CA2608087C - Methods for synthesizing heterocyclic compounds - Google Patents

Methods for synthesizing heterocyclic compounds Download PDF

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Publication number
CA2608087C
CA2608087C CA2608087A CA2608087A CA2608087C CA 2608087 C CA2608087 C CA 2608087C CA 2608087 A CA2608087 A CA 2608087A CA 2608087 A CA2608087 A CA 2608087A CA 2608087 C CA2608087 C CA 2608087C
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CA
Canada
Prior art keywords
compound
solvent
reaction
groups
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2608087A
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English (en)
French (fr)
Other versions
CA2608087A1 (en
Inventor
Gabriel Calvin
Eric Harwood
David Ryckman
Shuguang Zhu
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Novartis AG
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Novartis AG
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Publication of CA2608087A1 publication Critical patent/CA2608087A1/en
Application granted granted Critical
Publication of CA2608087C publication Critical patent/CA2608087C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA2608087A 2005-05-17 2006-05-17 Methods for synthesizing heterocyclic compounds Expired - Fee Related CA2608087C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68189305P 2005-05-17 2005-05-17
US60/681,893 2005-05-17
PCT/US2006/019349 WO2006125130A1 (en) 2005-05-17 2006-05-17 Methods for synthesizing heterocyclic compounds

Publications (2)

Publication Number Publication Date
CA2608087A1 CA2608087A1 (en) 2006-11-23
CA2608087C true CA2608087C (en) 2013-12-10

Family

ID=37431595

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2608087A Expired - Fee Related CA2608087C (en) 2005-05-17 2006-05-17 Methods for synthesizing heterocyclic compounds

Country Status (15)

Country Link
US (1) US8222413B2 (https=)
EP (2) EP2465857B1 (https=)
JP (2) JP5545925B2 (https=)
KR (1) KR101324863B1 (https=)
CN (1) CN101223157B (https=)
AT (1) ATE530533T1 (https=)
AU (1) AU2006247062A1 (https=)
BR (1) BRPI0610355A2 (https=)
CA (1) CA2608087C (https=)
ES (1) ES2376347T3 (https=)
MX (1) MX2007014381A (https=)
PL (1) PL1888556T3 (https=)
PT (1) PT1888556E (https=)
RU (1) RU2437878C2 (https=)
WO (1) WO2006125130A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2465857B1 (en) * 2005-05-17 2014-06-04 Novartis AG Methods for synthesizing heterocyclic compounds
JP5541454B2 (ja) * 2009-09-16 2014-07-09 Ｊｓｒ株式会社 液晶配向剤および液晶表示素子
KR102087662B1 (ko) 2018-06-20 2020-03-11 강원대학교산학협력단 4-[[4-[3-(사이클로프로필메톡시)-4-(디플루오로메톡시)페닐]-2-티아졸릴]아미노]페놀 화합물을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물
KR102087661B1 (ko) 2018-07-27 2020-03-11 강원대학교산학협력단 Ｇｅｂｒ―７ｂ 화합물을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물

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Also Published As

Publication number Publication date
JP2008540675A (ja) 2008-11-20
PT1888556E (pt) 2012-02-03
US8222413B2 (en) 2012-07-17
EP1888556A4 (en) 2009-12-02
EP1888556A1 (en) 2008-02-20
RU2007146394A (ru) 2009-06-27
BRPI0610355A2 (pt) 2010-06-15
ES2376347T3 (es) 2012-03-13
EP2465857B1 (en) 2014-06-04
EP2465857A1 (en) 2012-06-20
AU2006247062A1 (en) 2006-11-23
CN101223157A (zh) 2008-07-16
JP5545925B2 (ja) 2014-07-09
MX2007014381A (es) 2008-02-06
CN101223157B (zh) 2013-03-06
US20110046376A1 (en) 2011-02-24
ATE530533T1 (de) 2011-11-15
WO2006125130A1 (en) 2006-11-23
JP2014012682A (ja) 2014-01-23
PL1888556T3 (pl) 2012-03-30
KR20080026106A (ko) 2008-03-24
EP1888556B1 (en) 2011-10-26
KR101324863B1 (ko) 2013-11-01
CA2608087A1 (en) 2006-11-23
RU2437878C2 (ru) 2011-12-27

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