2008-11-20 |
| PT1888556E (pt) | 2012-02-03 |
| US8222413B2 (en) | 2012-07-17 |
| EP1888556A4 (en) | 2009-12-02 |
| EP1888556A1 (en) | 2008-02-20 |
| RU2007146394A (ru) | 2009-06-27 |
| BRPI0610355A2 (pt) | 2010-06-15 |
| ES2376347T3 (es) | 2012-03-13 |
| EP2465857B1 (en) | 2014-06-04 |
| CA2608087C (en) | 2013-12-10 |
| EP2465857A1 (en) | 2012-06-20 |
| AU2006247062A1 (en) | 2006-11-23 |
| CN101223157A (zh) | 2008-07-16 |
| JP5545925B2 (ja) | 2014-07-09 |
| MX2007014381A (es) | 2008-02-06 |
| CN101223157B (zh) | 2013-03-06 |
| US20110046376A1 (en) | 2011-02-24 |
| WO2006125130A1 (en) | 2006-11-23 |
| JP2014012682A (ja) | 2014-01-23 |
| PL1888556T3 (pl) | 2012-03-30 |
| KR20080026106A (ko) | 2008-03-24 |
| EP1888556B1 (en) | 2011-10-26 |
| KR101324863B1 (ko) | 2013-11-01 |
| CA2608087A1 (en) | 2006-11-23 |
| RU2437878C2 (ru) | 2011-12-27 |
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